Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)

Korean Environmental Mutagen Society (한국환경성돌연변이발암원학회)
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Cell transformation of bisphenol A in Syrian hamster embryo cells and mouse embryo BalB/c 3T3 cells

Syrian hamster embryo 세포와 mouse embryo BalB/c 3T3 세포에서의 bisphenol A의 세포 형질전환 연구

  • 김종원 (식품의약품안전청 국립독성연구소 유전독성과) ;
  • 한의식 (식품의약품안전청 국립독성연구소 유전독성과) ;
  • 박미선 (식품의약품안전청 국립독성연구소 유전독성과) ;
  • 엄미옥 (식품의약품안전청 국립독성연구소 유전독성과) ;
  • 전혜승 (식품의약품안전청 국립독성연구소 유전독성과) ;
  • 민수진 (식품의약품안전청 국립독성연구소 유전독성과) ;
  • 김인숙 (식품의약품안전청 국립독성연구소 유전독성과) ;
  • 정해관 (식품의약품안전청 국립독성연구소 유전독성과) ;
  • 심웅섭 (고려대학교 생물학과)
  • Published : 2001.03.01
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Abstract

To identify nongenotoxic carcinogen determined as negative by ICH guideline-recommended standard genotoxicity test battery; Ames test, chromosome aberration assay, mouse lymphoma $tk^{+/-}$ assay, in vivo micronucleus assay, we picked bisphenol A as a model compound. In this study, we applied in vitro BalB/c 3T3 cell transformation assay and Syrian hamster embryo (SHE) cell transfarmation assay. Bisphenol A was treated upto $769.2 ug/m{\ell}$ in BalB/c 3T3 cells and upto $125 ug/m{\ell}$ in SHE cells. bisphenol A didn't induced morphological transformation both with one stage treatment protocol and with two stage treatment protocol. But, treated far 48 hr, Bisphenol A induced morphological transformation significantly in SHE cells.

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