• Archives of Pharmacal Research
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• v.28 no.7
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• pp.756-760
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• 2005

Polyene macrolide amphotericin B (AmB) is the drug of choice for the treatment of disseminated fungal infections. However, because of its pronounced side effects, the drug has limited applicability. There are few interesting reports, which state that co-administration of the drug with homo-peptide of polyaspartic acid reduces the side effects of the drug. In our present study, an approach has been made to systematically synthesize low molecular weight heteropeptides consisting of L-aspartic acid and its derivative. It was hypothesized that such heteropeptides will reduce the toxic side effects of the drug by facile hydrophobic binding between the polymer and the drug. We have employed the strategy of solid phase peptide synthesis (SPPS) to synthesize low molecular weight hetero-peptides by using L-aspartic acid and benzyl-L-aspartic acid to induce the hydrophobic binding between the peptide and the drug. In future, the proposed methodology can be employed to tailor other polypeptides substituted with benzyl groups to reduce the nephrotoxicity of AmB.

• Journal of the Optical Society of Korea
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• v.15 no.1
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• pp.82-89
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• 2011

In this paper, we numerically study both band-pass and band-stop plasmonic filters based on Metal-Insulator-Metal (MIM) waveguides and circular ring resonators. The band-pass filter consists of two MIM waveguides coupled to each other by a circular ring resonator. The band-stop filter is made up of an MIM waveguide coupled laterally to a circular ring resonator. The propagating modes of Surface Plasmon Polaritons (SPPs) are studied in these structures. By substituting a portion of the ring core with air, while the outer dimensions of the ring resonator are kept constant, we illustrate the possibility of red-shift in resonant wavelengths in order to tune the resonance modes of the proposed filters. This feature is useful for integrated circuits in which we have limitations on the outer dimensions of the filter structure and it is not possible to enlarge the dimension of the ring resonator to reach to longer resonant wavelengths. The results are obtained by a 2D finite-difference time-domain (FDTD) method. The introduced structures have potential applications in plasmonic integrated circuits and can be simply fabricated.

• Journal of the Korean Society for Heat Treatment
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• v.35 no.4
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• pp.193-202
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• 2022

Manholes and underground spaces are installed to manage the buried heat transport pipes of the district heating system, and the corrosion damage of the equipment placed in this space often occurs. The purpose of this work is to identify locations with a high risk of corrosion damage in the air vent and to establish preventive measures based on precise analysis via sampling of heat transport pipes and air vents that have been used for about 30 years. The residual thickness of the air vent decreased significantly by reaching ~1.1 mm in thickness, and locations of 60~70 mm away from a transport pipe were the most vulnerable to corrosion. The energy dispersive X-ray spectroscopy (EDS) analysis was performed in the corroded oxides, and it was found that chloride ion was contained in the corrosion products. Anodic polarization tests were carried out on the air vent materials (SPPS250, SS304) with varying the amounts of chloride ions at two different temperatures (RT, 80℃). The higher concentration of chloride ions and temperature are, the lower corrosion resistances of both alloys are.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.176-176
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• 2023

The Tonle Sap is the richest and diverseness of freshwater ecosystem in Southeast Asia, receiving nurturing water flows from the Mekong and its immediate basin. In addition, the rapid development in the Tonle Sap Lake (TSL) Basin, and flood inundation may threaten the natural diversities and characteristics. The impacts of flood inundation in 11 sub-basins contributing to the Tonle Sap Lake were assessed using the Rainfall-Runoff-Inundation (RRI) model to quantify the potential magnitude and extent of the flooding. The RRI model is set up by using gauged rainfall data to simulate the information of river discharge and flood inundation of huge possible flood events. Moreover, two satellite precipitation products (SPPs), CHIRPS and GSMaP, within respectively spatial resolutions of 0.05° and 0.1°, are utilized as an input for the RRI model to simulate river discharge, flood depth, and flood extent for the great TSL Basin of Cambodia. This study used statistical indicators such as NSE, PBIAS, RSR, and R2 as crucial indices to evaluate the performance of the RRI model. Therefore, the findings of this study could provide promising guidance in hydrological modeling and the significant implications for flood risk management and disaster preparedness in the region.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.143-143
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• 2022

Precipitation plays an essential role in water resources management and disaster prevention. Therefore, the understanding related to spatiotemporal characteristics of rainfall is necessary. Nowadays, highly accurate precipitation is mainly obtained from gauge observation systems. However, the density of gauge stations is a sparse and uneven distribution in mountainous areas. With the proliferation of technology, satellite-based precipitation sources are becoming increasingly common and can provide rainfall information in regions with complex topography. Nevertheless, satellite-based data is that it still remains uncertain. To overcome the above limitation, this study aims to take the strengthens of machine learning to generate a new reanalysis of precipitation data by fusion of multiple satellite precipitation products (SPPs) with gauge observation data. Several machine learning algorithms (i.e., Random Forest, Support Vector Regression, and Artificial Neural Network) have been adopted. To investigate the robustness of the new reanalysis product, observed data were collected to evaluate the accuracy of the products through Kling-Gupta efficiency (KGE), probability of detection (POD), false alarm rate (FAR), and critical success index (CSI). As a result, the new precipitation generated through the machine learning model showed higher accuracy than original satellite rainfall products, and its spatiotemporal variability was better reflected than others. Thus, reanalysis of satellite precipitation product based on machine learning can be useful source input data for hydrological simulations in ungauged river basins.

• Korean Journal of Optics and Photonics
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• v.19 no.6
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• pp.429-434
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• 2008

We propose a wavelength filter based on long-range surface plasmon-polaritons (LR-SPP) supported by a asymmetric doubleelectrode LR-SPP structure. For the case of the asymmetric double-layered LR-SPP waveguide, LR-SPPs exist with a much broader range of index mismatches between core and clad materials. Thus, the asymmetric double-electrode LR-SPP waveguide is adequate to form a plasmonic band-gap device as we report in this paper by studying Bragg-reflection wavelength filter based on it. The structure for wavelength filter operating telecommunications wavelength is designed by using the method of line (MoL) and the transfer matrix method. The fabricated device shows a relatively high extinction ratio of 50 dB with a bandwidth of 2 nm, and the performance is very consistent with numerical simulations.

• Journal of the Korean Chemical Society
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• v.42 no.3
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• pp.251-265
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• 1998

Punch'ong and whiteware sherds excavated from four kilns located in Ch'unghyodong, Kwangju, Chollanamdo were analyzed for their body and glaze composition. They are classified into eight different groups by the site and layer from which they were collected. In principal component analysis of major composition, the punch'ong body separates out into several different groups. CHE2, made in early fifteenth century, has a higher aluminum and lower iron content compared to the later groups of lower grade. Whiteware body has a very high aluminum content of around 30 wt. in both soft type and hard type. Punch'ong glaze was determined to be lime type and whiteware alkali-lime type.

• Journal of the Korea Convergence Society
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• v.9 no.5
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• pp.99-104
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• 2018

The purpose of this study was to investigate the convergence factors affecting professional identity perceived by the emotional labor of clinical practice and self-esteem in some dental hygiene students. The questionnaire was conducted in 205 dental hygiene students from 3 university in Jeollanam-do area. The data were analyzed using SPSS 12.0. Professional identity correlated positively with self-esteem(r=0.366, p<0.01), negatively with emotional labor of clinical practice(r=-0.213, p<0.01). The convergence factors influencing professional identity were satisfaction level with majors(${\beta}=0.434$), self-esteem(${\beta}=0.236$) and emotional labor of clinical practice(${\beta}=-0.199$). The regression model explained 34.6% of professional identity. Therefore, to enhance professional identity in dental hygiene students, it is required to program development to improve satisfaction level of with majors, self-esteem and management of emotional labor of clinical practice.

• Journal of the Optical Society of Korea
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• v.20 no.1
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• pp.130-134
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• 2016

The influence of Au/Ni-based contact formed on a lightly-doped (7.3×1017cm−3, Zn-doped) InGaAsP layer for electrical compensation of surface plasmon polariton (SPP) propagation under various rapid thermal annealing (RTA) conditions has been studied. The active control of SPP propagation is realized by electrically pumping the InGaAsP multiple quantum wells (MQWs) beneath the metal planar waveguide. The metal planar film acts as the electric contact layer and SPP waveguide, simultaneously. The RTA process can lower the metal-semiconductor electric contact resistance. Nevertheless, it inevitably increases the contact interface morphological roughness, which is detrimental to SPP propagation. Based on this dilemma, in this work we focus on studying the influence of RTA conditions on electrical control of SPPs. The experimental results indicate that there is obvious degradation of electrical pumping compensation for SPP propagation loss in the devices annealed at 400℃ compared to those with no annealing treatment. With increasing annealing duration time, more significant degradation of the active performance is observed even under sufficient current injection. When the annealing temperature is set at 400℃ and the duration time approaches 60s, the SPP propagation is nearly no longer supported as the waveguide surface morphology is severely changed. It seems that eutectic mixture stemming from the RTA process significantly increases the metal film roughness and interferes with the SPP signal propagation.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.196-196
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• 2012

Graphene, two-dimensional one-atom-thick planar sheet of carbon atoms densely packed in a honeycomb crystal lattice, has grabbled appreciable attention due to its extraordinary mechanical, thermal, electrical, and optical properties. Based on the graphene's high carrier mobility, high frequency graphene field effect transistors have been developed. Graphene is useful for photonic components as well as for the applications in electronic devices. Graphene's unique optical properties allowed us to develop ultra wide-bandwidth optical modulator, photo-detector, and broadband polarizer. Graphene can support SPP-like surface wave because it is considered as a two-dimensional metal-like systems. The SPPs are associated with the coupling between collective oscillation of free electrons in the metal and electromagnetic waves. The charged free carriers in the graphene contribute to support the surface waves at the graphene-dielectric interface by coupling to the electromagnetic wave. In addition, graphene can control the surface waves because its charge carrier density is tunable by means of a chemical doping method, varying the Fermi level by applying gate bias voltage, and/or applying magnetic field. As an extended application of graphene in photonics, we investigated the characteristics of the graphene-based plasmonic waveguide for optical signal transmission. The graphene strips embedded in a dielectric are served as a high-frequency optical signal guiding medium. The TM polarization wave is transmitted 6 mm-long graphene waveguide with the averaged extinction ratio of 19 dB at the telecom wavelength of $1.31{\mu}m$. 2.5 Gbps data transmission was successfully accomplished with the graphene waveguide. Based on these experimental results, we concluded that the graphene-based plasmonic waveguide can be exploited further for development of next-generation integrated photonic circuits on a chip.