• Bulletin of the Korean Chemical Society
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• 제28권3호
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• pp.447-450
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• 2007

Trap effects on the formation of space-charge field (SCF) associated with the photorefractivity of nonlinear optical polymers were studied by the Monte Carlo simulation using modified Gaussian disorder model. The charge transport dynamics influenced by the presence of trap molecules controls the formation of SCF via the charge distribution. Temporal behavior of SCF formation and SCF dependence on the trap depth are discussed in terms of the concentration and distribution of charges (holes and ionized acceptors) developed following illumination of light. The correlation of the trap depth and the energetic disorder is presented for an optimal efficiency for the SCF formation.

• BMB Reports
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• 제48권1호
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• pp.25-29
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• 2015

Ubiquitination is a post translational modification which mostly links with proteasome dependent protein degradation. This process has been known to play pivotal roles in the number of biological events including apoptosis, cell signaling, transcription and translation. Although the process of ubiquitination has been studied extensively, the mechanism of polyubiquitination by multi protein E3 ubiquitin ligase, SCF complex remains elusive. In the present study, we identified UbcH5a as a novel stimulating factor for poly-ubiquitination catalyzed by $SCF^{hFBH1}$ using biochemical fractionations and MALDI-TOF. Moreover, we showed that recombinant UbcH5a and Cdc34 synergistically stimulate $SCF^{hFBH1}$ catalyzed polyubiquitination in vitro. These data may provide an important cue to understand the mechanism how the SCF complex efficiently polyubiquitinates target substrates.

• 대한전자공학회논문지
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• 제19권6호
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• pp.41-51
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• 1982

본 논문에서는 V[S(voltage inverter switch)를 사용한 SCF(switched capacitor filler)에 있어서 VIS의 비이상적인 동작이 여파기 특성에 미치는 영향을 여파기를 구성하는 각 소자들의 변화로써 분석하는 방법을 제시하였다. 또 위의 결과를 VIS가 없는 SCF의 경우에 응용함으로써 대부분의 SC(switched cavacito.) 회로를 쌍일차(bilinear) 변환된 영역에서 그 등가각로를 쉽게 구할 수 있어 SCF의 분석이 용이하고, 높은동작 주파수를 갖는 SCF를 적은 수의 능동 소자로 구현할 수 있는 방법에 대해 기술하였다. 그리고 저역 통과 여파기와 대역 저지 여파기를 실험하여 그 결과가 이론치와 잘 일치함을 보였다.

• Tribology and Lubricants
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• 제12권1호
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• pp.56-65
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• 1996

The result of wear test for ceramic materials was assessed by Scf parameter to verify the usefulness of the proposed Scf parameter. Friction and wear tests were carried out with ball on disk type. The materials used in this study were HIPed Alumina $(Al_2O_3)$, Silicon carbide (sic), Silicon nitride $(Si_3N_4)$ and Zirconia $(ZrO_2)$. The tests were carried out at room temperature with self mated couples of ceramic materials under lubricated condition. Turbine oil was used as a lubricant. In this test, increasing the load, specific wear rates and wear coefficients of four kinds of ceramic materials had a tendency to increase. The wear coefficients of ceramic materials were in order of $Al_2O_3, SiC, Si_3N_4, ZrO_2$. Worn surfaces investigated by SEM had residual surface cracks and wear particles caused by brittle fracture. As the fracture toughness of ceramic materials was higher, wear resistance more increased. The roughness of worn surface had correlation with wear rate. The wear rate(W$_{s}$) and Scf parameter showed linear relationship in log-log coordinates and the wear equation was given as $W_s = 5.52 $\times$ Scf^{5.01}$.

• Asian-Australasian Journal of Animal Sciences
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• 제33권11호
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• pp.1824-1836
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• 2020

Objective: On the hypothesis that grazing of cattle prompts organs to secrete or internalize circulating microRNAs (c-miRNAs) in parallel with changes in energy metabolism, we aimed to clarify biological events in adipose, skeletal muscle, and liver tissues in grazing Japanese Shorthorn (JSH) steers by a transcriptomic approach. Methods: The subcutaneous fat (SCF), biceps femoris muscle (BFM), and liver in JSH steers after three months of grazing or housing were analyzed using microarray and quantitative polymerase chain reaction (qPCR), followed by gene ontology (GO) and functional annotation analyses. Results: The results of transcriptomics indicated that SCF was highly responsive to grazing compared to BFM and liver tissues. The 'Exosome', 'Carbohydrate metabolism' and 'Lipid metabolism' were extracted as the relevant GO terms in SCF and BFM, and/or liver from the >1.5-fold-altered mRNAs in grazing steers. The qPCR analyses showed a trend of upregulated gene expression related to exosome secretion and internalization (charged multivesicular body protein 4A, vacuolar protein sorting-associated protein 4B, vesicle associated membrane protein 7, caveolin 1) in the BFM and SCF, as well as upregulation of lipolysis-associated mRNAs (carnitine palmitoyltransferase 1A, hormone-sensitive lipase, perilipin 1, adipose triglyceride lipase, fatty acid binding protein 4) and most of the microRNAs (miRNAs) in SCF. Moreover, gene expression related to fatty acid uptake and inter-organ signaling (solute carrier family 27 member 4 and angiopoietin-like 4) was upregulated in BFM, suggesting activation of SCF-BFM organ crosstalk for energy metabolism. Meanwhile, expression of plasma exosomal miR-16a, miR-19b, miR-21-5p, and miR-142-5p was reduced. According to bioinformatic analyses, the c-miRNA target genes are associated with the terms 'Endosome', 'Caveola', 'Endocytosis', 'Carbohydrate metabolism', and with pathways related to environmental information processing and the endocrine system. Conclusion: Exosome and fatty acid metabolism-related gene expression was altered in SCF of grazing cattle, which could be regulated by miRNA such as miR-142-5p. These changes occurred coordinately in both the SCF and BFM, suggesting involvement of exosome in the SCF-BFM organ crosstalk to modulate energy metabolism.

• 대한전자공학회논문지
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• 제18권4호
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• pp.1-11
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• 1981

본 논문에서는 VIS (voltage inverter switch)를 사용한 SCF(switched capacitor filter) 설계 방법에 있어서 종래에 발표된 clocking scheme을 일반화하고, 이로써 생기는 RC, RL 등의 병렬소자들과 유손실 또는 무손실 LC 병렬공진 소자들을 제시하였다. 또 이들 업자들을 SCF의 설계에 응용함으로써 종래의 방법에 비해 연산증폭기와 Capacitor의 수를 줄일 수 있는 설계 방법에 대해 기술하였다. 이 결과로 SCF를 더욱 작은 칩(chip) 면적으로 집적화 할 수 있겠다. 또 새로운 구조를 갖는 VIS를 제시하고 이를 사명한 저역통과 여파기와 간단한 대역골지 여파기를 실험하여 그 결과가 이론치와 잘 일치함을 보였다.

• 국제물리치료학회지
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• 제9권4호
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• pp.1602-1607
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• 2018

This study examined the correlation between power error (PE) and velocity error (VE) according to the condition and frequency of self-controlled feedback (SCF) during knee extension. One hundred participants were randomly assigned to 30% SCF, 70% SCF, 30% yoked feedback (YF), 70% YF and control group, respectively. The SCF group was provided with feedback when they requested it, whereas the YF group did not influence the feedback schedule. Participants in the control group were not given any visual feedback during the experiment. The isotonic, isometric, and isokinetic dynamometer (PRIMUS RS, BTE, USA) was used to measure the power and velocity error during knee extension. The collected data was analyzed using a Pearson test and SPSS 21.0. The correlation between PE and VE according to the condition and frequency of feedback on each phase during knee extension was significant. Both PE and VE were significantly higher when the feedback was provided with high frequency, passive, and no feedback. Our study suggests that application of SCF can help to improve the proprioception of the healthy person while reducing errors through low frequency and active feedback.

• 한국초전도ㆍ저온공학회논문지
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• 제20권4호
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• pp.65-69
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• 2018

Due to large in-field current carrying capacity and strong mechanical strength, a REBCO wire has been regarded as a viable high temperature superconductor (HTS) option for high field MRI and > 1 GHz (>23.5 T) NMR magnets. However, a REBCO magnet is well known to have an inherent problem of field inhomogeneity, so-called 'Screening Current induced magnetic Field (SCF)'. Recently, 'field shaking' and 'current overshoot operation' techniques have been successfully demonstrated to mitigate the SCF and enhance the field homogeneity by experiments. To investigate the effectiveness of current overshooting operation technique, a numerical simulation is conducted for a test REBCO magnet composed of a stack of double pancake coils using '2D edge-element magnetic field formulation' combined with 'domain homogenization' scheme. The simulation result demonstrates that an appropriate amount of current overshoot can negate the SCF. To verify the simulation results, current overshoot experiments are conducted for the REBCO magnet in liquid nitrogen. Experimental results also demonstrate the possible application of current overshoot technique to mitigate the SCF and enhance the field homogeneity.

• Elastomers and Composites
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• 제56권2호
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• pp.65-71
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• 2021

In recent times, the demand for electronic devices has increased because of advancements in the electronics industry. Consequently, research on shielding against electromagnetic interference (EMI) from electronic devices has also progressed significantly. In particular, research on imparting electrical conductivity to plastic has seen substantial progress. In this study, the effect of hybrid fillers comprising carbon fiber (CF) and carbon nanotubes (CNTs) on the electrical properties of polyamide 66 (PA66) composites was investigated. PA66 composites were prepared using a BUSS Co-Kneader single-screw extruder. EMI shielding effectiveness (SE) increased with the increasing addition of unsized CF (UCF), sized CF (SCF), and CNTs. For the PA66/SCF/CNT hybrid filler composites, EMI SE significantly increased with the increase in SCF content. Finally, the hybrid filler comprising SCF and CNTs may have a synergistic effect on the EMI SE and surface resistivity of PA66/SCF/CNT composites.

• Biomolecules & Therapeutics
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• 제31권1호
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• pp.89-96
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• 2023

Uric acid produced by guanine deaminase (GDA) is involved in photoaging and hyperpigmentation. Reactive oxygen species (ROS) generated by uric acid plays a role in photoaging. However, the mechanism by which uric acid stimulates melanogenesis in GDA-overexpressing keratinocytes is unclear. Keratinocyte-derived paracrine factors have been identified as important mechanisms of ultraviolet-induced melanogenesis. Therefore, the role of paracrine melanogenic growth factors in GDA-induced hypermelanosis mediated by uric acid was examined. The relationships between ROS and these growth factors were examined. Primary cultured normal keratinocytes overexpressed with wild type or mutant GDA and those treated with xanthine or uric acid in the presence or absence of allopurinol, H₂O₂, or N-acetylcysteine (NAC) were used in this study. Intracellular and extracellular bFGF and SCF levels were increased in keratinocytes by wild type, but not by loss-of-function mutants of GDA overexpression. Culture supernatants from GDA-overexpressing keratinocytes stimulated melanogenesis, which was restored by anti-bFGF and anti-SCF antibodies. Allopurinol treatment reduced the expression levels of bFGF and SCF in both GDA-overexpressing and normal keratinocytes exposed to exogenous xanthine; the exogenous uric acid increased their expression levels. H₂O₂-stimulated tyrosinase expression and melanogenesis were restored by NAC pretreatment. However, H₂O₂ or NAC did not upregulate or downregulate bFGF or SCF, respectively. Overall, uric acid could be involved in melanogenesis induced by GDA overexpression in keratinocytes via bFGF and SCF upregulation not via ROS generation.