• BMB Reports
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• v.56 no.3
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• pp.140-144
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• 2023

While CD8⁺ cytotoxic T cells have long been considered the primary effector in controlling tumors, the involvement of CD4⁺ "helper" T cells in anti-tumor immunity has been underappreciated. The investigations of intra-tumoral T cells, fueled by the recent advances in genomic technologies, have led to a rethinking of the indirect role of CD4⁺ T cells that have traditionally been described as a "helper". Accumulating evidence from preclinical and clinical studies indicates that CD4⁺ T cells can acquire intrinsic cytotoxic properties and directly kill various types of tumor cells in a major histocompatibility complex class II (MHC-II)-dependent manner, as opposed to the indirect "helper" function, thus underscoring a potentially critical contribution of CD4⁺ cytotoxic T cells to immune responses against a wide range of tumor types. Here, we discuss the biological properties of anti-tumor CD4⁺ T cells with cytotoxic capability and highlight the emerging observations suggesting their more significant role in anti-tumor immunity than previously appreciated.

• The Korean Journal of Franchise Management
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• v.6 no.1
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• pp.42-68
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• 2015

As franchise industry has grown, the role of a supervisor who is a contact point between franchisor and franchisees has become more vital to success of the business. This research, focusing on his/her specific role, explores communication type, leadership type, and followership type of the supervisor in relations with the organization, franchisor, and franchisees, respectively. Furthermore, we compared performance of franchises by the three types above through the franchise contract management leverage (FCML) which reflects business performance both qualitatively and quantitatively. According to the analysis on supervisors of a franchise business, 'Ganiyeok', the majority of supervisors' communication type were either supportive style or directive style. For the leadership type, team-type and impoverished-type leaders were the majority, while effective or passive followership appeared highest in followership type. In addition, supportive supervisors in communication style, team-type supervisors in leadership style, and effective supervisors in followership had highest FCML, while reflective and directive styles, impoverished style, and passive style had lowest FCML. Primary goal of a franchise business is stable profit generation. This study not only examined what characteristics supervisors need and which style is insufficient, but also proposed tailored solutions for each style. Thus, we confirmed that debates on franchise can be approached in perspective of both communication and business, and we further suggest diverse approaches on future franchise business.

• Culinary science and hospitality research
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• v.20 no.3
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• pp.50-63
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• 2014

The purpose of this study is to analyze the levels of career attitude maturity according to biological sex and sex-role identity types of college students majoring in foodservice. In order to achieve this purpose, 300 students majoring in foodservice-related fields from 4 colleges located in Kyonggi, Daejeon, and Daegu province were selected as a sample. A total of 266 copies of the questionnaire were analyzed after excluding 34 responses. The results of this study were as follows. First, perceived career attitude maturity level of male students was higher than that of female students(p<.05). Second, perceived career attitude maturity level of the students categorized as the androgynous type was the highest, followed by the masculine, feminine and undifferentiated types of students (p<.05). Third, the levels of decisiveness, purposiveness, self-reliance of male students categorized as androgynous, masculine, and undifferentiated types were higher than those of female students. The levels of decisiveness, purposiveness, self-reliance perceived by female students classified as femininity were higher than those of male students. These results show that the androgynous type is considered to be more desirable and positive for career development. Therefore, a career counseling program in needed to enhance androgyny based on biological sex.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.2
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• pp.267-273
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• 2017

The p53-inducible gene 3 (PIG3), initially identified as a gene downstream of p53, plays an important role in the apoptotic process triggered by p53-mediated reactive oxygen species (ROS) production. Recently, several studies have suggested that PIG3 may play a role in various types of cancer. However, the functional significance of PIG3 in cancer remains unclear. Here, we found that PIG3 was highly expressed in human colon cancer cell lines compared to normal colon-derived fibroblasts. Therefore, we attempted to elucidate the functional role of PIG3 in colon cancer. PIG3 overexpression increases the colony formation, migration and invasion ability of HCT116 colon cancer cells. Conversely, these tumorigenic abilities were significantly decreased in in vitro studies with PIG3 knockdown HCT116 cells. PIG3 knockdown also attenuated the growth of mouse xenograft tumors. These results demonstrate that PIG3 is associated with the tumorigenic potential of cancer cells, both in vitro and in vivo, and could play a key oncogenic role in colon cancer.

• Journal of the Korean Society of Costume
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• v.63 no.3
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• pp.166-175
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• 2013

The attire of businesspersons has a significant impact on their social status and career. In accordance with the norms of the work place, the types of office attire are diversified. This research was conducted to determine the relationship between the work role of men and their attire, and how satisfaction with their work attire influences their job satisfaction. This study classifies work attire into three categories: uniform, suit, and freestyle. Data from 268 respondents were analyzed, and four work attire satisfaction factors were extracted: symbolic, quality, role function, and aesthetic factors. The group members wearing uniforms displayed a high level of satisfaction with regard to symbolism, role function, and quality; those wearing suits displayed a high level of satisfaction with regard to aesthetics; and those wearing freestyle displayed a high level of satisfaction with regard to role function and aesthetics. Overall, satisfaction with work attire was the highest in the freestyle group. For people wearing uniforms and suits, symbolism, quality, and aesthetics had a significant influence on overall satisfaction, whereas for those wearing freestyle, symbolism had a negative influence and quality had a positive influence on overall satisfaction. To conclude, work attire satisfaction had a greater effect on the job satisfaction of the men in uniforms and suits than on those wearing freestyle.

• Journal of Korean Home Economics Education Association
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• v.11 no.1
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• pp.1-11
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• 1999

The purpose of this study were to analyze high school girls’sex role identity and underwear purchasing behaviors, and to provide the educational guidelines for high school girls as a underwear comsumer and the fundamental data necessary for the products planning of underwear manufacturing companies. The questionnaire was composed of questions about the types of sex role identity, pursuit factors and purchasing behaviors of underwear. The respondents were girls from 6 high schools in cities in Chonbuk Province. The questionnaires were collected from April 6th to May 12th in 1998. 510 questionnaires were used for data analysis. Frequency, percent, average, standard deviation, F-test, $$\chi$^2$-test, and Duncan’s multiple range test were followed. The results of this study were as follows：1. Among the sex role identity groups, the androgynous group was the largest, and the masculine group was the smallest among high school girls. 2. High school girls sought after practicality most when purchasing underwears, but sought after the brand least. The androgynous group recognized practicality, aesthetics, and sexual attraction most, but the undifferentiated group recognized them least. 3. The high school girls bought underwears objectively when they were worn out, made use of TV, newspaper, and radio advertisements as the information sources, and considered the size, comfort, and style. They recognized the prices of underwears as moderate. They depended on their mother most when purchasing underwears and reflected their dependents opinion on selecting underwears partially. They purchased at the underwear specialty store.

• Journal of Family Resource Management and Policy Review
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• v.17 no.3
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• pp.105-124
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• 2013

This study investigated the influence that the family rituals of unmarried males and females have on satisfaction with life and family role salience, recognizing the necessity to illuminate perceptions related to the original families of unmarried males and females through more diverse perspectives. Questionnaires were given to 601 unmarried male and female adults over 20 years of age. For data analysis, SPSS Win 18.0 was used, and the results are summarized as follows. First, the males and females were divided into three groups: "family with inactive family rituals", "family with active family rituals" or "family with moderate family rituals". There was a significant difference in family role salience depending on family type. Second, family type was classified as a degree of "relation" through common points of two variables, and each group was named as having a family with "satisfying relations," "general relations," or "deficient relations." Third, in the case of males, life satisfaction was high when the level of family economy was high, when parents' first marriage and family actively participated in family rituals.

• Korean Journal of Social Welfare
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• v.59 no.2
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• pp.223-249
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• 2007

In the health care setting which social work services are provided by interdisciplinary team approach, understanding the perception and expectation on the role of social workers worked with medical team is important for social workers to play their role effectively. This study is focused on the medical team members such as doctors, nurses, nutritionists and administrative staffs by researching the type of perception and each characteristics through using the Q methodology. It is concluded that perception on medical social workers is categorized into three types : psycho-social counselor, coordinator/developer of resources, multiple function player. Finding for this study suggest that the implications on social work practice in health care setting.

• The Plant Pathology Journal
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• v.30 no.3
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• pp.269-278
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• 2014

Remorins, a family of plant-specific proteins containing a variable N-terminal region and conserved C-terminal domain, play a role in various biotic and abiotic stresses, including host-microbe interactions. However, their functions remain to be completely elucidated, especially for the Arabidopsis thaliana remorin group 4 (AtREM4). To elucidate the role of remorins in Arabidopsis, we first showed that AtREM4s have typical molecular characteristics of the remorins, such as induction by various types of biotic and abiotic stresses, localization in plasma membrane and homo- and hetero-oligomeric interaction. Next, we showed that their loss-of-function mutants displayed reduced susceptibility to geminiviruses, Beet Curly Top Virus and Beet Severe Curly Top Virus, while overexpressors enhanced susceptibility. Moreover, we found that they interacted with SnRK1, which phosphorylated AtREM4.1, and were degraded by the 26S proteasome pathway. These results suggest that AtREM4s may be involved in the SnRK1-mediated signaling pathway and play a role as positive regulators of the cell cycle during geminivirus infection.

• BMB Reports
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• v.55 no.8
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• pp.380-388
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• 2022

The B cell translocation gene 1 (BTG1) and BTG2 play a key role in a wide range of cellular activities including proliferation, apoptosis, and cell growth via modulating a variety of central biological steps such as transcription, post-transcriptional, and translation. BTG1 and BTG2 have been identified by genomic profiling of B-cell leukemia and diverse lymphoma types where both genes are commonly mutated, implying that they serve as tumor suppressors. Furthermore, a low expression level of BTG1 or BTG2 in solid tumors is frequently associated with malignant progression and poor treatment outcomes. As physiological aspects, BTG1 and BTG2 have been discovered to play a critical function in regulating quiescence in hematopoietic lineage such as Hematopoietic stem cells (HSCs) and naive and memory T cells, highlighting their novel role in maintaining the quiescent state. Taken together, emerging evidence from the recent studies suggests that BTG1 and BTG2 play a central anti-proliferative role in various tissues and cells, indicating their potential as targets for innovative therapeutics.