• BMB Reports
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• v.55 no.8
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• pp.380-388
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• 2022

The B cell translocation gene 1 (BTG1) and BTG2 play a key role in a wide range of cellular activities including proliferation, apoptosis, and cell growth via modulating a variety of central biological steps such as transcription, post-transcriptional, and translation. BTG1 and BTG2 have been identified by genomic profiling of B-cell leukemia and diverse lymphoma types where both genes are commonly mutated, implying that they serve as tumor suppressors. Furthermore, a low expression level of BTG1 or BTG2 in solid tumors is frequently associated with malignant progression and poor treatment outcomes. As physiological aspects, BTG1 and BTG2 have been discovered to play a critical function in regulating quiescence in hematopoietic lineage such as Hematopoietic stem cells (HSCs) and naive and memory T cells, highlighting their novel role in maintaining the quiescent state. Taken together, emerging evidence from the recent studies suggests that BTG1 and BTG2 play a central anti-proliferative role in various tissues and cells, indicating their potential as targets for innovative therapeutics.

• Journal of the Korean housing association
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• v.26 no.5
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• pp.143-152
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• 2015

The purpose of this study was to analyze the usage characteristics and the role of spatial and social psychology of open spaces in urban neighborhoods. The survey for this study was conducted on 318 residents in Gyungsan. For analysis, the frequencies and means were calculated, the chi-square test, t-test, and analysis of variance were performed. Survey results revealed that, first, not only the preferred open space type but also the usage characteristics by gender were different. The tendency for males was to visit open spaces to exercise and to stay for longer than one hour. However, the females visited open spaces to care for their children and meet friends or neighbors. They also visited more often than males but stayed for a shorter time. Second, females tended to consider the open space as a place for rest and leisure. Females valued the social psychology aspects of the open space function. Third, regarding the spacial role of open space in urban neighborhoods, study participants believed that the waterside parks improve the quality of life, but were concerned for the safety of children. Considering the social psychology role of open spaces, study participants regarded the waterside parks as improving emotional health. Particularly, they believed the waterside parks played a greater role in daily life as a place for meeting, resting, and leisure than other open space types such as playground, children's parks, and sport parks.

• Journal of the Korean Society of Food Culture
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• v.32 no.6
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• pp.498-512
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• 2017

The aim of this study was to introduce the foods recorded in "Bongjeopyoram", a cookbook, of which the date of production and author are unknown. This was described in an old document belonging to the Hansan Lee family clan from Chungcheongnam-do and revealed its content and significance in the food culture history of Korea to academia for the first time, A close examination of "Bongjeopyoram" showed that, as with other cookbooks from the Joseon Dynasty, it started with methods of making alcoholic beverages. This was followed by recipes for different types of food in the following order: rice cakes and confectioneries, jeol-sik (seasonal foods), daily meals, foods made for jesa (ancestral rites) or a feast, food for weddings, and food for sijeol-jesa (seasonal ancestral rites). The book contained a total of 18 types of alcoholic beverages, 11 types of rice cakes and confectioneries, 20 types of daily meals, 28 types of jeol-sik and food for sijeol-jesa, 12 types of food for jesa and feasts, and 37 types of food for weddings, for a total of 126 types of food and beverages. "Bongjeopyoram" was an ancient cookbook with detailed records on how to carry out jesa, which was an important event hosted by jonggas, or the head family of a family clan, and how to receive and serve guests in the Joseon period. This book is expected to play a valuable role as a guidance with significance as a cookbook of a jongga from the Joseon Dynasty, a time when bongjesajeopbingaek (hosting jesa for one's ancestors and serving one's guest) was considered important.

• School Mathematics
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• v.19 no.1
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• pp.153-170
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• 2017

This study conducted an analysis of types of reasoning shown in students' solving a problem and processes of students' reasoning according to type of problem by posing an open-ended problem where students' reasoning activity is expected to be vigorous and a multiple-choice problem with which students are familiar. And it examined teacher's role of promoting the reasoning in solving an open-ended problem. Students showed more various types of reasoning in solving an open-ended problem compared with multiple-choice problem, and showed a process of extending the reasoning as chains of reasoning are performed. Abduction, a type of students' probable reasoning, was active in the open-ended problem, accordingly teacher played a role of encouragement, prompt and guidance. Teachers posed a problem after varying it from previous problem type to open-ended problem in teaching and evaluation, and played a role of helping students' reasoning become more vigorous by proper questioning when students had difficulty reasoning.

• Child Health Nursing Research
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• v.5 no.1
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• pp.5-17
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• 1999

This study was designed to determine the schemata and their characteristics of stress experience the subjectivity of stress experience(structure of subjectivity) would be a basic step for the effective clinical education through the stress management for characteristics of these types. Q-methodological method was used for that purpose. The research method statements were collected prior to the study through indepth interviews. For the study, 31 Q-statements were selected. There were 34 nursing students as subjects for the research. The 34 nursing students sorted the 31 statements using the principal of forced normal distribution. The principle of forced normal distribution, which has 9 scales to measure the individual opinions, was called. Q-factor analysis by using PC QUANL program supply the material. According to the outcomes of this study, there were 3 types of special opinion about the stress experience of clinical practice. The first type is called 'Influence of practical atmosphere type'. Members of this type experienced stress by an inadequate orientation and undesirable role model of nursing. The second type is called 'conflict of nursing role type'. Members of this type experienced stress by an inadequate orientation and undesirable role model of nursing. The third type is called 'Lack of confidence type'. Members of this type experienced stress because of a lack of confidence for their own nursing knowledge and skill. As a result, we now need further study to identify individual psychological aspects of stress for clinical practice. The findings will guide the development in effective approaches for clinical education. Finally, the result of the study will provide us the need for developing systematic and integrated practice education program for students and active involvement of clinical instructor.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1521-1525
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• 2014

Background: Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and the association between HPV infection and genital cancers has been well established. This study concerned the possible role of HPV infection in colorectal carcinoma (CRC) in the Iranian population. Materials and Methods: We examined 80 tissues obtained from patients with colorectal cancer consisting of 58 colon cancer samples and 22 rectal cancer samples and 80 tissues from patients with unremarkable pathologic changes as matched controls by sex, study center and anatomical sites. HPV infection and genotypes were detected using nested PCR and sequencing methods, respectively. Results: HPV DNA was detected in 5/80 (6.25%) cases including 1 of 22 (4.54%) patients with rectum cancer and 4 of 58 (6.9%) patients with colon cancer and 1/80 (1.25%) of controls. Furthermore, HPV-18 was detected as the most frequent type and we found no significant correlation between prevalence of HPV infection and anatomical sub- sites. Conclusions: Although a causal relation between human papillomavirus and colorectal cancer was not found through this study, analysis of medical records pointed to a possible role for high- risk types of HPV in increasing the potential of aggressiveness in colorectal cancer. This study shows a particular frequency of HPV genotypes in patients with colorectal cancer in Iran. Since HPV vaccines are limited to a few types of virus, using cohort studies in different geographical zones to screen for patterns of HPV infection in different organs might increase the efficacy and optimization of the current vaccines.

• Journal of Technology Innovation
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• v.18 no.1
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• pp.21-51
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• 2010

This paper examines the knowledge transfer effect in Korean venture systems. Existing literature has provided rich evidence of the effect of knowledge transfer, but we do not have micro mechanisms inherent in the process of knowledge transfer. This paper argues that knowledge transfer effects vary depending on the knowledge types, sources, and legacy. This paper also tests role of the two important pillars in knowledge transfer of Korean venture startups; venture capital and government. This paper also examines the role of absorptive capacity in the knowledge transfer process. With 1,862 sample of Korean venture firms, this study employed three methods depending on 3 different types of dependent variables: hierarchical regression, logistic regression, and survival analysis. Main findings include that 1) knowledge characteristic itself and its alignment with industry influence the knowledge transfer effects, 2) government support has a negative effect on financial performance of venture firms, but does not have significant interaction effect on knowledge transfer, and 3) the absorptive capacity of each firm moderates the knowledge transfer effects. The theoretical and practical implications are discussed.

• Child Health Nursing Research
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• v.8 no.3
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• pp.344-356
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• 2002

This study was conducted to analyse the current clinical education of pediatric nursing in baccalaurate nursing program, then to give basic data for enhancing the quality of future clinical education of pediatric nursing. Data were collected through self-reported questionnaire by mail from December 2001 to February 2002. The subjects were 29 schools of 50 baccalaurate nursing education programs. The data were analysed by double raters, researcher and assistant researcher. The results were summarized as follows: 1. Twenty-eight schools had the objectives of the clinical education of pediatric nursing, and 28 schools in pediatric ward, 23 schools in nursery, 22 schools in neonatal intensive care unit(NICU), 15 schools in objectives related to profession by clinical site. 2. Credits on clinical education of pediatric nursing were most 15 schools of 3 credits. 3. The clinical sites were mainly the hospital that sick children were admitted in. 4. The clinical teacher were 9 types including pediatric professor and field nurse. 5. On teacher's role, the professor instructed the case study and conference, and field nurse instructed the patient assignment and nursing procedures. 6. All of schools used explanation and conference as a method of clinical education, 1 or 2 schools used PBL or role play or field study. 7. On clinical education content, most of school included Apgar scoring system, physical examination in newborn assessment, respira- tion maintenance, temperature maintenance, infection prevention, nutrition, and bath in newborn care. 8. On clinical education content, most of school included care of incubator, phototheraty, infusion, gavage feeding and how to use the instruments in NICU. Eighteen schools included attachment promotion, and 20 schools case study. 9. On clinical education content, most of school included a checklist of nursing procedures, case study, assessment of growth and development in pediatric ward and other sites. 10.There were various evaluation types in scores, measuring items. In conclusion, the results of this study revealed that there were some discrepancy in the objectives and contents, clinical sites on hospital focused, teacher's role, and diversity of measurement items and ratings in clinical education of pediatric nursing. There is a need for a standardization of content, clinical site, and evaluation tool to improve a quality of clinical education of pediatric nursing based on this study.

• Journal of the Korean housing association
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• v.25 no.4
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• pp.83-91
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• 2014

The purpose of this study is to clarify the characteristics between the type of daily routine and spatial configuration of activity areas in classroom and provide alternatives for space planning of activity areas in classroom of child-care centers. This study used the content analysis on daily activity plan and floor plans through field survey. Analysis on floor plans was conducted for 35 classrooms in 9 child-care centers which allowed field survey. The results of this study were as follows; There was no significant difference for classroom size according to the type of daily routine in 3 to 5-year-old classrooms. The average size of classrooms was $61.6m^2$ for care oriented type, $41.4m^2$ for indoor activity oriented type and $48.8m^2$ for group activity oriented type. There was no significant difference in composition of activity areas in classrooms according to the type of daily routine. In case of 0 to 2-year-old classrooms, they were composed of 6 activity areas including gross-motor, role play, block building, language, creative expression, exploration/manipulation. Activity area of the most low frequency was gross-motor area. In case of 3 to 5-year-old classrooms, most classrooms were composed of all the 7 activity areas including art, tone and rhythmic, block building, role play, language, math and science. Most accessible and central areas in 0 to 2-year-old classrooms were gross-motor and role play. Also, most separate areas were exploration/manipulation and block building. Most accessible and central areas in 3 to 5-year-old classroom were art and math. Also, most separate areas were tone and rhythmic and science.

• The Journal of Information Systems
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• v.8 no.1
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• pp.149-176
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• 1999

Regional information infrastructure(RII) plays an increasingly important role in determining the competitiveness of companies operating within the region. The purposes of this research are (1) to identify the types of RII demanded by the companies operating within Pusan and KyungNam areas in Republic of Korea, (2) to explain the levels of RII demand using variables including organizational environment, organizational strategy, and the importance of information systems for the organization, and (3) to examine whether the types of RII demand are different depending on the competition strategies that companies are pursuing. The most important type of RII that region companies demand is information systems personnel having knowledge in systems control, systems planning, communication network, database administration, and system construction. In addition, demanded are TSDN, satellite communication network, and shareable software and hardware. The levels of RII demand are different depending on the importance of information systems(IS) roles for the businesses. The more important IS role is for a company, the more sharable computing equipments and facilities are demanded. The importance of IS role is affected by the organizational environment and organizational strategy. The levels of RII demand are different also depending on the competitive advantages that companies are pursuing. Companies focusing on achieving short-term and direct benefits using information technology tend to have higher demands on sharable computing equipments and facilities as well as on information communication services. This research is explorative in nature One major limitation of this research, therefore, is that the plausibility of the postulated hypotheses was not examined simultaneously. This research is meaningful in that it first attempted to measure the demands of regional companies for RII.