• Journal of Korean Society for Geospatial Information Science
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• v.4 no.2 s.8
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• pp.79-90
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• 1996

It is well known that point positioning using a C/A-code receiver is severely biased by errors in pseudorange. This paper shows the procedures of quantitive analysis for several error elements and that some methods to monitor SA(selective availability) of witch process is not opened are proposed. It is possible to verify the effects of SA in the Doppler shift and receiver clock drift variation. Easy methods to reduce SA effects are to fit second order polynomials for the one and a linear function for the other. With periodic autocorrelation functions. SA effects are analyzed and first order Gauss-Markov process parameters are decided.

• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1101-1106
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• 2009

Multivalent and multi-specific antibodies can provide valuable tools for bio-medical research, diagnosis and therapy. In antigen-antibody interactions, the avidity of antibodies depends on the affinity and the number of binding sites.$^1$ As artificial multivalent antibody agents, single chain Fv-streptavidin fusion tetramer proteins $(scFv-SA)_4$ have been previously tested.$^{1,\;2}$ Although, the Fab domain is known to be more stable than scFv in animal models,$^{3,\;4}$ it has never been used to make a multivalent agent with a streptavidin fusion. In this study, we prepared tetra-valent $(Fab-cSA)_4$ by fusing Fab with core streptavidin (cSA). This molecule was made using inclusion body production, refolding and chromatography purification. Affinities of the Fab-cSA tetramer and a scFv-cSA tetramer to a cell surface antigen were compared by ELISA using biotin-HRP. The Fab-cSA tetramer showed higher binding avidity than the scFv-cSA tetramer. The higher binding avidity of the Fab-cSA tetramer demonstrates its potential as a therapeutic agent for target-specific antibody therapy.

• Industrial Engineering and Management Systems
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• v.8 no.1
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• pp.22-28
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• 2009

We consider facility layout problems, where mn facility units are assigned into mn cells. These cells are arranged into a rectangular pattern with m rows and n columns. In order to solve this cell type facility layout problem, many approximation algorithms with improved local search methods were studied because it was quite difficult to find exact optimum of such problem in case of large size problem. In this paper, new algorithms based on Simulated Annealing (SA) method with two neighborhood generation methods are proposed. The new neighborhood generation method adopts the exchanging operation of facility units in accordance with adjacent preference. For evaluating the performance of the neighborhood generation method, three algorithms, previous SA algorithm with random 2-opt neighborhood generation method, the SA-based algorithm with the new neighborhood generation method (SA1) and the SA-based algorithm with probabilistic selection of random 2-opt and the new neighborhood generation method (SA2), are developed and compared by experiment of solving same example problem. In case of numeric examples with problem type 1 (the optimum layout is given), SA1 algorithm could find excellent layout than other algorithms. However, in case of problem type 2 (random-prepared and optimum-unknown problem), SA2 was excellent more than other algorithms.

• Journal of architectural history
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• v.27 no.2
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• pp.113-124
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• 2018

This study investigates the relationship of two architectures 'Kim Sa-haeng' and 'Park Ja-cheong.' They were the architects whose architecture were established and well known however they were not acknowledged by the people. Because they were not revealed under the large-scale national construction in complicated circumstances at home and abroad. The results were as follows; First, Kim Sa-haeng who was an overseas architect in Yuan dynasty stood out in all areas of architecture. Particularly in making royal tombs; His works were recognized as the most beautiful royal tombs ever existed and was later on followed by the Joseon dynasty. Second, Park completed the construction of Joseon's by faithfully reflecting on the discussed process of Neo-Confucian while coming after the time of the construction of Kim Sa-haeng. Third, although Kim Sa-haeng was a vassal of the Buddhist nation in Goryeo, he built the Moon-myo, a Confucian inspired temple of Joseon. Park Ja-cheong, who continued to build Kim Sa-haeng's architecture, reproduced Kim Sa-haeng's confucian's temple of Joseon dynasty while modifying it according to the situation in Joseon dynasty. The constructions of the two architects' monuments continues unabatedly. Their architecture has continued without massive changes.

• Korean Journal of Clinical Laboratory Science
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• v.42 no.1
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• pp.38-45
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• 2010

The aim of this study was to assess the Clinical Usefulness of Helicobacter pylori Stool Antigen (HpSA) immunochromatographic assay for the diagnosis of H. pylori infection. In this study, we had compared HpSA-immunochromatographic assay with CLO test and UBT test. From a total of 140 patients (M:F=88:52) with upper endoscopy, biopsy specimens were obtained for CLO test. Stool specimens was collected from all patients and tested using a HpSA-immunochromatic assay. H. pylori infection status was defined as infected if the results of both CLO test and UBT test were positive. CLO test and UBT test findings showed that 92 patients were H. pylori positive and 48 patients were H. pylori negative. According to this definition, the sensitivity, specificity, and positive or negative predictive value (PPV, NPV) of HpSA-immunochromatographic assay were 97.8%, 100%, 100%, and 96%, respectively. Cross reactivity test of HpSA-immunochromatographic assay were performed with 10 enteric bacteria strains in fecal habitat, and there were no false positive reaction. We evaluated the usefulness of HpSA assay for eradication therapy with 10 of 92 H. pylori positive patients, positive results of them at pre-eradication therapy were converted to negative at post-eradication. The HpSA-immunochromatographic assay is a highly sensitive and specific non-invasive diagnostic method for detection of H. pylori infection, a useful diagnostic method for H. pylori in post eradication stage.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.9
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• pp.6432-6438
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• 2015

In this paper, we analyzed by measuring the temperature and humidity inside of the Feed Bin, NV, EA, SA, $SA{\cdot}EA$, by applying the ventilation system offers an efficient management of the operating direction. In the period the target is not input and feed period to make a change in the Feed Bin within the temperature and humidity of the outdoor air temperature and relative humidity compared to accept the ventilation system. Internal temperature over a comparison of the external temperature and the relative humidity is $SA{\cdot}EA$, internal humidity can verify the efficiency and NV, SA ventilation applied.

• The Plant Pathology Journal
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• v.27 no.1
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• pp.53-58
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• 2011

Systemic acquired resistance is a form of inducible resistance that is triggered in systemic healthy tissues of local-infected plants. Several candidate signaling molecules emerged in the past two years, including the methylated derivatives of well-known defense hormones salicylic acid (SA) and jasmonic acid (JA). In our present study, the symptom on Cucumber mosaic virus (CMV) infected Arabidopsis leaves in 0.1 mM SA or 0.06 mM JA pre-treated plants was lighter (less reactive oxygen species accumulation and less oxidative damages) than that of the control group. JA followed by SA (JA${\rightarrow}$SA) had the highest inhibitory efficiency to CMV replication, higher than JA and SA simultaneous co-pretreatment (JA+SA), and higher than a JA or a SA single pretreatment. The crosstalk between the two hormones was further investigated at the transcriptional levels of pathogenesis-related genes. The time-course measurement showed JA might play a more important role in the interaction between JA and SA.

• Journal of the Korean Society for Railway
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• v.15 no.3
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• pp.278-285
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• 2012

The Service Availability (SA) in the viewpoint of passenger is used as the key performance indicator (KPI) of quality of service in Light Rail Transit (LRT) Public-Private Partnerships projects. But there are many disputes on the target value of SA because of the lack of experience in SA. The target value of SA should be set at an early stage of the project to be specified on the system specifications and operation plan. Therefore, this paper developed the quantitative prediction model of SA to set the reasonably achievable target value of SA at an early stage of the LRT project. Also this paper analyzed the relationship and differentiation of SA and Train Punctuality (TP) that is mostly compared with SA.

• The Journal of Korean Medicine
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• v.40 no.2
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• pp.89-93
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• 2019

Objectives: There are substantial variations on the methods of identifying Sa-sang typology in clinical practice. This review aimed to describe the clinical experiences on the classification of Sa-sang typology based on index signs for practice of Tae-Geuk acupuncture. Methods: Core physical signs and interpretation of treatment response for the classification of Sa-sang typology are suggested based on 42-year clinical experiences of the expert (the first author). Results: Epigastric tenderness and hepatic dullness sound are the most important physical sign in the classification of Sa-sang typology. Clinical experiences indicate that there may be a positive association between the presence of epigastric tenderness and hepatic dullness sound. Four sets of acupuncture points are matched for four types of Sa-sang institution, respectively. Appropriate match will resolve epigastric tenderness and hepatic dullness sound, while this will not happen if inappropriate match is employed. Conclusion: I suggest that two physical signs (i.e., epigastric tenderness and hepatic dullness sound) are essential for the classification of Sa-sang typology in Tae-Geuk acupuncture.

• Journal of the Optical Society of Korea
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• v.19 no.4
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• pp.403-408
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• 2015

To evaluate the effects of spherical aberration (SA) correction on optical quality in pseudophakic eyes, we simulated the optical quality of the human eye by computation of the modulation transfer function (MTF). We reviewed the medical records of patients who underwent cataract surgery in Asan Medical Center, retrospectively. A Zywave aberrometer was used to measure optical aberrations at 1-12 postoperative months in patients with AR40e intraocular lens implants. The MTF was calculated for a 5 mm pupil from measured wavefront aberrations. The area under the MTF curve (aMTF) was analyzed and the maximal aMTF was calculated while changing the SA ($-0.2{\sim}+0.2{\mu}m$) and the defocus (-2.0 ~ +2.0 D). Sixty-four eyes in 51 patients were examined. The maximal aMTF was $6.61{\pm}2.16$ at a defocus of $-0.25{\pm}0.66D$ with innate SA, and $7.64{\pm}2.63$ at a defocus of $0.08{\pm}0.53D$ when the SA was 0 (full correction of SA). With full SA correction, the aMTF increased in 47 eyes (73.4%; Group 1) and decreased in 17 eyes (26.6%; Group 2). There were statistically significant differences in Z(3, -1) (vertical coma; P = 0.01) and Z(4, 4) (tetrafoil; P = 0.04) between the groups. The maximal aMTF was obtained at an SA of $+0.01{\mu}m$ in Group 1 and an SA of $+0.13{\mu}m$ in Group 2. Optical quality can be improved by full correction of SA in most pseudophakic eyes. However, residual SA might provide benefits in eyes with significant radially asymmetric aberrations.