Simvastatin Induces Osteogenic Differentiation and Suppresses Adipogenic Differentiation in Primarily Cultured Human Adipose-Derived Stem Cells |
Sun, So-Hyun
(Department of Family Medicine, The Catholic University of Korea)
Lee, Il-Kyu (Department of Family Medicine, The Catholic University of Korea) Lee, Jee-Won (Department of Biochemistry, McGill University) Shim, In-Sop (Department of Integrative Medicine, The Catholic University of Korea) Kim, Se-Hong (Department of Family Medicine, The Catholic University of Korea) Kim, Kyung-Soo (Department of Family Medicine, The Catholic University of Korea) |
1 | Solomon, D. H., Avorn, J., Canning, C. F. and Wang, P. S. (2005). Lipid levels and bone mineral density. Am. J. Med. 118, 1414. DOI ScienceOn |
2 | Song, C., Guo, Z., Ma, Q., Chen, Z., Liu, Z., Jia, H. and Dang, G. (2003). Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells. Biochem. Biophys. Res. Commun. 308, 458-462. DOI ScienceOn |
3 | Li, X., Cui, Q., Kao, C., Wang, G. J. and Balian, G. (2003). Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARgamma2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures. Bone 33, 652-659. DOI ScienceOn |
4 | Lips, P. (2002). Statins and bone turnover. Eur. J. Clin. Invest. 32, 543-544. DOI ScienceOn |
5 | Mahmood, A., Lu, D. and Chopp, M. (2004). Marrow stromal cell transplantation after traumatic brain injury promotes cellular proliferation within the brain. Neurosurgery 55, 1185-1193. DOI |
6 | Reid, I. R., Hague, W., Emberson, J., Baker, J., Tonkin, A., Hunt, D., MacMahon, S. and Sharpe, N. (2001). Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease. Lancet 357, 509-512. DOI ScienceOn |
7 | Mundy, G., Garrett, R., Harris, S., Chan, J., Chen, D., Rossini, G., Boyce, B., Zhao, M. and Gutierrez, G. (1999). Stimulation of bone formation in vitro and in rodents by statins. Science 286, 1946-1949. DOI ScienceOn |
8 | Pedersen, T. R. and Kjekshus, J. (2000). Statin drugs and the risk of fracture. 4S Study Group. JAMA 284, 1921-1922. DOI ScienceOn |
9 | Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S. and Marshak, D. R. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147. DOI ScienceOn |
10 | Gimble, J. M., Morgan, C., Kelly, K., Wu, X., Dandapani, V., Wang, C. S. and Rosen, V. (1995). Bone morphogenetic proteins inhibit adipocyte differentiation by bone marrow stromal cells. J. Cell Biochem. 58, 393-402. DOI ScienceOn |
11 | Ho, M. L., Chen, Y. H., Liao, H. J., Chen, C. H., Hung, S. H., Lee, M. J., Fu, Y. C., Wang, Y. H., Wang, G. J. and Chang, J. K. (2009). Simvastatin increases osteoblasts and osteogenic proteins in ovariectomized rats. Eur. J. Clin. Invest. 39, 296-303. DOI ScienceOn |
12 | Im, G. I., Shin, Y. W. and Lee, K. B. (2005). Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrowderived cells? Osteoarthr. Cartil. 13, 845-853. DOI ScienceOn |
13 | Lange, C., Togel, F., Ittrich, H., Clayton, F., Nolte-Ernsting, C., Zander, A. R. and Westenfelder, C. (2005). Administered mesenchymal stem cells enhance recovery from ischemia/- reperfusion-induced acute renal failure in rats. Kidney Int. 68, 1613-1617. DOI ScienceOn |
14 | Karpisek, M., Stejskal, D., Kotolova, H., Kollar, P., Janoutova, G., Ochmanova, R., Cizek, L., Horakova, D., Yahia, R. B., Lichnovska, R. and Janout, V. (2007). Treatment with atorvastatin reduces serum adipocyte-fatty acid binding protein value in patients with hyperlipidaemia. Eur. J. Clin. Invest. 37, 637-642. DOI ScienceOn |
15 | Koc, O. N., Gerson, S. L., Cooper, B. W., Dyhouse, S. M., Haynesworth, S. E., Caplan, A. I. and Lazarusm, H. M. (2000). Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J. Clin. Oncol. 18, 307-316. DOI |
16 | Kopen, G. C., Prockop, D. J. and Phinney, D. G. (1999). Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc. Natl. Acad. Sci. U.S.A. 96, 10711-10716. DOI |
17 | Bauer, D. C., Mundy, G. R., Jamal, S. A., Black, D. M., Cauley, J. A., Ensrud, K., E., van der Klift, M. and Pols, H. A. (2004). Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials. Arch. Intern. Med. 164, 146-152. DOI ScienceOn |
18 | Blinc, A. and Poredos, P. (2007). Pharmacological prevention of atherothrombotic events in patients with peripheral arterial disease. Eur. J. Clin. Invest. 37, 157-164. DOI ScienceOn |
19 | Petite, H., Viateau, V., Bensaïd, W., Meunier, A., de Pollak, C., Bourguignon, M., Oudina, K., Sedel, L. and Guillemin, G. (2000). Tissue-engineered bone regeneration. Nat. Biotechnol. 18, 959-963. DOI ScienceOn |
20 | Castro-Malaspina, H., Gay, R. E., Resnick, G., Kapoor, N., Meyers, P., Chiarieri, D., McKenzie, S., Broxmeyer, H. E. and Moore, M. A. (1980). Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood 56, 289-301. |
21 | Chen, S. L., Fang, W. W., Ye, F., Liu, Y. H., Qian, J., Shan, S. J., Zhang, J. J., Chunhua, R. Z., Liao, L. M., Lin, S. and Sun, J. P. (2004). Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am. J. Cardiol. 94, 92-95. DOI ScienceOn |
22 | Deans, R. J. and Moseley, A. B. (2000). Mesenchymal stem cells: biology and potential clinical uses. Exp. Hematol. 28, 875-884. DOI ScienceOn |
23 | Fibbe, W. E. and Noort, W. A. (2003). Mesenchymal stem cells and hematopoietic stem cell transplantation. Ann. N. Y. Acad. Sci. 996, 235-244. DOI ScienceOn |
24 | Friedenstein, A. J., Deriglasova, U. F., Kulagina, N. N., Panasuk, A. F., Rudakowa, S. F., Luria, E. A. and Ruadkow, I. A. (1974). Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp. Hematol. 2, 83-92. |
25 | Gonyeau, M. J. (2005). Statins and osteoporosis: a clinical review. Pharmacotherapy 25, 228-243. DOI ScienceOn |
26 | Vaughan, C. J., Gotto, A. M. and Jr. Basson, C. T. (2000). The evolving role of statins in the management of atherosclerosis. J. Am. Coll Cardiol. 35, 1-10. DOI ScienceOn |
27 | Lin, C. P., Chen, Y. H., Lin, W. T., Leu, H. B., Liu, T. Z., Huang, S. L. and Chen, J. W. (2008). Direct effect of statins on homocysteine-induced endothelial adhesiveness: potential impact to human atherosclerosis. Eur. J. Clin. Invest. 38, 106-116. DOI ScienceOn |
28 | Ohnaka, K., Shimoda, S., Nawata, H., Shimokawa, H., Kaibuchi, K., Iwamoto, Y. and Takayanagi, R. (2001). Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem. Biophys. Res. Commun. 287, 337-342. DOI ScienceOn |
29 | Shepherd, J., Cobbe, S. M., Ford, I., Isles, C. G., Lorimer, A. R., MacFarlane, P. W., McKillop, J. H. and Packard, C. J. (1995). Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N. Engl. J. Med. 333, 1301-1307. DOI ScienceOn |
30 | Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F., Krause, D., Deans, R., Keating, A., Prockop, D. J. and Horwitz, E. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315-317. DOI ScienceOn |
31 | Horwitz, E. M., Prockop, D. J., Fitzpatrick, L. A., Koo, W. W., Gordon, P. L., Neel, M., Sussman, M., Orchard, P., Marx, J. C., Pyeritz, R. E. and Brenner, M. K. (1999). Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat. Med. 5, 309-313. DOI ScienceOn |
32 | Brasaemle, D. L., Dolios, G., Shapiro, L. and Wang, R. (2004). Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J. Biol. Chem. 279, 46835-46842. DOI ScienceOn |
33 | Le Blanc, K., Rasmusson, I., Sundberg, B., Götherström, C., Hassan, M., Uzunel, M. and Ringdén, O. (2004). Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363, 1439-1441. DOI ScienceOn |