• Title/Summary/Keyword: S-413

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Anti-Ulcer Activity of Newly Synthesized Acylquinoline Derivatives

  • Cheon, Hyae-Gyeong;Kim, Hyun-Jung;Mo, Hye-Kyoung;Shin, En-Joo;Lee, Yeon-Hee
    • Archives of Pharmacal Research
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    • v.22 no.2
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    • pp.137-142
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    • 1999
  • Anti-ulcer activity of newly synthesized acylquinoline derivatives was investigated. For the in vitro screening, the effects of compounds on gastric $H^{+}/K^{+}$ ATPase isolated from hog and rabbit were examined. Among them, AU-090, AU-091, AU-254, AU-413 and AU-466 exhibited good in vitro activity on both enzymes. To correlate the in vitro activity with in vivo action, the effects of the compounds on the basal gastric acid secretion were studied. Some derivatives showed considerable anti-secretory activities, and AU-413 was selected for further studies. AU-413 protected gastric damage induced by either ethanol or NaOH dose dependently when given orally. $ED_{50}$ values of 12 mg/kg, p.o. (ethanol) and 41 mg/kg, p.o. (NaOH) were obtained. In addition, histamine-stimulated gastric secretion was reduced upon AU-413 administration. Taken together, newly synthesized acylquinoline derivatives, especially AU-413, is worthy of further investigation to be developed as an anti-ulcer agent.

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S-100 기반의 격자형 해양기상정보 데이터 모델 설계에 관한 연구

  • 강동훈;엄대용
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2022.06a
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    • pp.422-423
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    • 2022
  • 국제해사기구의 e-Navigation 전략은 선박에 새로운 기술을 도입하여 더욱 편리하고 안전한 항해를 지원하는 것이다. e-Navigation 전략 이행을 위해 다양한 해양 정보 서비스에서 발생 가능한 요구사항을 수용할 수 있는 공통 데이터 모델이 필요하게 되었고, 최종적으로 국제수로기구의 S-100 표준이 선정되었다. 이 중 해양기상정보를 차세대 전자해도정보시스템에서 표출하기 위한 S-41X 제품표준은 현재 개발이 미완료된 의 논의가 시작되고 있는 상황이다. 본 논문은 S-41X 제품표준 중 격자 데이터 기반의 S-413 제품에 대한 데이터 모델을 설계하였다. 또한 격자 데이터 형식을 지원하는 타 S-100 데이터 제품을 참고하여 국내 원시자료인 기상청 수치예보모델 결과를 활용한 제품 인코딩 테스트 단계의 연구를 수행하였다.

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A Study on the HDF5 Data Model Design for Gridded Marine Weather Information Based on S-100 (S-100 기반의 격자형 해양기상정보 데이터 모델 설계에 관한 연구)

  • Kang, Donghun;Eom, Dae-Yong
    • Journal of Navigation and Port Research
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    • v.46 no.3
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    • pp.158-167
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    • 2022
  • The International Maritime Organization's e-Navigation strategy introduces new technologies to ships to support easier and safer navigation. To implement the e-Navigation strategy, it was necessary to develop a common data model, that could meet various requirements across all aspects of the maritime information service. The International Hydrographic Organization's S-100 Universal Hydrographic Data Model was selected, as the basis for the standardization of maritime data products. Three S-100 based product specifications for weather information, collectively called "S-41X", are currently under development by the NOAA's Ocean Prediction Center, for use in the Electronic Chart Display and Information System (ECDIS). This paper describes a design of a grid based S-413 data model out of three S-41X product specifications. Other S-100 data products, which support the gridded data format, were considered. To verify the data model, an encoding test was conducted, using the Korean Meteorological Adminstration's numerical prediction model results.