• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.269-270
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• 2008

TD-SCDMA combines TDMA and CDMA components to provide more efficient use of radio resources, and includes a new feature called HSDPA (high-speed downlink packet access) in the R5 stage. The TD-HSDPA supports high-speed traffic with a shared channel, but the adopted mechanism causes feedback problem for scheduling. In this paper, we propose an improved mechanism that transmits channel quality indicator (CQI) more frequently, so that the TD-HSDPA scheduler can utilize all possible information about the downlink channel status.

• The Korean Journal of Physiology and Pharmacology
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• 제12권2호
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• pp.51-58
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• 2008

Cardiac fibroblasts constitute one of the largest cell populations in the heart, and contribute to structural, biochemical, mechanical and electrical properties of the myocardium. Nonetheless, their cardiac functions, especially electrophysiological properties, have often been disregarded in studies. $Ca^{2+}$-activated $K^+\;(K_{Ca})$ channels can control $Ca^{2+}$ influx as well as a number of $Ca^{2+}$-dependent physiological processes. We, therefore, attempted to identify and characterize $K_{Ca}$ channels in rat Cardiac fibroblasts. First, we showed that the cells cultured from the rat ventricle were cardiac fibroblasts by immunostaining for discoidin domain receptor 2 (DDR-2), a specific fibroblast marker. Secondly, we detected the expression of various $K_{Ca}$ channels by reverse transcription polymerase chain reaction (RT-PCR), and found all three family members of $K_{Ca}$ channels, including large conductance $K_{Ca}$ (BK-${\alpha}1-\;and\;-{\beta}1{\sim}4$subunits), intermediate conductance $K_{Ca}$ (IK), and small conductance $K_{Ca}$ (SK$1{\sim}4$ subunits) channels. Thirdly, we recorded BK, IK, and SK channels by whole cell mode patch clamp technique using their specific blockers. Finally, we performed cell proliferation assay to evaluate the effects of the channels on cell proliferation, and found that the inhibition of IK channel increased the cell proliferation. These results showed the existence of BK, IK, and SK channels in rat ventricular fibroblasts and involvement of IK channel in cell proliferation.

• 한국컴퓨터정보학회논문지
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• 제22권6호
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• pp.17-24
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• 2017

In recent digital broadcasting, up to 250 channels are multiplexed and transmitted. The channel transmission is made in the form of MPEG-2 Transport Stream (TS) and transmits one channel (Video, Audio). In order to check if many broadcast channels are transmitted normally, in multi-channel multi-view system, ability of real-time monitoring is required. In order to monitor efficient multi-channel, a distributed system in which functions and load are distributed should be implemented. In the past, we used an inefficient system that gave all of the functionality to a piece of hardware, which limited the channel acceptance and required a lot of resources. In this paper, we implemented a distributed multi-view system which can reduce resources and monitor them economically through efficient function and load balancing. It is able to implement efficient system by taking charge of decoding, resizing and encoding function in specific server and viewer function in separate server. Through this system, the system was stabilized, the investment cost was reduced by 19.7%, and the wall monitor area was reduced by 52.6%. Experimental results show that efficient real-time channel monitoring for multi-channel digital broadcasting is possible.

• 한국어병학회지
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• 제5권2호
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• pp.143-152
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• 1992

Metallothionein은 세포내의 중금속의 농도을 조절하는 주요한 단백질로서 bacteria에서 척추동물에 이르기까지 모든 생명체에서 나타나는 공통된 단백질이다. 비록 metallothionein의 정확한 기능은 알려져 있지 않으나 독성을 나타내는 중금속에 대하여 세포내 방어기작에 관여할 뿐만 아니라 여러다른 유전자의 총괄적 조절기작 및 matalloprotein의 발현에 관여할 것으로 보고있다. 본 연구에서는 Channel Catfish의 metallothionein cDNA 유전자를 poly(A)를 갖는 mRNA로 부터 Reverse Transcriptase-Polymerase Chain Reaction(RT-PCR)에 의하여 cloning하였다. 증폭된 PCR products는 pBluescript SK+의 EcoRV site 및 pUC19의 Smal site에 dT tailing을 하여 cloning하였으며, PCR products는 multicloning site에 있는 EcoRI 및 HindIII 로 절단하여 확인하거나 신속한 PCR screening에 의하여 확인하였다. 여러 PCR clone 중 하나인 pMT150에 대한 DNA 염기서열을 조사한 결과 다른 어류의 metallothionein cDNA 유전자와 높은 유사성을 보였다.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.38-38
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• 2003

The electrical properties of neurons are produced by the coordinated activity of ion channels (Hille, 1992). $K^{+}$ channels play a key role in shaping action potentials and in determining neural firing patterns. Small conductance $Ca^{2+}$-activated $K^{+}$ (S $K_{Ca}$ ) channels are involved in modulating the slow component of afterhyperpolarization (AHP) (Kohler et al., 1996). Here we examine whether rat type 2 S $K_{Ca}$ (rSK2) channels can affect the shape of the action potential and the neural firing pattern, by overexpressing rat SK2 channels in Aplysia neuron R15. Our results show that rSK2 overexpression decreased the intraburst frequency and changed the regular bursting activity of neurons to an irregular bursting or beating pattern in R15, Furthermore, the overexpression of rSK2 channels increased AHP and reduced the duration of the action potential. Thus, our results suggest that ectopic S $K_{Ca}$ channels play an important role in regulating the filing pattern and the shape of the action potential.ntial.

• 수산해양기술연구
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• 제33권1호
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• pp.9-26
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• 1997

Stokes drift(SD) and Lagrangian discharge(LD) are important factors for analysis of flushing time, tidal exchange, solute transport and pollutant dispersion. The factors should be calculated using the approached method to flow phenomena. The aim of this paper re-examines the previous procedures for computing the SD and LD, and is to propose the new method approached to stratified flow field in the cross-section of coastal region, e.g. Masan Bay. The intensity of velocity near the bottom boundary layer(BBL) depends on the sea-bed irregularity in the coastal estuaries. So we calculated the depth mean velocity(DMV) considering that of BBL omitted in Kjerfve's calculation method. It revealed that BBL effect resulting in application of the bay acts largely on DMV in half more among 1l stations. The new expression of SD and LD per unit width in the cross-section using the developed DMV and proposed decomposition procedure of current were derived as follow : $$Q=u_0+\frac{1}{2}H_1{U_1cos(\varphi_h-\varphi_u)+U_3cos(\varphi_h-\varphi{ud})} LD ED SD$(Q_{skim}+Q_{sk2}) The third term, $Q_{sk2}$, on the right-hand of the equation is showed newly and arise from vertical oscillatory shear. According to the results applied in 3 cross-sections including 11 stations of the bay, the volume difference between proposed and previous SD was founded to be almost 2 times more at some stations. But their mean transport volumes over all stations are 18% less than the previous SD. Among two terms of SD, the flux of second term, $Q_{skim}$, is larger than third term, $Q_{sk2}$, in the main channel of cross-section, so that $Q_{skim}$ has a strong dependence on the tidal pumping, whereas third term is larger than second in the marginal channel. It means that $Q_{sk2}$ has trapping or shear effect more than tidal pumping phenomena. Maximum range of the fluctuation in LD is 40% as compared with the previous equations, but mean range of it is showed 11% at all stations, namely, small change. It mean that two components of SD interact as compensating flow. Therefore, the computation of SD and LD depend on decomposition procedure of velocity component in obtaining the volume transport of temporal and spacial flow through channels. The calculation of SD and LD proposed here can separate the shear effect from the previous SD component, so can be applied to non-uniform flow condition of cross-section, namely, baroclinic flow field.

• Biomolecules & Therapeutics
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• 제13권2호
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• pp.78-83
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• 2005

2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) has previously shown to induce neurotoxicity through intracellular $Ca^{2+}$ increase in rat neurons. In this study we investigated the role and signaling pathway of intracellular $Ca^{2+}$ in TCDD-induced inhibition of neuronal cell proliferation in SK-N-SH human neuronal cells. We found that TCDD(10nM) rapidly increased the level of intracellular $Ca^{2+}$, which was completely blocked by the extracellular $Ca^{2+}$ chelation with EGTA (1 mM) or by pretreatment of the cells with the non-selective cation channel blocker. flufenamic acid (200 ${\mu}M$). However, pretreatment of the cells with dantrolene (25 ${\mu}M$) and TMB-8(10 ${\mu}M$), intracellular $Ca^{2+}$-release blockers, or a voltage-sensitive $Ca^{2+}$ channel blocker, varapamil (100 ${\mu}M$), failed to block the TCDD-induced $Ca^{2+}$ increase in the cells. In addition, TCDD induced a rapid and transient activation of phatidvlinositol 3-kinase (PI3K) and extracellular signal-regulated kinase 1/2(ERK1/2), which was ingnificantly blocked by the pretreatment with BAPTA, an intracellular $Ca^{2+}$ chelator, and LY294002, a PI3K inhibitor. Furthermore, inhibitors of PI3K, ERK, or an intracellular $Ca^{2+}$ chelator further potentiated the anti-proliferative effect of TCDD in the cells. Collectively, the results suggest that intracellular $Ca^{2+}$ and PI3K-dependent activation of ERK 1/2 may be involved in the TCDD-induced inhibition of cell proliferation in SK-N-SH human neuronal cells.

• 한국통신학회논문지
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• 제30권9A호
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• pp.772-780
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• 2005

본 논문에서는 시공간블록부호화된 공간다중화 시스템에서 제한된 귀환채널을 효과적으로 활용할 수 있는 전처리 기법을 제안하고 성능을 분석한다. 전처리기는 기존의 대각-가중-시공간블록부호화 다이버서티 시스템을 공간다중화 시스템으로 확장하여 경험적으로 설계된다. 제안된 시스템에 대해 심볼 오율의 상위한계를 귀환채널 오류를 고려하여 분석하였다. 또한 모의 실험을 통해 4.akbps의 귀환채널 전송율에서 정규화된 도플러 주파수가 0.01이상이 되면 기존의 안테나선택기법과 코드북선택기법에 비해 심볼오율 성능이 우수함을 확인하였다.

• 한국컴퓨터정보학회논문지
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• 제22권10호
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• pp.63-71
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• 2017

In this paper, we develop the system for audio volume equalization of video on demand(VoD) content and propose the solution for it. In recent years, there has been a steady increase in the number of VoD users in addition to linear channels. However, viewers ought to sit in an uncomfortable way, adjusting the volume intermittently while they are broadcasted. Sudden changes of volume occur between the broadcasting channels, the programs from the co-channel, or the linear channels and the VoDs. Especially, upsurged dissatisfaction from the televiewers has been found due to the unequalized volume when shifting between the linear channel and the VoD. In order to solve this problem, multilateral efforts were put forth, such as a system for keeping the volume at a certain level in digital broadcasting program has been legislated domestically. It leads success in equalizing linear channel volume. On contrary, too little notice has been taken for distorted volume problem of video on demand(VoD) content. In this paper, we developed and applied the volume equalization system into VoD content to achieve uniformization, a similar condition with linear channel(-24LKFS). This suggestion helped uneven current of volume which was in the stage -16 ~ -20LKFS to stable condition by lowering into the stage of -24LKFS. It also brought 20% increase in perspective of volume quality satisfaction level.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 하계종합학술대회 논문집(1)
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• pp.201-204
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• 2000

In this paper, a new multiuser detector combining multicarrier and decorrelating detection schemes is proposed and analyzed in a frequency selective Rayleigh fading channel. The bit error probability is derived and compared with that of the conventional decorrelating detector. From the numerical results, it is shown that the proposed detector achieves better BER performance and lower computational complexity than those of the conventional decorrelating detector.