• Journal of Applied Biological Chemistry
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• 제60권2호
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• pp.133-136
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• 2017

Fermentation plays a vital role in the nutritional enrichment of food. Korea has a long tradition of adding fermented food to the daily diet and jeotgal is one of the common fermented and salted foods in Korean cuisine. In our study, we added soymilk as an additive to squid jeotgal to improve its functionality. We mixed different concentrations of soymilk (2, 5, and 10 mg/g) with squid jeotgal samples, fermented them for one week, and then tested their antioxidant and anticancer activities to compare with those of squid jeotgal samples without soymilk additive. To investigate the anticancer characteristics, glutathione-S-transferase (GST)-pi enzyme assay was used. To test the antioxidant activities, various assays were performed, including 2,2-diphenyl-1-picryl hydrazyl free radical scavenging activity, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium saltradical cation scavenging assay, and reducing power assay. Samples fermented with a small amount of soymilk showed excellent anticancer activity. The addition of only 2 mg/g of soymilk to squid jeotgal inhibited the activity of GST-pi by almost 50% when compared with the sample with no addition. Moreover, no undesirable bitterness or astringency was noticed. Our results could help to improve the current food status of squid jeotgal and it could be used to reduce the risk of chronic disease along with its basic nutritional function.

• 한국안전학회지
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• 제27권5호
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• pp.148-157
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• 2012

Reliability-based design optimization (RBDO) problem is usually formulated as an optimization problem to minimize an objective function subjected to probabilistic constraint functions which may include deterministic design variables as well as random variables. The challenging task is that, because the probability models of the random variables are often assumed based on limited data, there exists a possibility of selecting inappropriate distribution models and/or model parameters for the random variables, which can often lead to disastrous consequences. In order to select the most appropriate distribution model from the limited observation data as well as model parameters, this study takes into account a set of possible candidate models for the random variables. The suitability of each model is then investigated by employing performance and risk functions. In this regard, this study enables structural design optimization and fitness assessment of the distribution models of the random variables at the same time. As the first paper of a two-part series, this paper describes a new design method considering probability model uncertainties. The robust performance of the proposed method is presented in Part 2. To demonstrate the effectiveness of the proposed method, an example of ten-bar truss structure is considered. The numerical results show that the proposed method can provide the optimal design variables while guaranteeing the most desirable distribution models for the random variables even in case the limited data are only available.

• 한국안전학회지
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• 제27권5호
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• pp.219-223
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• 2012

For an off-site consequence analysis at nuclear power plant, MELCOR Accident Consequence Code System(MACCS) II code is widely used as a software tool. In this study, the algorithm of web-based off-site consequence analysis program(OSCAP) using the MACCS II code was developed for an Integrated Leak Rate Test (ILRT) interval extension and Level 3 probabilistic safety assessment(PSA), and verification and validation(V&V) of the program was performed. The main input data for the MACCS II code are meteorological, population distribution and source term information. However, it requires lots of time and efforts to generate the main input data for an off-site consequence analysis using the MACCS II code. For example, the meteorological data are collected from each nuclear power site in real time, but the formats of the raw data collected are different from each site. To reduce the efforts and time for risk assessments, the web-based OSCAP has an automatic processing module which converts the format of the raw data collected from each site to the input data format of the MACCS II code. The program also provides an automatic function of converting the latest population data from Statistics Korea, the National Statistical Office, to the population distribution input data format of the MACCS II code. For the source term data, the program includes the release fraction of each source term category resulting from modular accident analysis program(MAAP) code analysis and the core inventory data from ORIGEN. These analysis results of each plant in Korea are stored in a database module of the web-based OSCAP, so the user can select the defaulted source term data of each plant without handling source term input data.

• 한국멀티미디어학회논문지
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• 제20권10호
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• pp.1678-1688
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• 2017

Infiltration is one of detrimental problems occurring in nursing or medical settings. Early detection of infiltration is essential to minimize the risk of injury from infiltration. To perform a preliminary study on the point of care and automated infiltration detection system, bioelectrical impedance was investigated using bioelectrical impedance analyzer. We would like to report experimental results that allow impedance parameters to effectively distinguish infiltration. Electrodes were attached to both sides of the transparent dressing on the fusion site where IV solution was being infused. Then, impedance parameters before and after infiltration were measured as a function of time and frequency. The experimental results are as follows. After infiltration was intentionally induced by puncturing the vein wall with a needle, the resistance gradually decreased with time. That is, when an alternating current having a frequency of 20 kHz was applied to the electrodes, the resistance gradually decreased with time, reflecting the accumulation of IV solution in the extracellular fluid since the current could not pass through the cell membrane. Impedance parameters and equivalent circuit model for human cell were used to examine the mechanism of current flow before and after infiltration, which could be used for early detection of infiltration.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제21권12호
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• pp.792-797
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• 2015

효과적인 모니터링은 시스템을 진단하여 안정성을 향상시킨다. 하지만 타겟 시스템이 고장나거나 모니터링 시스템이 악의적인 공격을 당하면 신뢰성 있는 모니터링을 할 수 없다. 본 논문에서는 가상화를 이용하여 타겟 시스템이 고장나도 지속적인 모니터링이 가능한 시스템을 구현하고 해당 프레임워크를 제안한다. 제안한 프레임워크는 동적 바이너리 계측을 이용하였고, 하이퍼바이저 계층에서 해당 작업을 수행하기 때문에 상위에 있는 운영체제 종류에 상관없이 사용가능한 유연성과 격리성으로 시스템의 안정성을 보장한다. 또한 특별한 디버깅 장비가 필요 없기 때문에 모니터링 비용 면에서 이점을 가져올 수 있다. 본 프레임워크의 소개와 함께 이를 사용한 디버깅 기능을 소개한다. 모니터링 시스템으로 인한 오버헤드를 알기 위해 연산 성능, 메모리 성능, 메모리 대역폭을 측정하였으며 메모리 성능에서 추가 오버헤드가 2% 발생했다.

• 성인간호학회지
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• 제12권1호
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• pp.147-162
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• 2000

Predicting factors of post-stroke depression were investigated. The subjects were 254 stroke patients who had been discharged and visited regularly the outpatient clinic for follow up care. The influencing factors were classified into five categories : demographic, disease-related, current state, social support, and illness intrusiveness. Sex, age, job, and educational level were defined as the demographic factor. The disease-related factors included stroke type, illness duration, attack frequency, and NIH score. ADL, cognitive function, and social activity were considered as the current state factors. The social support was measured as the perceived amount of social support. Illness intrusiveness means the perceived illness induced life style disruptions. Demographic, disease-related, current state, and social support were hypothesized to directly and indirectly affect post-stroke depression through illness intrusiveness. The illness intrusiveness was hypothesized to directly affect post-stroke depression. The hierarchial multiple regression was used to identify significant factors. The result showed that this model explained 43.3% of variance of post-stroke depression. And the prevalence of post-stroke depression was 38.8%. Among the demographic factors, job was identified as a main contributor to indirectly increase the post-stroke depression. Among the disease-related factors, stroke type, attack frequency, and NIH score were found to indirectly affect the post-stroke depression. Among the current state factors, ADL and social activity indirectly affected the post-stroke depression through illness intrusiveness. Social support and illness intrusiveness were identified to directly affect the post-stroke depression. This study has proved the factors likely to be implicated in the development of post-stroke depression. Based upon these results, it is recommended that the nurses who take care of post-stroke patients consider the risk factors such as social support, illness intrusiveness et al. Also programs which decrease the illness intrusiveness and increase the social support to reduce post-stoke depression recommended to be developed.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10393-10396
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• 2015

Background: Endometral carcinoma is the most common malignant tumor of the female genital tract and the fourth most common cancer in women after breast, colorectal and lung cancers Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates cellular response to hypoxia HIF-1 plays important roles in the development and progression of cancer through activation of various genes that are involved in crucial aspects of cancer biology, including angiogenesis, energy metabolism, vasomotor function, erythropoiesis, and cell survival. In this study, we aimed to investigate the association between HIF-1 1772 C/T polymorphisms and endometrial cancer. Materials and Methods: 75 patients with endometrial carcinoma and 75 patients whose underwent hysterectomy for non tumoral indication selected for evaluation of HIF-1 1772 C/T polymorphisms by PCR-RFLP and sequencing. Results: For the 1772 C/T polymorphism, the analysis showed that the T allele and genotype TT were significantly associated with endometrial cancer risk. Conclusions: Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial cancers.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6643-6647
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• 2014

The breast and the thyroid are hormone responsive organs that are closely related with changes of endocrine function and glandular disease. An association between thyroid disorders and breast cancer (BC) risk has been suggested, although the results are inconclusive. The purpose of the present study was to summarize evidence supporting a relationship between BC and the level of thyroid hormones and antibodies. The MEDLINE and EMBASE electronic databases were searched for studies published between 2000 and 2014. The pooled effects were presented as weighted mean differences (WMD) with 95% confidence intervals (CI) using fixed or random effect models. We summarized the results of 8 cross-sectional studies with 4, 189 participants. The overall pooled results showed that the levels of $FT_3$ and $FT_4$ were significantly increased in patients with BC (WMD=1.592 pmol/l; 95% CI: 0.15-3.033 and WMD=0.461 ng/dl; 95% CI: 0.015-0.906; p=0.043). The TPOAb level in patients with BC was higher than that in the control group (WMD=81.4 IU/ml; 95% CI: 78.7-84.0; p=0.000). The overall pooled results of the TgAb with random effects analyses showed that the TgAb level was significantly increased in patients with BC (WMD=101.3 IU/ml; 95% CI: 48.7-153.9; p=0.000). The present results indicated that the serum levels of $FT_3$, TPOAb and TgAb are significantly higher in patients with breast cancer than in healthy controls.

• 한국콘텐츠학회논문지
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• 제17권12호
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• pp.558-568
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• 2017

본 연구의 목적은 노인 암 환자의 신체활동 부족의 영향요인을 파악하기 위하여 수행되었다. 본 연구를 위하여 2014년 노인실태조사 원시 자료가 사용되었으며, 이중 암을 진단 받고 현재 치료 중인 65세 이상 노인 암 환자 418명의 자료가 분석되었다. 신체활동 수준을 측정하기 위하여 연구대상자들이 자가보고한 신체활동의 종류, 일주일간 수행 빈도 및 시간을 이용하여 대사활동량(Metabolic Equivalent Tasks, MET hours)을 계산하였다. 단순 및 다중 로지스틱 회귀분석 방법을 이용하여 분석한 결과, 노인 암 환자의 신체 활동 부족 영향요인에는 일상생활수행능력 및 도구적 일상생활수행능력 제한, 현재 흡연자, 낮은 사회적 활동 참여 빈도, 우울증, 인지기능 저하, 낮은 사회여가활동 만족도 등이 포함되었다. 일반적 특성을 통제했을 때, 일상생활수행능력 제한이 있는 환자들은 제한이 없는 환자들보다 약 2.8배(OR=2.762, CI=1.110, 7.952), 현재 흡연자의 경우 비흡연자보다 약 2.4배(OR=2.426, CI=1.113, 5.288) 신체활동 부족 위험이 큰 것으로 나타났다.

• 한국항행학회논문지
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• 제21권1호
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• pp.107-112
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• 2017

최근 가정이나 산업용 건물에서 컴퓨터, TV, 냉장고, LED 조명 등 가전기기들의 누전전류에 의한 감전사고가 지속적으로 발생하고 있다. 그리고 가정 내 벽면에 설치된 콘센트에 직접 연결되어 제어 하는 누전차단 모듈들은 모듈 후단에 병렬로 연결된 각각의 가전기기들의 누전상태를 확인하기가 쉽지 않다. 또한 전류가 정상적인 전류의 통로 이외로 흐르는 누전전류를 기존의 누전차단기들은 배전함에 설치되어 누전시 전원을 차단해 주는 역할 을 한다. 가전기기의 누전으로 인한 감전, 화재 등 여러 가지 재해가 발생하여 누전전류의 위험성이 심각하게 제시되고 있다. 이에 근거리 무선통신시스템 중에서 저전력과 저가격 면에서 장점이 많은 IEEE 80215.4 기반의 지그비통신을 이용하여 상시 감시할 수 있는 누전상태 모니터링시스템 구현방안을 제시한다.