• 대한세포병리학회지
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• 제16권1호
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• pp.18-24
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• 2005

The objective of this study was to ascertain whether or not the high-risk human papillomavirus (HPV) test, when coupled with Papanicolaou (Pap) smears, would prove useful in the screening and management of patients in whom abnormal Pap smear results had been obtained. Concomitant high-risk HPV detection using the hybrid capture II test and colposcopy with a Pap smear were performed with 176 patients, all of whom had been screened for both cervical carcinoma and precancerous lesions. We concomitantly performed colposcopies on these patients. Upon the follow-ups, the histologic diagnoses of these patients were confirmed via either biopsy or hysterectomy. The rate of high-risk HPV detection was correlated with cytologic diagnoses and colposcopic findings. The group composed of the high-risk HPV-positive ASCUS patients exhibited a 55.7% rate of cervical intraepithelial neoplasia (CIN), a significantly higher rate than the 7.5% result obtained in the high-risk HPV-negative ASCUS group. HPV test showed high sensitivity (87%) and low specificity (62.6%) in detection of CIN and colposcopy also showed high sensitivity (88%) and low specificity (22%). Any combination of these tests improve sensitivity, but not specificity. High-risk HPV tests, when coupled with Pap smears, constituted a useful triage approach with regard to colposcopy-directed biopsies in patients in whom a cytologic diagnosis of ASCUS had been rendered.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5195-5199
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• 2012

Objectives: Global cancer statistical data show that India has one of the highest incidence rates of oral cancer worldwide. Early detection is extremely important as it results in lower morbidity and death rates. The present study was undertaken to assess awareness of oral cancer and knowledge of its early signs and risk factors in the general public of the semi-urban Gorakhpur area of Uttar Pradesh (India). It was also intended to educate the same population for early detection by increasing their ability to recognize signs and risk factors. Method: A questionnaire-based household survey was conducted over a period of one month in different parts of Gorakhpur district, a region where tobacco use is apparently very high. A total of 2,093 persons participated in the survey. The collected data were analyzed using SPSS software to assess and associate oral cancer awareness with the prevalence, and abstract risk factors, as well as other confounding variables. Results: The general awareness, knowledge of signs and risk factors of oral cancer were found to be proportionate to the literacy level with the highest rate of awareness being among high school and graduates and lowest among illiterates. It was also observed that on most of these dimensions the younger age groups (<30 years) were significantly more knowledgeable. Conclusion: Overall, the awareness of oral cancer in the high-risk population of Gorakhpur was not satisfactory, pointing to a need for further dissemination of information on this issue and its associated risks. This is especially important for the youngsters, as this may possibly help them keep away from the deleterious habit of tobacco indulgence in any form. If necessary risk factor cessation counselling should be provided.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권12호
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• pp.4531-4544
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• 2021

Because the traditional network information security vulnerability risk assessment method does not set the weight, it is easy for security personnel to fail to evaluate the value of information security vulnerability risk according to the calculation value of network centrality, resulting in poor evaluation effect. Therefore, based on the network security data element feature system, this study designed a quantitative assessment method of network information security vulnerability detection risk under single transmission state. In the case of single transmission state, the multi-dimensional analysis of network information security vulnerability is carried out by using the analysis model. On this basis, the weight is set, and the intrinsic attribute value of information security vulnerability is quantified by using the qualitative method. In order to comprehensively evaluate information security vulnerability, the efficacy coefficient method is used to transform information security vulnerability associated risk, and the information security vulnerability risk value is obtained, so as to realize the quantitative evaluation of network information security vulnerability detection under single transmission state. The calculated values of network centrality of the traditional method and the proposed method are tested respectively, and the evaluation of the two methods is evaluated according to the calculated results. The experimental results show that the proposed method can be used to calculate the network centrality value in the complex information security vulnerability space network, and the output evaluation result has a high signal-to-noise ratio, and the evaluation effect is obviously better than the traditional method.

• 한국안전학회지
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• 제31권4호
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• pp.136-142
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• 2016

The FMEA is a widely used technique to pre-evaluate and avoid risks due to potential failures for developing an improved design. The conventional FMEA does not consider the possible time gap between occurrence and detection of failure cause. When a failure cause is detected and corrected before the failure itself occurs, there will be no other effect except the correction cost. But, if its cause is detected after the failure actually occurs, its effects will become more severe depending on the duration of the uncorrected failure. Taking this situation into account, a risk metric is developed as an alternative to the RPN of the conventional FMEA. The severity of a failure effect is first modeled as linear and quadratic severity functions of undetected failure time duration. Assuming exponential probability distribution for occurrence and detection time of failures and causes, the expected severity is derived for each failure cause. A new risk metric REM is defined as the product of a failure cause occurrence rate and the expected severity of its corresponding failure. A numerical example and some discussions are provided for illustration.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1151-1158
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• 2012

High-risk human papillomavirus (HPV) genotypes are the major cause of cervical cancer. Hence, HPV genotype detection is a helpful preventive measure to combat cervical cancer. Recently, several HPV detection methods have been developed, each with different sensitivities and specificities. The objective of this study was to compare HPV high risk genotype detection by an electrochemical DNA chip system, a line probe assay (INNO-LiPA) and sequencing of the L1, E1 regions. A total of 361 cervical smears with different cytological findings were subjected to polymerase chain reaction-sequencing and electrochemical DNA chip assessment. Multiple infections were found in 21.9% (79/361) of the specimens, most prevalently in 20-29-year olds while the highest prevalence of HPV infection was found in the 30-39-year age group. The most prevalent genotype was HPV 16 at 28.2% (138/489) followed by HPV 52 at 9.6% (47/489), with the other types occurring at less than 9.0%. The electrochemical DNA chip results were compared with INNO-LiPA and sequencing (E1 and L1 regions) based on random selection of 273 specimens. The results obtained by the three methods were in agreement except for three cases. Direct sequencing detected only one predominant genotype including low risk HPV genotypes. INNO-LiPA identified multiple infections with various specific genotypes including some unclassified-risk genotypes. The electrochemical DNA chip was highly accurate, suitable for detection of single and multiple infections, allowed rapid detection, was less time-consuming and was easier to perform when compared with the other methods. It is concluded that for clinical and epidemiological studies, all genotyping methods are perfectly suitable and provide comparable results.

• Structural Monitoring and Maintenance
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• 제7권1호
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• pp.59-67
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• 2020

This study aims to develop the fuzzy risk assessment model of the debris flow to verify the accuracy of risk assessment in order to help related organizations reduce losses caused by landslides. In this study, actual cases of landslides that occurred are utilized as the database. The established models help us assess the occurrence of debris flows using computed indicators, and to verify the model errors. In addition, comparisons are made between the models to determine the best one to use in practical applications. The results prove that the risk assessment model systems are quite suitable for debris flow risk assessment. The reproduction consequences of highlight point discovery are shown in highlight guide coordinating toward discover steady and coordinating component focuses and effectively identified utilizing these two systems, by examining the variety in the distinguished highlights and the element coordinating.

• Genomics & Informatics
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• 제16권4호
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• pp.37.1-37.3
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• 2018

Gene-gene interaction is a key factor for explaining missing heritability. Many methods have been proposed to identify gene-gene interactions. Multifactor dimensionality reduction (MDR) is a well-known method for the detection of gene-gene interactions by reduction from genotypes of single-nucleotide polymorphism combinations to a binary variable with a value of high risk or low risk. This method has been widely expanded to own a specific objective. Among those expansions, fuzzy-MDR uses the fuzzy set theory for the membership of high risk or low risk and increases the detection rates of gene-gene interactions. Fuzzy-MDR is expanded by a maximum likelihood estimator as a new membership function in empirical fuzzy MDR (EFMDR). However, EFMDR is relatively slow, because it is implemented by R script language. Therefore, in this study, we implemented EFMDR using RCPP ($c^{{+}{+}}$ package) for faster executions. Our implementation for faster EFMDR, called EMMDR-Fast, is about 800 times faster than EFMDR written by R script only.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2023년도 봄 학술논문 발표대회
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• pp.405-406
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• 2023

In the era of AI, intelligent construction safety technologies are being introduced to the construction safety environment, but the application of AI has limitations due to the lack of accident images to learn in complex construction sites. In order to overcome this, we will introduce an intelligent risk detection system that dramatically improves risk detection accuracy by combining AI with digital twin technology, and introduce various cases.

• 한국물환경학회지
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• 제21권5호
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• pp.431-441
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• 2005

The study was carried out to improve and regulate the drinking water quality standard and drinking water quality monitoring substances. For the reliability and safety of finished water, It has been monitored for trace organic and inorganic compounds of 333 in finished water of water treatment plants during 1989 to 2003. As a result of monitoring, 51 compounds were detected from 333 compounds, and it has been regulated the drinking water quality standard of 26 substances and 20 mitoring substance. Improvement and regulation method of the drinking water quality standard was performed by comparing and analyzing with detection concentration, detection frequency, risk assessment and foreign drinking water quality standard.

• 한국산학기술학회논문지
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• 제19권12호
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• pp.863-871
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• 2018

본 논문에서는 기존의 취약점 분석 도구들의 미탐지, 오탐지, 과탐지를 발생시켜 정확한 취약점 탐지를 어렵게 하는 문제점을 해결하고 분석 대상이 되는 어플리케이션의 위험도를 평가하여 안전한 어플리케이션을 개발하거나 관리할 수 있는 정적 및 동적 분석을 이용한 크로스 체크기반의 취약점 탐지 기법을 제안한다. 또한 각각의 취약점이 가지고 있는 자체 위험도를 계산하고 정확도를 높인 취약점 탐지 기법을 바탕으로 최종적인 어플리케이션의 위험도를 평가, 제시함으로서 안전한 어플리케이션의 개발 및 운영을 돕는다. 제안하는 기법은 정적 분석 및 동적 분석 기법을 사용하는 도구들의 상호작용을 통해 각 기법의 단점들을 극복하여 취약점 탐지 정확도를 향상시킨다. 또한 기존의 취약점 위험도평가 시스템은 취약점 자체 위험도에 대해서만 평가하였으나, 제안하는 위험도 평가는 취약점 자체 위험도와 탐지 정확도를 복합적으로 반영하여 어플리케이션이 얼마나 위험에 노출되어 있는지를 평가한다. 제안하는 기법은 CWE에서 SANS top 25의 상위 10위 항목을 기준으로 기존의 분석 도구들과 탐지 가능한 목록, 탐지 정확도를 비교분석하였으며, 기존의 취약점 위험도에 대한 정량적 평가 시스템과 제안하는 어플리케이션 위험도 평가 결과를 비교 분석 및 평가하였다. 제안하는 기법으로 프로토타입 분석 툴을 구현하여 실험을 통해 어플리케이션의 취약점을 분석하였을 때, 기존의 분석 도구들의 취약점 탐지 능력보다 우수한 것으로 나타났다.