• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.3A
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• pp.497-512
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• 2006

In this paper, a simple but effective analysis procedure to estimate seismic capacities of multi-span continuous bridge structures is proposed on the basis of modal pushover analysis considering all the dynamic modes of structure. Unlike previous studies, the proposed method eliminates the coupling effects induced from the direct application of modal decomposition by introducing an identical stiffness ratio and an approximate elastic deformed shape. Moreover, in addition to these two introductions, the use of an appropriate distributed load {P} makes it possible to predict the dynamic responses for all kinds of bridge structures through a simpler analysis procedure. Finally, in order to establish the validity and applicability of the proposed method, correlation studies between rigorous nonlinear time history analysis and the proposed method are conducted for multi-span continuous bridges.

• Journal of Food Hygiene and Safety
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• v.16 no.3
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• pp.194-199
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• 2001

This study was designed to compare the effectiveness and applicability of the HApS$^{TM}$ (Hazard Analysis process System; HUKO, Seoul, Korea) based on Petrifilm$^{TM}$ (3M, St. Paul, MN, USA) with the AOAC (the Association of Official Analytical Chemists) standard total aerobic count (TAC) method and coliform count (CC) method for meat products. The comparisons were carried out using 230 meat samples collected from various retailers: 80 pork samples, 80 chicken samples, and 70 beef samples. In the comparison of the correlation coefficient (r) between conventional method and HApS$^{TM}$ method by a linear regression analysis, the correlation coefficients in total microorganism were 0.97767, 0.90712, and 0.95594 in pork, beef, and chicken samples, respectively. The correlation coefficients in coliform count were 0.82062, 0.94833, and 0.96839 in pork, beef and chicken samples, respectively. All the independent t-test on measurement values between conventional method and HApS$^{TM}$ method represented no significant differences in the means between two methods at the 0.05 of significance level($\alpha$=0.05). Based on the high correlation between HApS$^{TM}$ and the AOAC standard methods in the TAC and CC, it might be compatible to employ the HApS$^{TM}$ method to measure the microbial contamination in livestock products. HApS$^{TM}$ method was simpler and less time-consuming in sample preparation and procedures faster than the conventional method. These results suggested that the HApS$^{TM}$ method could be substitute for the conventional methods in the analysis of microbial contamination measurement in meat products.n meat products.

• Korean Journal of Medicinal Crop Science
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• v.16 no.6
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• pp.446-454
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• 2008

An advanced extraction method by ultrasonic extraction with applied solid phase extraction (SPE) has been developed for the determination of simultaneous eight major ginsenosides, namely ginsenosides Rg1, Re, Rf, Rb1, Rg2, Rc, Rb2, and Rd in the root of Panax ginseng. Four extraction methods including n-BuOH reflux extraction (Method A), 70% EtOH reflux extraction (Method B), 50% MeOH reflux extraction with SPE (Method C), and 50% MeOH ultrasonication with SPE clean-up process (Method D) were investigated for the determination of eight major ginsenosides. Total contents of ginsenosides were highest by extraction of Method C as $2.408{\pm}0.011%$. However, Method D was evaluated as relatively simpler and more efficient method due to short extraction time, small solvent consumption and less expensive, compared to conservative reflux method. Ginsenosides were also satisfactorily separated with good resolution and the accuracy range was between 1.05 and 4.06% as relative standard deviation (RSD) by Method D. SPE condition and HPLC condition were further optimized for determination of eight major ginsenosides by the ultrasonic extraction method. Conclusively, ultrasonic extraction of 2 g sample of ginseng using ultrasonic bath and 1 loading for SPE was evaluated as proper condition for extraction of ginseng.

• Journal of Pharmaceutical Investigation
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• v.31 no.4
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• pp.241-256
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• 2001

Alginate microspheres, containing fluorescein isothiocyanate-bovine serum albumin (FITC-BSA) or green fluorescent protein (GFP) were prepared and used as a model drug to develop the oral vaccine delivery system. The alginate microspheres were coated with poly-L-lysine or chitosan. Two methods, w/o-emulsion and spray, were used to prepare alginate microspheres. To optimize preparation conditions, effects of several factors on the particle size and particle morphology of microsphere, and loading efficiency of model antigen were investigated. In both preparation methods, the particle size and the loading efficiency were enhanced when the concentration of sodium alginate increased. In the w/o-emulsion preparation method, as the concentration of Span 80 was increased from 0.5% to 2%, the particle size was decreased, but the loading efficiency was increased. The higher the emulsification speed was, the smaller the particle size and loading efficiency were. The concentration of calcium chloride did not show any effect on the particle size and loading efficiency. In the spray preparation method, the particle size was increased as the nozzle pressure $(from\;1\;kgf/m^2\;to\;3\;kgf/m^2)$ and spray rate was raised. Increasing calcium chloride concentration (<7%) decreased the particle size, in contrast to no effect of calcium chloride concentration on the w/o-emulsion preparation method. Alginate microspheres prepared by two methods were different in the particle size and loading efficiency, the particle size of microspheres prepared by the spray method was about $2-6\;{\mu}m$, larger than that prepared by the w/o emulsion method $(about\;2{\mu}m)$, and the loading efficiency was also higher with spray method. Furthermore, drying process for the microspheres prepared by the spray was simpler and easier, compared with the w/o emulsion preparation. Therefore, the spray method was chosen to prepare alginate microspheres for further experiments. Release pattern of FITC-BSA in alginate microspheres was evaluated in simulated intestinal fluid and PBS (phosphate buffered saline). Dissolution rate of FITC-BSA from alginate/chitosan microsphere was lower than that from alginate microsphere and alginate/poly-L-lysine microsphere. By confocal laser scanning microscope, it was revealed that alginate/FITC-poly-L-lysine microspheres were present in close apposition epithelium of the Peyer's patches of rabbits following inoculation into lumen of intestine, which proved that microspheres could be taken up by Peyer's patch. In conclusion, it is suggested that alginate microsphere prepared by spray method, showing a particle size of & $10\;{\mu}m$ and a high loading efficiency, can be used as a model drug for the development of oral vaccine delivery system.

• Journal of Ocean Engineering and Technology
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• v.32 no.6
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• pp.447-457
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• 2018

In this study, a two-dimensional fully nonlinear transient wave numerical tank was developed using a desingularized indirect boundary integral equation method. The desingularized indirect boundary integral equation method is simpler and faster than the conventional boundary element method because special treatment is not required to compute the boundary integral. Numerical simulations were carried out in the time domain using the fourth order Runge-Kutta method. A mixed Eulerian-Lagrangian approach was adapted to reconstruct the free surface at each time step. A numerical damping zone was used to minimize the reflective wave in the downstream region. The interpolating method of a Gaussian radial basis function-type artificial neural network was used to calculate the gradient of the free surface elevation without element connectivity. The desingularized indirect boundary integral equation using an isolated point source and radial basis function has no need for information about the element connectivity and is a meshless method that is numerically more flexible. In order to validate the accuracy of the numerical wave tank based on the desingularized indirect boundary integral equation method and meshless technique, several numerical simulations were carried out. First, a comparison with numerical results according to the type of desingularized source was carried out and confirmed that continuous line sources can be replaced by simply isolated sources. In addition, a propagation simulation of a $2^{nd}$-order Stokes wave was carried out and compared with an analytical solution. Finally, simulations of propagating waves in shallow water and propagating waves over a submerged bar were also carried and compared with published data.

• The Korean Journal of Pesticide Science
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• v.2 no.3
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• pp.79-84
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• 1998

Tandem HPLC and atmospheric pressure chemical ionization(APcI) LC/MS method was used for the determination and confirmation of carbendazim residues in soybean sprout. Fluorescence(FL) detector was connected in tandem with the ultraviolet(UV) detector for dual detection of the carbendazim residue at the excitation and emission wavelength of 280 nm and 310 nm, respectively. The limit of detection for carbendazim was $0.1{\mu}g/kg$ sample. Recoveries of carbendazim from fortified soybean sprout at 0.5, 1.0 and 2.0 ppm were averaged 89.1%. Mass spectrometry using a APcI source confirmed the carbendazim residue in the soybean sprout sample. Fragmentation pattern on the APcI LC/MS spectrum of carbendazim was simpler than that from electron impact(EI) mass spectrum. Carbendazim produced 3 major ions including m/z 133, m/z 159 and m/z 191($M^{+}$). This method was sensitive enough to provide reliable and reproducible results for practical applications.

• KCI Concrete Journal
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• v.14 no.1
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• pp.36-42
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• 2002

Flexural behaviors of the two typical precast beam sections (inverted tee and rectangular) for buildings were investigated and compared. The height of web in the inverted tee beam was generally less than half of beam depth to be adapted to that of the nib in the ends of double-tee where the total building height limited considerably. The inverted-tee beams were designed for a parking live load - 500kgf/$m^2$ and a market - 1,200kgf/$m^2$ from the currently used typical shape of a domestic building site in Korea. The area and bottom dimension of rectangular beams were the same as those of inverted tee beams. These woo beams were also reinforced with a similar strength. following results were obtained from the studies above; 1) the rectangular beam is simpler in production, transportation, and erection, and more economic than the inverted tee beam in the construction test for these two beams with a same dimension and a similar strength, 2) all of the beams considered in the tests were generally failed in values close to those of the strength requirements in ACI Provisions. The ratios of test result to calculated value are averaged to 1.04. One rectangular and one inverted tee beams failed in a value only 2-3％ larger than the estimated volue of the Strength Design Methool the results of the Strain Compatibility Method wire slightly more accurate than those of the Strength Design Method, 4) the maximum deflections of all of the beams under the full service loads were less than those of the allowable limit in ACI Code Provisions. The rectangular beams experienced more deflection then inverted tee in the same loading condition and failed with more deflection, and 5) the rectangular and inverted tee beams showed good performances under the condition of service and ultimate loads. However, one inverted tee beams with fm span developed an initial flexural crackings under 88％ of the full service load even though they designed to satisfy the ACI tensile stress limit provisions.

• The Transactions of the Korea Information Processing Society
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• v.5 no.9
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• pp.2294-2301
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• 1998

The aim of this paper is to extract features from each news scenes for example, symbol icon which can be distinct each broadcasting corp, icon and caption which are has feature and important information for the scene in respectively, In this paper, we propose extraction methods of caption that has important prohlem of news videos and it can be classified in three steps, First of al!, we converted that input images from video frame to YIQ color vector in first stage. And then, we divide input image into regions in clear hy using equalized color histogram of input image, In last, we extracts caption using edge histogram based on vertical and horizontal line, We also propose the method which can extract news icon in selected key frames by the difference of inter-histogram and can divide each scene by the extracted icon. In this paper, we used comparison method of edge histogram instead of complex methcxls based on color histogram or wavelet or moving objects, so we shorten computation through using simpler algorithm. and we shown good result of feature's extraction.

• Clinical and Experimental Pediatrics
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• v.56 no.1
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• pp.19-25
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• 2013

Purpose: Childhood obesity is associated with nonalcoholic fatty liver disease (NAFLD), and it has become one of the most common causes of childhood chronic liver diseases which significant as a cause of liver related mortality and morbidity in children in the United States. The development of simpler and easier clinical indices for medical practice is needed to identify advanced hepatic fibrosis in childhood NAFLD instead of invasive method like liver biopsy. FibroScan and aspartate aminotransferase (AST)-to-platelet ratio index (APRI) have been proposed as a simple and noninvasive predictor to evaluate hepatic fibrosis in several liver diseases. APRI could be a good alternative to detect pathologic change in childhood NAFLD. The purpose of this study is to validate the efficacy of APRI for assessing hepatic fibrosis in childhood NAFLD based on FibroScan. Methods: This study included 23 children with NAFLD who underwent FibroScan. Clinical, laboratory and radiological evaluation including APRI was performed. To confirm the result of this study, 6 patients received liver biopsy. Results: Factors associated with hepatic fibrosis (stiffness measurement >5.9 kPa Fibroscan) were triglyceride, AST, alanine aminotransferase, platelet count, APRI and collagen IV. In multivariate analysis, APRI were correlated with hepatic fibrosis (>5.9 kPa). In receiver operating characteristics curve, APRI of meaningful fibrosis (cutoff value, 0.4669; area under the receiver operating characteristics, 0.875) presented sensitivity of 94%, specificity of 66%, positive predictive value of 94%, and negative predictive value of 64%. Conclusion: APRI might be a noninvasive, simple, and readily available method for medical practice to predict hepatic fibrosis of childhood NAFLD.

• Tribology and Lubricants
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• v.34 no.5
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• pp.169-174
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• 2018

A multi-stage compressor (MSC) is comprised of several impellers installed in the pinion gear shaft driven by a main bull gear. In the pinion shaft, a thrust collar (TC) is installed to support the thrust load. The TC makes the lubrication system simpler in the MSC; therefore, it is widely used in similar kinds of machinery. Typically, TCs are installed on both sides of the bull gear and pressure is developed in the lubricated area by creating a taper angle on the TC and bull gear surface. In the current study, we developed a numerical analysis model to evaluate the performance of the TC considering its design parameters. We sloved the Reynolds equation using the finite element method and applied the half Sommerfeld condition to consider cavitation. Based on the pressure calculated in the lubricated area, we calculated the power loss and minimum film thickness. In addition, we calculated stiffness and damping using perturbation method. We performed parametric studies using the developed model. The results of the analysis show that the maximum pressure presents in the center area of the TC and it increases with the taper angle. The area over which pressure is developed decreases with the taper angle. The results also show that there is an optimum taper angle providing minimum power loss and maximum film thickness. Additionally, the stiffness and damping decrease with the taper angle. As the applied load increases, the power loss increases and the minimum film thickness decreases. However, the stiffness and damping increase with the applied load.