• Journal of Life Science
• /
• v.19 no.2
• /
• pp.157-162
• /
• 2009

Nitric oxide (NO) is a diffusible, multifunctional and transcellular messenger that has been implicated in numerous physiological and pathological conditions. It has been reported that NO induced apoptosis in tumor cells, macrophage cells and inhibited apoptosis in normal cells, endothelial cells. To examine whether NO could induce apoptosis in MCF-7 cells, cells were treated with SIN-1 (3-morpholinosydnonimine), NO donor. Cell viability did not change in SIN-1 treated cells for 48 h and there was no significantly changes in cell cycle progression or growth pattern by FACS analysis. But p53 protein, an apoptosis-related factor, increased SIN-1 treatment time dependently. Bcl-2, MDM2 and p21 were also accumulated. Bax level did not change. A major role of inhibiting apoptosis by NO in MCF-7 cells, cobalt chloride ($CoCl_2$) was added to cells preincubated with SIN-1. Whereas $CoCl_2$ treated cells underwent apoptosis, for 24 h SIN-1 preincubated cells were not induced apoptosis. Inactivated proteins, MDM2 and bcl-2, by $CoCl_2$ levels also increased in SIN-1 pre-treated cells. These results suggested that SIN-1 blocked p53 by MDM2 activation and inhibited apoptosis by inducing p21 and bcl-2 expression.

• Communications of the Korean Mathematical Society
• /
• v.34 no.1
• /
• pp.1-16
• /
• 2019

Let a, b, P, and Q be real numbers with $PQ{\neq}0$ and $(a,b){\neq}(0,0)$. The Horadam sequence $\{W_n\}$ is defined by $W_0=a$, $W_1=b$ and $W_n=PW_{n-1}+QW_{n-2}$ for $n{\geq}2$. Let the sequence $\{X_n\}$ be defined by $X_n=W_{n+1}+QW_{n-1}$. In this study, we obtain some new identities between the Horadam sequence $\{W_n\}$ and the sequence $\{X_n\}$. By the help of these identities, we show that Diophantine equations such as $$x^2-Pxy-y^2={\pm}(b^2-Pab-a^2)(P^2+4),\\x^2-Pxy+y^2=-(b^2-Pab+a^2)(P^2-4),\\x^2-(P^2+4)y^2={\pm}4(b^2-Pab-a^2),$$ and $$x^2-(P^2-4)y^2=4(b^2-Pab+a^2)$$ have infinitely many integer solutions x and y, where a, b, and P are integers. Lastly, we make an application of the sequences $\{W_n\}$ and $\{X_n\}$ to trigonometric functions and get some new angle addition formulas such as $${\sin}\;r{\theta}\;{\sin}(m+n+r){\theta}={\sin}(m+r){\theta}\;{\sin}(n+r){\theta}-{\sin}\;m{\theta}\;{\sin}\;n{\theta},\\{\cos}\;r{\theta}\;{\cos}(m+n+r){\theta}={\cos}(m+r){\theta}\;{\cos}(n+r){\theta}-{\sin}\;m{\theta}\;{\sin}\;n{\theta},$$ and $${\cos}\;r{\theta}\;{\sin}(m+n){\theta}={\cos}(n+r){\theta}\;{\sin}\;m{\theta}+{\cos}(m-r){\theta}\;{\sin}\;n{\theta}$$.

• Proceedings of the PSK Conference
• /
• 2001.04a
• /
• pp.189.1-189.1
• /
• 2001

• Journal of Korean Ophthalmic Optics Society
• /
• v.6 no.2
• /
• pp.65-70
• /
• 2001

We obtained the sum of two curvature ($C_x+C_y$) in toric lens which two toroidal surface is the right angle each other. $$C_x+C_y=\frac{x^2+y^2}{2r_1}+\frac{x^2}{2}(\frac{1}{r_2}-\frac{1}{r_1})$$ and the sum of two curvature ($C_a+C_b$) in toric lens about the cross angle. $$(C_a+C_b)=\frac{x^2cos^2{\alpha}_1}{2r_1}+\frac{x^2cos^2{\alpha}_2}{2r_2}+\frac{y^2sin^2{\alpha}_1}{2r_1}+\frac{y^2sin^2{\alpha}_2}{2r_2}$$ and claculated the parameter S, C, ${\theta}$ of a combination power in toric lens of the cross angle including surface curvature ($C_x$, $C_y$) values. $$S=(n-1)\[\frac{C_x}{x^2}+\frac{C_y}{y^2}\]-\frac{C}{2},\;C=-\frac{2(n-1)}{sin2{\theta}}\[\frac{C_x}{x^2}+\frac{C_y}{y^2}\]$$ $${\theta}=\frac{1}{2}tan^{-1}\[-\frac{{C_xy^2sin2{\theta}_1}+{C_yx^2sin2{\theta}_2}}{{C_xy^2cos2{\theta}_1}+{C_yx^2cos2{\theta}_2}}\]$$.

• Fashion & Textile Research Journal
• /
• v.1 no.4
• /
• pp.387-392
• /
• 1999

The effects of the ratio of warp diameter to filling diameter (${\beta}$-ratio) and warp thread crash on the crimp factor and the yarn curvature were studied theoretically in this paper. The models of 2/2 twill fabric derived square cloth and sinusoidal curved cloth were used for the theoretical analysis. The crimp factors (C) for the models were given theoretically as follows; (1) Derived square cloth(general equation for b) $$C=\frac{(1+{\beta})({\theta}-sin{\theta})}{(1+{\beta})sin{\theta}+{\alpha}}$$ (2) Sihusoidal curved cloth $$C=\frac{(1+{\beta})sin{\theta}\[1+\{\frac{{\pi}(1-cos{\theta})}{4sin{\theta}}\}^2\]+{\alpha}}{(1+{\beta})sin{\theta}+{\alpha}}-1$$ The curvatures(${\kappa}$) for the models were given theoretically as follows; (1) Derived square cloth $${\kappa}=\frac{2}{d_w+d_f}$$ (2) Sinusoidal curved cloth $${\kappa}=\|{^{\;\;\prime\prime} \atop r}(s)\| \\ where \;s=\frac{p^'}{{\pi}}\(u+\frac{k^2u}{4}+\frac{k^2}{8}sin2u\)$$.

• 대한상한금궤의학회지
• /
• v.4 no.1
• /
• pp.57-65
• /
• 2012

Objective : The purpose of this study is to evaluate the effectiveness of Sin-Ga-Tang in the treatment of Hypogalactia. Method : After 4 weeks of dosing Sin-Ga-Tang, observe the changes and analyze results in 3 cases. Result : 1. Hypogalactia is exacerbated by the postpartum fatigue and digestive dysfunction. 2. After dosing Sin-Ga-Tang, Postpartum fatigue and digestive dysfunction resolved, Showed beneficial effects in the treatment of Hypogalactia. Conclusion : Sin-Ga-Tang is effective on Hypogalactia associated with digestive disorders, However, in-depth study for digestive dysfunction affecting Hypogalactia should be considered as progress.

• Proceedings of the KIEE Conference
• /
• 2005.07a
• /
• pp.87-89
• /
• 2005

This paper proposes new series and parallel Sin+Cos PSS(power system stabilizer) for the purpose to improve the existing PSS1A's performance. The purpose of PSS is used to enhance damping of power system oscillations through injection of auxiliary signal for an excitation control terminal. The Proposed series and Parallel Sin+Cos PSS is connected adding the Sin+Cos terms additionally with serial and with parallel connection in a conventional PSS1A. The proposed controller is aim to considering of a damping of oscillation when it changes parameter fluctuations or operational load variations in a power system. The object of electric power system is KEPCO system and the voltage of power transmission line is a 154kV and a 345kV. The PSCAD/EMTDC package is used to authorize the effect of the proposed controller. Simulations were shown by and compared with the waveforms for frequency, voltage and electric power.

• The Journal of Internal Korean Medicine
• /
• v.10 no.1
• /
• pp.125-136
• /
• 1989

This study was investigated to clarify the effect of Sin Bee Tang (神秘湯) on the renal function, arterial blood pressure and plasma cortisol. The results obtained were follows; 1. Urine volume and glomerular filtration rate were decreased significantly after Sin Bee Tang water extract, 0.1ml/kg, administration. 2. Glomerular filtration rate, renal plasma flow and urinary excretion of electrolytes were increased significantly after Sin Bee Tang water extract, 0.25ml/kg, administration. 3. Plasma cortisol concentration increased significantly after Sin Bee Tang water extract, 0.25ml/kg, administration. These results suggest that the therapeutic action of Sin Bee Tang for 'Su Chun (水喘)' has a relation with the increase of plasma cortisol and renal hemodynamic effect.

• Journal of Korean Medical classics
• /
• v.24 no.1
• /
• pp.47-55
• /
• 2011

Jeong(精) and Sin(神) have very close relation in "Hwangjenaegyeong(黃帝內經)", and jeong(精) is base of sin(神). Jeong is the origin of life force, Sin can be manifested through the Yin-yang inter conversion of Jeong, on the other hand, Jeong can be created through the same conversion of Sin. The Yin-yang inter conversion of Jeong or Sin, means the inclination of Taegeuk(太極) to Unification after division, in this process, life force and creative power are made.

• Journal of Microbiology
• /
• v.35 no.2
• /
• pp.92-96
• /
• 1997

A new site-specific recombinase sin, as a component of a putatie transposon has been cloned and its base sequence has been determined. The proposed sin shows a hish degree of homology with pI9789-sin and pSK1-sin. There is a large (16 bp) inverted repeat downstream of proposed sin and the postulate dhelix-turn-helix motif is located at the extreme C-terminus of the poposed Sin. The transposase gene (tnpA) and .betha.-lactamase gene (blaZ) are located upstream of sin and arsenate reductase gene (arsC) and arsenic efflux pump protein gene (ars B) are downstream. This genetic arrangement seems to be a part of a new putative transposon because there is no known transposon with a gene arrangement of tnpA-blaZ-sin-arsC.