• Electronics and Telecommunications Trends
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• v.38 no.4
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• pp.25-35
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• 2023

As the global semiconductor supply chain falters, major countries are pushing to increase their self-sufficiency in semiconductors. In accordance with these global changes, R&D cooperation is evolving in the semiconductor industry. Previously, as for the case of Interuniversity Microelectronics Center (IMEC) in Europe, many cooperation initiatives were established regardless of nationality for improving productivity through measures such as reducing the time and cost required for joint research. Recently, however, cooperation aimed at strengthening one's own industry has been prominent, such as that led by Taiwan Semiconductor Research Institute (TSRI) and the United States National Semiconductor Technology Center (NSTC). Hence, the Korean semiconductor industry also needs to respond. Internally, technology localization should be promoted by strengthening the foundation for domestic R&D cooperation, while externally, it should expand close cooperation with companies from countries leading the semiconductor industry, such as the United States, Europe, and Japan.

• Journal of the Korean Society of Fashion and Beauty
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• v.1 no.1 s.1
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• pp.27-47
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• 2003

This research is to build the foundation of systematic application of color in cosmetology by analyzing color attributes in women's makeup presentation. The result were as follows. 1. The most popular color series in make up were R then RP and YR. The most popular color tone is 'd' and 'lt'. 2. Colors in make up according to age was as follows. For eye shadow, people aged 18 to 24 used 'lt' tone of the R color series; people aged 25 to 34 used 'lt', 's', 'sf tone of the R color series, 'lt' tone of the PB color series, 'lt' tone of the YR color series; people over 35 'g' tone of the YR color series, 'sf' tone of the P color series. For lipstick, people aged 18 to 24 used 'd' tone of the R color series; people aged 25 to 34 used 'd', 'sf' tone of the R color series; people over 35 used 'd' tone of the R color series. For lip-gloss, people aged 18 to 24 used 'v', 'lt', 'b', 's' tone of the R color series; people aged 25 to 34 used 's' 'd' 'dp' 'sf' tone of the R color series; people over 35 used 'b' tone of the R color series. 3. Make up colors according to marital status was as follows. For eye shadow, while married interviewees used 's', 'dk' tone of the R color series, single interviewees used 'lt', 'sf' tone of the R color series. For lipstick, while married interviewees used 'd', 'g' tone of the R color series, single interviewees preferred to use madder 'd', 'sf' tone of the R color series. For lip-gross, while married interviewees used 'd' tone of the R color series, single interviewees used 'b' tone of the R color series the most.

• Membrane Journal
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• v.11 no.4
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• pp.143-151
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• 2001

We have fabricated mixed-ionic conducting membranes, L $a_{0.6}$S $r_{0.4}$ $Co_{0.2}$F $e_{0.8}$ $O_{3-}$$\delta$/ and L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ by the solid state method. Ceramic membranes consisted of perovskite-type structures and exhibited high relative density, >95%. Especially, dense L $a_{0.6}$S $r_{0.4}$Co $O_{3-}$$\delta$/ layer was coated on the L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ membranes by using screen printing technique in order to improve oxygen ion flux. We measured oxygen ion flux on uncoated L $a_{0.6}$S $r_{0.4}$ $Co_{0.2}$F $e_{0.8}$ $O_{3-}$$\delta$/, uncoated L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/, and coated L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ membranes. The L $a_{0.6}$S $r_{0.4}$ $Co_{0.2}$F $e_{0.8}$ $O_{3-}$$\delta$/ membranes showed the highest flux, 0.26 mL/min.$\textrm{cm}^2$ at 90$0^{\circ}C$, after steady state had been reached. The oxygen flux of coated L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ membranes showed higher value, 0.19 mL/min.$\textrm{cm}^2$ at 95$0^{\circ}C$. This flux was as much as 2 or 3 times higher than those of uncoated L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ membranes. 3-$\delta$/ membranes.X> 3-$\delta$/ membranes.membranes.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.810-814
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• 2003

For the phylogenetic analysis of procaryotes, 16S rRNA gene has been used. In spite of it's common use, so high conservative of 16S rRNA gene limited resolving power, hence other molecule was applied in this study and the result was compared with that of 16S rRNA. COG (Clusters of Orthologous of protein) algorithm revealed that three COGs were only detected in 42 procaryotes ; transcription elongation factor (COG0195), bacterial DNA primase (COG0358) and uridylate kinase (COG0528). Uridylate kinase gene was selected owing to the similarity and one single copy number in each genome. Phylogenetic tree of 16S rRNA gene and uridylate kinase showed similarities and differences. Uridylate kinase may help the problem of very high conservative of 16S rRNA gene in rhylogenetic analysis and it would help to access more accurate discrimination and phylogenetic analysis of bacteria.

• The Korean Journal of Mycology
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• v.26 no.2 s.85
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• pp.256-264
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• 1998

The 18S rDNA sequences of Tricholoma matsutake (TM=T. caligatum var. nauseoum) collected in Korea were analyzed for the ectomycorrhizal fungi in the roots of Pinus densiflora. The 514 base pairs of rDNA region were synthesized by UF-5 and UR-6 primers, and double checked in the base pair. The sequence of four strains synthesized were all identical in this work, but different from those done by the previous workers. The basidiocarps collected in this work. were identified to T. matstake after searching the 18s rDNA by the BLAST in NCBI. Only several base pairs of 18S rDNA analyzed from other related basidiocarps were different from our analyses of 18S rDNA. The dendrogram were made based on the sequences of the 514 bp 18S rDNA by CLUSTAL-X alignment program. The groupings of the species at the level of genus in the dendrogram were well constructed.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.6 no.2
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• pp.75-91
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• 2020

[^99mTc]Tc-Hexamethylpropylene amine oxime (HMPAO) is currently used as a regional cerebral blood flow imaging agent for single photon emission computed tomography (SPECT). The HMPAO ligand exists in two isomeric forms: d,l and meso showing different properties in vivo. Later studies indicated that brain uptake patterns of ^99mTc-complexes formed from separated enantiomers differed. Separation of enantiomers is difficult by fractional crystallizations method. Usually, the substance is obtained in low chemical yield in a time-consuming procedure. Furthermore, the final product still contains some impurity. So we have developed new efficient route for synthesis of R,R- and S,S-HMPAO enantiomeric compounds in 6-steps. Nucleophilic substitution (S_N2) reactions of 2,2-dimethylpropane-1,3-diamine either with S- (1a) or R-methyl2-chloropropanoate (1b) were performed to produce compounds R,R- (2a) or S,S-isomer (2b) derivatives protected with benzylchloroformate (Cbz), respectively. And then Weinreb amide and methylation reaction using Grignard reagent, oxime formation with ketone group and deprotectiion of Cbz group by hydrogenolysis gave S,S- (7a) or R,R-HMPAO (7b), respectively. Entaniomeric compounds were synthesied with high yield and purity without any undesired product. The 7a or 7b kits containing 10 ㎍ SnCl₂-2H₂O were labeled with ^99mTc with high radiolabeling yield (90%).

• The Korean Journal of Mycology
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• v.21 no.1
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• pp.16-22
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• 1993

Morphological and cultural characteristics of fungi causing rice sclerotial diseases were examined. Hyphal widths of R. solani and R. oryzae were same and ranged $6.0-12.0\;{\mu}m$ with average $9.0\;{\mu}m$, the widest among those of the sclerotial fungi examined. Hyphal width of R. oryzae sativae ranged $6.0-9.0{\mu}m$ with average $7.4{\mu}m$. Hyphal width of R. cerealis was the narrowest among those of Rhizoctonia species examined, and the same was hyphal width of S. oryzae among those of Sclerotium species. Nuclear staining by HCL-Giemsa method showed that R. solani and R. oryzae had many nuclei within one hyphal cell, S. oryzae one nucleus, and the other sclerotial fungi mostly two nuclei. The nuclear number of R. solani was the largest, which ranged 2-17 with average 6.3. Average size of sclerotia of the sclerotial fungi except S. hydrophilum and S. oryzae produced in lesions ranged 1.0-2.0mm. Average size of sclerotia of S. hydrophilum and S. oryzae was 0.5mm and 0.24mm, respectively. Sclerotia of R. solani and R. oryzae produced in culture were more variable in size and larger than those produced in lesions. However, the sclerotial sizes of the other sclerotial fungi produced in culture were almost the same as those produced in lesions. Sclerotial colors of sclerotial fungi produced in lesions were similar to those produced in culture, but sclerotial shapes of some sclerotial fungi exhibited somewhat difference between the sclerotia produced in lesions and in culture. Optimum temperature for mycelial growth of R. cerealis was $23^{\circ}C$, and that of the other sclerotial fungi ranged from $27\;to\;33^{\circ}C$. Maximum temperature for mycelial growth of some sclerotial fungi was as high as $41^{\circ}C$, while that of R. cerealis was as low as $31^{\circ}C$. Minimum temperature for mycelial growth of R. cerealis was $2^{\circ}C$, and that of the other sclerotial fungi ranged from $6\;to\;10^{\circ}C$.

• Molecules and Cells
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• v.40 no.3
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• pp.211-221
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• 2017

Transforming growth factor ${\beta}1$ $(TGF{\beta}1)/Smad4$ signaling plays a pivotal role in maintenance of the dynamic balance between bone formation and resorption. The microRNA miR-155 has been reported to exert a significant role in the differentiation of macrophage and dendritic cells. The goal of this study was to determine whether miR-155 regulates osteoclast differentiation through $TGF{\beta}1/Smad4$ signaling. Here, we present that $TGF{\beta}1$ elevated miR-155 levels during osteoclast differentiation through the stimulation of M-CSF and RANKL. Additionally, we found that silencing Smad4 attenuated the upregulation of miR-155 induced by $TGF{\beta}1$. The results of luciferase reporter experiments and ChIP assays demonstrated that $TGF{\beta}1$ promoted the binding of Smad4 to the miR-155 promoter at a site located in 454 bp from the transcription start site in vivo, further verifying that miR-155 is a transcriptional target of the $TGF{\beta}1/Smad4$ pathway. Subsequently, TRAP staining and qRT-PCR analysis revealed that silencing Smad4 impaired the $TGF{\beta}1$-mediated inhibition on osteoclast differentiation. Finally, we found that miR-155 may target SOCS1 and MITF to suppress osteoclast differentiation. Taken together, we provide the first evidence that $TGF{\beta}1/Smad4$ signaling affects osteoclast differentiation by regulation of miR-155 expression and the use of miR-155 as a potential therapeutic target for osteoclast-related diseases shows great promise.

• Bulletin of the Korean Mathematical Society
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• v.56 no.4
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• pp.1041-1057
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• 2019

Let ${\Gamma}$ be a nonzero commutative cancellative monoid (written additively), $R={\bigoplus}_{{\alpha}{\in}{\Gamma}}$ $R_{\alpha}$ be a ${\Gamma}$-graded integral domain with $R_{\alpha}{\neq}\{0\}$ for all ${\alpha}{\in}{\Gamma}$, and $S(H)=\{f{\in}R{\mid}C(f)=R\}$. In this paper, we study homogeneously divisorial domains which are graded integral domains whose nonzero homogeneous ideals are divisorial. Among other things, we show that if R is integrally closed, then R is a homogeneously divisorial domain if and only if $R_{S(H)}$ is an h-local $Pr{\ddot{u}}fer$ domain whose maximal ideals are invertible, if and only if R satisfies the following four conditions: (i) R is a graded-$Pr{\ddot{u}}fer$ domain, (ii) every homogeneous maximal ideal of R is invertible, (iii) each nonzero homogeneous prime ideal of R is contained in a unique homogeneous maximal ideal, and (iv) each homogeneous ideal of R has only finitely many minimal prime ideals. We also show that if R is a graded-Noetherian domain, then R is a homogeneously divisorial domain if and only if $R_{S(H)}$ is a divisorial domain of (Krull) dimension one.

• Research in Plant Disease
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• v.10 no.1
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• pp.63-68
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• 2004

Twenty-three strains of Serratia sp., isolated from surface-sterilized rice roots collected in Chonbuk and Chungnam province, were identified and characterized. They were Gram-negative, rod shaped and red pigmented typically and their endophytism was confirmed by inoculation and reisolation of the strains in planta. Their antifungal activity against 4 rice pathogenic fungi was compared and ranged from 62.4 to 85.2％ against Rhizoctonia solani and 68.0 to 88.5％ against Pyricularia grisea. Among the 23 strains tested, strain Rsm220 showed the strongest inhibition activity against 4 pathogenic fungi. The strain was, therefore, selected as a biocontrol candidate for both the pathogens and its bacteriological characteristics and 165 rDNA sequences were analyzed. Phenotypic and biochemical characteristics of the selected Rsm220 were highly related to the type strain of S. marcescens and 165 rDNA sequencing of Rsm220 showed a homology of 98.2％ to the type strain of S. marcescens. The strain Rsm220 was identified as S. marcescens and the inhibition result of this endophytic strain indicates that it is a potential biocontrol agent for R. solani and R grisea.