• Archives of Pharmacal Research
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• 제25권6호
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• pp.807-816
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• 2002

Dihydrofolate reductases (DHFR) of human, Candida albicans and E. coli were docked with their original ligands of X-ray crystal complex using QXP (Quick eXPlore), a docking program. Conditions to reproduce the crystal structures within the root mean square deviation (rmsd) of 2.00 $\AA$ were established. Applying these conditions, binding modes and species-specificities of a novel antibacterial compound, $N^4-(2-acetoxyethoxymethyl)-2-acetylpyridine$ thiosemicarbazone (MTSC), were studied. As the results, the docking program reproduced the crystal structures with average rmsd of six ligands as 0.91 $\AA$ ranging from 0.49 to 1.45 $\AA$. The interactions including the numbers of hydrogen bonds and hydrophobic interactions were the same as the crystal structures and superposition of the crystal and docked structures almost coincided with each other. For AATSC, the results demonstrated that it could bind to either the substrate or coenzyme sites of DHFR in all three species with different degrees of affinity. It confirms the experimentally determined kinetic behavior of uncompetitive inhibition against either the inhibitor or the coenzyme. The docked MTSC overlapped well with the original ligands and major interactions were consistent with the ones in the crystal complexes. The information generated from this work should be useful for future development of antibacterial and antifungal agents.

• 동의생리병리학회지
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• 제19권1호
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• pp.224-229
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• 2005

Ginseng radix, the root of Panax ginseng C.A.Meyer (Araliaceae), has traditionally been used for the treatment of various disorders including cerebrovascular accident (CVA). In the present study, the effect of Ginseng radix on c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia was investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced c-Fos-, TUNEL-, and caspase-3-positivities were detected in the hippocampal CA1 region in ischemic gerbils. Administration of the aqueous extract of Ginseng radix suppressed this ischemia-induced increment in the numbers of c-Fos-, TUNEL-, and caspase-3-positive cells. These results suggest that Ginseng radix has an inhibitive effect on the induction of c-Fos expression and apoptosis seen following transient global ischemia.

• Natural Product Sciences
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• 제16권4호
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• pp.291-294
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• 2010

In obesity, adipocytes undergo abnormal growth characterized by increased cell numbers and differentiation. Thus, inhibition of mitogenesis of preadipocytes and their differentiation to adipocytes would be beneficial for the prevention and progression of obesity. In the present study, we attempted to evaluate antiadipogenic activity of adlay (Coix seed, the seed of Coix lacryma-jobi L. var. ma-yuen Stapf) employing preadipocytes cell line, 3T3-L1 as an in vitro assay system. Because several varieties of adlay are in use in Korea, anti-adipogenic activity of three varieties of adlay such as Sang-Gang, Jo-Hyun and Yulmu-Ilho was evaluated. All the three varieties of adlay showed significant inhibitory activity on adipocyte differentiation as assessed by measuring fat accumulation using Oil Red O staining. Adlay, however, showed little effects on adipocyte proliferation. Further studies with interval treatment demonstrated that adlay exerted inhibitory activity on adipocyte differentiation via acting on early stage of adipogenesis. Taken together, adlay might be useful in the prevention of obesity.

• 원예과학기술지
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• 제17권5호
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• pp.569-571
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• 1999

백침계 오이 '샤프 1호'의 9월 파종 재배시 저온기(11월~익년 2월)에 다수확할 수 있는 정지방법을 구명코자 2개년간('98~'99)에 걸쳐 시험한 결과, $m^2$당 마디수, 엽면적, 수관 상부의 엽면적 분포비율 및 근중 등은 측지재배구가 가장 많았고, 주지+측지재배구, 주지재배구 순이었다. 총수량 및 상품과(商品果) 수량도 같은 경향 이었다. 유인작업에 소요되는 노동력은 측지재배구가 가장 적었고, 주지재배, 주지+측지재배구 순으로 많았다.

• 아시안잔디학회지
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• 제3권1호
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• pp.5-12
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• 1989

Tiller numbers per Unit area were increased as plant density heightened followed by little difference in tiller number in 110 days after transplanting(ll0DAT), this being caused by the immediate increment of tiller since' 90DAT During the growth period, the greatest number of green leaves per unit area was attained in 90DAT of both 160-density and 200-density plots, and in l00DAT of 40-, 80-, and I 20-density plots. Thus, the period to reach the maximum green leaf number with the high plant density was earlier than with the' low plant density. The increment of plant density increased the DM weight of ahoveground part and, with 40-densitytreatment. DNI weight was increased 6.1 times as much up to 110DAT as up to 7ODAT but 2 to 2.9 times with other ehe'nsity treatments. The' rate of increase in stolon length was greatest at the period between 80 and 90DAT when DM weight of stolon showed a large increment. Meanwhile, the average number of stolon was 1.7 at 70DAT but was increased up to 10 at 110DAT probably due to accelerative appeance of Ist stolon branch since 8.0DAT. DM weight of stolon was found to exceeded that of root after 90DAT Thus it was concluded that, when turfs is estahlished from sprig. it may be desirable for first mowing practice to be made at least within l00 days after planting.

• Animal Systematics, Evolution and Diversity
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• 제33권1호
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• pp.8-16
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• 2017

We firstly described a box jellyfish, Carybdea brevipedalia collected from the southern coasts of Korea. It is morphologically characterized by gastric phacellae, a special digestive system of cubozoan jellyfish, and velarium, the thin muscle flap forming the opening of the subumbrellar cavity. The phacellae are linear-shaped, comprising numerous cirri branched from multiple roots. Each root also has multiple numbers of cirrus bundles. Basis of velarial cannels parts into two branches in each octant of velarium. Its geographic distributions were limited to Jeju-do and the middle-southern coasts where the organisms are seriously hazardous to bathers in summer. Numerous individuals and/or large-sized populations were observed specifically from beaches at Jeju-do, Namhae-do and a small fishing port of Namildae, while only a small amount of the individuals was observed in Gamak Bay, Jaran-Goseung Bay, and Geoje-do. We confirmed molecular identity of the Korean C. brevipedalia with comparison of nuclear ribosomal DNA sequences. Until now, Carybdea brevipedalia is the only cubozoan species reported to be distributed in Korean waters.

• 대한기계학회논문집
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• 제19권8호
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• pp.1940-1949
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• 1995

A numerical study for a two dimensional multi-jet with crossflow of the spent fluid has been carried out. Three different distributions of mass-flow rate at 5 jet exits were assumed to see their effects upon the flow characteristics, especially in the jet-flow region. For each distribution, various Reynolds numbers ranging from laminar to turbulent flows were considered. Results show that a fully developed laminar flow exists above a certain Reynolds number whose exact value depends upon the mass flow rate distribution. AS the Reynolds number increases, the flow becomes transitional from downstream and finally a fully developed turbulent flow forms in the jet-flow region. The critical Reynolds number where the fully developed turbulent flow forms is quite dependent upon the distribution of mass-flow rate. One interesting result is that the distribution of the skin friction coefficient along the inpingement plate in the jet-flow region shows a consistent dependency on the Reynolds number, i.e. inversely proportional to the square root of the Reynolds number, regardless of flow regime.

• 대기
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• 제25권4호
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• pp.659-667
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• 2015

In this study, sensitivity of inflow wind speed and turbulent Schmidt number to pollutant dispersion in an urban street canyon is investigated, by comparing CFD-simulated results to wind-tunnel results. For this, we changed systematically inflow wind speed at the street-canyon height ($1.5{\sim}10.0m\;s^{-1}$ with the increment of $0.5m\;s^{-1}$) and turbulent Schmidt number (0.2~1.3 with interval of 0.1). Also, we performed numerical experiments under the conditions that turbulent Schmidt numbers selected with the magnitude of mean kinetic energy at each grid point were assigned in the street canyon. With the increase of the inflow wind speed, the model underestimated (overestimated) pollutant concentration in the upwind (downwind) side of the street canyon because of the increase of pollutant advection. This implies that, for more realistic reproduction of pollutant dispersion in urban street canyons, large (small) turbulent Schmidt number should be assigned for week (strong) inflow condition. In the cases of selectively assigned turbulent Schmidt number, mean bias remarkably decreased (maximum 60%) compared to the cases of constant turbulent Schmidt number assigned. At week (strong) inflow wind speed, root mean square error decreases as the area where turbulent Schmidt number is selectively assigned becomes large (small).

• 한국작물학회지
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• 제23권2호
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• pp.105-112
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• 1978

본 조사연구는 한국재배종 34개품종, 일본재배종 42개품종 및 미국재배종 32개품종등 총 108개품종을 공시하여 근류형성성을 구명하고자 실시하였던 바 그 결과를 요약하면 다음과 같다. 1. 근류형성의 조만은 품종간에 뚜렷한 차리가 있었던 바 파종 14일후에는 근류가 형성되지 않은 품종이 18개품종, 파종 28일후에도 6개품종이나 되었고 특히 42일후에도 미국품종 Flambew는 근류가 형성되지 않았다. 2. 근류수는 품종의 육성모지와 조사시기에 따라 크게 차리가 있었던 바 파종 42일후(3차조사)의 근류수는 일본품종이 26.5개로 가장 많았고 우리나라품종은 19.5개, 미국품종은 15.2개로서 가장 적었다. 3. 주당근류중은 일본품종이 75.9mg로서 가장 무거웠고 한국품종은 71.1mg, 그리고 미국품종은 49.6mg로서 가장 가벼웠다. 4. 근류중과 자실중 및 근류수와는 고도로 유의한 정상관관계가 인정되었으나 기타 몇가지 형질들과는 유의성이 인정되지 않았다.

• Journal of Ginseng Research
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• 제12권1호
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• pp.68-75
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• 1988

산지 반양직묘포 29개포장을 대상으로 육묘방법 및 묘삼생산량을 조사하고 그들 상호간의 관계를 분석하였던 바 그 결과는 다음과 같다. 1. 사용가능묘삼수는 간($180{\times}90$)당 362본, 전묘삼수에 대한 사용가능묘삼수비율(사용가능묘삼비율)은 45%였으며 농가간에 그들의 변이가 심했다. 2. 반양직묘포에서의 사용가능묘삼량은 중량미달묘삼량과 달랭이 묘삼량에 지배되었다. 3. 달랭이 묘삼비율은 상고 및 관수회수와 부의 상관이 각각 인정되었다. 4. 사용가능묘삼비율은 일복의 전.후주 높이와 곡선상관, 일복폭과 부의 상관, 관수회수와는 정의 상관이 각각 인정되었다.