• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2006년도 춘계학술대회
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• pp.294-300
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• 2006

This case study shows constructing the knowledge-based system using a rule-based approach for detecting transactions regarding money laundering in the Korea Financial Intelligence Unit (KoFIU). To better manage the explosive increment of low risk suspicious transactions reporting from financial institutions and to conjugate data converged into the KoFIU from various organizations, the adoption of a knowledge-based system is definitely required. We designed and constructed the knowledge-based system for anti-money laundering by committing experts of each specific financial industry co-worked with a knowledge engineer. The outcome of the knowledge base implementation shows that the knowledge-based system is filtering STRs in the primary analysis step efficiently and so has made great contribution to improve efficiency and effectiveness of the analysis process. It can be said that establishing the foundation of the knowledge base under the entire framework of the knowledge-based system for consideration of knowledge creation and management is indeed valuable.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3615-3617
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• 2016

Background: Breast cancer molecular analysis by linkage analysis has the advantage of facilitating early diagnosis in asymptomatic genetic carriers, with a view to the preventive follow-up of these subjects and genetic counseling. The aim of this study was to evaluate BRCA1 gene D17S855 and D17S1322 markers in breast cancer patients. Materials and Methods: A series of 85 BC patients and 85 unrelated healthy women were recruited for haplotype analysis performed using two short tandem repeat markers located within the BRCA1 gene locus. Each marker was amplified with PCR genomic DNA from each individual and fluorescently end-labeled primers. Results: Both D17S855 and D17S1322 markers included 12 kinds of alleles. Results indicate that most of the BC patients shared two common 121-150 (11.2%, RR=1.56 and p=0.02) and 121-146 (5.6%, RR=1.9 and p=0.02) haplotypes. Conclusions: Our results should be helpful to understand the haplotype phase in the BRCA1 gene and establish a genetic screening strategy in the Iranian population.

• 대한의생명과학회지
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• 제28권4호
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• pp.327-333
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• 2022

The DNA profiling of short tandem repeat (STR) markers is a powerful tool for forensic identification and forensic paternity testing. However, STR loci are susceptible to mutation that cause mismatches between parents and children when paternity is tested. Herein, we examined paternity disputes with 23 autosomal STR loci using two commercial human identification kits and revealed successive mismatches at the D13S317 locus across three generations of a Korean family. Additionally, we investigated 12 X-chromosomal STRs and discovered an inconsistency at the DXS10148 locus between the father and daughter of the same Korean family. Furthermore, we confirmed STR genotypes at the D13S317 and DXS10148 loci of the family using sequencing analysis. Consequently, we identified a successive single-step mutation at the D13S317 locus and one single-step mutation at the DXS10148 locus in three generations of the Korean family. Therefore, this case study may be useful for interpreting and understanding forensic paternity tests.

• 한국보육지원학회지
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• 제9권5호
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• pp.299-320
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• 2013

본 연구의 목적은 유치원 종일반 유아의 자아탄력성과 또래유능감 및 교사-유아 관계의 증진을 위한 집단치료놀이 프로그램을 개발하고 그 효과를 검증하는 것이다. 연구의 대상은 유아 14명이며 7명은 실험집단, 7명은 통제집단으로 나누어 실험집단 유아에게 매회 50분씩 10회기에 걸쳐 집단치료놀이 프로그램을 실시하였고 통제집단 유아에게는 아무런 처치를 하지 않았다. 집단치료놀이 실시 전과 후를 비교하고자 자아탄력성 척도, 또래유능감 척도, 교사-유아 관계 척도(STRS : Student-Teacher Relationship Scale)를 교사가 평정하였다. 자료분석은 각 집단별 사전-사후검사를 분류하여 채점한 후 맨휘트니(Mann-Whitney)검증과 윌콕슨(Wilcoxon)검증을 실시하였다. 집단치료놀이 프로그램 종료 후 실험집단 유아의 자아탄력성과 또래유능감은 유의미하게 향상되었고, 교사-유아 관계에서 친밀감이 유의미하게 증가하였다. 반면에 통제집단 유아에게는 아무런 변화도 나타나지 않았다.

• Animal Bioscience
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• 제35권4호
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• pp.527-532
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• 2022

Objective: In this study, we aimed to investigate the recent changes such as allele frequencies and total probability of exclusion (PE) in Thoroughbred horses in Korea using short tandem repeat (STR) parentage panels between 2006 and 2016. Methods: The genotype was provided for 5,988 horse samples with 15 microsatellite markers (AHT4, AHT5, ASB2, ASB17, ASB23, CA425, HMS1, HMS2, HMS3, HMS6, HMS7, HTG4, HTG10, LEX3 and VHL20). Results: In our study, the observed number of alleles per locus ranged from 3 (HMS1) to 9 (ASB17) in 2006 and 4 (HMS1) to 9 (ASB2) in 2016, with a mean value of 6.28 and 6.40, respectively. Of the 15 markers, HMS2, HTG4, and CA425 loci had relatively low polymorphism information content (<0.5000) in the Thoroughbred population. Mean levels of genetic variation in 2006 and 2016 were observed heterozygosity (H_O) = 0.708, and expected heterozygosity (H_E) = 0.685, as well as and H_O = 0.699 and H_E = 0.682, respectively. The PE was calculated for each group based on the allele frequencies of 14 or 15 STRs. The 2006 survey analyzed that PE was 0.9998, but it increased to 0.9999 in 2016 after the HMS2 marker was added in 2011. The current STR panel is still a powerful tool for parentage verification that contributes to the maintenance of integrity in the Thoroughbred population. Conclusion: The current STR panel is still a powerful tool for parentage verification that contributes to the maintenance of integrity in the Thoroughbred horses. However, continuous monitoring genetic variability is necessary.