• Journal of Chest Surgery
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• 제56권3호
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• pp.197-203
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• 2023

Background: The survival benefit of coronary artery bypass grafting (CABG) using the bilateral internal thoracic arteries (BITA) is well known; however, the role of BITA in concomitant aortic valve replacement (AVR) and CABG has not been studied. Methods: We retrospectively reviewed patients who underwent concomitant AVR and CABG. Cases not using an internal thoracic artery and less than 2 bypass grafts were excluded. We enrolled 114 patients in this study. The mean follow-up duration was 61.5±43.5 months. Results: Forty patients (35.1%) underwent CABG with a single internal thoracic artery (SITA) and 74 patients (64.9%) underwent CABG with BITA. The preoperative clinical characteristics were not significantly different between the 2 groups, with the exception of a higher prevalence of atrial fibrillation in the SITA group. Postoperative mortality and morbidity were not significantly higher in the BITA group than in the SITA group. In the univariable analysis, the survival of the BITA group was similar to that of the SITA group (p=0.157). Multivariable analysis showed that only mean age was a predictor of death (p=0.042), but using BITA was not an independent predictor (p=0.094). In low-risk patients whose preoperative ejection fraction was >45%, the survival of the BITA group was significantly better than that of the SITA group (p=0.043). Conclusion: BITA use in concomitant AVR and CABG showed no difference in mortality compared to using SITA. Although its impact on long-term survival was inconclusive, BITA use can be considered for low-risk patients.

• 정보과학회 논문지
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• 제44권3호
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• pp.223-231
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• 2017

본 논문에서는 최근 광범위하게 사용되고 있는 멀티 코어 환경에서의 모바일 장치의 성능에 대하여 연구하였다. 이전에 연구되어왔던 멀티 코어의 성능에 대한 분석은, 대부분 데스크톱 PC에서의 분석이었고, heterogeneous 멀티 코어에 대한 분석방법이 충분하지 않았다. 이러한 문제점을 보완하고자 homogeneous 멀티 코어의 분석 방법을 응용한 heterogeneous 멀티 코어 환경에서 성능을 분석하는 방법을 제안하였다. 본 연구에서는 이를 분석하는 데 있어서 작업의 할당에는 Size Interval Task Allocation (SITA) 기법을 사용하였고, 코어에서의 처리 방법은 Shortest Remaining Processing Time (SRPT) 기법을 사용하였다. 이 중 SITA 기법에서 가장 중요한 분석인 cutoff point에 대한 새로운 계산 방법을 제안하였고, 이를 체류 시간을 계산하는 데 사용함으로써 계산의 용이성과 정확성을 높였다. 또한, ESESC 시뮬레이터에서의 측정을 통해 분석값과 측정값에 큰 차이가 없음을 확인하였다.

• Journal of Chest Surgery
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• 제36권10호
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• pp.728-733
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• 2003

동맥편만을 이용한 관상동맥 우회술을 위한 한 방법으로 양측성 내흉동맥을 이용한 관상동맥우회술의 유용성에 대해 알아보고자 하였다. 대상 및 방법: 2000년 1월부터 2001년 12월까지 서울아산병원 흉부외과에서 심폐바이패스를 사용하지 않는 관상동맥 우회술을 시행받은 139명의 환자를 대상으로 의무기록을 이용한 후향적 분석을 시행하였다. 전체환자를 양측성 내흉동맥을 사용한 환자군을 양측 내흉동맥군(bilateral internal thoracic artery; BITA group, n=85), 단일 내흉동맥을 사용한 환자군을 단일 내흉동맥군(single internal thoracic artery; SITA group, n=54)으로 나누었고 수술결과를 비교하였다. 결과: 수술에 따른 사망은 양 군에서 각각 1예씩 발생하였다. 중환자실 재원일 및 퇴원기간은 양 군 간에 차이를 보이지 않았다(BITA군: 2.4$\pm$1.7일, 11.2$\pm$17.7일, SITA군 2.8$\pm$2.7일, 9.7$\pm$7.1일, p>0.05). 문합혈관수는 BITA군이 3.9$\pm$0.7개, SITA군이 3.1$\pm$0.8개로 BITA군이 더 많았다. 술 후 심근경색은 7예(BITA군 2예, SITA군 5예)에서 발생하였고 심부 흉골감염이 4예(BITA군 3예, SITA군 1예)발생하여 재수술이 시행되었다. 수술 직후 104명의 환자에서(BITA군 64/85, SITA군 40/54명) 관상동맥 조영술이 시행되었고 좌전하행지로의 문합부위 협착이 4예(BITA군: 2예, SITA군: 2예)에서 관찰되었다. 전체 관찰기간 동안의 문합부위 협착 발생은 총 8예였고 이 중 3명의 환자에서 경피적 관상동맥 성형술이 시행되었으며 관상동맥 우회술을 재시행한 경우는 얼었다. 걸론: 관상동맥 우회술 시행시 양측 내흉동맥의 사용은 수술 전후 이환율에서 큰 차이 없이 만족할 만한 개통률을 얻으면서 동맥편만을 이용한 관상동맥 우회술을 가능케 하는 유용한 대안이 될 수 있으리라 생각한다.

• BMB Reports
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• 제44권11호
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• pp.713-718
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• 2011

In this study, the effects of sitagliptin analogue (SITA) or pioglitazone (PIO) treatment on glucose homeostasis and ${\beta}$-cell dynamics in animal models of type 2 diabetes-Akita and db/db mice were evaluated. After 4-6 weeks of treatment, both SITA and PIO were shown to lower non-fasting glucose levels and reduced glycemic excursion in the intraperitoneal glucose tolerance test. In addition, both drugs preserved normal islet structure and the proportion of ${\beta}$-cells in the islets. Compared to the controls, SITA treatment induced a higher ${\beta}$-cell proliferation rate in Akita mice and a lower rate of apoptosis in db/db mice, whereas PIO treatment induced a lower rate of apoptosis in db/db mice and reduced proliferation rates in Akita mice. In conclusion, both SITA and PIO appear to exert some beneficial effects on the islet structure in addition to glycemic control via different mechanisms that involve ${\beta}$-cell dynamics in Akita and db/db mice.

• 수완나부미
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• 제13권1호
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• pp.89-110
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• 2021

The Ramayana is a very popular epic in Southeast Asia. It is the story of King Rama who must save his kidnapped wife, Sita. After Sita was abducted by the Demon King Ravana (Tosakanth) and taken to Lanka, Rama and his brother rescued her with the help of the monkey warriors, especially with the help of the Monkey King Hanuman. Along the way, the epic teaches Hindu life lessons. Today The Ramayana is told and retold through literature, theatre, orally, in movies, and is referenced in many other forms of popular culture. Nowadays, in Thailand, Ravana and Hanuman deconstruct the role of divine and become folk deities that also find their places in calendar art, advertising and stamps, etc. And in Vietnam, Ravana and Hanuman have become the two figures that can't be absent from Southern Vietnam Khmer ceremonies. In this article, our aim is to show how Ravana and Hanuman became symbols of popular culture (case studies in Thailand and Vietnam). The data provided in this article is drawn from field surveys with reliable reference resources.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.993-1001
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• 2016

Type 2 diabetes mellitus patients are at increased risk of many forms of malignancies, especially of the pancreas, colon and hepatocellular cancer. Unfortunately, little is known of the possible interaction between antidiabetic drugs and anticancer agents. The present study investigates the influence of metformin (MET) and sitagliptin (SITA) on the in vitro anticancer activity of the microtubule depolymerization inhibitor agent epothilone A (EpoA). Hepatocellular liver carcinoma cell line (HepG2) viability and apoptosis were determined by the MTT test and by double staining with PO-PRO-1 and 7-aminoactinomycin D, respectively, after treatment with EpoA, metformin or sitagliptin. The levels of nuclear factor NF-${\kappa}B$ and p53 were evaluated in the presence and absence of inhibitors. While EpoA and MET inhibited HepG2 cell proliferation, SITA did not. EpoA and SITA induced higher p53 levels than MET. All tested drugs increased the level of NF-${\kappa}B$. Only MET enhanced the proapoptotic effect of EpoA. The EpoA+MET combination evoked the highest cytotoxic effect on HepG2 cells and led to apoptosis independent of p53, decreasing the level of NF-${\kappa}B$. These findings support the link between NF-${\kappa}B$ and p53 in the modulation of apoptotic effects in HepG2 cells treated by EpoA. Our studies indicate that the combination of EpoA and MET applied in subtoxic doses has a stronger cytotoxic effect on liver cancer cells than each of the compounds alone. The therapeutic advantages of the combination of EpoA with MET may be valuable in the treatment of patients with diabetes mellitus type 2 (T2DM) and liver cancer.

• 동굴
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• 제7호
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• pp.29-36
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• 1998

It is written in the ancient Indian epic, the Ramayana, that Rama - deadly fatigued from the chase after the kidnappers of his wife, Sita, in the forests of the Vindhya Range - took refuge in a cave. Breathing in the balsamic cave air and gulping the crystal clear stream water, he and his companions regenerated very quickly and could soon resume their chase, successful in the end.(omitted)

• Journal of Korean Neurosurgical Society
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• 제55권3호
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• pp.173-177
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• 2014

Neurocysticercosis is the commonest parasitic disease of the human central nervous system. The incidence of intra ventricular form of neurocysticercosis (NCC) is less common accounting 10-20% that of total central nerve system cysticercosis. Intra ventricular NCC is complicated due, to its high incidence of acute hydrocephalus caused by ball valve mechanism. The only reliable tool for diagnosis of NCC is by neuroimaging with CT or MRI. MRI preferred over CT because of its high specificity and sensitivity. In emergency situations like acute hydrocephalus one can proceed with emergency endoscopic surgery. Through the endoscopic view, intra ventricular NCC (IVNCC) has distinguished morphological features like the full moon sign. This feature not only helps in identification of IVNCC, but also guides in further endoscopic treatment strategy. Authors report two cases of 3rd ventricular NCC with acute hydrocephalus managed with emergency endoscopy. Authors have discussed the clinical features, intra operative endoscopic findings and role of endoscopy in emergency surgery for NCC with acute hydrocephalus.

• Journal of Chest Surgery
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• 제36권5호
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• pp.303-308
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• 2003

배경: 관상동맥우회술 시 이용하는 내흉동맥은 그 장기 개통률이 다른 도판보다 우수하다고 알려져 있다. 또한 양측 내흉동맥을 이용하면 좋은 개통률로 보다 많은 관상동맥에 접근할 수 있다. 그러나 양측 내흥동맥의 박리로 수술조기 합병증이 증가할 것이라는 관점이 있어 보고자가 경험한 수술 조기결과를 보고하고자 한다. 대상 및 방법: 2001년 7월부터 2002년 5월까지 양측 내흉동맥을 이용하여 관상동맥우회술을 시행한 26예를 대상으로 하였다. 대상환자 중 당뇨병을 가진 8예와 당뇨병이 없는 18예를 비교하여 수술결과를 분석하였다. 또한 같은 기간에 단측 내흉맥을 이용하여 수술한 20예를 대상 환자군과 비교하여 그 수술결과를 분석하였다. 결과: 수술사망은 없었다. 수술 후 합병증은 창상감염으로 당뇨군과 정상군 각각 1예가 있었다. 당뇨군과 정상군 간에는 수술시간, 기관삽관시간, 출혈량, 강심제투여시간, 그리고 합병증 발생에서는 서로 차이가 없었다. 단측 내흉동맥군과 수술결과에 있어 차이가 없었다. 결론: 양측 내흉동맥을 이용한 관상동맥우회술의 수술 조기결과는 단측 내흉동맥을 이용한 수술결과와 차이가 없었고 양측 내흉동맥을 이용한 환자 중 당뇨병이 있는 경우에도 정상군과 수술결과의 차이는 없었다. 당뇨병 환자에 있어 양측 내흉동맥의 이용은 고려할 만하다고 생각한다.

• Journal of Microbiology and Biotechnology
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• 제14권3호
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• pp.547-552
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• 2004

Streptomyces thermovulgans malate synthase (stMS) is known to be more thermostable and thermoactive than S. coelicolor malate synthase (scMS). Therefore, based on the amino acid sequence of stMS, 3 scMS mutants, namely P186R, T8PL9P, and T8PL9PP186R, were created by site-directed mutagenesis in an attempt to engineer a more thermoactive and thermostable enzyme. An enzymatic analysis of the wild-type and mutant MS revealed that P186R and T8PL9PP186R were more thermoactive than the wild-type scMS and T8PL9P. Furthermore, all 3 mutants exhibited a greater thermo stability than scMS, thereby suggesting that both R186 and P8P9 can cause increased thermo stability in scMS.