• Title/Summary/Keyword: S-PHP

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Molecular and Phenotypic Characteristics of Patients with Pseudohypoparathyroidism: Single Center's Experience (가성부갑상선기능저하증 환자의 분자유전학적 및 임상적 특징: 단일기관의 경험)

  • Kim, Min-ji;Yoon, Ju Young;Yoo, Sukdong;Lee, Jun;Cheon, Chong Kun
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.21 no.1
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    • pp.7-14
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    • 2021
  • Purpose: Pseudohypoparathyroidism (PHP) is caused by genetic and epigenetic alteration in the GNAS locus, and characterized by the resistance to multiple hormones and the Albright's hereditary osteodystrophy (AHO) phenotype. This study investigated the phenotypic characteristics and molecular features of PHP. Methods: Eight patients who diagnosed as PHP were enrolled at Pusan National University Children's hospital and clinical features, biochemical and genetic findings were retrospectively reviewed. Results: Of a total of 8 patients, 5 were diagnosed with PHP1a, and 3 were diagnosed with PHP1b. Patients with PHP1a had three different mutations in the GNAS gene, and patients with PHPIb had imprinting defect in differentially methylated regions (DMRs) of the GNAS locus. Two novel GNAS variants were identified in patients with PHP1a, including c.313-2A>T and c.1094G>A. All patients with PHP1a displayed AHO features; short stature (80%), brachydactyly (80%), a round face (80%), obesity (40%), heterotopic ossification (60%), and intellectual disability (60%), whereas only one patient (33.3%) with PHP1b showed AHO feature such as a round face. When phenotypic features between PHP1a and PHP1b patients were compared, patients with PHP1b showed a tendency of higher current height standard deviation scores (SDS) compared to patients with PHP1a, (-3.2±2.1 vs.-1.1±0.8; P=0.06) Conclusions: This study summarizes the phenotypic and genetic features of the PHP patients. Although we found considerable clinical overlap between PHP1a and PHP1b, further long-term follow-up is needed to evaluate the growth and development of children with PHP, as well as the effects of end-organ resistances to endocrine hormones.

PHP index according to toothbrushing behavior and smoke status of some local residents (일부 지역주민의 잇솔질 행태와 흡연여부에 따른 PHP 지수)

  • Yoon, Sung-Uk;Yang, Won-Ho
    • Journal of Korean society of Dental Hygiene
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    • v.13 no.2
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    • pp.261-269
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    • 2013
  • Objectives : This research examined the Patient Hygiene Performance(PHP) index according to smoking and tooth brushing behavior, in order to analyze how they influence the oral hygiene. Methods : This research used PHP index and the structured questionnaire. The subjects were 203 men in their 20's who visited K university's dental hygiene department for oral prophylaxis from March to July of 2012. For data analysis SPSS WIN 12.0 was used. Results : 1. The average PHP index of all experimented subjects was 2.66, a very poor level. The PHP index according to general characteristics, smoking, drinking, and exercise showed statistical significance(p<0.05). 2. PHP index decreased with more frequencies and longer durations of toothbrushing(p<0.05). 3. The PHP index of smokers is higher than that of non-smokers. In the case of non-smokers, the frequency, method, and duration of tooth brushing had a statistical significance(p<0.05). 4. The PHP index of smokers who smoke less than or equal to ten cigarettes is 2.53 and smokers who smoked more than 10 cigarettes is 3.10. 5. The results of multiple regression analysis showed that smoking increased the PHP index, while the increase in tooth brushing frequency and the up and down tooth brushing method decreased the PHP index. All the coefficients were statistically significant (p<0.05). Conclusions : In order to increase Patient Hygiene Performance(PHP) index. there must be a decrease in smoking rate while people increase their tooth brushing frequency and use a proper tooth brushing method.

A Basic Study of the Snow Melting System for the Anti-Freezing Road using the Pulsating Heat Pipe (PHP를 이용한 도로융설 시스템에 관한 기초연구)

  • Kim, J.S.;Ha, S.J.;Son, K.J.
    • Journal of Power System Engineering
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    • v.14 no.3
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    • pp.19-24
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    • 2010
  • The purpose of this study is to develop a snow melting system using the pulsating heat pipe(PHP). The experimental apparatus is consisted of a PHP, a concrete structure, a constant water thermostatic bath and a flowmeter. The experiment was performed at the outdoor air temperature of $-8^{\circ}C$ and inlet temperature of hot water of $75^{\circ}C$. PHP is the closed and non-loop type heat exchanger which is charging R-410A as an operating fluid. As experimental results, the temperature profile of vertical and horizontal orientation of concrete structure was measured with operating time. The heat flux of the snow melting was required more than 300 $W/m^2$. We confirmed that the snow melting system using the PHP was useful for anti-freezing road.

Implementation of PHP extension for Altibase database server (알티베이스 데이터베이스 서버를 위한 PHP 확장 모듈 구현)

  • Hong, Dae-Yong;Kang, Woon-Hak;Lee, Sang-Won
    • Proceedings of the Korea Information Processing Society Conference
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    • 2012.11a
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    • pp.1392-1395
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    • 2012
  • PHP는 널리 쓰이는 웹 개발 언어이고, 다양한 데이터베이스 관리 시스템(DBMS)을 위하여 C로 작성된 인터페이스들을 갖고 있다. 특히 ODBC라는 표준화된 인터페이스를 통해 DBMS를 이용할 수 있지만, 이는 DBMS 고유의 인터페이스를 구현하여 사용하는 것에 비해 시스템을 활용하는 면에서 한계를 가진다. 국산 DBMS인 알티베이스는 고유의 C 인터페이스를 제공하고 있으며 본 논문에서는 이를 이용한 전용 PHP 인터페이스 구현에 대해 다루고, 구현의 결과 PHP스크립트에서 데이터베이스 연결 및 데이터 운용을 할 수 있었다.

Implementation of an Interactive Paper Airplane Game based on SMS Clients, a PHP Server, and Arduino (SMS 클라이언트, PHP 서버, 아두이노 기반 인터렉티브 종이비행기 게임 구현)

  • Kim, Min-Soo;Ko, Han-Sae;Lee, Byung-Man;Lim, Won-Jun;Lee, Kang-Hee
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2014.01a
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    • pp.67-70
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    • 2014
  • 본 논문에서는 아두이노를 이용하고 SMS와 PHP를 기반으로 구축된 인터렉티브 종이비행기 게임시스템을 설계하고 구현한다. 본 시스템은 LCD가 설치된 건물과 센서가 부착되어 물체가 들어오면 인식할 수 있는 각기 독립된 4개의 방, 게임 사용자의 문자 메시지를 읽고 출력하는 용도의 프린트와 개인서버로 이루어진다. 설계단계는 PHP를 이용한 웹 서버를 통해 사용자가 보낸 문자 메시지를 읽어 오는 첫 번째 단계, 사용자가 보낸 문자메시지의 내용을 프린트를 통해 출력하는 단계, 출력된 내용의 프린트물이 비행기로 접혀 센서가 부착된 각기 다른 4개의 방으로 들어갔을 때 프린트에 적힌 문자메시지의 내용이 LCD에 출력되는 단계로 이루어진다.

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Variations of Oral Cavity Environment according to Sodium Lauryl Sulfate Concentration of Toothpaste (세치제의 Sodium Lauryl Sulfate함유 정도에 따른 구강환경변화)

  • Jeong, Hwa-Yeong;Kim, Yoon-Shin;Jeong, Mi-Ae
    • The Journal of the Korea Contents Association
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    • v.10 no.8
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    • pp.240-248
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    • 2010
  • This study used 3 kinds of experimental toothpaste prepared with different contents of SLS, i.e. A (0%), B (1.1%), C (2.2%). These 150 subjects were subdivided again into three groups. After 4 weeks application of the three kinds of toothpaste, it was found that there were differences in dental plaque test (PHP) among the 3 groups; that is; a higher SLS content was associated with a lower PHP index. In addition, it was found that all 3 groups showed a reduction in simplified oral hygiene index (OHI-S). After 4 weeks application of the three groups of toothpaste, it was found that a higher SLS content was associated with a lower salivary flow, but there was no significant variation in salivary mucosity and pH. Further, it was found that SLS was negatively correlated with salivary flow, which supports the theory that SLS may induce xerostomia.

Variation in the Index of Dental Plaque Removal and Practice Assessment after Instruction on Toothbrushing (칫솔질 교육 후 치면세균막 지수와 수행도의 변화)

  • Kim, Ki-Eun;Ahn, Eunsuk;Han, Ji-Hyoung
    • Journal of dental hygiene science
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    • v.15 no.2
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    • pp.220-225
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    • 2015
  • This study was conducted to examine O'leary index, patient hygiene performance (PHP) index, and toothbrushing practice assessment in subjects of college students in 20s who had been randomly selected. The purpose of this study is to examine if it is easy for rolling method which is recommended by many dental professionals in Korea to implement and to effectively remove dental plaque. Also, the correlations between dental plaque index and toothbrushing practice assessment with the course of time was confirmed, after instruction session on toothbrushing was provided. STATA 11.0 (StataCorp) was used for analysis. There was no significant difference on the three ways of O'leary index, PHP index, and toothbrushing practice assessment in using rolling method, bass technique and toothpick method when comparing the average resulting from first to third instruction session on toothbrushing. O'leary index, PHP index, and toothbrushing practice assessment were inspected with Kruskal-Wallis test which is used for non-parametric statistics. They were checked three times: the first, before the toothbrushing instruction was given; the second, two weeks after the toothbrushing session was given; and the third, 4 weeks after the session. The results are as follows: O'leary index stood at the lowest in the first experiment but showed the highest in the second (p=0.0001). PHP index was the highest level in the first trial and decreased in the second time, but increased again in the last examination (p=0.0001). Toothbrushing practice assessment also showed a similar tendency with PHP index (p=0.0001). In conclusion, rolling method is not the best option for everyone, and it is thought that more various toothbrushing ways need to be reviewed and recommended to people. Also, institutional framework is required for the continuous education on toothbrushing to be in place as the effectiveness of the education is decreased with time.

A Comparison of Reduction of Dental Plaque Control and Oral Malodor according to Hardness of Detergent Food (일부 청정식품의 경도 차이에 따른 치면세균막 제거 및 구취감소 효과 비교)

  • Kim, Min-Ji
    • The Journal of the Korea Contents Association
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    • v.17 no.9
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    • pp.324-330
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    • 2017
  • The aim of this study was to make a comparison of dental plaque control and reduction of oral malodor according to hardness of detergent food. Subjects are 1 male(5.0%) and 19 females(95. 0%), the average age of 20.8 years old. The study was conducted from March 6 to April 24, 2014. Detergent foods which were selected during this experiment were cucumber, cabbage and tomato. The data were analyzed by using SPSS where the PHP Index, plaque rate, $H_2S$, $(CH_3)_2S$, Oral Gas, Expiration Gas were analyzed by Non-parametric Statistics and it was compared to the results of the compared mean whereas factors of detergent food before and after ingestion were analyzed by paired t-test. With all detergent foods, compared with the degree of control of dental plaque before and after ingestion showed a statistically significant difference between PHP index from cucumber, PHP index and plaque rate from tomato, and plaque rate from cabbage.

Efficacy of probiotics and coconut oil-based mouthrinses to improve oral health (프로바이오틱스와 코코넛 오일 기반 양치의 구강건강 개선 효과)

  • Yun-Jeong Kim;Jin-Ju Yang;Hyun-Ah Lee;Seon-Yeong Kim
    • Journal of Korean society of Dental Hygiene
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    • v.24 no.1
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    • pp.1-7
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    • 2024
  • Objectives: We analyzed the relative beneficial impacts of probiotics and coconut oil-based mouth rinses on oral health. Methods : A total of 33 subjects were enrolled and randomly assigned to three groups. Coconut oil and probiotics were given to the experimental group, and distilled water to the control group. We evaluated the possession site of Gingival index, CPITN index, BOP, Pocket depth, and PHP index. Results: In the coconut oil and probiotic groups, Gingival index significantly decreased on both days 15 and 30. CPITN significantly decreased on days 15 and 30 in the coconut oil group (p<0.01), and on day 30 in the probiotic group (p=0.002). There was a significant interaction between group and time for BOP and PHP index (p<0.001), and the coconut oil group was more effective in improving BOP and PHP index. Conclusions: The above results showed that the mediation effect of coconut oil and probiotics was more effective with coconut oil.

A Study on Cooling Performance of Heat Sink using Pulsating Heat Pip (PHP를 이용한 히트싱크의 냉각 성능에 관한 연구)

  • Choi, Woo-Seok;Kim, Jong-Soo
    • Proceedings of the KSME Conference
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    • 2007.05b
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    • pp.2438-2443
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    • 2007
  • In order to guarantee the performance of electronic products. It is needed to improve the cooling performance of heat sink. So this paper has been made to investigate the cooling performance for the aluminum heat sink using pulsating heat pipe(PHP). The pulsating heat pipe was used as a heat spreader. Working fluid was R-22. Heater (50 mm ${\times}$ 50 mm ${\times}$ 3mm) was attached to heat sink and it generated 30W, 60W, 80W, 100W. Heat sink was tested for forced convection with 1${\sim}$4m/s of inlet air velocity. And both type heat sinks were carried out by using CFD simulation. This study showed that pulsating heat pipe can be a good tool to improve cooling performance of heat sink.

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