• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.15
• /
• pp.6021-6024
• /
• 2014

Background: The STK15 gene located on chromosome 20q13.2 encodes a centrosome-associated kinase critical for regulated chromosome segregation and cytokinesis. Recent studies have demonstrated STK15 to be significantly associated with many tumors, with aberrant expression obseved in many human malignancies. The purpose of this study was to investigate expression of STK15 in esophageal squamous cell carcinomas (ESCCs) in a Mongolian population. Methods: Two non-synonymous single nucleotide polymorphisms in the coding region of STK15, rs2273535 (Phe31Ile) and rs1047972 (Val57Ile) were assessed in 380 ESCC patients and 380 healthy controls. We also detected STK15 mRNA expression in 39 esophageal squamous cell carcinomas and corresponding adjacent tissues by real time PCR. Results: rs2273535 showed a significant association with ESCC in our Mongolian population (rs227353, P allele = 0.0447, OR (95%CI) = 1.259 (1.005~1.578)). Real time PCR analysis of ESCC tissues showed that expression of STK15 mRNA in cancer tissues was higher than in normal tissues (p = 0.013). Conclusions: Our study showed that functional SNPs in the STK15 gene are associated with ESCC in a Mongolian population and up-regulation of STK15 mRNAoccurs in ESCC tumors compared adjacent normal tissues. STK15 may thus have an important role in the prognosis of ESCC and be a potential therapeutic target.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.2
• /
• pp.647-653
• /
• 2016

Background: Breast cancer is the most common type of cancer affecting Malaysian women. Recent statistics revealed that the cumulative probability of breast cancer and related deaths in Malaysia is higher than in most of the countries of Southeast Asia. Single nucleotide polymorphisms (SNPs) in CYP2E1 (rs6413432 and rs3813867), STK15 (rs2273535 and rs1047972) and XRCC1 (rs1799782 and rs25487) have been associated with breast cancer risk in a meta-analysis but any link in Southeast Asia, including Malaysia, remained to be determined. Hence, we investigated the relationship between these SNPs and breast cancer risk among Malaysian women in the present case-control study. Materials and Methods: Genomic DNA was isolated from peripheral blood of 71 breast cancer patients and 260 healthy controls and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Our study showed that the c1/c2 genotype or subjects with at least one c2 allele in CYP2E1 rs3813867 SNP had significantly increased almost 1.8-fold higher breast cancer risk in Malaysian women overall. In addition, the variant Phe allele in STK15 rs2273535 SNP appeared to protect against breast cancer in Malaysian Chinese. No significance association was found between XRCC1 SNPs and breast cancer risk in the population. Conclusions: This study provides additional knowledge on CYP2E1, STK15 and XRCC1 SNP impact of risk of breast cancer, particularly in the Malaysian population. From our findings, we also recommend Malaysian women to perform breast cancer screening before 50 years of age.

• Korean Journal of Materials Research
• /
• v.29 no.1
• /
• pp.30-36
• /
• 2019

We evaluate the properties of friction welded STK400 steel tube in terms of the relationship between microstructures and mechanical properties. Friction welding is conducted at a rotation speed of 1,600 rpm and upset time of 3-7 sec for different thicknesses of STK 400 tubes. To analyse the grain boundary characteristic distributions(GBCDs) in the welded zone, electron backscattering diffraction(EBSD) method is introduced. The results show that a decrease in welding time (3 sec.) creates a notable increase grain refinement so that the average grain size decreases from $15.1{\mu}m$ in the base material to $4.5{\mu}m$ in the welded zone. These refined grains achieve significantly enhanced microhardness and a slightly higher yield and higher tensile strengths than those of the base material. In particular, all the tensile tested specimens experience a fracture aspect at the base material zone but not at the welded zone, which means a soundly welded state for all conditions.

• Journal of the Korean Geosynthetics Society
• /
• v.15 no.4
• /
• pp.71-78
• /
• 2016

In this study, execution costs of the foundation system are compared with PHC and steel pile in the same soil layers and load condition. Steel piles installed on the thin weathered rock are reduced as 12.5% in comparison with the number of PHC piles. Steel piles installed on the soft rock through weathered rock with 1.7m of thickness reduce the number of piles as 35.7% (STK 400) and 46.4% (STK 490), respectively, in comparison with PHC piles installed on the weathered rock. Also, they reduce the number of piles as 26.5% (STK 400) and 38.8% (STK 490), respectively, in comparison with steel piles (STK 400) installed on the weathered rock. When the thickness of footings is constant, steel piles installed on the soft rock may reduce the area of footings up to 12.2% (STK 400) and 45.4% (STK 490), respectively, in comparison with PHC piles installed on the weathered rock. Total cost of foundation system installed on the soft rock with steel piles (STK 400) increases as 12%, whereas in case of replaced with steel piles (STK 490), it reduces as 16% in comparison with PHC piles installed on the weathered rock. This is because the cost reduction due to the number of piles and footing area is more effective despite high cost of steel piles (STK 490). When the thickness of weathered rock is less than 5m, installing steel piles (STK 490) on the soft rock through it is more economic in comparison with installing PHC piles on the weathered rock.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.4 no.3
• /
• pp.217-226
• /
• 2006

The structural and contamination characteristics of hot cells at KAERI were investigated. The SEM results showed that the size of the hot particulate on the inner surface of the hot cell ranged from 0.2 to $10{\mu}m$. It was found that an inlet flow rate of 15 m/sec was suitable for this developed cyclone with a 49 mm optimum vortex finder length. The results showed that the collection efficiency was about 85% for $3{\mu}m$ particles. The collection efficiency didn't show a sharp increase when the inlet flow rate was faster than 15m/sec. When the temperature of the inlet flow gas was increased, the collection efficiency of the cyclone was slightly decreased. The larger the vortex finder length was, the higher the pressure drop in the cyclone was. The cut size diameter decreased with an increment of the Reynolds number. It was established that the flow in the cyclone was a turbulent flow on the basis of the Reynolds number and this turbulent flow caused a pressure drop in the cyclone. $Stk^{1/2}_{50}$ decreased with increasing values of the Reynolds number and it gradually approached a constant value at a higher value of the Reynolds number Namely, $Stk^{1/2}_{50}$ approached approximately 0.045 between 6000 and 8000 of the Reynolds number.

• Proceedings of the KSRS Conference
• /
• 2008.03a
• /
• pp.63-66
• /
• 2008

2010년 5월에 발사 예정인 KOMPSAT-5(KOrea Multi-Purpose SATellite-5)는 KOMPSAT-1, 2호에 탑재된 광학센서와는 달리 기상상태와 태양고도에 제약을 받지 않고 자료 획득이 가능한 SAR 시스템이 탑재된다. 본 연구에서는 KOMPSAT-5의 SAR 시스템으로부터 radargrammetry 기법을 적용하기 위해 위성의 궤도와 영상 모드를 분석하였다. Radargrammetry 적용을 위한 SAR 영상 pair의 parallax의 height sensitivity를 이론상으로 계산하였다. 그리고 STK 소프트웨어를 사용하여 대전과 남극 세종기지에서의 최적 조건을 각각 예시하였다. 입사각이 20$^{\cric}$-45$^{\cric}$가 되는 nominal mode의 descending pass만을 사용하여 height sensitivity가 0.5-0.75 사이의 영상 조합을 찾았다. 그 결과 Pass Number 쌍으로서, 대전은 5-4, 7-5, 8-5의 영상 조합을 하였을 때 radargrammetry 적용이 용이하고, 남극 세종기지는 8-6, 9-7, 10-7, 11-8, 12-8, 13-9, 14-9, 15-9, 15-10, 15-11의 영상 조합을 하였을 때 radargrammetry 적용이 가능한 것으로 예측되었다.

• Korean Journal of Remote Sensing
• /
• v.24 no.4
• /
• pp.351-358
• /
• 2008

KOMPSAT-5 will be launched in 2010 carrying a SAR (Synthetic Aperture Radar) system to obtain high resolution images of the earth surface regardless of weather or solar condition. In this paper, the orbits of KOMPSAT-5 and the imaging modes of SAR were analyzed for radargrammetry, and the best image pairs were suggested. We set the pass number from the nearest orbit to a given ground point and selected image pairs for radargrarnmetry, with height sensitivity of parallax higher than 0.5 to achieve enough height resolution and with the value lower than 0.8 to avoid errors from geometric distortion. On the equator, for example, where the distance between two adjacent passes is fixed to 95 km, we solved the orbit geometry and found that the image pairs with the pass numbers of 3-2 and 5-3 are suitable for radargrarnmetry. As the examples with arbitrary latitude, we selected Daejeon and Sejong Antarctic stations and calculated the orbital elements by using STK software. Three image pairs (5-4, 7-5 and 8-5) were found suitable for radargrammetry at Daejeon while 10 pairs (8-6, 9-7, 10-7, 11-8, 12-8, 13-9, 14-9, 15-9, 15-10 and 15-11) at Sejong Antarctic station.

• Journal of Astronomy and Space Sciences
• /
• v.15 no.2
• /
• pp.427-436
• /
• 1998

The apogee manoeuvre of $KOREASAT-1{cdot}2{cdot}3$ is basic elliptical orbit transfer converting orbit plane. The KOREASAT-3 is planed for multi-burn manoeuvres using the liquid apogee engine while the $KOREASAT-1{cdot}2$ used the apogee kick motor that executes a single burn in the apogee of transfer orbit using the solid propellant. This study analyzed the multi-burn manoeuvres using the liquid apogee engine and the propellant control method and developed the simulation tools. For the purpose of precise simulation, We designed tools in the basic of orbit propagation software, COWELL5, that was developed by members of Center for Astrodynamics in Yonsei university and the results can be displayed in 3-D graphic of $STK/VO^{TM}$.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.16
• /
• pp.6709-6714
• /
• 2014

The rs2273535 polymorphism in the AURKA gene had proven to be associated with breast carcinoma susceptibility. Nevertheless, the results of different studies remain contradictory. A meta-analysis covering 28, 789 subjects from eleven different studies was here carried out in order to investigate the association in detail. The random effects model was used to analyze the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs). A significant relationship between the rs2273535 polymorphism and breast tumors was found in an allelic genetic model (OR: 1.076, 95% CI: 1.004-1.153, p=0.040, $P_{heterogeneity}$=0.002). No significant association was detected in a homozygote model (OR: 1.186, 95% CI: 0.990-1.423, P=0.065, $P_{heterogeneity}$=0.002), a heterozygote model (OR: 1.016, 95% CI: 0.959-1.076, p=0.064, $P_{heterogeneity}$=0.000), a dominant genetic model (OR: 1.147, 95% CI: 0.992-1.325, p=0.217, $P_{heterogeneity}$=0.294) and a recessive genetic model (OR: 1.093, 95% CI: 0.878-1.361, p=0.425, $P_{heterogeneity}$=0.707). A significant relationship between the rs2273535 polymorphism in the AURKA gene and breast tumor in Asian group was found in an allelic genetic model (OR: 1.124, 95% CI: 1.003-1.29, p=0.044, $P_{heterogeneity}$=0.034), a homozygote model (OR: 1.229, 95% CI: 1.038-1.455, p=0.016, $P_{heterogeneity}$=0.266) and a recessive genetic model (OR: 1.227, 95% CI: 1.001-1.504, p=0.049, $P_{heterogeneity}$=0.006). A significant association was thus observed between the rs2273535 polymorphism in the AURKA gene and breast cancer risk. Individuals with the rs2273535 polymorphism in the AURKA gene have a higher risk of breast cancer in Asian populations, but not in Caucasians.

• Asian-Australasian Journal of Animal Sciences
• /
• v.29 no.1
• /
• pp.36-42
• /
• 2016

Milk-related traits (milk yield, fat and protein) have been crucial to selection of Holstein. It is essential to find the current selection trends of Holstein. Despite this, uncovering the current trends of selection have been ignored in previous studies. We suggest a new formula to detect the current selection trends based on single nucleotide polymorphisms (SNP). This suggestion is based on the best linear unbiased prediction (BLUP) and the Fisher's fundamental theorem of natural selection both of which are trait-dependent. Fisher's theorem links the additive genetic variance to the selection coefficient. For Holstein milk production traits, we estimated the additive genetic variance using SNP effect from BLUP and selection coefficients based on genetic variance to search highly selective SNPs. Through these processes, we identified significantly selective SNPs. The number of genes containing highly selective SNPs with p-value <0.01 (nearly top 1% SNPs) in all traits and p-value <0.001 (nearly top 0.1%) in any traits was 14. They are phosphodiesterase 4B (PDE4B), serine/threonine kinase 40 (STK40), collagen, type XI, alpha 1 (COL11A1), ephrin-A1 (EFNA1), netrin 4 (NTN4), neuron specific gene family member 1 (NSG1), estrogen receptor 1 (ESR1), neurexin 3 (NRXN3), spectrin, beta, non-erythrocytic 1 (SPTBN1), ADP-ribosylation factor interacting protein 1 (ARFIP1), mutL homolog 1 (MLH1), transmembrane channel-like 7 (TMC7), carboxypeptidase X, member 2 (CPXM2) and ADAM metallopeptidase domain 12 (ADAM12). These genes may be important for future artificial selection trends. Also, we found that the SNP effect predicted from BLUP was the key factor to determine the expected current selection coefficient of SNP. Under Hardy-Weinberg equilibrium of SNP markers in current generation, the selection coefficient is equivalent to $2^*SNP$ effect.