• Title/Summary/Keyword: Rubus coreanus

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Attenuation of airway hyperreactivity (AHR) and inflammation by water extract of Rubus coreanus $M_{IQ.}$ (WRCM) (마우스 천식모델에서 복분자 물추출물의 기도 과민반응 및 염증의 억제 효과)

  • Kim, Kyung-Jun;Lee, Ho-Sub;Jo, Eun-Heui;Park, Min-Cheol
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.20 no.1 s.32
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    • pp.177-194
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    • 2007
  • Fructus of Rubus coreanus $M_{IQ.}$. (FRCM) has been used for stuttering urination, prostate gland disease, and impotence in Korean traditional medicine. Water extract of FRCM (WFRCM) treatment significantly attenuated airway hyperreactivity (AHR). Airway recruitment of leukocytes and eosinophils was also markedly reduced by WFRCM administration, suggesting that WFRCM can alleviate the airway inflammation. However, the level of cytokine (IL-4, IL-5, and IL-13) in bronchoalveolar lavage fluid (BALF) and lung was not different compared with positive control. WFRCM reduced the number of draining lymph node cells during OVA-induced allergic asthma. I further examined transcription level of cytokine in lung. WFRCM treatment reduced IL-4 and IL-13 mRNA in lung and inhibited IgE and IgG1 but not IgG2a. My data suggest that WFRCM attenuates OVA-induced allergic asthma through inhibition of Th2 cell response.

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Effects of Rubus Coreanus Miquel on the Apoptosis of U937 Cells (복분자가 U937세포의 apoptosis에 미치는 효과)

  • Lee, Kwang-Kyu;Han, Jong-Hyun;Oh, Chan-Ho
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.6
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    • pp.1404-1408
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    • 2009
  • Methanol extracts of Rubus Coreanus Miquel (RCM) were found to exhibit apoptosis induction of U937 human histiocytic leukemia cells. Treatment of RCM exerted strong cytotoxicity against U937 human leukemia cells. RCM induced apoptosis of U937 leukemia cells in a dose dependent manner. Nitric oxide (NO) production was increased in RCM-treated RAW264.7 macrophage cell line. RCM increased the p53 and $NF{\kappa}B$ gene and decreased the $I{\kappa}B$ gene expression in U937 cells. RCM also increased the $NF{\kappa}B$ protein expression, but decreased the PCNA and BcL-xL protein expression in cultured U937 cells. These data suggest that RCM are effective on the apoptosis induction of human leukemia cells and anti-cancer properties.

Physicochemical Characteristics of Rubus coreanus Miquel during Maturation (성숙단계별 복분자딸기의 이화학적 특성)

  • Youn, Aye-Ree;Park, Pill-Jae;Choi, Heh-Ran;Kim, Byeong-Sam;Cha, Hwan-Soo
    • Korean Journal of Food Science and Technology
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    • v.39 no.4
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    • pp.476-479
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    • 2007
  • In order to promote the utilization of Rubus coreanus Miquel as a functional food, its physicochemical properties were examined during maturation. Crude protein, crude ash, and dietary fiber contents were highest in the unripened fruit, but decreased thereafter; whereas as moisture and the soluble solid contents showed a reverse pattern. The free sugar concentration of the middle-ripened fruit (0.7 g/100 g) increased as it became a ripened fruit (4.1 g/100 g). Also, the acidity of R. coreanus Miquel was at its highest concentration in the middle-ripened fruit at 3.38%. Seventeen types of amino acids were analyzed from R. coreanus Miquel during maturation. The highest amino acid components in the unripened fruit were aspartic acid (546.55 mg/100 g) and glutamic acid (452.22 mg/100 g). Among the minerals studied during this research, R. coreanus Miquel contained a high level of potassium. The potassium concentrations of the unripened fruit, middle-ripened fruit, and ripened fruit were 306.0, 191.1, and 164.1 mg/100 g, respectively.

Antioxidant Activities and Skin-Whitening Effects of Nano-encapsuled Water Extract from Rubus coreanus Miquel (복분자 추출물의 나노입자화를 통한 항산화 및 미백 효과 증진)

  • Jeong, Hyang-Suk;Han, Jae-Gun;Han, Ji-Hye;Kim, Young;Oh, Sung-Ho;Kim, Seoung-Seop;Jeong, Myoung-Hoon;Choi, Geun-Pyo;Park, Uk-Yeon;Lee, Hyeon-Yong
    • Korean Journal of Medicinal Crop Science
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    • v.17 no.2
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    • pp.83-89
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    • 2009
  • This study was performed to improve antioxidant activities and skin-whitening effects of Rubus coreanus Miquel extracts by nano-encapsulation. R. coreanus was extracted at $60^{\circ}C$ and encapsulated by lecithin and gelagine. Nano-encapsulated extracts showed highest free radical scavengering effect as 97.62% in adding sample ($500\;{\mu}g/m{\ell}$), compared to the extracts from conventional processes. It was showed strong inhibition effect on melanin production test by Clone M-3 cells as 55.23%. High inhibitory potency on tyrosinase was also measured as 155.8% by adding nano-sample of 1 $mg/m{\ell}$. The improvement of biological activity was demonstrated by real time confocal microscope. We could consider that the water soluble extracts of R. coreanus could be definitely enhanced by nano-encapsulated as a potent natural resources for antioxidant and skin-whitening agent.

Characteristics of Rubus coreanus Miq. Fruits at Different Ripening Stages (숙성에 따른 토종 복분자 딸기의 특성)

  • Kim, Ji-Myoung;Shin, Mal-Shick
    • Korean Journal of Food Science and Technology
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    • v.43 no.3
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    • pp.341-347
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    • 2011
  • To develop a healthy functional food containing Rubus coreanus fruit (RCF) powder with different degrees of ripening, the composition, physicochemical properties, and antioxidant activity of native RCF during ripening were investigated and compared with Rubus occidentalis fruit (ROF). Ripened RCF was bright red in color, whereas ripened ROF was dull and dark red in color. The seeds of RCF were softer and smaller than those of ROF. Crude protein, crude lipid, and total sugar content of RCF powder increased with increased ripening time, whereas ash and total dietary fiber contents decreased with increased ripening time. Color differences increased with Increased ripening. Eighteen types of amino acids were analyzed from RCF, and glutamic acid had the highest content. RCF powder had the highest level of potassium and calcium and did not contain any hazardous metals. Mineral and organic acid contents decreased according to ripening.

Antioxidant activity and hepatic lipids improvement effects of Rubus coreanus in high-fat diet-fed rats (복분자(Rubus coreanus) 추출물의 라디칼 소거활성 및 고지방 식이에 대한 흰쥐의 간 지질 개선 효과)

  • Lee, Soo-Jung;Song, Yuno;Chung, Min-Sup;Jang, Sun-Hee;Won, Chung-kil;Song, Young-Min;Cho, Jae-Hyeon
    • Korean Journal of Veterinary Service
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    • v.38 no.2
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    • pp.117-125
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    • 2015
  • This study was investigated the effects on the radical scavenging activities and hepatic lipid levels in rats fed a high-fat diet (HFD) by the 70% ethanolic extract from Rubus coreanus. The Rubus coreanus extract (RCE) was administered through the gastrointestinal tract at 150 mg/kg BW/day for 5 weeks (HFD+RCE). Total phenol content was 157.93 mg gallic acid/g in the RCE. Scavenging activities to DPPH, ABTS, an d hydroxyl radicals by RCE significantly increased in a does-dependent manner of $50{\sim}500{\mu}g/mL$ concentration. DPPH and ABTS radical scavenging activities were over the 70% in the $500{\mu}g/mL$ concentration. During the five weeks study, the food efficiency ratio was no significant differences between the HFD and HFD+RCE. Liver weight of HFD+RCE (3.75 g/100 g BW) was significantly decreased compared to those of the HFD. Hepatic triglyceride and total cholesterol levels of HFD+RCE were significantly lower compared to those of the HFD. The hepatic TBARS contents in the HFD+RCE was significantly decreased to the HFD, radical scavenging activity was markedly increased in HFD+RCE as normal group. In histological observation of liver tissues, the hepatocytes of HFD+RCE appeared the reduced aspects on the size and numbers of lipid droplets in cytoplasm compared to the HFD. Our results suggest that RCE could have antioxidant activities and hepatic hypolipidemic effects by its phenolic compounds.

Antioxidant of Heating Pork and Antioxidative Activities of Rubus coreanus Miq. Extracts (복분자 추출물의 항산화활성과 가열 돈육의 산화 억제 효과)

  • Cho, Wan-Goo;Han, Seung-Kwan;Sin, Ji-Hye;Lee, Jang-Won
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.37 no.7
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    • pp.820-825
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    • 2008
  • We investigated the antioxidant of heating pork, the physicochemical properties and antioxidative activities of Rubus coreanus Miq. extracts. The contents of moisture, crude fat, crude protein, crude fiber, and crude ash were measured. Soluble solid, acidity, pH and mineral contents were also investigated. The ethanol extract of Rubus coreanus Miq. was evaporated, and then sequentially extracted by hexane, ethyl acetate, butanol and water. The contents of total polyphenol ranged from 24.5 mg tannic acid equivalents (TAE) per g to 82.5 mg in all fractions. Antioxidative effects were investigated through DPPH free radical scavenging, $ABTS{\cdot}^+$ scavenging and TBARS methods. It was found that ethanol extract ($2,000\;{\mg}/mL$) and butanol extract ($1,500\;{\mg}/mL$) had 89.93% and 89.68% of DPPH free radical scavenging activities. As for ABTS, all extracts ($1,000{\sim}2,000\;{\mg}/mL$) except hexane showed over 90% scavenging activities. The lowest TBARS values were obtained from extract of ethyl acetate and ethanol, and their antioxidative activities were higher than that of ascorbic acid. The results of this study indicate that the ethyl acetate and ethanol extract of Rubus coreanus Miq. may be substituted for ascorbic acid in heating pork.

Characteristics of Photosynthesis, Leaf and Fruit by Crown Layer in Rubus coreanus Miq. (복분자딸기(Rubus coreanus)의 수관 층위별 광합성 특성과 잎 및 과실 특성)

  • Han, Jingyu;Kim, Sea Hyun;Chung, Hun Gwan;Jang, Yong Seok;Cho, Yoon Jin
    • Journal of Korean Society of Forest Science
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    • v.95 no.3
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    • pp.328-333
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    • 2006
  • This study was conducted to find the characteristics of photosynthesis, leaf and fruit by crown layers in Rubus coreanus Miq. Light compensation points were shown PPFD 33, 20 and $5{\mu}mol\;m^{-2}\;S^{-1}$ at upper, middle and lower layer, respectively. Light saturation points were appeared PPFD 1000, 500 and 200 and their net photosynthesis rate were 8.52, 5.25 and $3.60{\mu}mol\;CO_2\;m^{-2}S^{-1}$ at upper, middle and lower layer, respectively. Uiryeong 7 which was viny type showed higher net photosynthetic rate than others at upper layer. Songgye 6 which was upright type showed lower net photosynthetic rate than others at lower layer. Chlorophyll contents of middle layer had the highest value in the all layers and upper layer showed the lowest value. Most characteristics of leaf morphology were showed that middle and lower layer had higher value than upper layer. That trend was contrary to characteristics of photosynthesis by crown layers. However, dry weight per leaf area and most characteristics of fruit had the highest value at upper layer and that was similar to characteristics of photosynthesis by crown layers. Also, sugar contents of fruit showed the highest value at middle layer.

Antibacterial activity from medicinal plant extracts on the Staphylococcus aureus (수종 한약재 추출물의 Staphylococcus aureus에 대한 항균활성)

  • Park, Chun-Geon;Bang, Kyong-Hwan;Lee, Seung-Eun;Cha, Moon-Seok;Sung, Jung-Sook;Park, Hee-Woon;Seong, Nak-Sul
    • Korean Journal of Medicinal Crop Science
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    • v.9 no.4
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    • pp.251-258
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    • 2001
  • Medicinal plant extracts including Rubus coreanus, Sanguisorba officinalis, Eriobotrya japonica, Prunus mume, Crataegus pinnatifida, Rosa leavaigate Prunus persica, Prunus japonica var. nakaii and Spiraea blumei were prepared for the test of antibacterial activity. Tryptic soy broth (TSB) containing $0{\sim}10mg/ml$ of medicinal plant extracts was inoculated with $10^6$ cells/ml of Staphylococcus aureus and incubated at $35^{\circ}C$ for 24 hours. The plate counting method and clear zone test were used to test inhibitory effect of the extracts. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was derived from the survival curves of S. aureus. The order of antibacterial activities of medicinal plant extracts on the S. aureus was Rubus coreanus > Sanguisorba officinalis > Eriobotrya japonica > Prunus mume > Crataegus pinnatfida. Minimum inhibitory concentration of Sanguisorba ofEcmalis on the Staphylococcus aureus was 2.5mg/ml and minimum bactericidal concentration of Rubus coreanus was 1.0%. Inhibition zone of Rubus coreanus, Sanguisorba officinalis, Eriobotrya japonica, Prunus mume, and Crataegus pinnatifida was 16.5mm, 14.3mm 11.0mm, 14.0mm and 12.7mm, respectively. The morphology of S. aureus cells treated with medicinal plant extracts showed damage of cell wall and cytoplasmic membrane. Severely damaged cells of S. aureus lost electron dense material and cytoplasm. This result suggests that medicinal plant extracts can be used as an effective natural antibacterial agent in food.

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The Quality Characteristics of Jelly Added with Bokbunja (Rubus coreanus Miquel) (복분자를 첨가한 젤리의 품질특성)

  • Yu, Ok-Kyeong;Kim, Ji-Eun;Cha, Youn-Soo
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.37 no.6
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    • pp.792-797
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    • 2008
  • The purpose of this study was to investigate the effects of adding various amounts of ingredients on the physicochemical and sensory characteristics of Bokbunja-jelly. The proximate composition of Bokbunja-jelly was 19.0% for the moisture and 0.8% for the crude protein. The Hunter L-values of Bokbunja-jelly prepared by adding 10 g RME or 120 g sucrose were higher than that of Bokbunja-jelly prepared by adding 20 g RME or 100 g sucrose. The Hunter b-values of Bokbunja-jelly prepared by adding 20 g RME or 120 g sucrose was higher than that of Bokbunja-jelly prepared by adding 10 g RME or 120 g sucrose. The hardness and chewiness were increased with decreasing Rubus coreanus Miquel extracts. According to the results of the sensory evaluation, no significant differences in flavor, sweetness, hardness, elasticity and overall qualities were found. According to the results of physicochemical properties and sensory evaluation, the optimal recipe for preparation of Bokbunja-jelly was determined to be 240 g water, 120 g sugar, 110 g glucose syrup, 4 g agar, 20 g Rubus coreanus Miquel extracts and 0.3 g Rubus coreanus Miquel flavor.