• Journal of Acupuncture Research
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• 제22권3호
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• pp.113-122
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• 2005

한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술이 STZ에 의해 유발된 생쥐의 당뇨병에 미치는 영향에 확인한 결과 다음과 같은 결론을 얻었다. 1. 한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술이 STZ에 의한 혈청 중 insulin 함량에는 변화를 나타내지 않았으나 혈청 중 glucose 함량은 감소시켰다. 2. 한약복합여방(韓藥複合濾方)의 경구 투여 및 약침 병용 시술이 STZ에 의해 상승된 혈청 중 triglyceride 함량을 유의하게 감소시켰으나 혈청 중 total cholesterol 함량에는 영향을 나타내지 못했다. 3. STZ 투여로 인해 혈청 내 지질과산화물의 함량이 증가되었으나 한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술은 이에 영향을 미치지 못 하였다. 4. STZ에 의해 증가된 catalase활성이 한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술에 의해 감소되었으나, GSH의 활성에는 유의한 변화가 나타나지 않았다.

• International Journal of Fluid Machinery and Systems
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• 제8권1호
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• pp.55-62
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• 2015

This study aims to present a hydraulic transitory study as MOC applications for solving the Saint-Venant equations in two case studies: 1) in a penstock of a small hydropower system as a simple pipeline in the case of valve-closure in the downstream boundary with a reservoir in the upstream boundary; and 2) for discharge propagation into a channel by velocity and depth of the flow channel along space evaluation. The proposed methodology by Chaudry [5] concerning the development of hydrodynamic models was used. The obtained results for first and second case study has been confirmed that MOC numerical approach is useful for several engineering purposes, including cases of hydraulic transients and discharge propagation in hydraulic systems.

• Molecules and Cells
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• 제38권5호
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• pp.441-451
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• 2015

Recognition of cytosolic DNA initiates a series of innate immune responses by inducing IFN-I production and subsequent triggering JAK1-STAT1 signaling which plays critical roles in the pathogenesis of infection, inflammation and autoimmune diseases through promoting B cell activation and antibody responses. The stimulator of interferon genes protein (STING) has been demonstrated to be a critical hub of type I IFN induction in cytosolic DNA-sensing pathways. However, it still remains unknown whether cytosolic DNA can directly activate the JAK1-STAT1 signaling or not. And the role of STING is also unclear in this response. In the present study, we found that dsDNA directly triggered the JAK1-STAT1 signaling by inducing phosphorylation of the Lyn kinase. Moreover, this response is not dependent on type I IFN receptors. Interestingly, STING could inhibit dsDNA-triggered activation of JAK1-STAT1 signaling by inducing SHP-1 and SHP-2 phosphorylation. In addition, compared with normal B cells, the expression of STING was significantly lower and the phosphorylation level of JAK1 was significantly higher in B cells from MRL/lpr lupus-prone mice, highlighting the close association between STING low-expression and JAK1-STAT1 signaling activation in B cells in autoimmune diseases. Our data provide a molecular insight into the novel role of STING in dsDNA-mediated inflammatory disorders.

• 현장농수산연구지
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• 제25권3호
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• pp.14-18
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• 2023

2022년 7월, 국내의 저염분 해수 흰다리새우 양식장에서 양식 중이던 흰다리새우가 이상유영과 식욕부진을 보이며 지속적으로 폐사하였다. 일일 평균 폐사율이 0.1%로 완만한 폐사를 보였으나, 2달 넘게 폐사가 지속되었고 성장 지체로 인한 경제적인 피해가 가중되었다. 질병 진단 과정 중, 폐사 새우의 간췌장에서 세균(KNUAF-SHP3)이 분리되었다. 본 세균의 16S rRNA 유전자의 시퀀스 분석 결과, 분리주 KNUAF-SHP3은 Shewanella에 속하는 균으로 동정이 되었고, S. algae MARS 14, S. chilikensis JC5T와 근연 관계를 보이며 같은 그룹으로 분류되었다. 실험 동물을 활용한 인위 감염 실험에서는 상대적으로 고농도(2.1×108CFU/ml와 2.1×109CFU/ml)를 적용한 군에서는 모든 새우들이 감염 증상을 보이며 감염 후 7일 내에 100% 폐사율을 나타내었다. 본 연구는 Shewanella 세균이 저염분 해수 양식 흰다리새우에서의 잠재적인 기회 감염균이 될 수 있음을 기술하고 있다.

• 한국가축번식학회지
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• 제15권3호
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• pp.189-193
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• 1991

This study was carried out ot investigate effects of X-537A on hydrogen ion concentration insperm washed solution and sperm acrosome reaction. The results obtained were as follows. 1. When bovine sperm was twice washed with SHP solutions of pH 6.8 and 7.4 and again washed with SHP solution containing 4$\mu$M of X-537A, in case of pH 6.8 the sperm washed with 4$\mu$M of X-537A showed signifciantly(p<0.01) higher hydrogen ion concentration in sperm washed solution than the sperm washed without X-537A. 2. When the sperm was twice washed with SHP solution and then washed with SHP solution containing 4$\mu$M of X-537A, sperm acrosome rection rate was signifciantly(p<0.01) increased from 12min after incubation in the sperm washed without X-537A, but was signifciantly(p<0.01) increased from 8 min after incubation in the sperm washed with 4$\mu$M of X-537A. 3. When the sperm was twice washed with SHP solution and then washed with SHP solution containing 0, 4 and 40$\mu$M of X-537A, and then incubated in m-TALP for 120 min, sperm acrosome reaction rate was significantly(p<0.01) increased from 15 min after incubation in 0, 4 and 40$\mu$m OF X-537A. However at 60 min incubation 40$\mu$M of X-537A showed significantly(p<0.01) higher sperm acrosome reaction rate than 0 and 4$\mu$M and at 120 min incubation 4 and 40$\mu$M of X-537A showed signifciantly(p<0.01) higher acrosome reaction rate than 0$\mu$M of X-537A.

• Tuberculosis and Respiratory Diseases
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• 제43권2호
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• pp.280-284
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• 1996

본 증례는 일본에서 과민성 폐장염의 원인 중 가장 높은 비율을 차지하고 있는 T. cutaneum에 의한 summer-type hypersensitivity pneumonitis가 우리나라에서 밝혀진 첫번째 예로서, 가정에 있을 때만 증상이 나타난 점, T. cutaneum에 대한 침전 항체가 양성으로 나온 점, 스테로이드 투여 후 증상 및 폐기능, 방사선 소견 등이 회복된 점 등을 볼 때 이 질환으로 진단할 수 있었다. 일본과 유사한 기후가 있는 우리나라에 있어 이 질환의 존재 가능성은 높을 것으로 생각되는데 앞으로 이 질환에 대한 연구가 요망된다.

• 근관절건강학회지
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• 제9권1호
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• pp.5-17
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• 2002

The purpose of this one group pre and post test study was to evaluate the effect of self-help programs(SHP) which has been conducted from 1997 to 2000. The SHP was held by Korean Rheumatology Health Professionals Society(KRHP) once a week for 6 weeks for chronic arthritis patients in Korea. Eight hundred fifty five subjects completed the program at 43 sites. The effect of SHP were evaluated by flexibility, pain, activities of daily living(ADL), fatigue, depression and self-efficacy. After SHP, followings were found: 1. Participants' characteristics of SHP were most common in living in Seoul, women, sixties, high school graduates, house wifes, osteoarthritis, completed in 1999. 2. The flexibility of arm, knee, ankle joint were significantly increased, but the flexibility of the shoulder was not changed. 3. Level of pain was decreased significantly from 5.21 to 3.99, and the number of painful joints were decreased from 4.96 to 4.18 significantly. 4. The score of ADL was increased from 53.74 to 54.97 significantly. 5. The score of depression and self-efficacy was not changed. In conclusion, SHP was clearly proved to be an effective nursing intervention to Increase the flexibility of arm, knee, ankle joint and enhanced ADL. Also SHP decreased pain and fatigue. More research is needed to determine the role of self-efficacy and depression in the SHP, use of a randomized design and longer follow up period to understand more about the effects of the program.

• 대한한방부인과학회지
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• 제21권3호
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• pp.143-166
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• 2008

Purpose: The purpose of this study is to ascertain the awareness or incidence of SHP and postnatal care. Methods: We analyzed the results of Questionnaires for 104 women who have experienced childbirth within the last 10 years and examined June 2007 to December 2007. We divided to three groups according to age and investigated. Results: 1. Awareness of SHP and postnatal care. Responses about "How informed are you about the syndrome known in Korea as SHP?", Person's ration who know is 72.11%. Responses about "Are you aware of current traditional postnatal practices in Korea?", Person's ration who know is 80.77%. "Do you think that postnatal care as practised is Korea is necessary?", Person's ration who know is 84.62%. "Do you think that in general postnatal care is necessary?", Person's ration who know is 93.27%. "Do you believe, if you are unable to practice postnatal care, you will subsequently develop health problems?", Person's ration who know is 91.35%. 2. Relevant comments of postnatal care. Responses about lifestyle after childbirth are Prevent bodily hard work 35.37%, Prevent cold stimulus 27.21 %, Hold body warmly 17.69%, Psychologically comfortably 7.48%, Eat good food 7.48% Etc 10.88%. Foods after childbirth are Avoid cold foods 22.38%, Avoid hard foods 17.48%, avoid hot foods 16.78%, avoid salty foods 10.49%, avoid excitative foods 8.39%. Medication after childbirth are Oriental medicine and restorative medicine 21.24%, iron was 15.04%, pumpkin 15.04%, vitamin 9.73%, calcium and snakehead each 7.96%. 3. Postnatal care practices Correlation postnatal care practices with present health condition are 19 items of 31 items. Conculsion: We hope these results could be helpful to diagnosis and treatment of SHP.

• Journal of Microbiology
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• 제38권3호
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• pp.183-186
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• 2000

Several types of bioluminescent reporter strains have been developed for the detection and monitoring of pollutant aromatics contaminating the environment. In this study, a bioluminescent reporter strain, E. coli SHP3, was constructed by fusing the luc gene of firefly luciferase with the promoter of pcbC responsible for the meta-cleavage of aromatic hydrocarbons. the bioluminescence expressed by the luc gene in the reporter was well triggered by the promoter when it was exposed to 2,3-dihydroxybiphenyI (2,3-DHBP) at 0.5 to 1 mM concentrations. The bioluminescent response was more extensive when the reporter strain was exposed to 5 mM catechol and 2 mM 4-chlorocatechol. These different types of bioluminescent responses by E. coli SHP3 appeared to be characterized by the nature of the aromatics to stress. Since E. coli SHP3 responded to 2,3-DHBP quite sensitively, this reporter strain could be applied for detecting some catecholic pollutants.

• 한국잠사곤충학회지
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• 제36권1호
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• pp.37-43
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• 1994

네 종의 서로 다른 인산염을 견정련 보조제로 사용한 경우에 있어서, 정련용수 중 금속이온의 봉쇄, 정련용액의 pH 변화, 그리고 연감효과에 대하여 검토하고 아래와 같은 결과를 얻었다. 1. 칼슘경도성분에 대한 봉쇄효과는 TSPP와 SPD가 높은 봉쇄효과를 나타내었으며, SPM과 SHP는 비교적 낮은 봉쇄효과를 보였다. 2. 철성분에 대한 봉쇄효과는 SHP와 TSPP가 우수한 봉쇄능력이 있었다. 3. 4종의 인산염 중 TSPP와 pH값이 가장 높지만 비누에 비해서는 낮다. 4. 정련속의 pH값은 인산염의 종류에 따라 많은 차이가 있었으나 pH값이 클수록 정련효과가 크게 나타났다.