• International Journal of Oral Biology
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• 제35권2호
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• pp.61-67
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• 2010

Selenoprotein S (SelS) is widely expressed in diverse tissues where it localizes in the plasma membrane and endoplasmic reticulum. We studied the potential function of SelS in erythrocyte differentiation using K562 cells stably over-expressing SelS wild-type (WT) or one of two SelS point mutants, $U_{188}S$ or $U_{188}C$. We found that in the K562 cells treated with $1\;{\mu}M$ Ara-C, SelS gradually declined over five days of treatment. On day 4, intracellular ROS levels were higher in cells expressing SelS-WT than in those expressing a SelS mutant. Moreover, the cell cycle patterns in cells expressing SelS-WT or $U_{188}C$ were similar to the controls. The expression and activation of SIRT1 were also reduced during K562 differentiation. Cells expressing SelS-WT showed elevated SIRT1 expression and activation (phosphorylation), as well as higher levels of FoxO3a expression. SIRT1 activation was diminished slightly in cells expressing SelS-WT after treatment with the ROS scavenger NAC (12 mM), but not in those expressing a SelS mutant. After four days of Ara-C treatment, SelS-WT-expressing cells showed elevated transcription of $\beta$-globin, $\gamma$-globin, $\varepsilon$-globin, GATA-1 and zfpm-1, whereas cells expressing a SelS mutant did not. These results suggest that the suppression of SelS acts as a trigger for proerythrocyte differentiation via the ROS-mediated downregulation of SIRT1.

• The Korean Journal of Pain
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• 제22권3호
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• pp.249-252
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• 2009

Spinal epidural lipomatosis (SEL) is a rare condition of pathological overgrowth of fat tissue in the vertebral canal. SEL leads to back pain, radiculopathy or paraparesis. Glucocorticoids seem to play a major role in the development of SEL. SEL is best diagnosed by magnetic resonance imaging. The treatment of SEL is directed at reducing the body weight and decreasing the excess glucocorticoid. In severe cases, decompressive laminectomy with removal of the excess epidural fat might become necessary to alleviate the neurological symptoms caused by spinal cord compression.

• Journal of Korean Neurosurgical Society
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• 제50권2호
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• pp.130-133
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• 2011

Spinal epidural lipomatosis (SEL) is an overgrowth of the normally encapsulated adipose tissue in the epidural space around the spinal cord in the thoracic and lumbar spine causing compression of the neural components. Idiopathic SEL in non-obese patients is exceptional. Idiopathic SEL can result in thoracic myelopathy and lumbar radiculopathy. A thoracic radiculopathy due to idiopathic SEL has not been reported yet. We report a case of idiopathic SEL with intractable chest pain and paresthesia. We suggest that idiopathic SEL should be considered as a cause of chest pain.

• Journal of Korean Neurosurgical Society
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• 제55권6호
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• pp.365-369
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• 2014

Spinal epidural lipomatosis (SEL) is a rare disorder, regarded in literature as a consequence of administration of exogenous steroids, associated with a variety of systemic diseases, endocrinopathies and the Cushing's syndrome. Occasionally, SEL may occur in patients not exposed to steroids or suffering from endocrinopathies, namely, idiopathic SEL. Thus far, case studies of SEL among Korean have been published rather sporadically. We reviewed the clinical features of SEL cases, among Koreans with journal review, including this report of three operated cases. According to this study, there were some differences between Korean and western cases. Koreans had higher incidences of idiopathic SEL, predominant involvement in the lumbar segments, very few thoracic involvement and lower MBI, as opposed to westerners.

• Nutrition Research and Practice
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• 제5권3호
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• pp.205-213
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• 2011

Exercise training (ET) and selenium (SEL) were evaluated either individually or in combination (COMBI) for their effects on expression of glucose (AMPK, PGC- $1{\alpha}$, GLUT-4) and lactate metabolic proteins (LDH, MCT-1, MCT-4, COX-IV) in heart and skeletal muscles in a rodent model (Goto-Kakisaki, GK) of diabetes. Forty GK rats either remained sedentary (SED), performed ET, received SEL, ($5\;{\mu}mol{\cdot}kg$ body $wt^{-1}{\cdot}day^{-1}$) or underwent both ET and SEL treatment for 6 wk. ET alone, SEL alone, or COMBI resulted in a significant lowering of lactate, glucose, and insulin levels as well as a reduction in HOMA-IR and AUC for glucose relative to SED. Additionally, ET alone, SEL alone, or COMBI increased glycogen content and citrate synthase (CS) activities in liver and muscles. However, their effects on glycogen content and CS activity were tissue-specific. In particular, ET alone, SEL alone, or COMBI induced upregulation of glucose (AMPK, PGC-la, GLUT-4) and lactate (LDH, MCT-1, MCT-4, COX-IV) metabolic proteins relative to SED. However, their effects on glucose and lactate metabolic proteins also appeared to be tissue-specific. It seemed that glucose and lactate metabolic protein expression was not further enhanced with COMBI compared to that of ET alone or SEL alone. These data suggest that ET alone or SEL alone or COMBI represent a practical strategy for ameliorating aberrant expression of glucose and lactate metabolic proteins in diabetic GK rats.

• 한국방사선학회논문지
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• 제11권3호
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• pp.101-108
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• 2017

DC/DC 컨버터는 임의의 직류전원을 부하가 요구하는 형태의 직류전원으로 변환시키는 효율이 높은 전력변환기이다. 고급형 DC/DC 컨버터는 MOSFET(산화물-반도체 전계 효과 트랜지스터)를 제어하기 위해 OP-Amp.(연산 증폭기)를 실장한 PWM-IC(펄스폭 변조 집적회로)를 사용한다. OP-Amp.는 증폭기 기능을 수행하는데 방사선 영향으로 전기적 특성이 변화하는데 본 논문에서는 코발트 60 (60Co) 저준위 감마발생기를 이용한 TID실험과 5종류의 중이온 입자를 이용하여 SEL 실험을 수행하는데 바이어스(bias) 전류가 순간적으로 과전류가 흘러 SEL이 발생된다. OP-Amp.의 TID 실험은 조사율은 5 rad/sec.로 전체 조사량을 30 krad 까지 수행하였으며, SEL 실험은 제어보드를 구현한 후 LET($MeV/mg/cm^2$)별 cross section($cm^2$)을 이용하여 성능평가를 하는데 있다.

• 한국가정과교육학회지
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• 제35권1호
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• pp.15-34
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• 2023

본 연구는 청소년기 학생들이 자신을 이해하고 타인과 건강한 관계를 맺으며 건강한 공동체를 형성할 수 있는 교육을 제공하기 위한 이론적 관점으로서 사회정서학습(SEL)에 주목하여 2015 개정 가정과 교육과정에서 드러난 사회정서학습의 의미와 핵심역량을 분석하였다. 그 결과 가정과 교육과정의 성격, 목표, 교과 역량, 핵심 개념, 일반화된 지식, 성취기준에 사회정서학습의 핵심역량이 모두 포함된 것으로 분석되었다. 이에 대한 시사점은 첫째, 학교 현장에서 따로 사회정서학습 프로그램을 도입하지 않아도 가정과수업의 명시적 교육을 통해 사회정서학습 핵심역량이 충분히 함양될 수 있다. 둘째, 가정과교육은 실천을 강조하는 교과이기 때문에 사회정서학습의 역량들을 학교 밖에서의 실제적 삶과 연계하여 적용할 수 있다. 마지막으로 사회정서학습의 최종목표인 부모와 가정과의 연계를 중시하고 건강하고 안전하며 정의로운 커뮤니티 형성은 가정과교육의 목표와 유사성이 높으므로 가정과교육을 통해 사회정서학습의 실효성을 높일 수 있다.

• 콘크리트학회지
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• 제2권3호
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• pp.89-95
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• 1990

모르타르와 콘크리트의 파괴특성 연구에 있어 할열인장실험 방법의 가능성을 알아보았다. 이를 위하여 할열인장 실험을 통해 초기노치가 주어져 있는 원형 공시체의 크기가 커질 때 모르타르와 콘크리트의 파괴하중의 변화를 구하였다. 이로부터 SEL방법에 의한 수렴정도가 가장 빠른 것으로 나타났으며 SEL방법이 모르타르와 콘크리트의 파괴에너지 및 파괴인성을 구하는 데 매우 효과적인 방법이 될 수 있음을 보였다.

• 한국소음진동공학회논문집
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• 제16권5호
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• pp.503-513
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• 2006

The duration time of aircraft noise event is also an important factor for the evaluation of civil aircraft noise, which is considered as a notable characteristic of military aircraft noise. SEL is proved as a suitable noise metric for the measuring military aircraft noise of various flight pattern considering the duration time of noise event. This study reviews whether SEL is a suitable for measuring civil aircraft noise and study shows SEL is fairly compensating the duration time of civil aircraft noise event for the evaluation of aircraft noise. Noise metric for the evaluation aircraft noise based on SEL is more appropriate than based on $L_{MAX}$ for compensating duration time of noise event either military aircraft or civil aircraft. In this reason, current formula of WECPNL based on energy average of measured $L_{MAX}$ for the evaluation of aircraft noise impact in 'Test Method of Noise and Vibration of Korea' is recommended to be amended to formula of WECPNL based on energy average of measured SEL considering compensation of noise event duration time, if WECPNL is not based on measured EPNL, a metric compensating duration time.

• Journal of Information Processing Systems
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• 제18권3호
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• pp.411-427
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• 2022

Digging historical and cultural information from seals in ancient books is of great significance. However, ancient Chinese seal samples are scarce and carving methods are diverse, and traditional digital image processing methods based on greyscale have difficulty achieving superior segmentation and recognition performance. Recently, some deep learning algorithms have been proposed to address this problem; however, current neural networks are difficult to train owing to the lack of datasets. To solve the afore-mentioned problems, we proposed an SEL-RefineMask which combines selector of feature pyramid network (SEL-FPN) with RefineMask to segment and recognize seals. We designed an SEL-FPN to intelligently select a specific layer which represents different scales in the FPN and reduces the number of anchor frames. We performed experiments on some instance segmentation networks as the baseline method, and the top-1 segmentation result of 64.93% is 5.73% higher than that of humans. The top-1 result of the SEL-RefineMask network reached 67.96% which surpassed the baseline results. After segmentation, a vision transformer was used to recognize the segmentation output, and the accuracy reached 91%. Furthermore, a dataset of seals in ancient Chinese books (SACB) for segmentation and small seal font (SSF) for recognition were established which are publicly available on the website.