• 대한유전성대사질환학회지
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• 제1권1호
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• pp.23-27
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• 2001

Fanconi-Bickel Syndrome (FBS) is a rare autosomal recessive disorder of carbohydrate metabolism recently demonstrated to be caused by mutations in the GLUT 2 gene for the glucose transporter protein 2 expressed in liver, pancreas, intestine, and kidney. This disease is characterized by hepatorenal glycogen accumulation, both fasting hypoglycemia as well as postprandial hyperglycemia and hyperglactosemia, and generalized proximal renal tubular dysfunctions. We report the first Korean patient with FBS diagnosed based on clinical manifestations and identification of a novel mutation in the GLUT 2 gene. She was initially diagnosed having a neonatal diabetes mellitus due to hyperglycemia and glycosuria at 3 days after birth. In addition, newborn screening for galactosemia revealed hypergalactosemia. Thereafter, she has been managed with lactose free milk, insulin therapy. However, she failed to grow and her liver has been progressively enlarging. Her liver functions were progressively deteriorated with increased prothrombin time. Liver biopsy done at age 9 months indicated micronodular cirrhosis with marked fatty changes. She succubmed to hepatic failiure with pneumonia at 10 months of age. Laboratory tests indicated she had generalized proximal renal tubular dysfuctions; renal tubular acidosis, hypophosphatemic rickets, and generalized aminoaciduria. Given aforementioned findings, the diagnosis of FBS was appreciated at age of 2 months. The DNA sequencing analysis of the GLUT 2 gene using her genomic DNA showed a novel mutation at 5th codon; Lysine5 Stop (K5X).

• Journal of Chest Surgery
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• 제39권11호
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• pp.854-857
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• 2006

환자는 8세 여자 환자로 확장성 심근병증을 진단 받은 환자이다. 환자는 심부전으로 인하여 양심실 순환보조를 15일간 시행하였다. 15일 중 후반기 7일은 급성 신부전증이 발생하여 지속적 정맥-정맥간 혈액투석을 시행하였다. 이후 뇌사상태의 A형 혈액형을 가진 심장 공여자에게서 심장을 이식받아 심장이식술을 시행하였다. 면역 억제제는 급성 신부전증을 고려하여 사용하였다. 신부전 상해는 2주간 지속되었고, 심장 이식술 후 약 14일 후 배뇨가 시작되었다. 환자는 수술 후 12일째에 시행한 우심실 조직검사에서 특별한 거부반응의 증거가 없었으며, 면역요법 후 수술 후 52일째에 특별한 문제 없이 퇴원하였다. 환자는 술 후 약 14개월간 조직검사에서 면역 거부반응 없이 외래 경과관찰 중이다.

• 패션비즈니스
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• 제1권3호
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• pp.1-18
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• 1997

The purpose of this study is to investigate Modernism of Gabrielle Chanel in respect to her fashion business. Chanel always considered the work of a fashion designer 'a technique, a craft, a trade' and chastised couturiers who looked upon themselves as artists. She was the first to cater to the public in its broader sense and to produce standard which appealed to every taste, the first to democratize the art of dressmaking for purely economic reasons. The results were as follows; 1. Chanel personified ~his new spirit of independence and evolved a style of dress for the modern, liberated woman. 2. Chanel excelled at fabrics, their interpretation, and an ability to use them. She had taken a humble material, one that was used by men and that they had shunned, and turned it into a fashionable fabric. In the process she also accelerated the growth of the ready-to-wear industry for it was a fabric within the financial reach of the majority of woman who wanted to dress fashionably but were not well off. 3. Chanel thought black chic and would never go out of fashion. As American Vogue for 1 October 1926 prognosticated, her little black dress became a kind of uniform. 4. Chanel represented an exception among couturiers because she was flattered that her styles were so popular and widely copied. She believed that her style would be affirmed by high-street copies-after all, copying is the sincerest form of flattery. 5. Chanel changed the concept of costume jewellery. It was not an original idea of Chanel's. Whereas Poiret had pioneered the original idea of costume jewellery, it was Chanel's avant-garde way with it not to mention her usual deceptive simplicity and supreme artistry that made costume jewellery evolve a successful and lucrative part of the fashion industry.

• 한국수학교육학회지시리즈C:초등수학교육
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• 제14권3호
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• pp.303-316
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• 2011

본 연구는 1에서 9까지의 숫자 카드를 이용하여 10의 보수를 찾는 게임에서 초등학교 1학년 학생이 보여주는 수 감각을 분석한 사례 연구이다. 이를 위해서 초등학교 1학년 학생 1명과 연구자가 실제 게임을 진행하였고, 게임과정에서 대화 내용을 중심으로 학생의 수 감각을 분석하였다. 본 연구의 결과 두 장의 카드를 이용하여 10을 만드는 게임에 매우 흥미를 가졌으며, 보수를 찾는 게임이 자연스럽게 덧셈을 구하는 상황으로 전환되었다. 연구 대상인 학생은 합이 10이 되는 경우, 즉 10의 보수를 찾는 경우는 규칙을 쉽게 이해하고 수를 만들어 내었지만 합이 12가 되는 경우는 쉽게 해결하지는 못하였다. 연구에 참여한 학생은 자신의 카드를 관찰하고 2장, 3장, 4장을 이용하여 10을 만드는 게임으로 자연스럽게 규칙을 확장하였고 어떤 경우에는 쉽게 10을 만들었지만 대부분의 경우에는 3장 이상을 이용하여 10을 만들지는 못하였다.

• Journal of Yeungnam Medical Science
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• 제35권1호
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• pp.84-88
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• 2018

A 33-year-old woman visited the emergency department presenting with fever and dyspnea. She was pregnant with gestational age of 31 weeks and 6 days. She had dysuria for 7 days, and fever and dyspnea for 1 day. The vital signs were as follows: blood pressure 110/70 mmHg, heart rate 118 beats/minute, respiratory rate 28/minute, body temperature $38.7^{\circ}C$, and oxygen saturation by pulse oximetry 84% during inhalation of 5 liters of oxygen by nasal prongs. Crackles were heard over both lung fields. There were no signs of uterine contractions. Chest X-ray and chest computed tomography scan showed multiple consolidations and air bronchograms in both lungs. According to urinalysis, there was pyuria and microscopic hematuria. She was diagnosed with community-acquired pneumonia and urinary tract infection (UTI) that progressed to severe sepsis and acute respiratory failure. We found extended-spectrum beta-lactamase producing Escherichia coli in the blood culture and methicillin-resistant Staphylococcus aureus in the sputum culture. The patient was transferred to the intensive care unit with administration of antibiotics and supplementation of high-flow oxygen. On hospital day 2, hypoxemia was aggravated. She underwent endotracheal intubation and mechanical ventilation. After 3 hours, fetal distress was suspected. Under 100% fraction of inspired oxygen, her oxygen partial pressure was 87 mmHg in the arterial blood. She developed acute kidney injury and thrombocytopenia. We diagnosed her with multi-organ failure due to severe sepsis. After an emergent cesarean section, pneumonia, UTI, and other organ failures gradually recovered. The patient and baby were discharged soon thereafter.

• 동양고전연구
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• 제73호
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• pp.385-414
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• 2018

이 글에서는 유교적 종법질서에 변화가 일어난 19세기 격변기에 가문 경영의 주체로서의 여성. 특히 문중에서 종부로서의 지위를 가진 여성의 구체적인 삶의 여정을 한글편지를 통해 재구성해 보았다. 해남윤씨가 8대 종부 광주이씨는 혼인 초부터 남편의 부재로 전통사회의 일반적인 환경에서 벗어났기 때문에 자신이 학습 받은 남성중심의 사회적 질서가 아닌 자신만의 독자적인 정체성을 찾으려는 시도를 하였다. 광주이씨는 종부로서의 지위를 자신이 찾고 자신이 지킬 수밖에 없는 독립적인 주체로 자신을 인식한 것이다. 광주이씨가 종부가 되어 해남윤씨가로 왔을 때 종가의 가세는 많이 기울어져 있었다. 이러한 경제적 어려움은 그 당시 사회적 흐름인 노비제도의 변화로 인한 노주(奴主) 관계의 갈등과 수세의 감소 때문이었다. 그리고 시숙들의 간섭은 종가의 경제적 형편을 더욱 어렵게 했다. 광주이씨는 종가에서 종부로서의 자신의 지위를 확고히 하고 피폐해진 종가를 바로 세우기 위하여 지친들의 간섭에서 자유로울 수 있는 방법으로 종부의 입후권을 이용하였다. 그 때까지 해남윤씨가에서 이루어진 입양은 모두 지친간에 이루어졌는데 광주이씨는 시숙들의 간섭에서 자유롭고 종부로서의 자신의 위치를 굳건히 할 수 있는 장치로 입양문제를 이용한 것이다. 따라서 시숙들의 이해관계에서 자유로울 수 있도록 오히려 멀리 있는 일가 중에서 양자를 골랐다. 광주이씨는 또한 종부로서의 권위를 확고히 하는 데는 종가의 경제권을 장악하는 것이 가장 필수적인 요건이라고 생각하였다. 그 당시 가정 경제를 지탱하는 가장 중요한 수단인 노비노동을 자신을 중심으로 결속시키기 위해서도 자신이 종가의 경제권을 제대로 행사해야 한다고 생각했다. 남편은 물론 자신의 피붙이 하나 없는 종가에서 광주이씨는 19세기라는 사회적 격변기에 종가를 바로 세우고 이름뿐인 종부가 아닌 명실상부한 종가의 안주인으로서의 자리를 차지하게 되었다.

• 대한한방부인과학회지
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• 제29권3호
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• pp.78-90
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• 2016

Objectives: The purpose of these cases is to report the effects of Korean medicine on two women with recurrent miscarriage.Methods: One women who had recurrent miscarriage with myoma uteri was 39 years old. She was treated with herbal medicine and acupuncture until intrauterine pregnancy (IUP) 14 wks. the other who had recurrent miscarriage with adenomyosis was 40 years old. she was also treated with these until IUP 11 wks.Results: After treatment, one women delivered successfully by normal full term spontaneous delivery. The other succeeded in normal pregnancy and she is 15 weeks pregnant.Conclusions: Two cases show that Korean Medicine has effects on recurrent miscarriage with old age and underlying diseases.

• Journal of Korean Neurosurgical Society
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• 제41권2호
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• pp.134-136
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• 2007

A woman who had a spontaneous subarachnoid hemorrhage [SAH] and temporal intracerebral hemorrhge [ICH] without any causative lesions on computed tomography [CT] and digital angiography at the day of the stroke. She was considered to have an angiographically negative SAH and scheduled for a repeated angiography. While she was waiting for the next study, she developed a second hemorrhage. CT angiography showed an aneurysmal shadow in the course of the posterior cerebral artery. After the operation, the aneurysm proved to be a pseudoaneurysm.

• Journal of Gastric Cancer
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• 제13권4호
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• pp.263-265
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• 2013

Intussusception is a rare cause of postoperative intestinal obstruction in adults. Many retrograde intussusceptions occur during the period following gastrectomy. A 77-year-old woman visited our hospital because of detected gastric adenocarcinoma. She received radical total gastrectomy with Roux-en-Y esophagojejunostomy. On the fifth postoperative day, she complained of abdominal pain, and we found leakage at the esophagojejunostomy site and dilatation of the Roux limb and the afferent limb of the jejunojejunostomy. Emergency surgery was performed. Retrograde jejunojejunal intussusception accompanied with a nasojejunal feeding tube was found at the efferent loop of the jejunojejunostomy. No ischemic change was found; therefore, manual reduction and primary repair of esophagojejunostomy was performed. She was discharged without complications on the 23rd re-postoperativeday. We suggest that the nasojejunal feeding tube acted as a trigger of intussusception because there was no definitive small bowel mass or postoperative adhesion. We present our findings here along with a brief review of the literature.

• 한국환경성돌연변이발암원학회지
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• 제21권1호
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• pp.44-50
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• 2001

To identify nongenotoxic carcinogen determined as negative by ICH guideline-recommended standard genotoxicity test battery; Ames test, chromosome aberration assay, mouse lymphoma $tk^{+/-}$ assay, in vivo micronucleus assay, we picked bisphenol A as a model compound. In this study, we applied in vitro BalB/c 3T3 cell transformation assay and Syrian hamster embryo (SHE) cell transfarmation assay. Bisphenol A was treated upto $769.2 ug/m{\ell}$ in BalB/c 3T3 cells and upto $125 ug/m{\ell}$ in SHE cells. bisphenol A didn't induced morphological transformation both with one stage treatment protocol and with two stage treatment protocol. But, treated far 48 hr, Bisphenol A induced morphological transformation significantly in SHE cells.