• Title/Summary/Keyword: SDC

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Dissolution Characteristics of Biphenyl Dimethyl Dicarboxylate from Solid Dispersions and Permeation through Rabbit Deuodenal Mucosa (고체분산체로부터 비페닐디메칠디카르복실레이트의 용출 특성 및 토끼의 십이지장 점막 투과)

  • Hyun, Jean;Chun, In-Koo
    • Journal of Pharmaceutical Investigation
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    • v.24 no.2
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    • pp.57-65
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    • 1994
  • To increase the dissolution rate of practically insoluble biphenyl dimethyl dicarboxylate (DDB), various solid dispersions were prepared with water soluble carriers, such as povidone (PVP K-30), poloxamer 407, sodium deoxycholate (SDC) and polyethylene glycol (PEG) 6000, at drug to carrier ratios of 1:3, 1:5 and 1:10 (w/w) by solvent or fusion method. Dissolution test was performed by the paddle method. The dissolution rate of DDB tablets (25 mg) on market was found to be very low (11.44, 9.02 and 6.42% at pH 1.2, 4.0 and 6.5 after 120 min, respectively). However, dissolution rates of DDB from various solid dispersions were very fast and reached supersaturation within 10 min. DDB-PEG 6000 solid dispersion appeared to be better in enhancing the in vitro dissolution rate than others. Furthermore, the incorporation of DDB and phosphatidylcholine (PC) into ${\beta}-cyclodextrin$ at ratios of 1:2:20, 1:5:20 and 1:10:20 resulted in a 4.9-, 11.2- and 19.6-fold increase in DDB dissolution after 120 min as compared with the pure drug, respectively. This might be attributed to the formation of lipid vesicles which entrapped a certain concentration of DDB during dissolution. On the other hand, the permeation of DDB through rabbit duodenal mucosa was examined using some enhancers such as SDC, sod. glycocholate (SGC) and glycyrrhizic acid ammonium salt (GAA). Only trace amounts of DDB were found to permeate through deuodenal mucosa in the absence of enhancer. SDC was found to markedly decrease the permeation flux of DDB, however, SGC and GAA (5 mM) enhanced the flux of DDB 1.6 and 2.4 times higher as compared with no additive, respectively.

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MODE : Managed Objects(MOs) Development Environment for TMN-based ATM Network Management (MODE :TMN 체계의 ATM 망 관리를 위한 관리 객체 개발 환경)

  • Gang, Won-Seok;Kim, Gi-Hyeong;Kim, Yeong-Tak
    • The Transactions of the Korea Information Processing Society
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    • v.6 no.2
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    • pp.415-424
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    • 1999
  • Systematic telecommunication network management is essential for operating large-scale integrated networks which consist of various network components manufactured by different vendors. ISO and ITU-T recommend the CMIP-based TMN architecture for this purpose. TMN uses GDMO for the definition of managed objects, and various GDMO compilers have been developed. However, the development of management objects by using these compilers is still a difficult task. In this paper, we present a GUI-based managed objects development environment, MODE. MODE divides managed object codes by system independent code(SIC) and system dependent cede(SDC). By providing development environments for SIC and SDC, MODE can ease the development of managed objects. To show the efficiency of MODE, we develop the managed objects of an ATM switch in MODE.

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Extraction of Snowmelt Parameters using NOAA AVHRR and GIS Technique for 5 River Basins in South Korea (NOAA AVHRR 영상 및 GIS 기법을 이용한 국내 5대강 유역의 융설 매개변수 추출)

  • Shin, Hyung-Jin;Park, Geun-Ae;Kim, Seong-Joon
    • Korean Journal of Remote Sensing
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    • v.23 no.2
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    • pp.119-124
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    • 2007
  • The few observed data related snowmelt was the major cause of difficulty in extracting snowmelt factors such as snow cover area, snow depth and depletion curve. Remote sensing technology is very effective to observe a wide area. Although many researchers have used remote sensing for snow observation, there were a few discussions on the characteristics of spatial and temporal variation. Snow cover maps were derived from NOAA AVHRR images for the winter seasons from 1997 to 2006. Distributed snow depth was mapped by overlapping between snow cover maps and interpolated snowfall maps from 69 meteorological observation stations. Model parameters (Snow Cover Area: SCA, snow depth, Snow cover Depletion Curve: SDC) building for 5 major watersheds in South Korea. Especially SDC is important parameter of snowmelt model.

Error Resilient Video Coding Techniques Using Multiple Description Scheme (다중 표현을 이용한 에러에 강인한 동영상 부호화 방법)

  • 김일구;조남익
    • Journal of Broadcast Engineering
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    • v.9 no.1
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    • pp.17-31
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    • 2004
  • This paper proposes an algorithm for the robust transmission of video in error Prone environment using multiple description codingby optimal split of DCT coefficients and rate-distortionoptimization framework. In MDC, a source signal is split Into several coded streams, which is called descriptions, and each description is transmitted to the decoder through different channel. Between descriptions, structured correlations are introduced at the encoder, and the decoder exploits this correlation to reconstruct the original signal even if some descriptions are missing. It has been shown that the MDC is more resilient than the singe description coding(SDC) against severe packet loss ratecondition. But the excessive redundancy in MDC, i.e., the correlation between the descriptions, degrades the RD performance under low PLR condition. To overcome this Problem of MDC, we propose a hybrid MDC method that controls the SDC/MDC switching according to channel condition. For example, the SDC is used for coding efficiency at low PLR condition and the MDC is used for the error resilience at high PLR condition. To control the SDC/MDC switching in the optimal way, RD optimization framework are used. Lagrange optimization technique minimizes the RD-based cost function, D+M, where R is the actually coded bit rate and D is the estimated distortion. The recursive optimal pet-pixel estimatetechnique is adopted to estimate accurate the decoder distortion. Experimental results show that the proposed optimal split of DCT coefficients and SD/MD switching algorithm is more effective than the conventional MU algorithms in low PLR conditions as well as In high PLR condition.

Seismic Performance Evaluation of Steel Moment Resisting Frame Systems According to an Improved Design Method of RBS-B Connections (RBS-B 접합부 설계식 개선에 따른 철골모멘트골조 시스템의 내진성능평가)

  • Han, Sang-Whan;Kang, Ki-Byung;Moon, Ki-Hoon;Hwang, Seong-Hoon
    • Journal of the Earthquake Engineering Society of Korea
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    • v.14 no.6
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    • pp.75-84
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    • 2010
  • In current seismic design provisions, a reduced beam section with bolted web (RBS-B) connections is only permitted for intermediate moment frames (IMF). This study evaluated the seismic performance of steel moment resisting frame systems having RBS-B connections designed according to current seismic design provisions. For this purpose, 12 archetypal IMF systems having two different span lengths (9m, 6m) were designed considering two design load levels (SDC $C_{max}$, SDC $C_{min}$). A nonlinear analytical model that can simulate hysteretic behavior of an RBS-B connection was also developed in this study. The procedures specified in ATC 63 are used to conduct a seismic performance evaluation. Moreover, this study conducts the seismic performance evaluation of IMF systems designed according to a new design method proposed by the authors in the previous study. It was observed that several model frames designed according to current seismic design provisions did not provide satisfactory collapse margin ratios (ACMR). This study also showed that the model frames designed according to the new design procedures had a sufficient ACMR.

Performance of Single Cells with Anode Functional Layer for SOFC

  • Choi, Jin-Hyeok;Lee, Tae-Hee;Park, Tae-Sung;Yoo, Young-Sung
    • New & Renewable Energy
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    • v.5 no.1
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    • pp.11-17
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    • 2009
  • To improve the performance of the anode-supported Solid Oxide Fuel Cell (SOFC) which can be operated at an intermediate temperature, the functional layer (FL) is introduced on a anode substrate. And the scandia-stabilized zirconia (ScSZ) and samaria-doped ceria (SDC) which have higher ionic conductivity and better chemical stability than yttria-stabilized zirconia (YSZ) are used as material for the anode FL with the Ni, The fabrication process of anode-supported single cell with the anode FL was established and the power density of those was evaluated. As a result, the sample with anode FL (Ni-YSZ) has higher power density than normal cell. The single cell which was composed of the FL (Ni-YSZ) and electrolyte (YSZ) showed about $550mW/cm^2$ of the maximum power density at $650^{\circ}C$ and $1430mW/cm^2$ at $750^{\circ}C$ respectively, In case of the single cell using the ScSZ and SDC as anode FL, the performance of samples decreased rapidly and those showed unstable voltage during long-term test. In case of using methane as a fuel, the cell performance with each FL decreased comparing with $H_2$ fuel. In the region of a high current density, there are large concentration polarizations.

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Shunt Active Filter for Multi-Level Inverters Using DDSRF with State Delay Controller

  • Rajesh, C.R.;Umayal, S.P.
    • Journal of Power Electronics
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    • v.18 no.3
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    • pp.863-870
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    • 2018
  • The traditional power control theories for the harmonic reduction methods in multilevel inverters are found to be unreliable under unbalanced load conditions. The unreliability in harmonic mitigation is caused by voltage fluctuations, non-linear loads, the use of power switches, etc. In general, the harmonics are reduced by filters. However, such devices are an expensive way to provide a smooth and fast response to secure power systems during dynamic conditions. Hence, the Decoupled Double Synchronous Reference Frame (DDSRF) theory combined with a State Delay Controller (SDC) is proposed to achieve a harmonic reduction in power systems. The DDSRF produces a sinusoidal harmonic that is the opposite of the load harmonic. Then, it injects this harmonic into power systems, which reduces the effect of harmonics. The SDC is used to reduce the delay between the compensation time for power injection and the generation of a reference signal. The proposed technique has been simulated using MATLAB and its reliability has been verified experimentally under unbalanced conditions.