• The Korean Journal of Physiology and Pharmacology
• /
• v.5 no.1
• /
• pp.87-92
• /
• 2001

Carbon monoxide (CO) binds to soluble guanylate cyclase to lead its activation and elicits smooth muscle relaxation. The vascular tissues have a high capacity to produce CO, since heme oxygenase-2 (HO-2) is constitutively expressed in endothelial and smooth muscle cells, and HO-1 can be greatly up-regulated by oxidative stress. Moreover, the substrate of HO, heme, is readily available for catalysis in vascular tissue. Although the activation of heme oxygenase pathway under various stress conditions may provide a defence mechanism in compromised tissues, the specific role of HO-1-derived CO in the control of aortic contractility still remains to be elucidated. The present study was done to determine the effect of HO-1 induction on the aortic contractility. Thus, the effects of incubation of aortic tissue with S-nitroso-N-acetylpenicillamine (SNAP) for 1 hr on the aortic contractile response to phenylephrine were studied. The preincubation with SNAP resulted in depression of the vasoconstrictor response to phenylephrine. This effect was restored by HO inhibitor or methylene blue but not by NOS inhibitor. The attenuation of vascular reactivity by preincubation with SNAP was also revealed in endothelium-free rings. $AlF4^--evoked$ contraction in control did not differ from that in SNP-treated group. These results suggest that increased production of CO was responsible for the reduction of the contractile response to phenylephrine in aortic ring preincubated with SNAP and this effect of SNAP was independent on endothelium.

• The Korean Journal of Pain
• /
• v.34 no.1
• /
• pp.124-131
• /
• 2021

Background: Sciatic nerve injury due to intramuscular injection (SNIII) is still a health problem. This study aimed to determine whether there is a correlation between neuropathic pain and electrodiagnostic findings in SNIII. Methods: Patients whose clinical and electrodiagnostic findings were compatible with SNIII participated in this retrospective cohort study. Compound muscle action potential (CMAP) and sensory nerve action potential (SNAP) amplitudes of the sural, superficial peroneal, peroneal, and tibial nerves were graded from 1 to 4. Leeds assessment of neuropathic symptoms and signs scale (LANSS) was applied to all patients. Results: Forty-eight patients were included in the study, 67% of whom had a LANSS score ≥ 12. Sural SNAP amplitude abnormalities were present in 8 (50%) out of 16 patients with a LANSS score < 12, and 28 (87.5%) out of 32 patients with a LANSS score ≥ 12, with significant differences between the groups (P = 0.011). There was a positive correlation between the LANSS score and the sural SNAP amplitude grading (P = 0.001, r = 0.476). A similar positive correlation was also found in the LANSS score and the tibial nerve CMAP amplitude grading (P = 0.004, r = 0.410). Conclusions: This study showed a positive correlation between the severity of tibial nerve CMAP/sural SNAP amplitude abnormality and LANSS score in SNIII. Neuropathic pain may be more common in SNIII patients with sural nerve SNAP amplitude abnormality.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 2008.04a
• /
• pp.282-287
• /
• 2008

Since glass-fiber reinforced composite decks have high-strength, light-weight and high durability, many researchs on the composite decks for bridges are currently performed and many composite decks are developed. In this paper, a composite deck with snap-fit connection for pedestrian bridge is developed and studied. A study on behavior of snap-fit connection of composite deck for pedestrian bridge during assembling or disassembling is performed by analysis and experiment.

• The Journal of the Korean dental association
• /
• v.56 no.10
• /
• pp.538-547
• /
• 2018

ITK-SNAP (http://www.itksnap.org) and 3D Slicer (CMFreg extension module; www.slicer.org) are open-source softwares which can be used for superimposition of cone-beam CT images. For superimposition, segmentation of bone is done with ITK-SNAP, and then voxel based superimposition of CBCT images can be performed using 3D Slicer. 3D Slicer has various visualization modules which are not provided in common commercial programs. 'Models' module is used to visualize two overlapping three-dimensional images, and this allows various visualizations by changing view mode and color of the model. In addition, differences between two CBCT images can be represented in a color map using 'ShapePopulationViewer' module. This report introduces how to superimpose and visualize CBCT images using ITK-SNAP and 3D Slicer, and the usefulness and limitations of both softwares will be discussed in comparison with commercial softwares.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2005.05a
• /
• pp.662-667
• /
• 2005

Nonlinear dynamics of active piezolaminated plates are investigated with respect to the thermopiezoelastic behaviors. For largely deformed structures with small strain, the incremental total Lagrangian formulation is presented based on the virtual work principles. A multi field layer wise finite shell element is proposed for assuring high accuracy and non-linearity of displacement, electric and thermal fields. For dynamic consideration of thermopiezoelastic snap through phenomena, the implicit Newmark's scheme with the Newton-Raphson iteration is implemented for the transient response of various piezolaminated models with symmetric or eccentric active layers. The bifurcate thermal buckling of symmetric structural models is first investigated and the characteristics of piezoelectric active responses are studied for finding snap through piezoelectric potentials and the load path tracking map. The thermoelastic stable and unstable postbuckling, thermopiezoelastic snap through phenomena with several attractors are proved using the nonlinear time responses for various initial conditions and damping loss factors. Present results show that thermopiezoelastic snap through phenomena can result in the difficulty of buckling and postbuckling control of intelligent structures.

• Transactions on Electrical and Electronic Materials
• /
• v.4 no.2
• /
• pp.15-19
• /
• 2003

In this paper, the new dual trench gate Emitter Switched Thyristor (DTG-EST) is proposed for improving snap-back effect which leads to a lot of serious problems of device applications. Also the parasitic thyristor that is inherent in the conventional EST is completely eliminated in this structure, allowing higher maximum controllable current densities for ESTs. The conventional EST exhibits snap-back with the anode voltage and current density 2.73V and 35A/$\textrm{cm}^2$, respectively. But the proposed DTG-EST exhibits snap-back with the anode voltage and current density 0.96V and 100A/$\textrm{cm}^2$, respectively.

• Transactions of the Korean Society of Machine Tool Engineers
• /
• v.15 no.6
• /
• pp.121-126
• /
• 2006

Snap-fit is being used in manufacture of plastic products. Integral features using snap-fit are classified as locks, locators and enhancements. Locking features complete the process of attachment by providing physical interference to prevent separation. Looking feature pairs consist of two components, i.e., a flexible latch and a rigid catch and require particular care and attention for their selection. We can make several locking feature pairs by selecting latch and catch, but some parts restrict freedom of selection. Therefore, part designers must know the characteristic properties of generic locking feature forms as considering a specific design problem. In this paper, it has been presented about problem of small size products using locking feature and then introduced new locking feature applicable to small parts.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2003.05b
• /
• pp.27-30
• /
• 2003

In this paper, the new dual trench gate Emitter Switched Thyristor (DTG-EST) is proposed for improving snap-back effect which leads to a lot of serious problems of device applications. And the parasitic thyristor that is inherent in the conventional EST is completely eliminated in this structure, allowing higher maximum controllable current densities for ESTs. The conventional EST exhibits snap-back with the anode voltage and current density 2.73V and $35A/cm^2$, respectively. But the proposed DTG-EST exhibits snap-back with the anode voltage and current density 0.96V and $100A/cm^2$, respectively.

• Computational Structural Engineering
• /
• v.9 no.3
• /
• pp.107-114
• /
• 1996

The performance for the algorithm of the arc length method has been examined in terms of the choice of the tangential stiffness matrix through the analysis for the snap buckling phenomenon of the arch beam. The curved beam element with 2 nodes including shear effect has been formed by strain element technique and then it has been used in this nonlinear analysis. Snap-through characteristics has been examined with respect to the ratios of the arch beam length to hight.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 2010.04a
• /
• pp.158-161
• /
• 2010

고중량, 부식 등의 문제를 안고 있는 목재/강재 리그매트를 대체할 수 있는 고강도 경량 고내구성 특성을 갖는 복합소재 리그매트를 전통 목재 연결방식의 결구시스템을 응용한 새로운 개념의 스냅핏 방식으로 개발하였다. 본 논문에서는 기존에 개발한 리그매트와 이를 개선한 개선형 리그매트의 스냅핏(snap-fit) 연결부의 안전성을 검증하기 위해 연결부 착탈 거동에 대한 해석 및 구조성능 시험을 실시하였고, 그 결과를 비교 분석하여 스냅핏 연결부의 긍정적인 효과를 입증하였다.