• Journal of applied mathematics & informatics
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• 제31권5_6호
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• pp.651-659
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• 2013

A graph is $s$-regular if its automorphism group acts regularly on the set of its $s$-arcs. In this paper, the cubic $s$-regular graphs of order 12p, 36p, 44p, 52p, 66p, 68p and 76p are classified for each $s{\geq}1$ and each prime $p$. The number of cubic $s$-regular graphs of order 12p, 36p, 44p, 52p, 66p, 68p and 76p is 4, 3, 7, 8, 1, 4 and 1, respectively. As a partial result, we determine all cubic $s$-regular graphs of order 70p except for $p$ = 31, 41.

• Journal of Cancer Prevention
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• 제23권4호
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• pp.153-161
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• 2018

Imbalance of protein homeostasis (proteostasis) is known to cause cellular malfunction, cell death, and diseases. Elaborate regulation of protein synthesis and degradation is one of the important processes in maintaining normal cellular functions. Protein degradation pathways in eukaryotes are largely divided into proteasome-mediated degradation and lysosome-mediated degradation. Proteasome is a multisubunit complex that selectively degrades 80% to 90% of cellular proteins. Proteasome-mediated degradation can be divided into 26S proteasome (20S proteasome + 19S regulatory particle) and free 20S proteasome degradation. In 1980, it was discovered that during ubiquitination process, wherein ubiquitin binds to a substrate protein in an ATP-dependent manner, ubiquitin acts as a degrading signal to degrade the substrate protein via proteasome. Conversely, 20S proteasome degrades the substrate protein without using ATP or ubiquitin because it recognizes the oxidized and structurally modified hydrophobic patch of the substrate protein. To date, most studies have focused on protein degradation via 26S proteasome. This review describes the 26S/20S proteasomal pathway of protein degradation and discusses the potential of proteasome as therapeutic targets for cancer treatment as well as against diseases caused by abnormalities in the proteolytic system.

• 한국언론정보학보
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• 제67권
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• pp.62-87
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• 2014

이 연구는 현재의 디지털기술과 연결된 사진행위를 이해하기 위한 협업적 연구이며 동시에 자기민속지학 방법을 이용해 연구의 자기 치료적 효과와 지식의 권력관계를 엿볼 수 있는 기회도 제공한다. 두 연구자는 디지털 카메라, SNS, 스마트폰과 같은 디지털미디어를 이용하는 사진행위가 갖는 의미를 개인의 정체성 구성, 개인적 삶의 다큐멘터리 만들기라는 관점에서 접근했다. 그 결과, 디지털 사진을 다큐멘트가 아닌 아카이브로 볼 수 있으며 디지털 사진행위를 ANT의 관점에서 인간과 비인간 행위자들의 네트워크 형성과 변화의 과정이라고 이해할 수 있다는 것을 발견했다.

• 복식
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• 제58권1호
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• pp.61-78
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• 2008

Comedy costumes worn on the comedians/gag men express the information of the performances such as character's era, place, social rank, present environment, age, sex, occupation, emotion, relationships between the characters, importance and mood in visual language. The comic is found when these informations are reversed, revealed, exaggerated or distorted. To analyse the TV comedy costumes, 5 subordinate concepts of the comic which are Body, Gender, Age, T.P.O.(Time, Place, Occasion) and Role could be identified, and the results from the analysis focused on (10 shows were selected from each of the first and second half of the years from 2003 to 2007) are as follows: Distorted and ugly body implies the resistance against the ideal body. Reversed or confused sex are usually expressed as men dressed in women, and these mean breaking the dichotomy between male and female, and coexistence of the masculinity and feminity, and satirizing the social custom restricting women by moral rules. It could be recognized that the way of men's dressing in women have been changing keeping pace with the times. The discord between age and costume was often expressed with children's wear and childish props. This implies the liberation from the age role. The comic expressed from the inadequate costume for T.P.O. usually appeared with the costumes 20-30years behind the times. When there were discordance with the acts and acts expected from the outfit(appearance) also made an ironical laugh. The comics acquired by vulgarization and exaggeration of the characteristics of role(figures/occupation) were from the imitation and deformation of the objects in stereotypes, and through this dissolving the custom was under way.

• 한국의류학회지
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• 제23권3호
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• pp.402-413
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• 1999

The objectives of this study were to investigate the relationships among the degree of delinquency and clothing buying behavior information search and fashion involvement and to examine the causal relationships of adolescent delinquency demographic variables and fashion involvement on information search. Subjects for this study were 537 high school students(male ; 225, female : 312) in Seoul Korea. the results of the study were as follow. 1. Four factors of adolescent's delinquency derived by factor analysis : F. 1 'general position delinquency' F. 2 'school-norm delinquency' F3. 'personal delinquency' : F.4 'sexual delinquency'. 2. There were partially significant correlations between the degree of adolescent's delinquency and information search and fashion involvement. There were significant relationships between degree of delinquency and degree of clothing purchasing frequency. companion while shopping and source of clothing expenses. 3. In the case of male students fashion involvement and sexual delinquency had a direct effect on information search(R2 =.278) General position delinquency and allowance had a indirect effect on information search through Father's level of education had a direct effect on allowance. the present findings provide that in general the more allowance students received the higher the general position delinquency for both males and females, The higher the general position delinquency the higher the degree of fashion involvement and information search. Therefore it can be concluded that relatively mild delinquency acts such as drinking. smoking and going to discothque have more influence on fashion involvement and information search that serious delinquency acts such as violence and robbery.

• Molecules and Cells
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• 제38권2호
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• pp.122-129
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• 2015

DBM-2198, a six-membered azasugar nucleotide (6-AZN)-containing phosphorothioate (P = S) oligonucleotide (AZPSON), was described in our previous publication [Lee et al. (2005)] with regard to its antiviral activity against a broad spectrum of HIV-1 variants. This report describes the mechanisms underlying the anti-HIV-1 properties of DBM-2198. The LTR-mediated reporter assay indicated that the anti-HIV-1 activity of DBM-2198 is attributed to an extracellular mode of action rather than intracellular sequence-specific antisense activity. Nevertheless, the antiviral properties of DBM-2198 and other AZPSONs were highly restricted to HIV-1. Unlike other P = S oligonucleotides, DBM-2198 caused no host cell activation upon administration to cultures. HIV-1 that was pre-incubated with DBM-2198 did not show any infectivity towards host cells whereas host cells pre-incubated with DBM-2198 remained susceptible to HIV-1 infection, suggesting that DBM-2198 acts on the virus particle rather than cell surface molecules in the inhibition of HIV-1 infection. Competition assays for binding to HIV-1 envelope protein with anti-gp120 and anti-V3 antibodies revealed that DBM-2198 acts on the viral attachment site of HIV-1 gp120, but not on the V3 region. This report provides a better understanding of the antiviral mechanism of DBM-2198 and may contribute to the development of a potential therapeutic drug against a broad spectrum of HIV-1 variants.

• 한국항공우주학회지
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• 제49권5호
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• pp.425-435
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• 2021

무인항공기를 비롯한 도심항공교통을 위한 수직이착륙 항공기와 같은 신기술 항공기를 기존의 국가공역 시스템에 통합하려는 다양한 노력이 시도되고 있다. 새로운 항공기의 안전한 정착을 위해서는 기술적인 개발뿐 아니라 관련 규제에 대한 마련 또한 중요하며, 이를 위해서는 해외 감항당국의 동향을 면밀히 살펴보고 연구하는 과정이 필수적이라고 할 수 있다. 이러한 신기술 항공기의 등장에 따른 관련 법규와 관련하여 최근 유럽의 EASA가 빠른 움직임을 보이고 있으나 EU 법령체계 외에도 EASA 규정의 복잡성으로 인해서 이에 대한 이해 수준은 상대적으로 다소 미흡한 것으로 보인다. 이를 감안하여 본 논문에서는 EASA 규정의 기반이 되는 EU 법령체계에 대한 이해와 함께 EASA 무인항공기 관련 규정에 대한 사례를 분석하고 이를 통해서 무인항공기를 중심으로 국내 관련 항공법의 발전 방향에 기여하고자 한다.

• BMB Reports
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• 제55권6호
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• pp.287-292
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• 2022

The acute response to hypoxia is mainly driven by hypoxia-inducible factors, but their effects gradually subside with time. Hypoxia-specific histone modifications may be important for the stable maintenance of long-term adaptation to hypoxia. However, little is known about the molecular mechanisms underlying the dynamic alterations of histones under hypoxic conditions. We found that the phosphorylation of histone H3 at Ser-10 (H3S10) was noticeably attenuated after hypoxic challenge, which was mediated by the inhibition of aurora kinase B (AURKB). To understand the role of AURKB in epigenetic regulation, DNA microarray and transcription factor binding site analyses combined with proteomics analysis were performed. Under normoxia, phosphorylated AURKB, in concert with the repressor element-1 silencing transcription factor (REST), phosphorylates H3S10, which allows the AURKB-REST complex to access the MDM2 proto-oncogene. REST then acts as a transcriptional repressor of MDM2 and downregulates its expression. Under hypoxia, AURKB is dephosphorylated and the AURKB-REST complex fails to access MDM2, leading to the upregulation of its expression. In this study, we present a case of hypoxia-specific epigenetic regulation of the oxygen-sensitive AURKB signaling pathway. To better understand the cellular adaptation to hypoxia, it is worthwhile to further investigate the epigenetic regulation of genes under hypoxic conditions.

• 의료법학
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• 제9권2호
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• pp.77-107
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• 2008

In Republic of Chaina (Taiwan), Natural Death Act named "Anning Huauhe Yiliao Tiaoli" which means palliative and hospice care act was enacted in year of 2000. And enforced in the same year. Many scholars say that Taiwan's Act took Many U.S.A.'s acts such as 'Federal Patient Self-Determination Act 1990', 'California Natural Death Act 1976' and 'Washington Natural Death Act 1979' for a model. Taiwan's Act adopts a few outstanding systems - 'advance declarations' including 'living will' and 'durable power of attorney for health care', 'family-determination system' for a patient who is in a persistent unconscious state. This paper disusses this Act. 'The content is as follow: 1. A background of legislation. 2. The purpose of legislation. 3. The concept of terms. 4. Patient's self-determination. 5. Subrogated determination by family. 6. Keeping documents. 7. Punitive provision. 8. The relationship with euthanasia. 9. Controversial issues.

• Journal of applied mathematics & informatics
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• 제30권3_4호
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• pp.455-462
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• 2012

The cyclic group $Cn={\langle}(12{\cdots}n){\rangle}$ acts on the set ($^{[n]}_k$) of all $k$-subsets of [$n$]. In this action of $C_n$ the number of orbits of size $d$, for $d|n$, is $$O^{n,k}_d=\frac{1}{d}\sum_{\frac{n}{d}|s|n}{\mu}(\frac{ds}{n})(^{n/s}_{k/s})$$. Stanton and White[7] generalized the above identity to construct the orbit polynomials $$O^{n,k}_d(q)=\frac{1}{[d]_{q^{n/d}}}\sum_{\frac{n}{d}|s|n}{\mu}(\frac{ds}{n})[^{n/s}_{k/s}]{_q}^s$$ and conjectured that $O^{n,k}_d(q)$ have non-negative coefficients. In this paper we give a combinatorial proof for the positivity of coefficients of the orbit polynomial $O^{n,3}_d(q)$.