• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.22 no.2
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• pp.123-128
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• 2022

The torque of the SRM((Switched Reluctance Motor)) is proportional to the inductance slope, so it has a non-linear torque characteristic, and has a disadvantage in that the torque pulsation is large and noise is severe. In particular, the biggest obstacle to the commercialization of SRM is the pulsating torque generated from the rotating shaft, which has various adverse effects not only on the device itself but also on the peripheral devices. Therefore, various methods for reducing the pulsating torque have been published by domestic and foreign researchers, and there is a study result that the hysteresis controller has an advantage in that it can flow a smooth current compared to the chopping control. However, in determining the hysteresis band, if the band is too small, it has a disadvantage in that it may cause a switching loss due to many switching and an unstable initial start when the encoder is used. Therefore, in this paper, a variable hysteresis controller that can reduce torque ripple in a steady state while having a more stable and fast speed response through the change of the hysteresis band according to the speed error.

• Journal of Integrative Natural Science
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• v.11 no.2
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• pp.121-129
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• 2018

CXCR6 is a major target in drug design as it is a determinant receptor in many diseases like AIDS, Type I Diabetes, some cancer types, atherosclerosis, tumor formation, liver disease and steatohepatitis. In this study, we propose the active site residues of CXCR6 molecule. We employed homology modelling and molecular docking approach to generate the 3D structure for CXCR6 and to explore its interaction between the antagonists and agonists. 3D models were generated using 14 different templates having high sequence identity with CXCR6. Surflex docking studies using pyridine and pyrimidine derivatives enabled the analysis of the binding site and finding of the important residues involved in binding. 3D structure of CXCL16, a natural ligand for CXCR6, was modelled using PHYRE and protein - protein docking was performed using ClusPro. The residues which were found to be crucial in interaction with the ligand are THR110, PHE113, TYR114, GLN160, GLN195, CYS251 and SER255. This study can be used as a guide for therapeutic studies of human CXCR6.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.4
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• pp.62-69
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• 2023

This study investigated the electromechanical properties of cement based smart repair materials (SRMs) according to the different amounts of fine steel slag aggregates (FSSAs). SRMs can self-diagnose the quality of repairing and self-sense the damage of repaired zone. The replacement ratios of FSSAs to sand for SRMs were 0% (FSSA00), 25% (FSSA25), and 50% (FSSA50) by sand weight. The electrical resistivity of SRMs generally decreased as the compressive stress of SRMs increased: the electrical resistivity of FSSA25 at the age of 7 hours decreased from 78.16 to 63.68 kΩ-cm as the compressive stress increased from 0 to 22.37 MPa. As the replacement ratio of FSSAs by weight of sand increased from 0% to 25%, the stress sensitivity coefficient (SSC) of SRM at the age of 7 h increased from 0.471 to 0.828 %/MPa owing to the increased number of partially conductive paths in the SRMs. However, as the replacement ratio of FSSAs further increased up to 50%, the SSC decreased from 0.828 to 0.649 %/MPa because some of the partially conductive paths changed to continued conductive ones. SRMs are expected to self-sense the quality and future damage of repaired zone only by measuring the electrical resistivity of the repaired zone in addition to fast recovery in the mechanical resistance of structures.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.3
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• pp.123-128
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• 2021

For accurate speed and current control in industrial applications, SRM (Switched Reluctance Motor) is very important to synchronize the stator phase excitation and rotor position in the drive due to its nature. In general, position sensors such as encoder and resolver are used to generate rotational force by exciting the stator winding according to the rotor position and to control the motor by using speed and position information. However, for these sensors, 1) the cost of the sensors is quite large in terms of price, so the proportion of the motor system to the total system cost is high. 2) In terms of mechanical, position sensors such as encoders and resolvers are attached to the stator to increase the size and weight. In conclusion, in order to drive the SRM, control based on the rotor position information should be basically performed, and it is important to design the SRM driving system according to the environment in consideration of the application field. Therefore, in this paper, we intend to study the driving and control characteristics of SRM through variable switching duty control by designing a low-cost analog driving device, deviating from the general control system using the conventional encoder and resolver.

• Journal of Integrative Natural Science
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• v.17 no.1
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• pp.13-20
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• 2024

Female breast cancer is the fifth highest cause of mortality. Breast cancer is the most prevalent type of cancer in women globally, while it can also affect men. STAT5A plays a role in its development and progression. Given that activation of STAT5a is frequently linked to the growth and progression of tumors, STAT5a has been identified as a possible target for the therapy of several cancers. STAT5A, in particular, has proven to be overexpressed in various breast cancer cell lines and tumors, and it has been associated to the promotion of tumour cell proliferation and survival. STAT5A inhibition has been shown in vitro and in vivo to reduce the development of breast cancer cells. As a result, we have screened compounds from the FDA database that might serve as potential inhibitors of STAT5a through virtual screening, docking, DFT and MD simulation approaches. The drug Nilotinib has shown promising results inhibiting STAT5a. Further, in-vitro analysis will be carried forward to understand the anti-cancer activity.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.22 no.4
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• pp.127-132
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• 2022

Among the electrical components mounted on railroad cars, the largest load is the main transformer, which has a low power density of 0.2~0.4 MVA/ton due to the low operating frequency(60Hz), which is an important factor for weight reduction. Therefore, research on molded transformers, semiconductor transformers, etc. is being actively conducted at Domestic and foreign in order to improve the main transformer for railway vehicles. Meanwhile, attempts are being made to apply a permanent magnet synchronous motor (PMSM) to replace an induction motor as a traction motor that is mostly applied to domestic and foreign railway vehicles. Permanent magnet synchronous motors (PMSMs) can secure higher power density and efficiency compared to induction motors, but have disadvantages in that the materials required for manufacturing are expensive and design is somewhat difficult compared to induction motors. Considering these problems, in this paper, we suggest that a small and lightweight semiconductor transformer is applied, and a simple structure, high torque, low cost SRM can be applied in accordance with the requirements such as weight reduction and high efficiency of railroad vehicles. content.

• Journal of Integrative Natural Science
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• v.7 no.3
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• pp.166-172
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• 2014

Caspases, a family of cysteinyl aspartate-specific proteases plays a central role in the regulation and the execution of apoptotic cell death. Activation of caspases-3 stimulates a signaling pathway that ultimately leads to the death of the cell. Hence, caspase-3 has been proven to be an effective target for reducing the amount of cellular and tissue damage. In this work, comparative molecular field analysis (CoMFA) was performed on a series of 3, 4-dihydropyrimidoindolones derivatives which are inhibitors of caspase-3. The best predictions were obtained for CoMFA model ($q^2=0.676$, $r^2=0.990$). The predictive ability of test set ($r^2_{pred}$) was 0.688. Statistical parameters from the generated QSAR models indicated the data is well fitted and have high predictive ability. Our theoretical results could be useful to design novel and more potent caspase-3 derivatives.

• Journal of Integrative Natural Science
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• v.9 no.2
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• pp.136-143
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• 2016

KiSS1-derived peptide receptor, a GPCR protein, binds with the hormone kiss peptin. They are important in the neuroendocrine regulation of reproduction and in the secretion of gonadotrophin-releasing hormone. Thus, analysing the structural features of the receptor becomes important. However, the three dimensional structure of the protein is unavailable. Hence in this study, we have performed the homology modelling of KiSS1-derived peptide receptor with 5 different templates. 30 models were constructed using two platforms - Easymodeller and ITasser. The optimal models were chosen based on the model validation. Two models were selected after validation. The developed models could provide useful for analysing the structural features of KiSS1-derived peptide receptor and their pathophysiological role in various disorders related to them.

• Journal of Integrative Natural Science
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• v.10 no.2
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• pp.74-77
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• 2017

Bradykinin receptor B2 (B2R) is a GPCR protein which binds with the inflammatory mediator hormone bradkynin. Kallidin, a decapeptide, also signals through this receptor. B2R is crucial in the cross-talk between renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS) and in many processes including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Thus the structural study of the receptor becomes important. We have predicted the peptide structures of Bradykinin and Kallidin from their amino acid sequences and the structures were docked with the receptor structure. The results obtained from protein-protein docking could be helpful in studying the B2R structural features and in the pathophysiology in various diseases related to it.

• Journal of Integrative Natural Science
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• v.8 no.1
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• pp.75-79
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• 2015

Thromboxane A2 receptors (TXA2-R) are the G protein coupled receptors localized on cell membranes and intracellular structures and play pathophysiological role in various thrombosis/hemostasis, modulation of the immune response, acute myocardial infarction, inflammatory lung disease, hypertension and nephrotic disease. TXA2 receptor antagonists have been evaluated as potential therapeutic agents for asthma, thrombosis and hypertension. The role of TXA2 in wide spectrum of diseases makes this as an important drug target. Hence in the present study, homology modeling of TXA2 receptor was performed using the crystal structure of squid rhodopsin and night blindness causing G90D rhodopsin. 20 models were generated using single and multiple templates based approaches and the best model was selected based on the validation result. We found that multiple template based approach have given better accuracy. The generated structures can be used in future for further binding site and docking analysis.