• Archives of Pharmacal Research
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• v.27 no.8
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• pp.834-839
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• 2004

In human neuroblastoma SK-N-BE(2) cells undergoing apoptotic death induced by ginsenos-ide Rh2, a dammarane glycoside that was isolated from Panax ginseng C. A. Meyer, caspase-1 and caspase-3 were activated. The expression of Bax was increased in the cells treated with ginsenoside Rh2, whereas Bcl-2 expression was not altered. Treatment with caspase-1 inhibi-tor, Ac-YVAD-CMK, or caspase-3 inhibitor, Z-DEVD-FMK, partially inhibited ginsenoside Rh2-induced cell death but almost suppressed the cleavage of the 116 kDa PARP into a 85 kDa fragment. When the levels of p53 were examined in this process, p53 accumulated rapidly in the cells treated early with ginsenoside Rh2. These results suggest that activation of caspase-1 and -3 and the up-regulation of Bax are required in order for apoptotic death of SK-N-BE(2) cells to be induced by ginsenoside Rh2, and p53 plays an important role in the pathways to promote apoptosis.

• 월간 기계설비
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• s.304
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• pp.76-85
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• 2015

최근들어 전력 소비량이 크게 늘어나자 정부는 원활한 전력 공급을 위해 제5차 및 제6차 전력수급계획을 세우고 2022년까지 발전소 건설을 목표로 함에 따라 전국 곳곳에서 발전소 건설공사가 한창이다. 이 중 PMP(주)가 경기도 파주시에 건설 중인 장문 천연가스발전소는 1,820MW 규모의 천연가스복합화력 발전소다. 지난 6월 1일 착공에 들어가 오는 2017년 3월 말까지 완공될 예정이다. 장문 천연가스발전소는 제5차 전력 수급기본계획에 따른 국가 기간산업으로 수도권 북부지역에 전력을 충분히 공급함은 물론 주변지역의 대규모 산업단지와 기업체에도 공급 가능성이 큰 대규모 발전소다. 또한 SK그룹은 풍부한 발전소 운영경험을 기반으로 고효율 발전설비를 갖춤으로써 전력시장에서 높은 경쟁력을 확보할 수 있을 것으로 기대하고 있다. (주)세일엔지니어링(대표 오세현)은 장문 현장에서 #11, #12의 2기 HRSG(Heat Recovery steam Generator) 설치공사를 SK건설(현장소장 이원기)로부터 하도급 받아 시공하고 있다. 본지는 2017년 3월 말까지의 완공을 목표로 무결점 시공에 올인하고 있는 (주)세일엔지니어링의 주남식 현장소장을 만났다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.39 no.3
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• pp.205-213
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• 2013

This study was to improve cosmetical activity of thiamine di-lauryl sulfate (TDS) by encapsulation of nanoparticle with lecithin. Results showed that most of the nanoparticles containing the TDS were well formed in round shape with below 150 ~ 200 nm diameter as well as they were fairly stable in various pH ranges by measuring zeta potentials. The nanoparticles of TDS resulted in 85% cell viability of human normal fibroblast cells (CCD-986sk) when added at the highest concentration (1.0 mg/mL). The nanoparticles of Acer mono sap showed highest free radical scavengering effect as 88.1% in adding sample (1.0 mg/mL), compared to TDS solution of non-encapsulation (81.6%). The nanoparticles of TDS reduced the expression of MMP-1 on UV-irradiated CCD-986sk cells down to as 41.4%. The TDS solution and nanoparticles showed significant anti-microbial activities agaionst the salmonella typhimurium and listeria monocytogenes at 5 and 6 days as compared with control. Anti-microbial activities of TDS nanoparticles were similar to positive control. These results indicated that TDS nanoparticles may be a source for functional cosmetic agents capable of improving cosmetical activity such as antioxidant, whitening, and anti-wrinkling effects and can be further developed as natural preservative in cosmetics.

• International Area Studies Review
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• v.20 no.2
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• pp.85-111
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• 2016

Global semiconductor companies is investing enormous capital worldwide. And direct investment in China is increasing greatly these days, Especially, global semiconductor companies are setting up a factory in China due to expanding market rather than utilizing low labor cost. Therefore, this study is trying to analyze the background and process of direct investment from global Korean and Taiwanese semiconductor companies in China. Firstly, In 1996, Samsung semiconductor established a back end process factory in Suzhou. And in 2014, Samsung semiconductor set up a front and back end factory in Xian. Secondly, In 2006, SK Hynix built a front and back end factory in Wuxi. and SK Hynix set up a back end factory named Hitech semiconductor with Chinese company in 2009. Later in 2015, SK Hynix established a back end factory in Chongqing. Thirdly, In 2004, TSMC started to operate a factory in Shanghai, and in 2018, TSMC is going to establish a factory in Nanjing. Lastly, UMC bought a stock to produce product in Chinese local company named HJT, and at the end of 2016, UMC is going to finish building a factory in Xiamen. As a result, it was proved that most companies hoped to expand the chinese market by setting up a factory in china. In addition, Samsung expected to avoid a risk by setting up a factory in china, and SK Hynix wanted to avoid a countervailing duty by setting up a factory in china. Based on the result of this study, this study indicates some implications for other semiconductor companies which are very helpful for their future foreign direct investment.

• Journal of Korea Society of Industrial Information Systems
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• v.22 no.1
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• pp.53-59
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• 2017

This Paper Proposes a New High-speed Design Methodology for Delay Insensitive Asynchronous Circuits Combining with a Pseudo-NMOS Structure used for High Performance in Synchronous Circuits. Null Convention Logic(NCL) of Conventional Delay-Insensitive Asynchronous Design Methodologies has many Advantages of High Reliability, Low Power Consumption, and Easy Design Reuses not Dependant on Semiconductor Technology. However. the Conventional NCL Gates has a Complicated Stack Structure, so it Suffers from Increased Circuit Delay. Therefore, a New NCL Gates and its Pipeline Structure for High Performance, and the Proposed Methodology has been Designed and Evaluated by a $4{\times}4$ Multiplier Designed using SK-Hynix 0.18 um CMOS Technology. The Experimental Results are Compared with a Conventional NCL in Terms of Power and Delay and shows that the Propagation Delay of the Proposed Multiplier is Reduced by 85% Compared with the Conventional NCL Multiplier.

• Microbiology and Biotechnology Letters
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• v.20 no.2
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• pp.178-182
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• 1992

For an industrial-scale purification and production of cephalosporin C from a culture broth of Ceplzalos#mium nmemonium CSA-2.8A3 mutant, ultrafiltration, column chromatography, reverse osmosis, and spray drying were empolyed. Above 90% of yield and high purity of cephalosporin C were obtained through WA-30, HP-20, XAD-2000 and SK-1B column chromatographies. Especially, in the tendom operation of the columns, the recovery yield was increased up to 96%. The purified cephalosporin C was stable at $4^{\circ}C$ and in acidic condition, while it was unstable at room temperature and in alkaline condition at pH above 8.0. Cephalosporin C powder or a final product prepared by spray drying contained 85.554 of sodium cephalosporin C, 6.3%' of water, 4.63% of free $Na^+$ ions. and traces of metal ions.

• Journal of Ginseng Research
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• v.19 no.1
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• pp.51-55
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• 1995

The DNA fragment containing ginseng ribulose-1,5-bisphosphate carboxytase/oxygenase large subunit(rbcL) gene was cloned from the ginseng chloroplast EcoRl library by colony lift hybridization with tobacco rbcL gene probe. From the screened clone, the DNA fragment containing ginseng rbcL gene was digested with several restriction enzyme and analyzed by Southern blot hybridization for the construction of restriction map. The ginseng rbcL gene fragment was subcloned in pBluescript II SK + vector and sequence analysis was performed. The nucleotide sequence of ginseng rbcL gene was compared with those of petunia, tobacco, alfalfa, rice and barley, which showed a homology of 93.1%, 95.2%, 90.5%, 85.5% and 84.3%, respectively.

• 한국IT서비스학회:학술대회논문집
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• 2005.11a
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• pp.85-90
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• 2005

IT서비스 관리에 대한 국내 시장은 전문 SI기업들의 IT아웃소싱 사업 모델을 대상으로 한다. 국내 SI기업들은 전격적으로 IT아웃소싱을 선택하고 SLA를 체결한 그룹 관계사들을 대상으로 IT서비스를 제공해왔기에, 상대적으로 해외 open market에 비해 SLA 적용 효과에 대한 해석과 설명의 노력을 간과했다. 본 연구에서는 12개 고객 기업 사례를 바탕으로, S기업의 4개년간 서비스수준 관리 이력을 분석함으로써 IT서비스 제공자의 서비스 품질 제고에 기여한 서비스수준 관리의 효과를 규명하였다. 첫째로 서비스수준 관리 항목별 목표수준 설정의 효과, 둘째, 서비스 유형별 Target-time 설정의 효과, 셋째, 고객 기업의 사업 영향도에 따른 중요도 구분의 효과, 넷째, 제재와 보상의 적용을 통한 서비스수준 관리의 효과를 분석하였다. 본 연구는 고객 기업과 SLA 체결을 통한 IT서비스 제공자의 서비스수준 관리 효과를 수치적 결과로 입증했다는 데 의의가 있으며, 본 연구를 기반으로 한 후속 연구과제는 IT서비스 제공자의 서비스수준 관리를 통한 서비스 품질 제고 효과가 IT아웃소싱의 비용 절감 효과에 미치는 영향 분석이 되어야 할 것으로 기대한다.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.7 no.1
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• pp.16-20
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• 2001

In order to optimize designing process of corrugated fiberboard boxes for agricultural products, first of all, compression strength of each liner were experimentally evaluated on the various conditions of relative humidity and analyzed by liner regression analysis. At the 66 percents of relative humidity, IK(imported kraft liner) liner board lost little of its compression strength compared to others. At the relative humidity 93 percents, KA liner board lost its compression strength only 40 percents while SK liner board lost up to 56 percents. From the result of prediction modeling of ring crush strength in various humidity conditions, R square values were ranged from 0.59 to 0.97. At 56 percents of RH or below, R square values were relatively low, but at 66 percents of RH or higher, the values were 0.85 or higher. The significance values were lower than 0.001 at every RH condition. Level of significance of experimented values was about 80 percents of predicted values and R square values were between 0.89 to 0.95.

• Archives of Pharmacal Research
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• v.19 no.4
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• pp.286-291
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• 1996

Phenolic compounds are prevalent as toxins or environmental pollutants, but they are also widely used as drugs for various purpose including anticancer agent. A novel biphenolic compound, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane (GERI-BPO02-A) was isolated from the fermentation broth of Aspergillus fumigatus F93 previously, and it has revealed cytotoxicity against human solid tumor cells. Its effective doses that cause 50% inhibition of cell growth in vitro against non-small cell lung cancer cell A549, ovarian cancer cell SK-OV-3, skin cancer cell SK-MEL-2 and central nerve system cancer cell XF498 were 8.24, 10.60, 8.83, $9.85\mug/ml$ respectively. GERI-BPO02-A has also revealed cytotoxicity against P-glycoproteinexpressed human colon cancer cell HCT15 and its multidrug-resistant subline HCT15/CL02, and its cytotoxicity was not affected by P-glycoprotein. We have also tested cytotoxicities of structurally related compounds of GERI-BPO02-A such as diphenylmethane, 1,1-bis(3,4dimethylphenyl)ethane, 2,2-diphenylpropane, 2-benzylpyridine, 3-benzylpyridine, $4,4^I-di-tert-butylphenyl$, bibenzyl, $2,2^I-dimethylbibenzyl$, cis-stilbene, trans-stilbene, 3-tert-butyl-4-hydroxy-5-methylphenyisulfide, sulfadiazine and sulfisomidine for studying of structure and activity relationship, and from these data we could suppose that hydroxyl group of GERI-BPO02A conducted important role in its cytotoxicity.