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http://dx.doi.org/10.7314/APJCP.2014.15.16.6643

Relationship between Breast Cancer and Levels of Serum Thyroid Hormones and Antibodies: a Meta-analysis  

Shi, Xin-Zhu (Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University)
Jin, Xing (Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University)
Xu, Peng (Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University)
Shen, Hong-Mei (Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.16, 2014 , pp. 6643-6647 More about this Journal
Abstract
The breast and the thyroid are hormone responsive organs that are closely related with changes of endocrine function and glandular disease. An association between thyroid disorders and breast cancer (BC) risk has been suggested, although the results are inconclusive. The purpose of the present study was to summarize evidence supporting a relationship between BC and the level of thyroid hormones and antibodies. The MEDLINE and EMBASE electronic databases were searched for studies published between 2000 and 2014. The pooled effects were presented as weighted mean differences (WMD) with 95% confidence intervals (CI) using fixed or random effect models. We summarized the results of 8 cross-sectional studies with 4, 189 participants. The overall pooled results showed that the levels of $FT_3$ and $FT_4$ were significantly increased in patients with BC (WMD=1.592 pmol/l; 95% CI: 0.15-3.033 and WMD=0.461 ng/dl; 95% CI: 0.015-0.906; p=0.043). The TPOAb level in patients with BC was higher than that in the control group (WMD=81.4 IU/ml; 95% CI: 78.7-84.0; p=0.000). The overall pooled results of the TgAb with random effects analyses showed that the TgAb level was significantly increased in patients with BC (WMD=101.3 IU/ml; 95% CI: 48.7-153.9; p=0.000). The present results indicated that the serum levels of $FT_3$, TPOAb and TgAb are significantly higher in patients with breast cancer than in healthy controls.
Keywords
Breast cancer; serum thyroid hormones; thyroid antibodies;
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1 Ali AM, Mir R, Bashir S, et al (2011). Relationship between the levels of serum thyroid hormones and the risk of breast cancer. J Biology Agriculture Healthcare, 1, 56-9.
2 Altman DG (1998). Sbe24: metan-an alternative meta-analysis command. Stata Tech Bull Reprints, 8, 86-100.
3 Altman DG (2001). Systematic reviews of evaluations of prognostic variables. BMJ, 323, 224-8.   DOI   ScienceOn
4 Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101.   DOI   ScienceOn
5 Biondi B, Cooper DS (2008). The clinical significance of subclinical thyroid dysfunction. Endocr Rev, 29, 76-131.   DOI   ScienceOn
6 Cengiz O, Bozkurt B, Unal B, et al (2004). The relationship between prognostic factors of breast cancer and thyroid disorders in Turkish women. J Surg Oncol, 87, 19-25.   DOI
7 Colditz GA, Burdick E, Mosteller F (1995). Heterogeneity in meta-analysis of data from epidemiologic studies: a commentary. Am J Epidemiol, 142, 371-82.
8 Dai G, Levy O, Carrasco N (1996). Cloning and characterization of the thyroid iodide transporter. Nature, 379, 458-60.   DOI   ScienceOn
9 DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88.   DOI   ScienceOn
10 Dinda S, Sanchez A, Moudgil V (2002). Estrogen-like effects of thyroid hormone on the regulation of tumor suppressor proteins, p53 and retinoblastoma, in breast cancer cells. Oncogene, 21, 761-8.   DOI
11 Ditsch N, Liebhardt S, Von Koch F, et al (2010). Thyroid function in breast cancer patients. Anticancer Res, 30, 1713-7.
12 Egger M, Smith GD, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34.   DOI   ScienceOn
13 Farahati J, Roggenbuck D, Gilman E, et al (2012). Anti-thyroid peroxidase antibodies are associated with the absence of distant metastases in patients with newly diagnosed breast cancer. Clin Chem Lab Med, 50, 709-14.
14 Giustarini E, Pinchera A, Fierabracci P, et al (2006). Thyroid autoimmunity in patients with malignant and benign breast diseases before surgery. Eur J Endocrinol, 154, 645-9.   DOI   ScienceOn
15 Harris RJ, Bradburn MJ, Deeks JJ, et al (2008). metan: fixed-and random-effects meta-analysis. Stata J, 8, 3-28.
16 Hellevik AI, Asvold BO, Bjoro T, et al (2009). Thyroid function and cancer risk: a prospective population study. Cancer Epidemiol Biomarkers Prev, 18, 570-4.   DOI
17 Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58.   DOI   ScienceOn
18 Kogai T, Curcio F, Hyman S, et al (2000). Induction of follicle formation in long-term cultured normal human thyroid cells treated with thyrotropin stimulates iodide uptake but not sodium/iodide symporter messenger RNA and protein expression. J Endocrinol, 167, 125-35.   DOI   ScienceOn
19 Kuijpens JL, Nyklictek I, Louwman MW, et al (2005). Hypothyroidism might be related to breast cancer in postmenopausal women. Thyroid, 15, 1253-9.   DOI
20 Mittal A, Poudel B, Pandeya DR, et al (2012). Metabolic changes enhance the cardiovascular risk with differentiated thyroid carcinoma a case control study from Manipal Teaching Hospital of Nepal. Asian Pac J Cancer Prev, 13, 2335-8.   과학기술학회마을   DOI
21 Nogueira CR, Brentani MM (1996). Triiodothyronine mimics the effects of estrogen in breast cancer cell lines. J Steroid Biochem Mol Biol, 59, 271-9.   DOI
22 Simon MS, Tang MT, Bernstein L, et al (2002). Do thyroid disorders increase the risk of breast cancer? Cancer Epidemiol Biomarkers Prev, 11, 1574-8.
23 Prinzi N, Baldini E, Sorrenti S, et al (2014). Prevalence of breast cancer in thyroid diseases: results of a cross-sectional study of 3, 921 patients. Breast Cancer Res Treat, 144, 683-8.   DOI
24 Saito T, Endo T, Kawaguchi A, et al (1997). Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. J Clin Endocrinol Metab, 82, 3331-6.
25 Saraiva PP, Figueiredo NB, Padovani CR, et al (2005). Profile of thyroid hormones in breast cancer patients. Braz J Med Biol Res, 38, 761-5.
26 Smyth P, Smith D, Dermott EM, et al (1996). A direct relationship between thyroid enlargement and breast cancer. J Clin Endocrinol Metab, 81, 937-41.
27 Stroup DF, Berlin JA, Morton SC, et al (2000). Meta-analysis of observational studies in epidemiology: a proposal for reporting. meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA, 283, 2008-12.   DOI   ScienceOn
28 Szychta P, Szychta W, Gesing A, et al (2013). TSH receptor antibodies have predictive value for breast cancerretrospective analysis. Thyroid Res, 6, 8.   DOI   ScienceOn
29 Tazebay UH, Wapnir IL, Levy O, et al (2000). The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nat Med, 6, 871-8.   DOI   ScienceOn
30 Turken O, NarIn Y, DemIrbas S, et al (2003). Breast cancer in association with thyroid disorders. Breast Cancer Res, 5, 110-3.   DOI   ScienceOn
31 Weiss HA, Brinton LA, Potischman NA, et al (1999). Breast cancer risk in young women and history of selected medical conditions. Int J Epidemiol, 28, 816-23.   DOI
32 Uyeturk U, Tatli AM, Gucuk S, et al (2013). Risk factors for stage IV breast cancer at the time of presentation in Turkey. Asian Pac J Cancer Prev, 14, 7445-9.   과학기술학회마을   DOI   ScienceOn
33 Vadiveloo T, Donnan PT, Cochrane L, Leese GP (2011). The Thyroid Epidemiology, Audit, and Research Study (TEARS): the natural history of endogenous subclinical hyperthyroidism. J Clin Endocrinol Metab, 96, 1-8.
34 Vanderpump MP (2011). The epidemiology of thyroid disease. Br Med Bull, 99, 39-51.   DOI