• Journal of Korean Neurosurgical Society
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• v.63 no.5
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• pp.539-549
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• 2020

The efficacy of P2Y12 reaction unit (PRU) of VerifyNow still remains as a controversial issue in neurointervention. So we investigated the usefulness of PRU of VerifyNow to predict the peri-procedural thromboembolic events (TE) and hemorrhagic events (HE). And we evaluated the safety of modified dual antiplatelet therapy (DAPT) or triple antiplatelet therapy (TAPT) for clopidogrel hyporesponders. We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science and Scopus on August 19 2018. Data was collected the 1) incidence of TE between clopidogrel responder and clopidogrel hypo-responder, 2) incidence of HE between clopidogrel hyper-responder and clopidogrel responder and hypo-responder, and 3) incidence of TE and HE between modified DAPT or TAPT and standard DAPT in clopidogrel hypo-responder. High cut-off value of PRU was defined as PRU >40% or <220. Fifteen studies were enrolled. Clopidogrel responder showed lower incidence of TE than hypo-responder (risk ratio [RR], 0.32; 95% confidence interval [CI], 0.17-0.61; p<0.001). With the high cut-off value of PRU, clopidogrel responder showed more lower incidence of TE than hypo-responder (RR, 0.11; 95% CI, 0.02-0.45; p=0.002). The incidence of periprocedural HE have higher on clopidogrel hyper-responder than clopidogrel responder and hypo-responder (RR, 4.26; 95% CI, 1.10-16.44; p=0.04; I²=66%). The incidence of periprocedural TE after changing regimen of DAPT for clopidogrel hypo-responder have a tendency to reduce, but there was no significant difference between modified DAPT or TAPT group and standard DAPT group (p>0.05). The incidence of periprocedural HE after changing regimen of DAPT for clopidogrel hypo-responder was no significant difference between modified DAPT or TAPT group and standard DAPT group (p>0.05). PRU is a useful tool as a predictor of peri-procedural TE or HE on neurointervention. PRU has a threshold effect of cut-off value to predict the peri-procedural TE. Modified DAPT or TAPT to prevent TE in clopidogrel hypo-responders could not reduce the incidence of TE. We should investigate the further research about modification of regiment on neurointervention.

• Journal of KIISE:Computer Systems and Theory
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• v.26 no.8
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• pp.918-929
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• 1999

동기식 스트림 암호통신 방식을 사용하는 암호통신에서는 암/복호화 과정 수행시 암호통신 과정에서 발생하는 사이클슬립으로 인해 키수열의 동기이탈 현상이 발생되고 이로 인해 오복호된 데이타를 얻게된다. 이러한 위험성을 감소하기 위한 방안으로 현재까지 암호문에 동기신호와 세션키를 주기적으로 삽입하여 동기를 이루는 주기적인 동기암호 통신방식을 사용하여 왔다. 본 논문에서는 CDMA(Cellular Division Multiple Access) 이동망에서 데이타서비스를 제공할 때 사용되는 점대점 프로토콜의 주소영역의 특성을 이용하여 단위 측정시간 동안 측정된 주소비트 정보와 플래그 패턴의 수신률을 이용하여 문턱 값보다 작은경우 동기신호와 세션키를 전송하는 비주기적인 동기방식을 사용하므로써 종래의 주기적인 동기방식으로 인한 전송효율성 저하와 주기적인 상이한 세션키 발생 및 다음 주기까지의 동기이탈 상태의 지속으로 인한 오류확산 등의 단점을 해결하였다. 제안된 알고리즘을 링크계층의 점대점 프로토콜(Point to Point Protocol)을 사용하는 CDMA 이동망에서 동기식 스트림 암호 통신방식에 적용시 동기이탈율 10-7의 환경에서 주기가 1sec인 주기적인 동기방식에서 요구되는 6.45x107비트에 비해 3.84x105비트가 소요됨으로써 전송율측면에서의 성능향상과 오복호율과 오복호 데이타 비트측면에서 성능향상을 얻었다. Abstract In the cipher system using the synchronous stream cipher system, encryption / decryption cause the synchronization loss (of key arrangement) by cycle slip, then it makes incorrect decrypted data. To lessen the risk, we have used a periodic synchronous cipher system which achieve synchronization at fixed timesteps by inserting synchronization signal and session key. In this paper, we solved the problem(fault) like the transfer efficiency drops by a periodic synchronous method, the periodic generations of different session key, and the incorrectness increases by continuing synchronization loss in next time step. They are achieved by the transfer of a non-periodic synchronous signal which carries synchronous signal and session key when it is less than the threshold value, analyzing the address field of point-to-point protocol, using the receiving rate of address bits information and flag patterns in the decision duration, in providing data services by CDMA mobile network. When the proposed algorithm is applied to the synchronous stream cipher system using point-to-point protocol, which is used data link level in CDMA mobile network, it has advanced the result in Rerror and Derror and in transmission rate, by the use of 3.84$\times$105bits, not 6.45$\times$107bits required in periodic synchronous method, having lsec time step, in slip rate 10-7.

• Journal of KIISE:Software and Applications
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• v.33 no.5
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• pp.508-524
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• 2006

We present our experience of combining, in a realistic setting, a static analyzer with a statistical analysis. This combination is in order to reduce the inevitable false alarms from a domain-unaware static analyzer. Our analyzer named Airac(Array Index Range Analyzer for C) collects all the true buffer-overrun points in ANSI C programs. The soundness is maintained, and the analysis' cost-accuracy improvement is achieved by techniques that static analysis community has long accumulated. For still inevitable false alarms (e.g. Airac raised 970 buffer-overrun alarms in commercial C programs of 5.3 million lines and 737 among the 970 alarms were false), which are always apt for particular C programs, we use a statistical post analysis. The statistical analysis, given the analysis results (alarms), sifts out probable false alarms and prioritizes true alarms. It estimates the probability of each alarm being true. The probabilities are used in two ways: 1) only the alarms that have true-alarm probabilities higher than a threshold are reported to the user; 2) the alarms are sorted by the probability before reporting, so that the user can check highly probable errors first. In our experiments with Linux kernel sources, if we set the risk of missing true error is about 3 times greater than false alarming, 74.83% of false alarms could be filtered; only 15.17% of false alarms were mixed up until the user observes 50% of the true alarms.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.18 no.4
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• pp.679-700
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• 1996

Inferior alveolar nerve dysfunction may be the result of trauma, disease, or iatrogenic injury. Inferior alveolar nerve injury is inherent risk in endodontic therapy, orthognathic surgery of the mandible, and extraction of mandibular teeth, particularly the third molars. The sensory disturbances of inferior alveolar nerve associated with such injury have been well documented clinical problem that is commonly evaluated by several clinical sensory test including Tinels sign, Von Frey test(static light touch detection), directional discrimination, two-point discrimination, pin pressure nociceptive discrimination, and thermal test. These methods used to detect and assess inferior alveolar nerve injury have been subjective in nature, relying on the cooperation of the patients. In addition, many of these techniques are sensitive to differences in the examiners experience and skill with the particular technique. Data obtained at different times or by different examiners are therefore difficult to compare. Prior experimental studies have used electro diagnostic methods(sensory evoked potential) to objectively evaluate inferior alveolar nerve after nerve injury. This study was designed with inferior alveolar nerve of rabbit. Several types of injury including mind, moderate, severe compression and perforation with 19 gauze, 21 gauze needle and 6mm, 10mm traction were applied for taking the sesory evoked ppterntial. Latency and amplitude of injury rabbit inferior alveolar nerve were investigated with sensory evoked potential using unpaired t-test. The results were as follows : 1. Intensity of threshold (T1) was $128{\pm}16{\mu}A$ : latency, $0.87{\pm}0.07$ microsecond : amplitude, $0.4{\pm}0.1{\mu}V$ : conduction velocity, 23.3 m/s in sensory evoked potential of uninjured rabbit inferior alveolar nerve. 2. Rabbit inferior alveolar nerve consists of type II and III sensory nerve fiber. 3. Latency was increased and amplitude was decreased in compression injury. The more injured, the more changed in latency and amplitude. 4. Findings in perforation injury was similar to compression injury. Waveform for sensory evoked potential improved by increasing postinjured time. 5. Increasing latency was prominent in traction injury rabbit inferior alveolar nerve. 6. In microscopic histopathological findings, significant degeneration and disorganization of the internal architecture were seen in nerve facicle of severe compression and 10mm traction group. From the above findings, electrophysiological assessment(sensory evoked potential) of rabbit injured inferior alveolar nerve is reliable technique in diagnosis and prognosis of nerve injury.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.10
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• pp.2181-2190
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• 1997

The synchronous stream cipher has the problem of synchronization loss by cycle slip. Synchronization loss make the state which sender and receiver can't communicate and it may make the receiving system disordered. To lessen the risk, we usually use a continuous resynchronization which achieve resynchronization at fixed timesteps by inserting synchronization pattern and session key. While we can get effectively resynchronizationby continuous resynchronization, there are some problems. In this paper, we proposed an adaptive resynchronization algorithm for cipher system using LAPB protocol. It is able to solve the problem of the continunous resynchronization.The proposed adaptive algorithm make resynchronization only in the case that the resynchronization is occurred by analyzing the address field of LAPB. It measure the receiving rate of the address field in the decesion duration. If the receiving rate is smaller than threshold value, it make resynchronization or not. By using adaptively resynchronization, it solves the problems of continunous resynchronization. When the proposed adaptive algorithm is applied to the synchronous stream cipher system which is used in X.25 packet network, it reduced the time for resynchronization by ten times. It means that 11.3% of total data for transmit is compressed.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.2
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• pp.136-143
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• 2018

The rate pressure product (RPP) is expressed as a product of the heart rate and systolic blood pressure as an index indirectly measuring the myocardial oxygen consumption, and it indicates the burden on the myocardium. The aim of this study was to determine the optimal level of RPP for preventing metabolic syndrome in a treadmill exercise test in Korean adults. Metabolic syndrome was the diagnosis of the third executive summary report on the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. According to the criteria, the metabolic syndrome diagnosis group (MetS, N=25), pre-metabolic syndrome group (Pre-MetS, N=106), and non-risk factor group (Non-MetS, N=65) were classified. The exercise stress test was performed based on the Bruce protocol. The RPP was calculated as (heart rate${\times}$systolic blood pressure)${\div}1,000$. The results showed that the maximum systolic blood pressure was high despite the low daily dose reached in the diagnostic group of metabolic syndrome. The optimal threshold of the RPP at the time of the exercise treadmill test for a metabolic syndrome prediction was $12.56mmHg{\times}beats/min{\times}10^{-3}$ in the first stage of the exercise stress test. The second stage of the exercise test was $16.94mmHg{\times}beats/min{\times}10^{-3}$, and at the third stage of the exercise test was $21.11mmHg{\times}beats/min{\times}10^{-3}$.

• Journal of Navigation and Port Research
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• v.27 no.2
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• pp.137-143
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• 2003

The prevention of marine accidents has been a important topic in marine society for long time, and various safety policies and countermeasures have been developed and applied to prevent those accidents. In spite of these efforts, however, significant marine accidents have taken place intermittently. Ship is being operated under a highly dynamic environments, and many factors are related with ship's collision, whose factors are interacting. So, the analysis on ship's collision causes are very important to prepare countermeasures which will ensure the safe navigation. This study analysed the ship's collision data over the past 10 years(1991-2000), which is compiled by Korea Marine Accidents Inquiry Agency. The analysis confirmed that‘ship's collision’is occurred most frequently and the cause is closely related with human factor. The main purpose of this study is to analyse human factor. For this, the structure of human factor is analysed by the questionnaire methodology. Marine experts were surveyed based on major elements that were extracted from the human factor affecting to ship's collision. FSM has been widely adopted in modeling a dynamic system which is composed of human factors. Then, the structure analysis on the causes of ship's collision using FSM are performed. This structure model could be used in understanding and verifying the procedure of real ship's collision. Furthermore it could be used as the model to prevent ship's collision and reduce marine accidents.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.9
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• pp.1916-1932
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• 1997

The synchronous stream cipher which require absoulte clock synchronization has the problem of synchronization loss by cycle slip. Synchronization loss makes the state which sender and receiver can't communicate with each other and it may break the receiving system. To lessen the risk, we usually use a continuous resynchronization method which achieve resynchronization at fixed timesteps by inserting synchronization pattern and session key. While we can get resynchronization effectively by continuous resynchroniation, there are some problems. In this paper, we proposed an adaptive resynchronization algorithm for cipher system using HDLC protocol. It is able to solve the problem of the continuous resynchronization. The proposed adaptive algorithm make resynchronization only in the case that the resynchronization is occurred by analyzing the address field of HDLC. It measures the receiving rate of theaddress field in the decision duration. Because it make resynchronization only when the receiving rate is greateer than the threshold value, it is able to solve the problems of continuous resynchronization method. When the proposed adaptive algorithm is applied to the synchronous stream cipher system in packet netork, it has addvance the result in R_e and D_e.

• Korean Journal of Community Nutrition
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• v.23 no.5
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• pp.397-410
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• 2018

Objectives: An association between dietary patterns and mental health in children has been suggested in a series of studies, yet detailed analyses of dietary patterns and their effects on ADHD (attention deficit hyperactivity disorder) are limited. Methods: We included 4569 children who had dietary intake data as part of the CHEER (Children's Health and Environmental Research) study conducted nationwide from 2005 to 2010. We assessed ADHD (Attention Deficit Hyperactivity Disorder) by the DuPaul's ADHD Rating Scales and dietary intake by a semi-quantitative food frequency questionnaire. Using intake data, we constructed five dietary patterns: "Plant foods & fish," "Sweets," "Meat & fish," "Fruits & dairy products," and "Wheat based." Results: The overall proportion of ADHD was 12.3%. Boys (17.8%) showed a higher rate of ADHD than girls (6.5%). The total intake of calories (85 kcal) and plant fat (2g) in the ADHD group was significantly higher than that of the normal group. ADHD was significantly negatively associated with dietary habits such as having breakfast and meal frequency, and positively associated with eating speed, unbalanced diet, overeating, and rice consumption. Regarding dietary patterns, the "Sweets" category was relevant to high ADHD risk (OR 1.59, 95% CI: 1.18, 2.15 for Q5 vs. Q1) in a linear relationship. An inverse, non-linear association was found between "Fruits & dairy products" and ADHD (OR 0.55, 95% CI: 0.39, 0.76 for Q4 vs. Q1). Conclusions: Our study confirms both positive and negative associations between diet and ADHD in elementary school age children. Moreover, linear or nonlinear associations between diet and ADHD draw attention to the possible threshold role of nutrients. Further studies may consider characteristics of diet in more detail to develop better intervention or management in terms of diet and health.

• The Journal of the Acoustical Society of Korea
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• v.34 no.2
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• pp.138-145
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• 2015

Although it is well-known that environmental noise can lead to hearing loss in individuals, the true extent of subway noise effects in the general population remains poorly understood. The purpose of the present study is to see changes of acoustic reflex thresholds and speech perception scores when passengers listen to music presented from their personal listening device in the subway. Forty subjects with normal hearing participated being divided into two groups, experimental and control groups. As a baseline, all subjects were measured by acoustic reflex thresholds in five test frequencies and Korean speech perception in noise (KSPIN) test at 0 and -5 dB SNR. In the experiment, the control group read newspaper or magazine in the subway noise, whereas the experimental group listened to music presented from their smartphone under the subway noise through speakers at 73.45 dBA for 60 min. After completing the experiment, two groups also conducted both acoustic reflex thresholds and KSPIN tests in the same condition as the baseline. The results showed that there was a significant difference of correct percent in speech-in-noise test between experimental and control groups and of that between two signal-to-noise ratios, which means the double noise exposure of 60 min might cause some degradation of speech perception when noise increases compared to only subway noise condition that was not statistically significant difference. We concluded that a risk of some degraded speech perception ability would be expected when passengers have a habit of listening to music in the subway noisy situation for a long duration.