• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2521-2523
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• 2013

Background: Papillary thyroid cancer or papillary thyroid carcinoma (PTC) is the most common thyroid cancer. The fact that it occasionally occurs in women aged 30-40 years old suggests that genetic alterations are involved its genesis. Recently, activator mutations in BRAF gene have been relatively frequently discovered. Materials and Methods: In this study, we tested 63 DNA samples from PTC patients to identify the V600E mutation frequency in the Ahvaz population. DNA was isolated from formalin fixed paraffin-embedded (FFPE) PTC tumor tissues. Genotyping was performed by PCR-RFLP and confirmed by direct DNA sequencing of a subset of PCR products. PCR-RFLP data were reported as genotype frequencies and percentages. Results: Forty nine out of 63 patients (77.8%) had a mutated heterozygote form while 14 (22.2%) showed normal genotype but none demonstrated a mutant homozygote genotype. The frequency of V600E mutation was significantly high in PTC patients. Conclusions: These findings support involvement of V600E mutations in PTC occurrence in Iran. Assessment of correlations between BRAF V600E mutations and papillary thyroid cancer progression needs to be performed.

• Restorative Dentistry and Endodontics
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• v.41 no.3
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• pp.196-201
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• 2016

Objectives: The aim of this in vitro study was to evaluate the effect of incorporating three different nanobiomaterials into bleaching material on microhardness of bleached enamel. Materials and Methods: The crowns of 24 extracted sound human molars were sectioned. Sixty enamel specimens ($2{\times}3{\times}4 mm$) were selected and divided into five groups (n = 12): Group 1 received no bleaching procedure (control); Group 2 underwent bleaching with a 40% hydrogen peroxide (HP) gel; Groups 3, 4, and 5 were bleached with a 40% HP gel modified by incorporation of bioactive glass (BAG), amorphous calcium phosphate (ACP) and hydroxyapatite (HA), respectively. The enamel microhardness was evaluated. The differences in Knoop microhardness data of each group were analyzed by one-way ANOVA, followed by post hoc Tukey tests. Results: Significant differences were observed between the study groups. The enamel microhardness changes in Groups 1, 3, 4, and 5 were significantly lower than that of Group 2 (p < 0.001). Conclusions: Within the limitations of this study, it can be concluded that incorporation of each one of the three tested biomaterials as remineralizing agents might be effective in decreasing enamel microhardness changes subsequent to in-office bleaching.

• Safety and Health at Work
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• v.7 no.4
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• pp.354-362
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• 2016

Background: The present study aims at investigating whether and how (1) job demands and job resources are associated with work-to-private-life interference (WLI) and (2) job resources moderate the relationship between job demands and WLI. Methods: Data were collected by a self-report questionnaire from three hospitals in Italy. The sample consisted of 889 health-care workers. Results: All job demands (i.e., quantitative demands, disproportionate patient expectations, and verbal aggression) and job resources (i.e., job autonomy, support from superiors and colleagues, fairness, and organizational support), with the exception of skill discretion, were related to WLI. The effects of quantitative demands on WLI were moderated by support from superiors; fairness and organizational support moderate the effects of all job demands considered. Support from colleagues moderated only verbal aggression. Job autonomy did not buffer any job demands. Conclusion: The present study suggests that the work context has a central importance in relation to the experience of WLI among health-care workers. The results indicated that intervention in the work context may help to contain WLI. Such interventions would especially be aimed at improving the social climate within the unit and quality of the organizational process.

• Nutrition Research and Practice
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• v.5 no.3
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• pp.230-235
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• 2011

Insomnia has become a major public health issue in recent times. Although quality of sleep is affected by environmental, psychophysiological, and pharmacological factors, diet and nutrient intake also contribute to sleep problems. This study investigated the association between nutrient intake and co-morbid symptoms associated with sleep status among selected adults. Subjects in this study included 87 men and women aged 21-45 years. Presence of insomnia was assessed using the Insomnia Screening Questionnaire, and dietary intake was measured over three consecutive days by dietary survey. Descriptive analysis, ANOVA, and Chi-Square tests were performed to compute and interpret the data. Approximately 60% of the participants were insomniacs. People with insomnia consumed significantly lesser quantities of nutrients as compared to normal sleepers. Differences in intakes of energy, carbohydrates, folic acid, and $B_{12}$ were highly significant (P < 0.002). Further, intakes of protein, fat, and thiamine were significantly different (P < 0.021) between insomniacs and normal sleepers. The nutrient intake pattern of the insomniacs with co-morbid symptoms was quite different from that of the normal sleepers. Based on these results, it is probable that there is an association between nutrition deficiency, co-morbid symptoms, and sleep status. More studies are required to confirm these results.

• Structural Engineering and Mechanics
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• v.72 no.5
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• pp.653-673
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• 2019

This work investigates a novel quasi-3D hyperbolic shear deformation theory is presented to discuss the buckling of new type of sandwich plates. This theory accounts for both shear deformation and thickness stretching effects by a hyperbolic variation of all displacements through the thickness. The enhancement of this formulation is due to the use of only five unknowns by including undetermined integral terms, contrary to other theories where we find six or more unknowns. It does not require shear correction factors and transverse shear stresses vary parabolically across the thickness. A new type of FGM sandwich plates, namely, both FGM face sheets and FGM hard core are considered. The governing equations and boundary conditions are derived using the principle of virtual displacements. Analytical solutions are obtained for a simply supported plate. The accuracy of the present theory is verified by comparing the obtained results with quasi-3D solutions and those predicted by higher-order shear deformation theories. The comparison studies show that the obtained results are not only more accurate than those obtained by higher-order shear deformation theories, but also comparable with those predicted by quasi-3D theories with a greater number of unknowns.

• Asian-Australasian Journal of Animal Sciences
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• v.9 no.1
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• pp.63-67
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• 1996

An experiment was conducted to compare the effects of early feed restriction on the performance and abdominal fat deposition in broilers. The treatments consisted of providing feed ad libitum (Full-fed) and three feed restriction treatments of restricting feeding between 8-21 days of age (DOA) either for a duration of 7 days or 14 days. The three feed restriction treatments were Restrict 8-14 DOA, Restrict 8-21 DOA and Restrict 15-21 DOA. Live weights and feed consumption were obtained at weekly intervals. Samples of both male and female broilers were taken at 43 DOA to determine the weight of abdominal fat, liver and gizzards. Feed efficiency was generally improved by feed restriction, but a compensatory gain was not observed in the restricted groups. Broilers on restricted feeding also had lower mortality as compared to the full-fed broilers. There is no effect of early feed restriction on the weight of the abdominal fat and the dressing percentages but the weights of the liver and gizzard were affected by restriction. Also there was an effect of sex on the weights of the abdominal fat, the liver and gizzard of the males and females.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2107-2117
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• 2015

Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is autosomal dominantly and gain of function mutations in the RET proto-oncogene are well known to contribute to its development. MTC occurs as hereditary (25%) and sporadic (75%) forms. Hereditary MTC has syndromic (multiple endocrine neoplasia type 2A, B; MEN2A, MEN2B) and non-syndromic (Familial MTC, FMTC) types. Over the last two decades, elucidation of the genetic basis of tumorigenesis has provided useful screening tools for affected families. Advances in genetic screening of the RET have enabled early detection of hereditary MTCs and prophylactic thyroidectomy for relatives who may not show any symptom sof the disease. In this review we emphasize the main RET mutations in syndromic and non syndromic forms of MTC, and focus on the importance of RET genetic screening for early diagnosis and management of MTC patients, based on American Thyroid Association guidelines and genotype-phenotype correlation.

• Journal of the Korean Mathematical Society
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• v.49 no.5
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• pp.1031-1051
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• 2012

In this paper, we will investigate the concept of the torsion-graph of an R-module M, in which the set $T(M)^*$ makes up the vertices of the corresponding torsion graph, ${\Gamma}(M)$, with any two distinct vertices forming an edge if $[x:M][y:M]M=0$. We prove that, if ${\Gamma}(M)$ contains a cycle, then $gr({\Gamma}(M)){\leq}4$ and ${\Gamma}(M)$ has a connected induced subgraph ${\overline{\Gamma}}(M)$ with vertex set $\{m{\in}T(M)^*{\mid}Ann(m)M{\neq}0\}$ and diam$({\overline{\Gamma}}(M)){\leq}3$. Moreover, if M is a multiplication R-module, then ${\overline{\Gamma}}(M)$ is a maximal connected subgraph of ${\Gamma}(M)$. Also ${\overline{\Gamma}}(M)$ and ${\overline{\Gamma}}(S^{-1}M)$ are isomorphic graphs, where $S=R{\backslash}Z(M)$. Furthermore, we show that, if ${\overline{\Gamma}}(M)$ is uniquely complemented, then $S^{-1}M$ is a von Neumann regular module or ${\overline{\Gamma}}(M)$ is a star graph.

• Clinical and Experimental Pediatrics
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• v.51 no.5
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• pp.528-532
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• 2008

Drug-induced toxic hepatitis is a relatively common hepatic disease in children, and it is usually self-limiting upon cessation of the offending drugs. Antituberculous drugs are well known for inducing hepatitis. Some cases of drug-induced hepatitis with autoimmune features have been reported; in these cases, the offending drugs were usually methyldopa, nitrofurantoin, minocycline, and interferon. The authors report the first case in Korea of drug-induced autoimmune hepatitis associated with thyroiditis and multiple autoantibodies that was induced by the antituberculous drugs isoniazid and rifampin.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.1
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• pp.110-114
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• 2020

Gastric xanthoma is frequently an incidental finding on upper endoscopy in adults. Gastric xanthomas (GX) can be mistaken for malignancies and warrant prompt histologic diagnosis. The underlying etiology is not fully understood; however, it has been linked to Helicobacter pylori gastritis and gastric cancer. GX in the pediatric population is largely unreported in the literature. Because of the relative rarity, documentation with case reports are essential to provide as much data as possible to see if there is a correlation between GX and malignant potential in the pediatric population. Our group is reporting two cases, a 10-year-old male and a 7-year-old male, both who presented with chronic dysphagia, upper abdominal pain, nausea, vomiting, and loss of appetite. Upper endoscopies for both patients revealed small polypoid lesions located in the antrum with foamy histiocytes on histology, leading to the diagnosis of gastric xanthoma.