• Asian-Australasian Journal of Animal Sciences
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• v.24 no.9
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• pp.1184-1191
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• 2011

We attempted to generate a linkage map using Illumina Porcine 60K SNP Beadchip genotypes of the $F_2$ offspring from Korean native pig (KNP) crossed with Yorkshire (YS) pig, and to identify quantitative trait loci (QTL) using the line-cross model. Among the genotype information of the 62,136 SNPs obtained from the high-density SNP analysis, 45,308 SNPs were used to select informative markers with allelic frequencies >0.7 between the KNP (n = 16) and YS (n = 8) F0 animals. Of the selected SNP markers, a final set of 500 SNPs with polymorphic information contents (PIC) values of >0.300 in the $F_2$ groups (n = 252) was used for detection of thirty meat quality-related QTL on chromosomes at the 5% significance level and 10 QTL at the 1% significance level. The QTL for crude protein were detected on SSC2, SSC3, SSC6, SSC9 and SSC12; for intramuscular fat and marbling on SSC2, SSC8, SSC12, SSC14 and SSC18; meat color measurements on SSC1, SSC3, SSC4, SSC5, SSC6, SSC10, SSC11, SSC12, SSC16 and SSC18; water content related measurements in pork were detected on SSC4, SSC6, SSC7, SSC10, SSC12 and SSC14. Additional QTL of pork quality traits such as texture, tenderness and pH were detected on SSC6, SSC12, SSC13 and SSC16. The most important chromosomal region of superior pork quality in KNP compared to YS was identified on SSC12. Our results demonstrated that a QTL linkage map of the $F_2$ design in the pig breed can be generated with a selected data set of high density SNP genotypes. The QTL regions detected in this study will provide useful information for identifying genetic factors related to better pork quality in KNP.

• Nuclear Engineering and Technology
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• v.33 no.2
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• pp.209-224
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• 2001

The SSC-K system analysis code is under development at the Korea Atomic Energy Research Institute (KAERI) as a part of the KALIMER project. The SSC-K code is being used as the principal tool for analyzing a variety of off-normal conditions or accidents of the preliminary KALIMER design. The SSC-K code features a multiple-channel core representation coupled with a point kinetics model with reactivity feedback. It provides a detailed, one-dimensional thermal-hydraulic simulation of the primary and secondary sodium coolant circuits, as well as the balance-of-plant steam/water circuit. Recently a two-dimensional hot pool model was incorporated into SSC-K for analysis of thermal stratification phenomena in the hot pool. In addition, SSC-K contains detailed models for the passive decay heat removal system and a generalized plant control system. The SSC-K code has also been applied to the computational engine for an interactive simulation of the KALIMER plant. This paper presents an overview of the recent activities concerned with SSC-K code model development This paper focuses on both descriptions of the newly adopted thermal hydraulic and neutronic models, and applications to KALIMER analyses for typical anticipated transients without scram.

• Journal of Animal Science and Technology
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• v.63 no.4
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• pp.854-863
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• 2021

Weaning induces physiological changes in intestinal development that affect pigs' growth performance and susceptibility to disease. As a posttranscriptional regulator, microRNAs (miRNAs) regulate cellular homeostasis during intestinal development. We performed small RNA expression profiling in the small intestine of piglets before weaning (BW), 1 week after weaning (1W), and 2 weeks after weaning (2W) to identify weaning-associated differentially expressed miRNAs. We identified 38 differentially expressed miRNAs with varying expression levels among BW, 1W, and 2W. Then, we classified expression patterns of the identified miRNAs into four types. ssc-miR-196a and ssc-miR-451 represent pattern 1, which had an increased expression at 1W and a decreased expression at 2W. ssc-miR-499-5p represents pattern 2, which had an increased expression at 1W and a stable expression at 2W. ssc-miR-7135-3p and ssc-miR-144 represent pattern 3, which had a stable expression at 1W and a decreased expression at 2W. Eleven miRNAs (ssc-miR-542-3p, ssc-miR-214, ssc-miR-758, ssc-miR-4331, ssc-miR-105-1, ssc-miR-1285, ssc-miR-10a-5p, ssc-miR-4332, ssc-miR-503, ssc-miR-6782-3p, and ssc-miR-424-5p) represent pattern 4, which had a decreased expression at 1W and a stable expression at 2W. Moreover, we identified 133 candidate targets for miR-196a using a target prediction database. Gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed that the target genes were associated with 19 biological processes, 4 cellular components, 8 molecular functions, and 7 KEGG pathways, including anterior/posterior pattern specification as well as the cancer, PI3K-Akt, MAPK, GnRH, and neurotrophin signaling pathways. These findings suggest that miRNAs regulate the development of the small intestine during the weaning process in piglets by anterior/posterior pattern specification as well as the cancer, PI3K-Akt, MAPK, GnRH, and neurotrophin signaling pathways.

• Tuberculosis and Respiratory Diseases
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• v.83 no.4
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• pp.312-320
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• 2020

Background: Systemic sclerosis (SSc) involves multiple organ systems and has the highest mortality among connective tissue diseases. Interstitial lung disease is the most common cause of death among SSc patients and requires closer studies and follow-ups. This study aimed to identify lung function changes and predictors of progressive disease in systemic sclerosis-related interstitial lung disease (SSc-ILD). Methods: A retrospective study extracted SSc patients from an electronic database January 2002-July 2019. Eligible cases were SSc patients >age 15 diagnosed with SSc-ILD. Factors associated with progressive disease were analyzed by univariate and multivariate logistic regression analyses. Results: Seventy-eight SSc-ILD cases were enrolled. Sixty-five patients (83.3%) were female, with mean age of 44.7±14.4, and 50 (64.1%) were diffuse type SSc-ILD. Most SSc-ILD patients had crackles (75.6%) and dyspnea on exertion (71.8%), and 19.2% of the SSc-ILD patients had no abnormal respiratory symptoms but had abnormal chest radiographic findings. The most common diagnosis of SSc-ILD patients was non-specific interstitial pneumonia (43.6%). The lung function values of diffusing capacity of the lung for carbon monoxide (DLCO) and DLCO per unit alveolar volume declined in progressive SSc-ILD during a 12-month follow-up. Male and no previous aspirin treatment were the two significant predictive factors of progressive SSc-ILD with adjusted odds ratios of 5.72 and 4.99, respectively. Conclusion: This present study showed that short-term lung function had declined during the 12-month follow-up in progressive SSc-ILD. The predictive factors in progressive SSc-ILD were male sex and no previous aspirin treatment. Close follow-up of the pulmonary function tests is necessary for early detection of progressive disease.

• Journal of the Korean Chemical Society
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• v.51 no.5
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• pp.433-446
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• 2007

The purpose of this study was to examine the effect of Small-Scale Chemistry(SSC) lab program on the academic self-efficacy and the science-related affective domain of 11th grade science-majored students. For this study, a SSC lab program was developed on the basis of analyzing the textbook of high school chemistry I in the 7th curriculum, and the experimental group was received SSC experiment lessons(SSC group), and the comparison group was received traditional experiment lessons. After students were grouped high and low level according to the students' prior science achievement score, the differences between the two groups were investigated using 2-way ANCOVA. From the result of this study, we found that the SSC lab program was more effective than the traditional Large-Scale lab program based on the textbook in academic self-efficacy. And the scores of interest toward science-related careers and creativity for the SSC group, which are subcategories of science-related affective domain were significantly higher than those for the comparison group. In students' perceptions on the SSC lab program, majority of students thought that the SSC lab program was convenient, effective and interesting.

• Journal of The Korean Association For Science Education
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• v.27 no.9
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• pp.787-795
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• 2007

The purpose of this study was to examine the effects of experimental learning using Small-Scale Chemistry (SSC) on science achievement and scientific attitude of high school students. SSC experiments were devised for 5 experiment themes of high school science textbook. Two classes were chosen from a high school in Busan and adopted into the comparison group and the experimental group; one group with thirty-four students participated in the class with an experimental learning using the SSC (experimental group), and another group with thirty-seven students participated in the class with the traditional learning (comparison group). The major discoveries of this study were as follows: Experimental learning using SSC has shown a significant difference between two groups in the science achievement of the students. Also there was a statistical difference between these two groups in the test which was conducted after a month to find out the durability of the experiment. Thus, the learning using SSC is assumed to be durable. Furthermore, there was a significant difference in scientific attitude between the two groups. It seemed that the learning using SSC had a good influence on fanning students' scientific attitude. In conclusion, an experimental learning using SSC has a positive effect on scientific achievement, the durability and scientific attitude of the students. We hope to develop suitable and various experimental learning materials using the SSC program that can be adopted in the classroom soon.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.130-130
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• 1998

Two novel compounds SSC1 and SSC2 were isolated from culture broth produced from the strain of Stereum hirsutum by using of YM broth. They were isolated through HP-20 column chromatography, silica gel column chromatography and preparative HPLC, successively. The molecular formulas of SSC1 and SSC2. were determined as C$\sub$15/H$\sub$22/O$_3$ by high resolution EI -mass. The chemical structures of SSC1 and SSC2 were determined as sesquiterpenoid compounds by spectroscopic analysis of UV, IR, $^1$H NMR, $\^$13/C NMR, DEPT, HMQC and HMBC spectrum.

• Journal of Science Education
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• v.35 no.2
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• pp.119-126
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• 2011

The purpose of this study was to examine the effects of experimental learning using the small-scale chemistry (SSC) on high school students' academic achievement, scientific attitude and science-related attitude in high school chemistry I. For this study, two high school 2nd grade classes were divided into an experimental group and a control group. Experimental learning using the SSC in the experimental group, traditional experimental learning presented in the textbook in the control group were performed. The results showed that experimental learning using the SSC compared to traditional experimental learning was effective in improving academic achievement. The experimental learning also was effective in improving voluntary, patience, cooperativity in the scientific attitudes and social implications of science, attitude for science curriculum, attitude toward science in the science-related attitudes. Therefore, experimental learning using the SSC is necessary to actively utilize in high school chemistry curriculum.

• Reproductive and Developmental Biology
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• v.32 no.4
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• pp.211-215
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• 2008

The HMG box containing protein (HBP) has a high mobility group domain and involved in the regulation of proliferation and differentiation of tissues. We screened HBP2 in glioblastoma using Suppression Subtractive Hybridization (SSH) and isolated human spermatogonial stem cell-like cells (hSSC-like cells) derived from patients of nonobstructive azoospermia (NOA). Expression of HBP2 was analyzed by RT-PCR in undifferentiated stem cells (human Embryonic Stem Cells, hSSC-like cells 2P) and spontaneous differentiated stem cells (hSSC-like cells 4P). It was overexpressed in hESC and hSSC-like cells 2P but not in hSSC-like cells 4P. Also, the expression level of HBP2 was downregulated in colon tumor tissues compared to normal tissues. Specifically in synchronized WI-38 cells, HBP2 was highly upregulated until the G1 phase of the cell cycle and gradually decreased during the S phase. Our results suggest that HBP2 was downregulated during the spontaneous differentiation of hSSC-like cells. HBP2 was differently expressed in colon tissues and was related to G1-progression in WI-38 cells. It may playa role in the maintenance of an undifferentiated hSSC-like cell state and transits from G1 to S in WI-38 cells. This research was important that it identified a biomarker for an undifferentiated state of hSSC-like cells and characterized its involvement to arrest during cell cycle in colon cancer.

• Nuclear Engineering and Technology
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• v.47 no.3
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• pp.253-259
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• 2015

The fast neutron reactor BOR-60 is one of the key experimental facilities worldwide to perform large-scale tests of fuel, absorbing, and structural materials for advanced reactors. The BOR-60 reactor was put into operation in December 1969, and by the end of 2014 it had been operating on power for ~265,000 hours. BOR-60 still demonstrates potential capabilities to extend the lifetime of sodium-cooled fast reactors. The BOR-60 lifetime should have expired at the end of 2014. Over the past few years, a great scope of work has been performed to justify the possibility of extending its lifetime. The work included inspection of the equipment conditions, calculations and experimental research on operating parameters and the conditions of nonremovable components, investigation of the structural material samples after their long-term operation under irradiation, etc. Based on the results of the work performed, the residual lifetime was evaluated and the reactor operator made a decision to extend the lifetime period of the BOR-60 reactor. After considering both a set of documents about the reactor conditions and the positive decision of independent experts, the Regulatory Authority of the Russian Federation extended the BOR-60 operating license up to 2020.