• The Korean Society of Law and Medicine
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• v.21 no.2
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• pp.163-207
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• 2020

Korea has been positioned as the leading country in the industry of clinical trials as the clinical trail of Korea has developed for the recent 10 years. Clinical trial has plays a significant role in the development of medicine and the increase of curability. However, it has inevitable risk as the purpose of the clinical trial is to prove the safety and effectiveness of new drugs. Therefore, the clinical trial should be controlled properly to protect the health of the subjects of clinical trial and to ensure that they exercise a right of self-determination. In this context, the fiduciary duties of doctors who conduct clinical trials is especially important. The Pharmaceutical Affairs Act and the relevant regulations define several duties of doctors who conduct clinical trials. In particular, the duty to protection of subjects and the duty to provide information constitute the main fiduciary duties to the subjects. Those are essentially similar to the fiduciary duties of doctors in usual treatment from the perspective of the values promoted by the law and the content of the law. Nonetheless, clinical trials put more emphasis on the duties to provide explanation than in usual treatment. Further research and study are required to establish the concrete standard for the duty of care. However, if the blind pursuit of higher standards for the duty of care or to pass the burden of proof to doctors may result in disrupting the development of clinical trials, limiting the accessibility of patients to new treatment and even violating the principle of sharing damage equally and properly. In addition to these duties, the laws of clinical trials define several duties of doctors. Any decision on whether the violation of the law constitutes the violation of the fiduciary duty and justifies the demand for compensation of damages should be based on whether relevant law aims to protect the safety and benefit of subjects, even if in an incidental way, the degree to which such violation breaches the values promoted by the law and the concrete of violation of benefit of law, the detailed acts of such violation. The legal interests of the subjects can be protected effectively by guaranteeing compliance with those duties and establishing judicial and administrative controls to ensure that the benefit of subjects are protected properly in individual cases.

• Journal of Navigation and Port Research
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• v.32 no.1
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• pp.97-102
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• 2008

According to the trend of a large-sized vessel and a industrial carrier, the role of the independent contractors such as transport terminal operators, stevedores and warehousemen is increasing the base of cargo distribution that include the function of storage, warehousing, loading, unloading, trimming, dunnaging and lashing. But the common law doctrine of privity of contract has been a perennial source of difficulty for litigants seeking to enforce rights and obligations arising under a bill of lading contract. When carriage contract is negotiated, the concerned parties will be aware that some portion of obligations arising from the contract will be performed by the independent contractors engaged to carry out a particular function. It is reasonable for the independent contractors to be allowed the benefit of the carrier under the contract of carriage. As a part of the alleviating measures for the liability of independent contractors has been allowed various schemes, specially including 'Himalaya Clause'. Therefore, this study performed the validity of 'Himalaya Clause' by means of a recent judicial precedent by the Supreme Court and analyzed the rights of third parties, specially transport terminal operators, under the contract of carriage.

• Korean Journal of Veterinary Service
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• v.35 no.4
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• pp.327-332
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• 2012

This study aimed to see if as companion animals living with human beings, dogs could provide emotional stability or play a therapeutic role for human beings. Of 12 middle school boys as victims of school violence, 6 were assigned to the experimental group that was provided with an animal-assisted therapy program over a total of 12 sections, one section per week, 60 minutes per section, between September and November 2011, followed by post-test 1 and, one month later, post-test 2. In the experimental composition, the remaining 6 boys were assigned to the comparison group that was allowed to read freely. Analysis was performed by using the scales of depression and self-esteem, and the results showed that the experimental group provided with the animal-assisted therapy program generated more significant therapeutic effects than the comparison group. The therapeutic effects were found to persist one month after the completion of the program. Therefore, it is believed that sensitive adolescents who suffer from depression or have lost self-esteem because of school violence can significantly benefit from an animal-assisted therapy program by reducing the recovery time or by getting lots of help with emotional stability. Further research on the basis of this study is expected to help adolescents with emotional therapy in other areas.

• Journal of Gastric Cancer
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• v.20 no.2
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• pp.115-126
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• 2020

Peritoneal metastasis (PM) frequently occurs in patients with gastric cancer (GC) and confers a dismal prognosis despite advances in systemic chemotherapy. While systemic chemotherapy has poor peritoneal penetration, intraperitoneal (IP) chemotherapy remains sequestered, resulting in high peritoneal drug concentrations with less systemic side-effects. The first application of IP treatment was hyperthermic intraperitoneal chemotherapy (HIPEC) with cytoreductive surgery (CRS) for gastric cancer peritoneal metastasis (GCPM); but was associated with an increased morbidity and mortality rate without significantly improving overall survival (OS). While CRS confers limited benefit, the potential role of prophylactic HIPEC and laparoscopic neoadjuvant HIPEC are currently being evaluated. Combination systemic and IP chemotherapy (SIPC) gained popularity in the 1990s, since it provided the benefits of IP treatment while reducing surgical morbidity, demonstrating promising early results in multiple Phase II trials. Unfortunately, these findings were not confirmed in the recent PHOENIX-GC randomized controlled trial; therefore, the appropriate treatment for GCPM remains controversial. Small observational studies from Japan and Singapore have reported successful downstaging of PM in GC patients receiving SIPC who subsequently underwent conversion gastrectomy with a median OS of 21.6-34.6 months. Recently, the most significant development in IP-directed therapy is pressurized IP aerosol chemotherapy (PIPAC). Given that aerosol chemotherapy achieves a wider distribution and deeper penetration, the outcomes of multiple ongoing trials assessing its efficacy are eagerly awaited. Indeed, IP-directed therapy has evolved rapidly in the last 3 decades, with an encouraging trend toward improved outcomes in GCPM, and may offer some hope for an otherwise fatal disease.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.2
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• pp.115-122
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• 2016

The classical statistical approach using test data samples to estimate true value of Random Variables by calculating mean and variation (standard deviation or coefficient of variation) of samples is very useful to understand the existing condition of the structure. But with this classical approach, our prior knowledge through educational background and professional experience cannot provide any benefit to make decisions by the structural engineers. This paper shows the role of Bayesian methodology by providing chance of using valuable prior knowledge to come up with more accurate estimation of structural condition. This paper also shows how important it is to have a proper prior estimate of Random Variables and corresponding confidence level through gathering and studying more relevant information.

• Journal of Digital Contents Society
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• v.19 no.6
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• pp.1145-1150
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• 2018

In order to realize the new diplomatic development for the establishment of 'Asia Fate Community', Xi Jinping has adopted a "One Road, One Belt" policy. Based on five core philosophies, One Road, One Belt with neighboring countries has been established to full-sided cooperation and mutual benefit relations. In this paper, I would like to suggest some suggestions on how to use China's One Road, One Belt policy and Korea's Eurasian Initiative in Development strategy of tourism contents. First, The bridge role of Korean companies should lead to the development of tourism contents. Second, the promotion of tourism contents development for Chinese individual tourists should lead to another tourism contents. Third, we need to find ways to win joint orders with local companies in China so that they can lead to tourism contents. Fourth, seeking active use of workers and international students living in Korea. Fifth, the development of tourism contents based on cooperative relationship with North Korea.

• Journal of The Korean Society of Agricultural Engineers
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• v.57 no.4
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• pp.11-19
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• 2015

The important properties of EVA (ethylene vinyl acetate) redispersible polymer was waterproof, densification of internal pore space of concrete and ball bearing and micro filler. Also, the significant role of polypropylene(PP) fiber was crack control and blockade of movement for deterioration factors. The most studies for EVA were limited in the field of mortar and PP fiber reinforced concrete had been studied in the state of being restricted unit water content, rich mix and mixing much of the fiber without considering construction site. Therefore, the control mix design were applied in ready mixed concrete using 10 % fly ash of total cement weight used in batch plant. On the basis of control mix design, EVA contents ranging from 0 % to 10 % of total cement weight and PP fiber contents ranging from 0 % to 0.5 % of EVA concrete volume were used in the mix designs. The results showed the maximum compressive strength value was measured at EVA 5.0 % and PP fiber 0.1 %, the minimum water absorption ratio was at EVA 10 % and PP fiber 0 %, the durability factor for freezing and thawing resistance was at EVA 5.0 % and PP fiber 0.3 % and the minimum weight reduction ratio of resistance to sulfuric acid attack was at EVA 10 % and PP fiber 0.5 % after curing age 42days. Meanwhile, From these results, PP fiber reinforced EVA concrete would be very benefit, if each optimal mix types were used in hydraulic structures, underground utilities and agricultural structures.

• Journal of the Korea Society of Computer and Information
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• v.25 no.1
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• pp.151-157
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• 2020

This study explored the moderating effects of security ability on the influence of privacy concerns on internet activity using Korea media panel survey data. To this end, we applied between-subjects factorial design between 2 (privacy concern high / low) × 2 (security ability high / low) groups and compared five types of internet activity among four groups by variance analysis. As a result, privacy concerns have a main effect on internet activity, and security ability have a moderating role in this relationship. Despite the privacy concerns, people do their internet activities in order to enjoy the benefit from the internet. This study have academic implication in that it focus on the issue of privacy paradox in terms of the type of internet activity. In addition, practical implications are that, in order to activate online activities of individuals in an internet-connected society, efforts for enhancing their security abilities are necessary.

• Journal of Korean Neurosurgical Society
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• v.63 no.1
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• pp.14-25
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• 2020

Proximal flow control achieved with a balloon guide catheter (BGC) during endovascular treatment of acute ischemic stroke is reviewed in this article. In clinical practice, BGCs offer a multi-faceted approach for clot retrieval by creating proximal flow arrest, reducing embolic burden, and shortening procedure time. Evaluation of frontline thrombectomy procedures with BGCs revealed advantages of combined use over the conventional guide catheter (CGC), notably in the significant reduction of distal emboli to both the affected and previously unaffected territories. Recently, new measures of early and complete reperfusion at first thrombectomy pass have been identified as independent predictors of improved outcomes, which were consistently demonstrated with use of BGC as a safe and effective option to minimize number of passes during intervention. Prior randomized controlled trials reported the positive correlation between BGC-treated patients and a lower risk of mortality as well as shortened procedure time. While BGC use is more common in stent retriever-mediated mechanical thrombectomy, preliminary data has shown the potential benefit of device application during contact aspiration thrombectomy to achieve successful recanalization. However, the question of which major endovascular strategy reigns superior as a frontline remains to be answered. Along with clinical case assessments, BGC performance during in-vitro simulation was analyzed to further understand mechanisms for optimization of thrombectomy technique.

• Journal of the Korean Society of Costume
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• v.56 no.7 s.106
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• pp.69-78
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• 2006

In the early Joseon when royal authority was not still firmly established, King Taejong, or Lee Bang Won tried to make their political position guaranteed through relationships with Ming, making efforts to develop relations with the Chinese nation positively. This political orientation towards Ming by of the king Taejong was also clearly reflected in the settlement of official uniform in the early Joseon, which can be described as follows. Gaoming(誥命), Yinxin(印信) and Mianfu(冕服) granted by Ming for the first time since the foundation of Joseon suggested that the Chinese nation recognized the formal settlement of Joseon dynasty and the inauguration of King Taejong. presumedly, the grants played a critical role in the firm establishment by King Taejong of his royal authority under unstable political conditions. Under the reign of King Taejong, Joseon tried to abolish ancient regime and, instead, accept systems and institutions of Ming as it maintained smooth relations with the Chinese nation. King Taejong whose royal authority was locally deemed lack in legitimacy and morality wanted to receive the moral recognition of his reign. So the monarch tried to not only strengthen his authority, but also take in advanced culture and civilization through submissive diplomatic relations with Ming. This was a practical diplomatic strategy that was clearly discriminated from toadyism. It was a policy towards Ming, pursuing substantial national benefit. Therefore, official uniform system under the reign of King Taejong should be understood accordingly.