• The Korean Journal of Food And Nutrition
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• 제36권1호
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• pp.6-16
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• 2023

To investigate the anti-inflammatory activity of submerged culture using Cordyceps militaris mycelium, culture-including mycelia was extracted and lyophilized into postbiotics (hot-water extract; CM-HW). HW was fractionated into crude polysaccharide (CM-CP) by ethanol precipitation, and CM-CP was further dialyzed into CM-DCP by dialysis with running water using 12~14 kDa dialysis tube. When the cytotoxicity of subfractions against cells was assessed, no subfraction had a cytotoxic impact that was substantially different from the control groups. In an inflammatory model using LPS-stimulated RAW 264.7 cells, CM-DCP significantly decreased IL-6 and MCP-1 production levels compared to the LPS-control group. CM-DCP also inhibited IL-6 and IL-8 secretion in HaCaT keratinocytes stimulated with TNF-α and IFN-γ. In the meanwhile, the neutral sugar content and mannose ratio of anti-inflammatory CM-DCP were higher than the other fractions, and CM-DCP contained β-1,3/1,6-glucan of 216.1 mg/g. High pressure size exclusion chromatography revealed that CM-DCP contained molecules with a molecular weight range of 5.6 to 144.0 kDa. In conclusion, postbiotics of C. militaris mycelium significantly promoted anti-inflammatory activity, suggesting that neutral polysaccharides including Glc and Man contribute to the anti-inflammation in RAW 264.7 or HaCaT cells.

• Journal of Korean Medicine for Obesity Research
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• 제22권2호
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• pp.125-135
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• 2022

Objectives: A restrospective chart review were conducted to investigate the overall weight loss effect of the integrated Korean medicine treatment on obese patients (body mass index [BMI] ≥25 kg/m²) in Korean medicine clinic and analyze the difference in the effect according to lifestyle behaviors. Methods: The medical records of 43 obese patients were retrospectively analyzed including body weight, BMI, waist circumference, hip circumference, and body composition who received integrated Korean medicine treatment for 4 weeks at 24 Korean medicine clinics in Daejeon metropolitan city. All outcome measures were evaluated again 8 weeks after the end of treatment at week 12 for follow-up. EuroQol-5D (EQ-5D), the Korean version of the obesity-related quality of life scale (KOQOL) and patient's satisfaction were also evaluated. The analysis was divided according to the treatment period and observation period, and subgroup analysis was performed according to drinking and exercise habits. Results: Body weight, body fat, waist circumference, hip circumference, body fat were significantly reduced at week 4 and week 12. Theses weight reduction effects were significantly greater within treatment period (0 to 4 week) than observation period (4 to 12 week). Especially in the non-exercise group, the changes in body fat mass and body fat percent showed a significant difference between the treatment period and the observation period. KOQOL were also significantly improved at 12 week, but not in EQ-5D. No severe adverse events were observed. Conclusions: The integrated Korean medicine treatment could be effective to treat obesity including weight loss. It is necessary to prevent additional weight regain through regular exercise even after Korean medicine treatment.

• Korean Journal of Culture and Social Issue
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• 제28권4호
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• pp.749-772
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• 2022

This study aimed at investigating the validity of WHR (or waist-to-hip ratio) and Golden ratio as standards of physical attractiveness. Each of 60 male and 60 female college students were divided into two groups of 30. Using the 3D game program, each person in one group drew a physically attractive figure of the opposite sex while the other group drew a physically attractive figure of the same sex. Then, WHR and Golden ratio of the figures were measured and compared with the ideal WHR (.7 for women and .9 for men) and Golden ratio 1.618. It was found that WHR and Golden ratio for the physically attractive figures were lower than the ideal standards regardless of the participant's gender. That is, the participants preferred to men and women having curvaceous body shapes with a narrow waist and a wide pelvis. In most cases, Golden ratios measured in many ways were not correspondent to the ideal ratio, 1.618. In regards to BR (or Body Ratio), the legs and waist of the physically attractive figures were shorter relative to the Golden ratio and this was more salient for physically attractive man figures. Regarding the facial ratio measured by FR(or facial ratio) and FR_VP(or facial ratio_vertical point), the faces of figures made by participants, regardless of their sex, were shorter and wider compared to the Golden ratio. Further, the participants preferred baby-faced woman and masculine man figures. Finally, implications of the findings, limitations the of the present study, and the suggestions for future research were discussed.

• Journal of Life Science
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• 제33권1호
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• pp.91-101
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• 2023

Bacteriocins are antimicrobial peptides synthesized on ribosomes, produced by bacteria, that inhibit the growth of similar or closely related bacterial strains. Since the discovery of nisin, many bacteriocins with unique structures and various modes of antibacterial activity have been described, and genes encoding production, secretion, and immunity have been reported. Nisin is one of the bacteriocins applied in cheese, liquid eggs, sauces and canned foods. Many of the bacteriocins of the genus Bacillus belong to lantibiotics, which are modified peptides after translation. Other genus Bacillus also produce many non-lantibiotic bacteriocins. Bacteriocins of the genus Bacillus are sometimes becoming more important because of their broader antibacterial spectrum. Bacteriocins are considered attractive compounds in the food and pharmaceutical industries to prevent food spoilage and growth of pathogenic bacteria. Bacteriocins can be used as biological preservatives in a variety of ways in the food system. Biopreservation refers to extending shelf life and improving safety of foods using microorganisms and/or their metabolites. The demand for new antimicrobial compounds has generated great interest in new technologies that can improve food microbiological safety. Applications of bacteriocins are expanding from food to human health. Today, many researchers are shifting their interest in bacteriocins from food preservation to the treatment of bacteria that cause infections and antibiotic-resistant diseases. This exciting new era in bacteriocin research will undoubtedly lead to new inventions and new applications. In this review, we summarize the various properties and applications of bacteriocins produced by the genus Bacillus.

• International Journal of Computer Science & Network Security
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• 제22권12호
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• pp.63-70
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• 2022

The essence of the definition of "tolerance" is analyzed. Motivational, knowledge and behavioral criteria for tolerance of future teachers are highlighted. Indicators of the motivational criterion are the formation of value orientations, motivational orientation, and the development of empathy. Originality and productivity of thoughts and judgments, tact of dialogue, pedagogical ethics and tact are confirmed as indicators of the knowledge criterion. The behavioral criterion includes social activity as a life position, emotional and volitional endurance, and self-control of one's own position. The formation of tolerance is influenced by a number of factors: the social environment, the information society, existing stereotypes and ideas in society, the system of education and relationships between people, and the system of values. The main factors that contribute to the education of tolerance in future teachers are highlighted. Analyzing the structure of tolerance, it is necessary to distinguish the following functions of tolerance: - motivational (determines the composition and strength of motivation for social activity and behavior, promotes the development of life experience, because it allows the individual to accept other points of view and vision of the solution; - informational (understanding the situation, the personality of another person); - regulatory (tolerance has a close connection with the strong - willed qualities of a person: endurance, selfcontrol, self-regulation, which were formed in the process of Education); - adaptive (allows the individual to develop in the process of joint activity a positive, emotional, stable attitude to the activity itself, which the individual carries out, to the object and subject of joint relations). The implementation of pedagogical functions in the information society: educational, organizational, predictive, informational, communicative, controlling, etc. provides grounds to consider pedagogical tolerance as an integrative personal quality of a representative of any profession in the field of "person-person". The positions that should become conditions for the formation of tolerance of the future teacher in the information society are listed.

• Journal of Environmental Health Sciences
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• 제48권6호
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• pp.324-330
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• 2022

Background: Lung injuries due to exposure to humidifier disinfectants (HDs) were reported in 2011 in South Korea. As a result of the government's epidemiological investigation and toxicity test study, it was found that HDs caused health damage such as lung disease. Objectives: The purpose of this study was to classify HD exposure ratings and analyze the affecting factors that could identify the relationship with lung disease. Methods: Exposure assessment for HDs was conducted using a questionnaire during face-to-face interviews with the applicants. Ratings of high exposure (Class 1) and low exposure (Class 2) were cross-tabulated with clinical ratings (acceptable and unacceptable). Logistic regression analysis was carried out by setting the clinical rating of lung disease as a dependent variable and the socio-demographic and exposure characteristics obtained through the questionnaire as independent variables. Results: The concentration in air of polyhexamethylene guanidine (PHMG) was 71.96±107.47 ㎍/m³, and the exposure concentration was 15.21±23.28 ㎍/m³ . The exposure rating was overestimated with 97.1% of affected subjects having high exposure using margin of exposure (MOE), but only 9.9% matching the clinical class. In the overestimated group, it could be explained by the fact that the exposure time was long and the subjects had already recovered from damage symptoms. As a result of logistic regression analysis, ten variables were found to be significant influencing factors. Conclusions: A new exposure rating could be calculated based on the MOE, and factors affecting lung disease could be estimated through comparative evaluation with the clinical rating.

• The Mathematical Education
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• 제62권2호
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• pp.211-236
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• 2023

The purpose of this study is to derive implications of preservice mathematics teacher education in Korea by analyzing the case of edTPA used in the preservice teacher training process in the United States. Recently, there has been a growing interest in promoting professional competencies considering not only the cognitive dimension related to knowledge development of preservice mathematics teachers but also the situational dimension considering reality in the classroom. The edTPA in the United States is a performance-based assessment based on lessons conducted by preservice teachers at school. This study analyzes the professional competencies required of preservice mathematics teachers by analyzing handbooks that described the case of edTPA in which preservice mathematics teachers in the United States participate. The edTPA includes planning, instruction, and assessment tasks, and continuous tasks are performed in connection with classes. Thus, the analysis is conducted on the points of linkage between the description of evaluation items and criteria in the planning, instruction, and assessment tasks, as well as the professional competencies required from that linkage. As a result of analyzing the edTPA handbooks, the professional competencies required of preservice mathematics teachers in the edTPA assessment were the competency to focus on and implement specific mathematics lessons, the competency to reflectively understand the implementation and assessment of specific mathematics lessons, and the competency to make a progressive determination of students' achievement related to their learning and their uses of language and representations. The results of this analysis can be used as constructs for competencies that can be assessed in the preservice in the organization of the preservice mathematics teacher curriculum and practice training semester system in Korea.

• Wind and Structures
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• 제36권4호
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• pp.237-247
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• 2023

The emergence of high-rise buildings has necessitated frequent structural health monitoring and maintenance for safety reasons. Wind causes damage and structural changes on tall structures; thus, safe structures should be designed. The pressure developed on tall buildings has been utilized in previous research studies to assess the impacts of wind on structures. The wind tunnel test is a primary research method commonly used to quantify the aerodynamic characteristics of high-rise buildings. Wind pressure is measured by placing pressure sensor taps at different locations on tall buildings, and the collected data are used for analysis. However, sensors may malfunction and produce erroneous data; these data losses make it difficult to analyze aerodynamic properties. Therefore, it is essential to generate missing data relative to the original data obtained from neighboring pressure sensor taps at various intervals. This study proposes a deep learning-based, deep convolutional generative adversarial network (DCGAN) to restore missing data associated with faulty pressure sensors installed on high-rise buildings. The performance of the proposed DCGAN is validated by using a standard imputation model known as the generative adversarial imputation network (GAIN). The average mean-square error (AMSE) and average R-squared (ARSE) are used as performance metrics. The calculated ARSE values by DCGAN on the building model's front, backside, left, and right sides are 0.970, 0.972, 0.984 and 0.978, respectively. The AMSE produced by DCGAN on four sides of the building model is 0.008, 0.010, 0.015 and 0.014. The average standard deviation of the actual measures of the pressure sensors on four sides of the model were 0.1738, 0.1758, 0.2234 and 0.2278. The average standard deviation of the pressure values generated by the proposed DCGAN imputation model was closer to that of the measured actual with values of 0.1736,0.1746,0.2191, and 0.2239 on four sides, respectively. In comparison, the standard deviation of the values predicted by GAIN are 0.1726,0.1735,0.2161, and 0.2209, which is far from actual values. The results demonstrate that DCGAN model fits better for data imputation than the GAIN model with improved accuracy and fewer error rates. Additionally, the DCGAN is utilized to estimate the wind pressure in regions of buildings where no pressure sensor taps are available; the model yielded greater prediction accuracy than GAIN.

• Journal of Internet of Things and Convergence
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• 제9권1호
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• pp.71-76
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• 2023

Recently, in order to store and manage big data, research and development of a high-performance storage system capable of stably accessing large data have been actively conducted. In particular, storage systems in data centers and enterprise environments use large amounts of SSD (solid state disk) to manage large amounts of data. In general, SSD uses FTL(flash transfer layer) to hide the characteristics of NAND flash memory, which is a medium, and to efficiently manage data. However, FTL's algorithm has a limitation in using DRAM more to manage the location information of NAND where data is stored as the capacity of SSD increases. Therefore, this paper introduces FTL policies that apply virtual memory to reduce DRAM resources used in FTL. The virtual memory-based FTL policy proposed in this paper manages the map data by using LRU (least recently used) policy to load the mapping information of the recently used data into the DRAM space and store the previously used information in NAND. Finally, through experiments, performance and resource usage consumed during data write processing of virtual memory-based FTL and general FTL are measured and analyzed.

• KIPS Transactions on Software and Data Engineering
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• 제12권6호
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• pp.275-284
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• 2023

Virtual reality simulations are used for education and training in various fields, and are especially widely used in the medical field recently. The education/training simulator consists of tactile/force feedback generation and image/sound output hardware that provides a sense similar to a doctor's treatment of a real patient using real surgical tools, and software that produces realistic images and tactile feedback. Existing simulators are complicated and expensive because they have to use various types of hardware to simulate various surgical instruments used during surgery. In this paper, we propose a dental surgical simulation system using a force feedback device and a morphable haptic controller. Haptic hardware determines whether the surgical tool collides with the surgical site and provides a sense of resistance and vibration. In particular, haptic controllers that can be deformed, such as length changes and bending, can express various senses felt depending on the shape of various surgical tools. When the user manipulates the haptic feedback device, events such as movement of the haptic feedback device or button clicks are delivered to the simulation system, resulting in interaction between dental surgical tools and oral internal models, and thus haptic feedback is delivered to the haptic feedback device. Using these basic techniques, we provide a realistic training experience of impacted wisdom tooth extraction surgery, a representative dental surgery technique, in a virtual environment represented by sophisticated three-dimensional models.