• Biomolecules & Therapeutics
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• v.17 no.4
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• pp.353-361
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• 2009

Recent in vitro and in vivo animal studies have reported that statin, a cholesterol-lowering drug, stimulate osteogenic differentiation. In the present study, we investigated the effect of simvastatin on osteogenic and adipogenic differentiation in primarily cultured human adipose-derived stem cells (hADSCs). The simvastatin treatment significantly increased the positive cell numbers in alkaline phosphatase and von Kossa staining, and enhanced the expression levels of bone morphogenic protein (BMP)-2, core binding factor alpha 1 (cbfa1), collgen type I and osteonectin mRNAs. Lastly, hADSCs were cultured in the adipogenic media with or without simvastatin to examine the effect of simvastatin on adipogenic differentiation. In the RT-PCR analysis, there were notable decreases in mRNA expression of aP1, C/EBP-$\alpha$ and PPAR-$\gamma$ in hADSCs cultivated in simvastatin-added medium, compared to those in simvastatin-free medium. It suggests that the adipogenic differentiation was significantly inhibited by simvastatin treatment. These observations indicate that simvastatin induces osteogenic differentiation and suppresses adipogenic differentiation in hADSCs.

• Proceedings of the KSPS conference
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• 1996.02a
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• pp.79-84
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• 1996

The two existing romanization systems in Korea, namely the recently promulgated Ministry of Education version sponsored by the National Academy of Sciences incorporating for the most part the McCune-Reischauer system and the Hangeul Haghoe or the Korean Language Society's version, must be judged as failures: He fennel for its disregard of Korean orthography and pronunciation, use of Latin-oriented pronunciation despite its assertion that English is the standard used, and the greatest weakness of all, its use of phonetic symbols neither found in regular typewriters, teleprinters, word processors and telex machines nor understood by laymen, sometimes not even by specialists. And the latter suffers from its undue emphasis on Korean orthography, Latin-oriented pronunciation being only partly capable of representing Korean pronunciation, among other shortcomings. Since the two existing romanization systems of Korean in South Korea, and romanization system of Japanese with Latin-oriented pronunciation are woefully inadequate, in today's world where English is used as if it were the international language almost all over the world, the present writer has invented a completely new system of romanizing Korean and Japanese by the so-called pseudo-phonetic method. This method employs the roman letters only and uses thorn in place of phonetic symbols as long as the letters thus applied are believed to have constant sound value. The English pronunciation is the standard used for this system.

• Journal of the Korean housing association
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• v.21 no.6
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• pp.53-60
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• 2010

Built-in wardrobe is constructing after ordering and making, because built-in wardrobe's size is fixed as housing measurement. It is hard to speak built-in wardrobe components of construction in these ways, and application of an MC (Modular Coordination) design system is meaningless too. And above all, measurement before construction isn't to expect standardization, and to increase custom-made furniture. So I suggest the standardization of built-in wardrobe utilizing standard last finish and reference plane in order to prevent an evil influence of built-in wardrobe's construction. And we utilized a reference plane, and we present construction document and design plan in order to solve these problems. The first stage, we investigate manufacture of a preferential domestic system kitchen and construction state, and we derive from a problem in viewpoints of standardization for this. And we analyze an effect got by application of the assembly basis aspect that we presented, and we can raise efficiency of standardization of housing and construction industry, and we light ultimately up. I will apply a standardization plan as above, and define that this assures a standardization of components and an economic effect.

• Journal of Technologic Dentistry
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• v.9 no.1
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• pp.39-49
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• 1987

This study done to evaluate some surface treatment methods in metal coping which can increase the bond strength between porcelain and metal. Therefore this experiment was performed according to the Mc Lean's Theory of bond strength between porcelain and strength between porcelain and metal. In the experiment the author measured respective thermal expansion coefficents in three types of metal(Tallasium, Vera Bond and Rexillium) and Vita Porcelain to get the differences in the coefficents between porcelain and metals. And using insteron testing machine, the author also performed Planar interface shear bond tests on the 45 specimens(15 specimens in oxide surface, rough surface and fine surface treatment methods respectively) to measure bond strength between metal and porcelain. The results Were as follows, 1. The differences in thermal expansion coefficients between three types of metal and Vita procelain: Talladium - $1.2\;10^{-6/0}\;C$, Vera Bond - $1.6\;10^{-6/0}\;C$, Rexillium - $1.9\;10^{-6/0}\;C$. 2. The bond strength in oxide surface on the Shear bond test was the lowest among the treatment methods. 3. There was no significant differences in treatment methods of rough surface of fine surface. 4. In the oxide surface treatment method, there were significant differences(P<0.05)between Vera bond and Rexillium, and between Talladium and Rexillium. 5. In the fine surface treatment, there was a significant difference(P<0.05)between Talladium and Rexillium.

• Health Policy and Management
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• v.4 no.2
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• pp.111-125
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• 1994

In developing total hospital information system, large amount of time and expense are to be spent while its results are likely to lead itself to end-users' dissatisfaction. Some of the main complaints on the part of end-users come from insufficient consideration of end-users environment as well as inappropriate representation of their requirement in the system alalysis and design. This papre addresses some advantages of Essential Logical Modeling Process for better analysis and design, explaining by example the developmental process of the Patent Management and Accounting System for a tertiary care hospital. In the case, the Essential Model, suggested by McMenamin and Palmer, proved to be an effective tool for clear separation of analysis and design phase and for better communication among system developers and with end-users. The modeling process itself contributed to better program modularity as well, shown in a Structured Chart. Difficulties in learning how to identify' essential activities' for the modeling practice were experienced in the beginnins stage, which were, however, overcome by elaborating some heuristic guideling and by rdferring to necessary tools including State Transition Diagram, Control Flow Diagram, and so many. While full evaluation of the Essential Model usag remains to wait till the completion of the case project, its strengt in making clear distinction between analysis and design phase was enough to be attractive to system analysts. The model concepts are open to many further application fields, particularly such areas as business re engineering, process remodeling, office automation, and organizational restructuring.

• Journal of information and communication convergence engineering
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• v.8 no.1
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• pp.89-94
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• 2010

The most important of rule-base system is the knowledge base that determines the power of rule-base system. The important form of this knowledge is how to descript kinds of rules. The Rule-Base System (RBS) has been using in many field that need reflect quickly change of business rules in management system. As far, when develop the Rule-Based System, we must make a rule engine with a general language. There are three disadvantage of in this developed method. First, while there are many data that must be processed in the system, the speed of processing data will become very slow so that we cannot accept it. Second, we cannot change the current system to make it adaptive to changes of business rules as quickly as possible. Third, large data make the rule engine become very complex. Therefore, in this paper, we propose the two important methods of raising efficiency of Rule-Base System. The first method refers to using the Relational database technology to process the rules of the Rule-Base System, the second method refers to a algorithm of according to Quine McCluskey formula compress the rows of rule table. Because the expressive languages of rule are still remaining many problems, we will introduce a new expressive language, which is Rule-Base Data Model short as RBDM in this paper.

• International Journal of Contents
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• v.6 no.4
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• pp.62-68
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• 2010

More and more researchers and practitioners in the field of e-commerce are paying attentions to the retention of online customers. However, only a few researches can be addressed in the context of internet shopping mall repurchase intention. This study aims at investigating and delineating the important characteristic factors which affect consumers' repurchase intentions by conducting an empirical analysis. In order to fulfill this purpose effectively, a comprehensive review of previous studies regarding information system success model was performed in order to render a stronger theoretical foundation for our study. Finally, based on the DeLone and McLean (2003) IS success model, information quality, system quality, service quality, customer satisfaction and repurchase intention were employed as five constructs in the research model and hypotheses on mutual relationships between these constructs were established accordingly. Structural equation modeling was employed to analyze the data collected from 204 internet shopping mall consumers in China. Our theoretical model exhibited a good fit with the observed data. The empirical results showed particularly strong support for the effects of information quality, service quality and user satisfaction. The findings of this research contributed to the extension of repurchase intention study in the context of Internet shopping malls. Our research also offered implications for practitioners in regards to devising internet shopping malls so as to increase consumers' repurchase intention to use these services.

• Microbiology and Biotechnology Letters
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• v.25 no.2
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• pp.144-150
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• 1997

After DNA damage, umuDC is the only SOS operon that must be induced to promote SOS mutagenesis in Escherichia coli. The recombinant plasmid pBC401 and pBC402 were constructed to fuse the lac structural genes with promoter region of umuDC operon to induce the expression of lacZ gene by DNA damage. We transformed the plasmid pBC401 and pBC402 into E. coli MC1061, lacZ deleted strain and determined the activity of $\beta$-galactosidase for various mutagen; UV, mitomycin C (MMC), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 4-nitroqunoline-1-oxide (NQO), ethyl methanesulfonate (EMS). The $\beta$-galactosidase activities of PBC401 and pBC402 for UV, MMC, and NQO were increased in proportion to expression time until 3 hours thereafter, the activities were constant or slightly decreased. The activities for MNNG and EMS were not so high as for UV, MMC, and NQO. When MNNG and EMS were treated, $\beta$-galactosidase activity of pBC402 was slightly lower than pBC401 but when UV, MMC, and NQO were treated in pBC402, $\beta$-galactosidase activity was slightly higher than in pBC401. Therefore, the pBC402 was better than the pBC401 in terms of sensitivity for frameshift mutagen. We suggest that the plasmid pBC401 and pBC402 are easy to detect mutagens which cause frameshift mutation rather than point mutation.

• Journal of Korean Society on Water Environment
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• v.21 no.5
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• pp.448-457
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• 2005

The conventional activated sludge processes were operated as a combined organic substrate removal and nitrification. So, it was necessary to provide with oxygen for both carbon and ammonia removal. But, in the BNR processes, nitrification is separated from carbon removal that causes fast ammonia oxidation and reduced oxygen demands. And most of the substrate is utilized by denitrification organisms and phosphorus accumulating organisms. with these appearances, mathematical model for BNR processes different from IWA ASM can be simplified and applied. In this study, it was performed that the existing equations as McKinney model, nitrification model published by U.S. EPA and oxygen demands from stoichiometry and the relationship between NUR and OUR were applied to full-scale BNR processes and the results were compared with the measured. and it is possible to make out the optimum design parameter from those equations.

• Journal of East-West Nursing Research
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• v.11 no.1
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• pp.5-11
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• 2005

Purpose: This study is to examine the effect of electrical muscle stimulation therapy on chronic knee pain for aged. Method: Design was randomized one-group pretest-posttest design. Samples were total 15 elderly on 60 years old and above with chronic knee pain. Measures were S-F McGill Pain Questionnaire and Arthritis Impact Measurement Scale for knee pain. Electrical muscle stimulation therapy, experimental treatment was applied on chronic knee pain for 4 weeks, 3 times/week, 15 min/time. Data were collected from half March 2005 to May 2005. Data were analyzed using SPSS PC+ 12 version. Descriptive statistics was used for analysis of general characteristics in sample, and paired t-test was used to analysis the effect of electrical muscle stimulation therapy. Results: After receiving the electrical muscle stimulation therapy chronic knee pain was significantly decreased (t=-29.163, P=.000 in S-F MPQ; t=-37.005, P=.000 in AIMS). Conclusion: Electrical muscle stimulation therapy can be a better effective primary nursing intervention on chronic knee pain for aged in community.