• Journal of Life Science
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• v.33 no.1
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• pp.50-55
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• 2023

This study was designed to determine the activities of Rosa davurica Pall. leaf extract and their regulatory mechanisms in macrophage inflammation. Anti-inflammatory potential of Rosa davurica Pall. leaf extract was evaluated by measuring the nitric oxide (NO) release and inducible nitric oxide synthase (iNOS) synthesis in lipopolysaccharide (LPS)-treated macrophage Raw 264.7 cells. Rosa davurica Pall. leaf extract potently inhibited LPS-induced NO release in a dose dependent manner. However, cell viability decreased to about 50% at high dose of 500 ㎍/ml, resulting in cytotoxicity. LPS-induced iNOS protein expression was also reduced significantly after treatment with Rosa davurica Pall. leaf extract. Furthermore, extract of Rosa davurica Pall. attenuated LPS-mediated phosphorylation of IκB and nuclear factor (NF-κB). Suppression of NF-κB signaling by treatment with PDTC, an NF-κB specific inhibitor, accelerated the inhibition of NO production and iNOS protein expression. These results suggest that Rosa davurica Pall. exhibits the anti-inflammatory potential in LPS-induced macrophage inflammation, partly through inhibition of NO production by down-regulation of NF-κB signaling.

• Horticultural Science & Technology
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• v.33 no.1
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• pp.11-17
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• 2015

The study was conducted to investigate the effect of rootstock on growth and early yield of stenting-propagated cut roses (Rosa hybrida Hort.) 'Pink Aurora' and 'Yellow King'. The scions, prepared as single-node cuttings, each with a five-leaflet leaf, were grafted onto cuttings of Rosa indica 'Major', Rosa multiflora 'Chille Wonye No. 1', Rosa multiflora 'K-1', or Rosa multiflora 'Burr' as the rootstock. The rootstock cuttings were removed of all leaves and buds before grafting. The base of scion and the top of rootstock were held together and simultaneously cut at a $45^{\circ}$ angle for ease of grafting. Scion-rootstock unions were stuck in rockwool cubes and placed on a misted glasshouse bench for rooting before being transplanted into a rockwool slabs for cultivation. Rooting was the greatest in the 'Pink Aurora' and 'Yellow King' grafted on the rootstock Rosa indica 'Major'. In 'Pink Aurora', stem length, stem diameter, five-leaflet leaves per stem, and stem fresh weight of the harvested cut flowers were not affected by the rootstock. The greatest total yield of 'Pink Aurora' was obtained in plants grafted onto the Rosa indica 'Major' rootstock. Overall growth of 'Yellow King' was the greatest in plants grafted onto Rosa multiflora 'Burr' rootstock, although total yield was not affected by the rootstock. These results suggest that Rosa indica 'Major' is the most effective rootstock not only for rooting, but also for early yield and growth for stenting propagation of these cut roses.

• Journal of the East Asian Society of Dietary Life
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• v.20 no.2
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• pp.321-327
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• 2010

Two different mixing ratios of Rosa rugosa and Rubus crataegifolius (Korean raspberry), including Rosa rugosa and one part Rosa rugosa vs five parts Rubus crataegifolius were prepared, and their fermentation characteristics were investigated during 28 days of ethanol fermentation and subsequent aging. The final $^{\circ}Brix$ and pH of Rosa rugosa wine were 12.0 and 2.9, respectively, while those of Korean raspberry-Rosa rugosa wine were $7.0^{\circ}Brix$ and pH 3.4, respectively. The final ethanol contents were 5.0% (v/v) in Rosa rugosa wine and 9.8% in Korean raspberry-rugosa wine. The level of antocyanine content, color intensity, organic acid, and free amino acid concentrations in Rosa rugosa wine were lower than those of Korean raspberry-Rosa rugosa wine. Thus, our results demonstrate that supplementation of Rosa rugosa with Korean raspberry prior to alcohol fermentation may help improve the fermentation characteristics of Rosa rugosa wine in the final product.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.5
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• pp.866-871
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• 2010

The antidiabetic effects of Rosa rugosa Radix were investigated in streptozotocine-induced diabetic rats. Research methods and procedure: In the present study, effects of oral administration of Rosa rugosa Radix extract(100, 250, and 500 mg/kg body wt.) for 28 days on the level of serum glucose, total cholosterol, triglycerides, cereatinine, aspartate amino transferase(AST) and alanine amino transferase(ALT) in normal and streotozotocine-induced diabetic rats were evaluated. Oral administrations of the Rosa rugosa Radix extract significantly decreased serum glucose, total cholesterol, triglyceride, AST, and ALT levels, while increased serum insulin and HDL-C in diabetic rats(p<0.05). The hypoglycemic effect of the Rosa rugosa Radix extract was more effective than normal group. It is concluded that the Rosa rugosa Radix must be considered as excellent candidate for future studies on diabetes mellitus.

• Korean Journal of Plant Resources
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• v.34 no.3
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• pp.197-202
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• 2021

We found Rosa laevigata Michx., a newly alien plant in Songjinpo-ri, Jangmok-myeon, Geoje-si, Gyeongsang nam-do. Rosa laevigata is native to China, Taiwan, and Vietnam. It is reported as a naturalized species in Japan, South Africa, United States, and the Pacific Islands. Rosa laevigata is distinguished from R. multiflora by the large size of its flower. Its Korean name is 'Wang-jjil-re-na-mu' based on the large flower. Here, we provide precise description, taxonomic key to Korean Rosa species, illustrations and photographs of its habit.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10351-10354
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• 2015

Background: Rosa Roxburghii Tratt is a promising wild fruit crop in Southwest China. Its extracts have been used as traditional Chinese medicine, which benefit immune responses and cure various health disorders. However, whether Rosa Roxburghii Tratt polysaccharides could inhibit metastasis and invasion of ovarian cancer cells remains unknown. Materials and Methods: Effects of crude polysaccharides from Rosa Roxburghii Tratt on the viability of ovarian cancer A2780 cells were detected by MTT assay. Ovarian carcinoma cell migration and invasion after exposure to Rosa Roxburghii Tratt polysaccharides were quantified by wound healing and Transwell assays, respectively. Western blotting was applied to assess protein levels of MMP-9. Results: The results indicated that Rosa Roxburghii Tratt polysaccharides significantly reduced wound closure rate of A2780 cells, inhibited their migration and invasion, and suppressed the expression of MMP-9. Conclusions: Our findings indicated that Rosa Roxburghii Tratt polysaccharides have potential for develop as anti-metastatic cancer drug preparations for ovarian cancer patients.

• Nuclear Engineering and Technology
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• v.41 no.6
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• pp.753-764
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• 2009

JAEA started the LSTF experiments in 1985 for the fourth stage of the ROSA Program (ROSA-IV) for the LWR thermal-hydraulic safety research to identify and investigate the thermal-hydraulic phenomena and to confirm the effectiveness of ECCS during small-break LOCAs and operational transients. The LSTF experiments are underway for the ROSA-V Program and the OECD/NEA ROSA Project that intends to resolve issues in thermal-hydraulic analyses relevant to LWR safety. Six types of the LSTF experiments have been done for both the system integral and separate-effect experiments among international members from 14 countries. Results of four experiments for the ROSA Project are briefly presented with analysis by a best-estimate (BE) code and a computational fluid dynamics (CFD) code to illustrate the capability of the LSTF and codes to simulate the thermal-hydraulic phenomena that may appear during SBLOCAs and transients. The thermal-hydraulic phenomena dealt with are coolant mixing and temperature stratification, water hammer up to high system pressure, natural circulation under high core power condition, and non-condensable gas effect during asymmetric SG depressurization as an AM action.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.3
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• pp.459-465
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• 2011

The nuclear factor of activated T cells (NFAT) protein induces transcriptions of cytokine genes including IL-2 for T-cell activation. Normally activation of NFAT is important to induce immune responses but excessive NFAT activation provokes immunopathological reactions such as autoimmunity, transplant rejection, and inflammation. Thus, for the treatment of autoimmune diseases drugs repressing the activation of NFAT have been searched. In this study, immnunosuppressive effects of Rosa chinensis Jacq. extracts identified as a potent NFAT inhibitor from a natural product library were examined. NFAT reporter assay, MTS assay, real time PCR, IL-2 ELISA, MLR, and FACS (Fluorescent Activated Cell Sorting) were used to measure inhibitory immunocyte activities of Rosa chinensis Jacq. The variety of natural products have been screened and some were found to show inhibitory activities against the NFAT transcription factor. Among them, extract of Rosa chinensis Jacq. showed an strong inhibitory effect on the activation of NFAT without affecting cell viability. Levels of IL-2 transcripts as well as IL-2 protein were decreased with treatment of Rosa chinensis Jacq. extract. In addition, immunosuppressive activity of Rosa chinensis Jacq. extract was exhibited in the mixed leukocytes reaction. The increasement of CD4+CD25+ (Treg) immunocyte was also detected in the analysis using FACS after applying Rosa chinensis Jacq. extract. Immunosuppressive effects of the Rosa chinensis Jacq. extracts were clearly demonstrated in the present study. In addition, Rosa chinensis Jacq. extract also positively affected regulatory T cell induction. Further investigations in particular on purification of single substance responsible for the immunosuppressive effects from the extract and analysis on possible actions of the extract in interfering cell signaling and cytokine production will be needed.

• The Korean Journal of Food And Nutrition
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• v.28 no.2
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• pp.320-327
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• 2015

Since Korean ancient times, powder of Rosa rugosa Thunberg has been used as a folk remedy. This study was conducted to verify the effects of Rosa rugosa Thunberg powder on in vitro antioxidant properties and serum lipid levels of high-fat diet-induced mice from a nutritional viewpoint. In the case of Rosa rugosa Thunberg powders, measurement of TPC, ABTS radical scavenging activity of trolox, DPPH radical scavenging activity, and measured value of FRAP were higher in ethanol extract than water extracts. For LDL-cholesterol concentration, mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a high numerical value compared with other groups (p<0.05). When testing for triglyceride concentrations in blood, mice fed 10% and 20% powder of Rosa rugosa Thunberg with high-fat diets showed the lowest numerical values (p<0.05). When testing for blood insulin concentrations, the high-fat diet group showed higher levels than compared to the control group (p<0.05). When testing for blood leptin concentrations, the high-fat diet group was $5.88{\pm}3.53ng/dL$, whereas mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a blood leptin level of $10.36{\pm}5.96ng/dL$ (p<0.05). Therefore, results prove that powder of Rosa rugosa Thunberg reduces triglyceride concentrations in the blood, and could be used as an excellent natural antioxidant in the future.

• Natural Product Sciences
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• v.9 no.2
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• pp.49-51
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• 2003

The underground part of Rosa rugosa Thunb. has been used in Korean folk medicine for treating diabetes. The $^{1}H-NMR$ signal of procyanidin B3 isolated from Rosa rugosa was fully assigned by utilizing $^{1}H-^{1}H$ COSY. Procyandin B3 showed a moderate inhibitory activity against HIV-1 protease.