• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2209-2213
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• 2015

DNA methylation of tumor suppressor gene promoters is the most frequent phenomenon leading to inactivation of function, consequently driving malignant cell transformation. Cyclin D2 is implicated in tumor suppression. In our study, we carried out the MSP assay to evaluation the methylation status at CpG islands in the cyclin D2 promoter in breast cancer cases from the Vietnamese population. The results showed that the frequency of methylation reached 62.1% (59 of 95 breast cancer tumors), but was low in non-cancer specimens at 10% (2 of 20 non-cancer specimens). Additionally, with an RR (relative risk) and OR (odd ratios) of 6.21 and 14.8, DNA hypermethylation of cyclin D2 increased the possibility of malignant transformation. Our results confirmed the cyclin D2 hypermethylation could be used as the potential biomarker which could be applied in prognosis and early diagnosis of Vietnamese breast cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2187-2191
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• 2015

Background: Protrusive structures formed by migrating and invading cells are termed lamellipodia, filopodia, invadopodia and podosomes. Lamellipodia and filopodia appear on the leading edges of migrating cells and function to command the direction of the migrating cells. Invadopodia and podosomes are special F-actin-rich matrix-degrading structures that arise on the ventral surface of the cell membrane. Invadopodia are found in a variety of carcinomatous cells including squamous cell carcinoma of head and neck region whereas podosomes are found in normal highly motile cells of mesenchymal and myelomonocytic lineage. Invadopodia-associated protein markers consisted of 129 proteins belonging to different functional classes including WASP, NWASP, cortactin, Src kinase, Arp 2/3 complex, MT1-MMP and F-actin. To date, our current understanding on the role(s) of these regulators of actin dynamics in tumors of the orofacial region indicates that upregulation of these proteins promotes invasion and metastasis in oral squamous cell carcinoma, is associated with poor/worst prognostic outcome in laryngeal cancers, contributes to the persistent growth and metastasis characteristics of salivary gland adenoid cystic carcinoma, is a significant predictor of increased cancer risk in oral mucosal premalignant lesions and enhances local invasiveness in jawbone ameloblastomas.

• 대한한방소아과학회지
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• 제31권3호
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• pp.24-36
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• 2017

Objectives The purpose of this study is to provide clinical evidence of herbal medicine treatment for cerebral palsy by reviewing randomized controlled trials conducted in China. Methods We searched literatures dated up to 17 May, 2017 in China National Knowledge Infrastructure (CNKI), and evaluated methodological quality of those studies using 'Risk of Bias' tool. Results Sixteen studies were selected for analysis. These studies indicated that the total effective rate, motor function, self-care, muscle spasticity were significantly improved in the herbal medicine treatment group, as compared to the control group. The most-commonly-used herbs were Poria (茯?), Astragali Radix (黃?), Glycyrrhizae Radix (甘草), and Atractylodis Rhizoma Alba (白朮). There were no serious adverse events found that were associated with herbal medicine treatment. The methodological quality of included studies was generally unclear or low. Conclusions This study shows that the herbal medicine treatment can be effective and safe in treating cerebral palsy. Further well-designed clinical trials with high methodological quality and appropriate assessment tools need to be performed to solidify these findings.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.706-709
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• 2006

Cancer is one of the major causes of death; however, the survival rate can be increased if discovered at an early stage for timely treatment. According to the statistics of the World Health Organization of 2002, breast cancer was the most prevalent cancer for all cancers occurring in women worldwide, and it account for 16.8% of entire cancers inflicting Korean women today. In order to classify the type of breast cancer whether it is benign or malignant, this study was conducted with the use of the discriminant analysis and the decision tree of data mining with the breast cancer data disclosed on the web. The discriminant analysis is a statistical method to seek certain discriminant criteria and discriminant function to separate the population groups on the basis of observation values obtained from two or more population groups, and use the values obtained to allow the existing observation value to the population group thereto. The decision tree analyzes the record of data collected in the part to show it with the pattern existing in between them, namely, the combination of attribute for the characteristics of each class and make the classification model tree. Through this type of analysis, it may obtain the systematic information on the factors that cause the breast cancer in advance and prevent the risk of recurrence after the surgery.

• 대한조선학회논문집
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• 제33권2호
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• pp.96-110
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• 1996

노후선박은 부식, 피로균열 등의 구조손상을 입고 있으며, 구조손상이 심각하면 중대한 해난사고를 초래할 위험성이 높다. 선각붕괴에 의한 선박의 침몰사고를 미연에 방지하기 위하여는 구조손상에 기인된 각종 불확실성을 고려한 노후선박의 최종강도 신뢰성을 평가할 필요가 있다. 본 논문에서는 부식에 의한 선체구조부재의 판두께 감소효과를 고려하여 선체구조의 최종강도를 기준으로한 신뢰성 평가기법을 제시하였다. 이를 위해 선체구조의 부식 속도모델을 선급에서 제시하는 데이타를 바탕으로 설정하고, 부식효과를 고려한 신뢰성 한계상태방정식을 도출하였으며, 최종강도 신뢰성은 SORM (second-order reliability method)을 적용하여 계산하였다. 본 기법을 이중선체 유조선에 적용하여 선령의 증가에 따른 단면계수 및 최종강도 신뢰성의 감소특성을 고찰하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3959-3962
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• 2016

The ten-eleven-translocation-2 (TET2) gene is a novel tumor suppressor gene involved in several hematological malignancies of myeloid and lymphoid origin. Besides loss-of-function mutations and deletions, hypermethylation of the CpG island at the TET2 promoter has been found in human cancers. The TET2 encoded protein regulates DNA methylation. The present study aimed to examine DNA promoter methylation of TET2 in 100 childhood acute lymphoblastic leukemia (ALL) cases and 120 healthy children in southeast Iran. In addition, mRNA expression levels were assessed in 30 new cases of ALL and 32 controls. Our ndings indicated that promoter methylation of TET2 signi cantly increases the risk of ALL (OR=2.60, 95% CI=1.31-5.12, p=0.0060) in comparison with absent methylation. Furthermore, the TET2 gene was signi cantly downregulated in childhood ALL compared to healthy children (p=0.0235). The results revealed that hypermethylation and downregulation of TET2 gene may play a role in predisposition to childhood ALL. Further studies with larger sample sizes and different ethnicities are needed to con rm our ndings.

• 복식문화연구
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• 제16권1호
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• pp.100-114
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• 2008

The purpose of this study was to analyze the characteristics of supermodern fashion designer's work, which is shown by responding to supermodern environment where non-spaces such as road, railroad and airport are surplus in modern city environment. For the study, the researcher used existing study and specialized book basically and analyzed photograph materials by selecting them in specialized fashion book, internet site and designer's homepage. The results of this study showed that supermodern fashion design is the functional fashion responding to the change of time and space concept of supermodern society directly. As the common points of supermodern designer's works, first, they try to create private space enabling wearer to cope with risk caused by the environmental change and transitional space by adding architectural factor to fashion. Second, they display the design with protective function and metaphorical expression of concealment and deception in the supermodern environment where nonspace is increasing. Third, designers search the functional design from the aspect of fabric and detail while intending the technology in order to cope with supermodern environment.

• 대한장애인치과학회지
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• 제3권1호
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• pp.26-30
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• 2007

전신적으로 면역이 결핍된 백혈구 접착 결핍증 환아에서는 정기적인 구강 위생 관리는 매우 중요하다. 치면세균막의 제거를 통해 국소적인 자극원을 감소시킴으로써 구강 내 자극에 대한 동통이나 구취 감소가 가능하고 진행되는 치주조직의 파괴 양상을 어느 정도 지연시킬 수 있을 것으로 사료된다. 내원을 통한 관리도 중요하지만 잇솔질 교육을 통하여 환자 스스로 가정에서도 구강 위생 관리를 시행토록 하여야 하며 향후 감염원이 될 수 있는 원인을 감소시키는 노력이 필요하다.

• 한국주거학회논문집
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• 제26권6호
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• pp.93-102
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• 2015

Most existing residential environment of disabled people has made them exposed to the risk of safety accidents, and therefore hinders their independent living. In this regard, the importance of desirable residential environment has emerged. Some preceding studies have addressed the characteristics of disabled people's residential environment plan; however, the information on what environmental benefits are offered through such characteristics is insufficient. This study aims to analyze the housing design guidelines for disabled people in respect of the benefit of disabled people who are actual users. In this study, essential design guidelines for disabled people verified through expert workshop panel was analyzed based on user benefit theory. According to the study results, the total guidelines have the most characteristics supporting behavioral facilitation, and mainly consist of physiological maintenance characteristics related to disabled people's health and safety. Also, it is founded that environmental affordance essentially required depending on each spatial function was different. The ratio of physiological maintenance item is high in access route, unlike living room, kitchen and bed room where behavioral facilitation is especially emphasized. These findings can be utilized as basic data for customized residential environment plan to realize residential welfare for disabled people.

• IMMUNE NETWORK
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• 제12권6호
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• pp.223-229
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• 2012

Clinical and preclinical in vivo immune cell imaging approaches have been used to study immune cell proliferation, apoptosis and interaction at the microscopic (intra-vital imaging) and macroscopic (whole-body imaging) level by use of ex vivo or in vivo labeling method. A series of imaging techniques ranging from non-radiation based techniques such as optical imaging, MRI, and ultrasound to radiation based CT/nuclear imaging can be used for in vivo immune cell tracking. These imaging modalities highlight the intrinsic behavior of different immune cell populations in physiological context. Fluorescent, radioactive or paramagnetic probes can be used in direct labeling protocols to monitor the specific cell population. Reporter genes can also be used for genetic, indirect labeling protocols to track the fate of a given cell subpopulation in vivo. In this review, we summarized several methods dealing with dendritic cell, macrophage, and T lymphocyte specifically labeled for different macroscopic whole-body imaging techniques both for the study of their physiological function and in the context of immunotherapy to exploit imaging-derived information and immune-based treatments.