• Title/Summary/Keyword: S/N Ratio

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Robust Reference Intervals for Serum Kappa and Lambda Free Light Chains from a Multi Centre Study Population from Hyderabad, India: Myeloma Diagnostic Implications

  • Mohammed, Noorjahan;Chandran, Priscilla Abraham;Kandregula, Madhavi;Mattaparthi, Ratna Deepika;Gundeti, Sadasivudu;Volturi, Jyotsna;Darapuneni, Radhika;Raju, Sree Bhushan;Dattatreya, Palanki Satya
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.5
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    • pp.2605-2610
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    • 2016
  • The International Myeloma Working Group considers the serum free light chain (SFLC) assay to be an adjunct to traditional tests. Apart from the FLC ratio, the absolute values of individual free light chains also are gaining importance as they appear to be more relevant in certain clinical settings. Automated assays are available for their determination. As laboratories put new test systems into use catering to different disease populations, they are required by accreditation and certification bodies to verify or establish performance specifications, including reference intervals (RIs) representative of their population. Our aim was to establish local RIs for SFLC in a multicentre representative healthy population using a robust method. There was no significant relationship between SFLC levels and age, gender and creatinine levels. The 95% RI for ${\kappa}SFLC$ was 4.81 to 33.86mg/L, for ${\lambda}$ SFLC was 5.19 to 23.67mg/L and for ${\kappa}/{\lambda}SFLC$ was 0.36 to 2.33, significantly higher than the values given by the manufacturer. The ${\kappa}/{\lambda}$ SFLC ratio at 2.23, covering 100% of the data, showed 72% sensitivity (95% CI=39.0 - 94.0), 100% specificity (95% CI=71.5 - 100.0), 100% PPV (95% CI=21.5 - 100.0), 95% NPV (95% CI=75.4 - 99.9), and 79% accuracy (95% CI=56.0 - 93.0). In the patient group, kit RI for ${\kappa}/{\lambda}$ SFLC ratio classified 45.5% (n=5) as positive vs 9.1% (n=1) positive by the study RI, while the kit RI for kappa FLC classified 90.9% (n=10) as positive vs 54.5% (n=6), indicating increased probability of false positive test results with the kit RI when applied to our patient population. Appropriate and specific reference intervals and criteria values result in fewer false-positive and false-negative results which means fewer wrong or missed diagnoses.

Effects of Supplemental Vegetable Oils on Ruminal Characteristics, Digestibility and Formation of Fatty Acid Soaps in Sheep (식물성유 첨가가 면양의 반추의 발효특성과 소화율 및 지방산염 형성에 미치는 영향)

  • Kim, D.I.;Choi, J.R.;Cho, S.H.;Lee, D.H.;Chung, T.Y.
    • Journal of Animal Science and Technology
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    • v.46 no.5
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    • pp.783-798
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    • 2004
  • This experiment were conducted to determine the formation of fatty acid soaps, digestibility and ruminal characteristics when vegetable oils were added. Three Corriedale${\times}$ 3 Latin square design. Sheep were fed one of three diets consisting of alfalfa hay and concentrates in a ratio of 70:30. Dietary treatments were 1) no oil, 2) 7% soybean oil and 3) 7% corn oil. At the end of each experimental period, rumen contents from each sheep were collected before feeding and at 1, 3, 6 and 9h after feeding. pH decreased up to the 3 hour after feeding and increased until the end of the collection(p<0.0001). Whereas the concentration of $NH_3$-N showed inverse changes to pH(p<0.0001). Type of oil did not affect the molar concentration of total VFA, acetate, propionate and butyrate. Acetic/propionic acid (A/P) ratio decreased with increasing time(P<0.0001), but the ratio at the end of the experiment became similar to the initial value. No effects were found in the digestibility of dry matter, total-N, crude fiber, ash, NFE, NDF and ADF. The formation of fatty acid soaps(FAS) increased after feeding than 1 hour before feeding(P<0.05) and increased in 7% oils than no oil addition(P<0.05). Long chain fatty acids formed mainly FAS. ince the formation of FAS might decrease negative effects on ruminal haracteristics and total tract digestibility.

항만운영정보시스템의 데이터전송방식 개선에 관한 연구

  • 김칠호;박남규;최형림
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 1999.10a
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    • pp.187-197
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    • 1999
  • 해양수산부가 개발 .운영 중인 항만운영정보시스템(PORT-MIS)은 선박입출항 관련 업무, 수출입 화물 반출입에 관한 업무, 항만시설물관리에 관한 업무, 의사결정지원시스템에 관한 업무 등 크게 4개 업무오 구성되어 있으며, 총 19개의 전자문서와 1,500여개의 단위 프로그램으로 구성되어 있다. 그동안 PORT-MIS를 권역별로 확대 운영하면서 발생한 여러 가지 문제점들을 보완하기 위해 해양수산부와 정보통신부(한국전산원)가 공동으로 $\ulcorner$수출입화물 일괄처리시스템 구축$\lrcorner$ 용역 사업을 현재 진행 중에 있다. 본 연구는 용역과업 내용에 포함되어 있지 않으면서 개선이 필요한 외항선(국전선.외국전선 포함) 선박입항보고서(최초.변경.최종)와 선박출항보고서(최초.변경.최종), 내항선입.출항신고서, 예선사용허가신청서 및 지정서, 도선사용허가신청서 및 지정서 등의 민원업무를, 사용자로 하여금 최소한의 노력으로 처리할 수 있도록 제출방법을 개선(EDI방식에서 온라인방식으로)하여 행정소요시간을 단축함으로써 PORT-MIS의 효율성을 높일 수 있는 방안을 제시하고자 한다. 이러한 노력을 통해 PORT-MIS EDI업무가 개선되어 선박입.출항보고를 1회롤 처리할 수 있다면 연간 29만9천건의 서류절감으로 약 1억3천7백만원의 물류비를 줄일 수 있으며, 시간 단축에 따른 간접비용을 계산하면 보다 많은 효과가 있다고 판단된다. 그리고 내항선입.출항신고서 및 예.도선업무를 EDI방식에서 온라인방식으로 전환함으로써 선사와 예선업체 및 도선사협회가 대화형식으로 업무처리가 이루어져 분쟁을 최소화 할 수 있다면, 전자문서 31만6천건/년 절감으로 1억3백만원/년의 예산이 절감될 것으로 예상된다.rr로 변화시켰고 inductive power는 200~800watt, bias voltage는 0~-200voltage로 변화시켰으며 식각마스크로는 SiO2를 patterning 하여 사용하였다. n-GaN, p-GaN 층 이외에 광소자 제조시 필수적인 InGaN 층을 100% Cl2로 식각한 경우에 InGaN의 식각속도가 GaN에 비해 매우 낮은 식각속도를 보였다. Cl2 gas에 소량의 CH4나 Ar gas를 첨가하는 경우와 공정압력을 감소시키는 경우 식각속도는 증가하였고, Cl2/10%Ar 플라즈마에서 공정 압력을 감소시키는 경우 식각속도는 증가하였고, Cl2/10%CHF3 와 Cl2/10%Ar 플라즈마에서 공정압력을 15mTorr로 감소시키는 경우 InGaN과 GaNrks의 선택적인 식각이 가능하였다. InGaN의 식각속도는 Cl2/Ar 플라즈마의 이온에 의한 Cl2/CHF3(CH4) 플라즈마에서의 CHx radical 형성에 의하여 증가하는 것으로 사료되어 진다.$ 이상을 나타내었다. 박막의 Sn/In atomic ratio는 0.12, O/In의 비율은 In2O3의 화학양론적 비율인 1.5보다 작은 1.3을 나타내었다.로 보인다.하면 수평축과 수직축의 분산 장벽의 비에 따라 cluster의 두께비가 달라지는 성장을 볼 수 있었고, 한 축 방향으로의 팔 넓이는 fcc(100) 표면의 경우 동일한 Ed+Ep값에 대응하는 팔 넓이와 거의 동일한 결과가 나타나는 것을 볼 수 있다. 따라서 이러한 비대칭적인 모양을 가지는 성장의 경우도 cluster 밀도, cluster 모양, cluster의 양 축 방향 길이 비, 양 축 방향의 평균 팔 넓이로부터 각 축 방향의 분산 장벽을 얻어낼 수 있을 것으로 보인다. 기대할 수 있는 여러

Simulation of Conceptual Designs of a Three-Surface Stealth Strike Fighter

  • Kuizhi, Yue;ShiChun, Chen;Wenlin, Liu;Dazhao, Yu
    • International Journal of Aeronautical and Space Sciences
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    • v.15 no.4
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    • pp.366-373
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    • 2014
  • A conceptual design of a three-surface strike fighter was studied and stealth performance was taken into account to enhance survivability and battle effectiveness. CATIA was used to design the aircraft's three-dimensional prototype model and the weapon carriage arrangement was also studied. The aircraft's RCS characteristics and distributions under X, S, C, and L bands were simulated using the RCSPlus software, which is based on the PO method. Pressure and velocity distributions of the flow field were also simulated using CFD. A turbulence model was based on standard $k-{\varepsilon}$ function and N-S functions were used during the CFD computation. Lift coefficients, drag coefficients, and lift-to-drag ratio were obtained by aerodynamic simulation. The results showed that: (1) the average value of head-on RCS between ${\pm}30^{\circ}$ is below -3.197 dBsm, and (2) the lift coefficient is 0.34674, the drag coefficient is 0.04275, and the lift-to-drag ratio is 8.11087 when the attack angle is $2.5^{\circ}$.

Fabrication of a shadow mask for OTFT circuit (유기 박막 트랜지스터 회로를 위한 섀도 마스크의 제작)

  • Yi S.M.;Park M.S.;Lee Y.S.;Lee H.S.;Chu C.N.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2005.06a
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    • pp.1277-1280
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    • 2005
  • A high-aspect-ratio and high-resolution stainless steel shadow mask for organic thin-film transistors (OTFTs) circuit has been fabricated by a new method which combines photochemical machining, micro-electrical discharge machining (micro-EDM), and electrochemical etching (ECE). First, connection lines and source-drain holes are roughly machined by photochemical etching, and then the part of source and drain holes is finished by the combination of micro-EDM and ECE processes. Using this method a $100\;\mu{m}$ thick stainless steel (AISI 304) shadow mask for inverter can be fabricated with the channel length of $30\;\mu{m}\;and\;10\;\mu{m}\;respectively.\;The\;width\;of\;connection line\;is\;150\;\mu{m}$. The aspect ratio of the wall is about 5 and 15, respectively. Metal lines and source-drain electrodes of OTFTs were successfully deposited through the fabricated shadow mask.

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A Study on the Vibration Analysis and Optimization for the Composite Optical Structure of an Aircraft (복합재료를 적용한 항공기용 카메라 구조 경량화 설계 및 최적조건 선정에 관한 연구)

  • Kim, Byeong-Jun;Lee, Jun-Ho;Lee, Haeng-Bok;Jung, Dae-Yoon;Cheon, Seong-Sik
    • Composites Research
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    • v.25 no.6
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    • pp.230-235
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    • 2012
  • This paper presents the vibration characteristics and the optimization using the orthogonal array about applied composite optical structure of an aircraft. To acquire the vibration characteristics for stable line of sight, modal analysis are performed by using multi-body program ADAMS. And to optimize optical structure, for design variables were selected, larger-the-better characteristics were considered using results of S/N ratio and orthogonal array $L_9(3^4)$. When bearing constraints are selected, radial, axial and moment stiffness value are used to analysis for optimization until now. But B.S.R which is non-dimensional parameter is proposed, structures including bearings can be used for optimization. And then having a result of lager-the-better, the optimized values of each design variable were successfully suggested.

Study on crystal texture of PIT processed Bi-2223 multi-filamentary tape (PIT 공정으로 제조한 Bi-2223 다심 고온 초전도 선재의 결정 배향성에 관한 연구)

  • Choi, J.K.;Oh, S.S.;Ha, H.S.;Yang, J.S.;Yun, J.K.;Lee, N.J.;Ha, D.W.;Kwan, Y.K.
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.04a
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    • pp.59-63
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    • 2002
  • The purpose of this paper is to investigate the crystal texture of the 2223 phase and its relationship with PIT processing parameter. Ag-sheathed Bi-2223 multi-filament tapes were prepared by changing rolling reduction ratio. We analysed the degree of texture for 2223 phase after heat-treatment. According to X-ray pole-figure, the texture of the filaments located near surface and center were not so different each other for all rolling conditions. we found a little higher degree of texture for 60% rolling reduction. But its difference is not so high compared with those tapes with a lower rolling reduction ratio. Reaction induced texturing seemed to contribute with a large portion under present condition.

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Availability of Marine bacteria (Erythrobacter sp. $S{\pi}-1$) for enrichment of livefood in the slime flounder larvae, Microstomus achne (찰가자미 자어에 있어서 먹이생물의 영양강화을 위한 해양세균 (Erythrobacter sp. $S{\pi}-1$)의 이용)

  • KANG Suck-Jung;LIM Young Soo;PARK Sang Un;LEE Won Jae;CHO Byeong-Dae;PARK Heum Gi;PARK You-Soo;OH He-Young
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.32 no.6
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    • pp.798-802
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    • 1999
  • This study was performed to compare the effect of enrichement of rotifer and Artemia fed marine bacteria (Erythrobacter sp. S$\pi$-1) with those fed the different diets-(Super Selco, $\omega$-yeast and marine Chlorella) on the slime flounder larvae, Microstomus achne. Because the ratio of docosahexaenoic acid (DHA) to fatty acids in rotifer (dry weight $\%$) fed on Super Selco and ESP-SR including Erythrobacter sp. S$\pi$-1 was higher than that in rotifer fed marine Chlorella, the growth of the slime larvae fed the former showed better than the latter. And the ratio of DHA and highly unsaturated fatty acid (n-3 HUFA) to fatty acids in Artemia (dry weight $\%$) enriched by ESP-A including Erythrobacter sp. S$\pi$-1 were also higher than those in Artemia enriched by others or Artemia without enrichment. Larvae fed on Artemia enriched by ESP-A showed better growth and survival rate than those fed on Artemia enriched by others or Artemia without enrichment. With regard to dietary value of Erythrobacter sp. S$\pi$-1, its use could improve the quality of the live foods for the slime flounder larvae.

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Fabrication of $100{\mu}m$ thick mold and electroplating using thick photoresist (후막 감광제를 이용한 $100{\mu}m$ 두께 몰드 제작과 전해도금)

  • Jung, Hyoung-Kyoon;Ahn, Si-Hong;Kim, Yong-Kweon
    • Proceedings of the KIEE Conference
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    • 2002.07c
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    • pp.2008-2010
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    • 2002
  • Process conditions of a novel negative thick photoresist, JSR THB-$430N^{(R)}$, are established in this paper. Although SU-8 obtains uniform and high-aspect-ratio structures, it is hard to remove the SU-8 mold after electroplating. The JSR THB-$430N^{(R)}$ can be more easily removed than the SU-8 and has a low internal stress. Introducing two step strip processes using acetone and the jSR THB-$S1^{(R)}$, the JSR THB-$430N^{(R)}$ electroplating mold was removed completely and a JSR THB-$430N^{(R)}$ film stress is compressive less than 2 MPa. In this paper, we obatined $200{\mu}m$ thick PR structure and $100{\mu}m$ thick electroplated nickel structure using the JSR THB-$430N^{(R)}$ photoresist.

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Study on Gaseous Nitrocarburizing Treatment (가스침질탄화법(浸窒炭化法)에 관한 연구(硏究))

  • Lee, S.Y.;Bell, T.
    • Journal of the Korean Society for Heat Treatment
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    • v.1 no.1
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    • pp.8-12
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    • 1988
  • This study has been carried out to evaluate gaseous nitrocarburizing treatment undertaken for pure iron at $570^{\circ}C$ in an atmosphere containing 50% endothermic gas, generated from natural gas, and 50% ammonia. The results obtained from the experiment are as follows ; 1) The microstructure of gaseous nitrocarburized pure iron consists of the compound layer on the surface and the diffusion zone beneath it. The compound layer progresses uniformly into ferrite with a thickness of $20{\mu}$ obtained after treating for 3 hours. 2) Chemical analysis has shown that the compound layer has a C/N ratio of 0.19 and that the average combined interstitial content of the compound layer is about 30 atomic percent, which is close to the lower limit of the ${\varepsilon}$-carbonitride phase field in Fe-C-N phase diagram. 3) X-ray diffraction analysis has revealed that the compound layer consists mainly of the c.p.h. phase, ${\varepsilon}-Fe_3$(C.N) and a small amount of $Fe_4N$ and traces of ferrite are also present in the compound layer. 4) The microhardness of the compound layer is about 600 V.H.N and shows a relatively sharp fall-off at the compound layer/diffusion zome interface. 5) The average actual degree of ammonia dissociation is calculated to be 27% for a gaseous nitrocarburizing treatment carried out at $570^{\circ}C$.

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