• BMB Reports
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• 제52권1호
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• pp.35-41
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• 2019

Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally evolved to limit the proliferation of old or damaged cells. However, it has been recently shown that cellular senescence is a physiological and pathological program contributing to embryogenesis, immune response, and wound repair, as well as aging and age-related diseases. Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. Thus, cellular senescence has also been considered suppressive mechanism of tumorigenesis. Current studies have revealed that therapy-induced senescence (TIS), a type of senescence caused by traditional cancer therapy, could play a critical role in cancer treatment. In this review, we outline the key features and the molecular pathways of cellular senescence. Better understanding of cellular senescence will provide insights into the development of powerful strategies to control cellular senescence for therapeutic benefit. Lastly, we discuss existing strategies for the induction of cancer cell senescence to improve efficacy of anticancer therapy.

• Journal of Contemporary Eastern Asia
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• 제19권2호
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• pp.1-19
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• 2020

Trends toward an influx of new migrants have been pronounced in East Asia through a development we call the third round of migrant incorporation. At the same time, other features of East Asian societies, such as strong levels of ethnic nationalism, have changed little, posing challenges to multiculturalism. In this introduction to this special issue, we review the latest research trends broadly concerning multiculturalism, migrant groups that have received little attention, racism and xenophobia. We first discuss the state of migrant incorporation in East Asia and the limits of multiculturalism in this region, where various features of the developmental state persist. We then introduce research on voices opposing multiculturalism in East Asia. This introduction highlights what is peculiar―and ordinary―about migrant incorporation and the associated challenges in East Asia.

• 한국자기공명학회논문지
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• 제26권2호
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• pp.21-23
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• 2022

High-pressure (HP) NMR is a powerful method to elucidate various structural features of amyloidogenic proteins. Following the previous mini-review recapitulating the HP-NMR application for amyloid-β peptides of the last issue [J. H. Kim, J. Kor. Mag. Reson. Soc. 26, 17 (2022)], the recent advancements in the HP NMR application for α-synuclein (α-Syn) are briefly summarized and discussed here. Although α-Syn is a well-known intrinsically disordered protein (IDP), several studies have shown that it can also exhibit heterogeneous yet partially folded conformations, which may correlate with its amyloid-forming propensity. HP NMR has been a valuable tool for investigating the dynamic and transient structural features of α-Syn and has provided unique insights to appreciate its aggregation-prone characters.

• 대한조현병학회지
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• 제23권2호
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• pp.45-50
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• 2020

Schizophrenia is one of serious mental illnesses and is often described as a heterogeneous disorder. Approximately one-third of schizophrenia cases are treatment-resistant schizophrenia (TRS). The aim of this study was to review the definitions and clinical features of TRS. Though it was found that the criteria for TRS were considerably diverse, the Treatment Response and Resistance in Psychosis (TRRIP) consensus criteria were recently introduced. According to the TRRIP criteria, TRS should be suspected if symptoms persist alongside psychotic symptoms despite sufficient treatment for ≥12 weeks, or two or more symptoms persist significantly for ≥6 weeks. The clinical characteristics of TRS includes an earlier age of onset, more severe and familial form, possibly more rural residence, unlikely association with male sex, and an increase in cognitive deficits.

• Journal of Sport and Applied Science
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• 제7권1호
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• pp.1-10
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• 2023

Purpose: This paper analyzed the features of Winter Olympics mascots in chronological order by examining the evolution of mascots and presented the attributes of the Winter Olympics mascots from Innsbruck 1976 to Beijing 2022. Research design, data, and methodology: This paper conducted an exploratory study on the thinking to understand the characteristics of 13 Winter Olympics Mascots through literature review. Results: First, the mascot is a fictional character, usually an artificial character that represents the locality of the host city, including animals, human figures, and local inhabitants. Second, Schneemann, Innsbruck 1976 was known as the first official Winter Olympics mascot. Third, 19 mascots out of a total of 24 mascots were created using animals. Conclusions: The six attributes of the Winter Olympics mascots were identified: friendliness, symbolic meaning, originality, diversity, value, and identity of a special location. Above all, Winter Olympics has a locality that includes areas covered with ice and snow. From this point of view, the Olympics mascot highlights the image of snow and ice and the physical environment that includes it.

• Clinical Pain
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• 제20권1호
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• pp.7-14
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• 2021

Musculoskeletal ultrasound has evolved as the essential tool to diagnose and guide intervention procedures in people with neuromusculoskeletal conditions. Image optimization and understanding device operations are core components for ultrasound guided intervention procedure training. All ultrasound machines share the common operative features and there are various buttons for the features in the device control panel. Ultrasound "knobology" refers to the thorough understanding of imaging optimization. This review addressed basic information for the transducers, depth setting, gain and focus control, different modes focusing on brightness and doppler modes.

• Journal of Korean Neurosurgical Society
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• 제65권3호
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• pp.397-407
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• 2022

Abusive head trauma (AHT) is the most common and serious form of child abuse and a leading cause of traumatic death in infants and young children. The biomechanics of head injuries include violent shaking, blunt impact, or a combination of both. Neuroimaging plays an important role in recognizing and distinguishing abusive injuries from lesions from accidental trauma or other causes, because clinical presentation and medical history are often nonspecific and ambiguous in this age group. Understanding common imaging features of AHT can increase recognition with high specificity for AHT. In this review, we discuss the biomechanics of AHT, imaging features of AHT, and other conditions that mimic AHT.

• 천문학회보
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• 제46권1호
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• pp.47.3-47.3
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• 2021

In this talk I will review recent progress that the SDSS-IV / eBOSS collaboration has made in constraining cosmology from the clustering of galaxies, quasars and the Lyman-alpha forest. The SDSS-IV / eBOSS collaboration has measured the baryon acoustic oscillation (BAO) and redshift space distortion (RSD) features in the correlation function in redshift bins from z~0.15 to z~2.33. These features constitute measurements of angular diameter distances, Hubble distances, and growth rate measurements. A number of consistency tests have been performed between the BAO and RSD datasets and additional cosmological datasets such as the Planck cosmic microwave background constraints, the Pantheon Type Ia supernova compilation, and the weak lensing results from the Dark Energy Survey. Taken together, these joint constraints all point to a broad consistency with the standard model of cosmology LCDM + GR, though they remain in tension with local measurements of the Hubble parameter.

• Korean Journal of Radiology
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• 제25권1호
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• pp.33-42
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• 2024

Focal enhancement typically suggests local tumor progression (LTP) after renal cell carcinoma is percutaneously ablated. However, evaluating findings that are false positive or negative of LTP is less familiar to radiologists who have little experience with renal ablation. Various imaging features are encountered during and after thermal ablation. Ablation procedures and previous follow-up imaging should be reviewed before determining if there is LTP. Previous studies have focused on detecting the presence or absence of focal enhancement within the ablation zone. Therefore, various diagnostic pitfalls can be experienced using computed tomography or magnetic resonance imaging examinations. This review aimed to assess how to read images during or after ablation procedures, recognize imaging features of LTP and determine factors that influence LTP.

• Korean Journal of Radiology
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• 제21권1호
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• pp.15-24
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• 2020

Mammography is the primary screening method for breast cancers. However, the sensitivity of mammographic screening is lower for dense breasts, which are an independent risk factor for breast cancers. Automated breast ultrasound (ABUS) is used as an adjunct to mammography for screening breast cancers in asymptomatic women with dense breasts. It is an effective screening modality with diagnostic accuracy comparable to that of handheld ultrasound (HHUS). Radiologists should be familiar with the unique display mode, imaging features, and artifacts in ABUS, which differ from those in HHUS. The purpose of this study was to provide a comprehensive review of the clinical significance of dense breasts and ABUS screening, describe the unique features of ABUS, and introduce the method of use and interpretation of ABUS.