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Effects of Rubus Coreanus Miquel on the Apoptosis of U937 Cells  

Lee, Kwang-Kyu (College of Oriental Medicine, Woosuk University)
Han, Jong-Hyun (College of Oriental Medicine, Wonkwang University)
Oh, Chan-Ho (Department of Food & Biotechnology, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.6, 2009 , pp. 1404-1408 More about this Journal
Abstract
Methanol extracts of Rubus Coreanus Miquel (RCM) were found to exhibit apoptosis induction of U937 human histiocytic leukemia cells. Treatment of RCM exerted strong cytotoxicity against U937 human leukemia cells. RCM induced apoptosis of U937 leukemia cells in a dose dependent manner. Nitric oxide (NO) production was increased in RCM-treated RAW264.7 macrophage cell line. RCM increased the p53 and $NF{\kappa}B$ gene and decreased the $I{\kappa}B$ gene expression in U937 cells. RCM also increased the $NF{\kappa}B$ protein expression, but decreased the PCNA and BcL-xL protein expression in cultured U937 cells. These data suggest that RCM are effective on the apoptosis induction of human leukemia cells and anti-cancer properties.
Keywords
Rubus Coreanus Miquel; apoptosis; p53; $NF{\kappa}B$; BcL-xL; PCNA;
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Times Cited By KSCI : 5  (Citation Analysis)
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