• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2083-2087
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• 2016

A new compound namely (13-(3,3-dihydroxypropyl)-1,6-dihydroxy-3,4-dihydro-1H-isochromen-8(5H)-one (1) was isolated from an ethyl acetate extract of the borne fungi Screlotium rolfsii. Its chemical structure was elucidated by spectroscopic analysis. Screlotiumol 1 were evaluated for their effects on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) of the soil borne fungi. The multidrug resistant P-glycoprotein is a target for chemotherapeutic drugs in cancer cells. In the present study rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma which showed excellent MDR reversing effect in a dose dependent manner against mouse T-lymphoma cell line. Moreover, molecular docking studies of compound-1 also showed better results as compared with the standard. Therefore the preliminary results obtained from this study suggest that screlotiumol 1 could be used as a potential agent for the treatment of cancer.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권2호
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• pp.137-145
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• 2000

Carcinogenesis is a multi-stage process that generally consists of at least three steps; initiation, promotion, and progression. If one of these carcinogenic steps were suppressed or delayed, the cancer could be prevented. Cancer chemoprevention is defined to be inhibition or reversal of the carcinogenic process by the specific chemical agents and is a novel approach to cancer management alternative to conventional chemotherapy. Chlorophylln(CHL), a water-soluble derivative of chlorophyll, containing sodium and copper, has been known to be strong antimutagen in several test systems, but its mechanism of antimutagenic action is unknown. In the present experiment, the possibility of CHL as chemopreventive drugs on 7,12-dimethylbenz[a]anthracene(DMBA)-induced hamster buccal pouch carcinogenesis was investigated by mutagenicity test, carcinogenicity test, and frequency or spectrum of H-ras mutations in the both of DMBA-induced and chlorophylln-pretreated-DMBA induced tumor by polymerase chain reaction and non-isotopic restriction fragment length polymorphism. The treatment of CHL reduced the yields and multiplicity of the 0.5% DMBA-induced tumor, 86% to 62.5% and $3.7{\pm}0.6$ to $1.4{\pm}0.3$, respectively. The occurrence of histidine revertant by $20{\mu}mole$ DMBA was inhibited 25.6 to 81.7% by 1 to $5{\mu}M$ CHL in a dose-dependent manner. The mutation rates of H-ras gene in DMBA-induced and CHL-pretreated-DMBA induced tumor were 96%, 94% of which the most mutations were in codon 12/13. These results suggest that CHL inhibits the carcinogenic action of DMBA by the formation of complex between CHL and DMBA or the inhibition of the activation of DMBA in vivo. But CHL did not affect the mutation rates or its spectrum in already formed tumor.

• 한국항공우주학회지
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• 제30권7호
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• pp.105-112
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• 2002

높은 받음각 상태에 있는 연장된 앞전을 갖는 편요된 삼각날개 주위의 와류 유동 특성에 대하여 날개 윗면에서의 압력 측정을 통하여 연구하였다. 본 연구에서는 와류 유동의 물리적 현상, 특히 높은 받음각 상태에서 받음각과 옆미끄럼각이 날개 형상 주위의 공력 특성에 미치는 영향에 중점을 두었다. 실험 데이터로부터 LEX 와류가 날개와류에 유익한 효과를 부여함을 명확하게 알 수 있었다. 이는, 작은 옆미끄럼각 상태에서는 비교적 높은 받음각에 이르기까지 와류의 붕괴 없이 날개와류를 안정화시킴을 알 수 있다. 특정 범위의 받음각과 옆미끄럼각 상태에서는 롤링 모멘트가 역전되는 흥미로운 유동 현상을 관찰할 수 있었다.

• 대한수의학회지
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• 제27권1호
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• pp.27-34
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• 1987

To verify the direct effects of the thyroid hormone ($T_3$) on the rabbit heart, $T_3$-Tyrode solution in vitro was perfused on the normal atrial muscles and enzymatically isolated ventricular myocytes of the rabbit. All the experimental procedures were conducted at $35^{\circ}C$ and the same procedures were repeated after Ca. 120 minutes from the beginning of $T_3$-Tyrode perfusion. Compared to the state between the normal Tyrode solution and $T_3$-Tyrode solution, results were observed on the same cells by electrophysiological methods (conventional intracellular recording and whole cell patch clamping) as soon as possible. The results obtained were as follows : 1. Action potential duration (APD) on the left atrial muscle was reduced under the perfusion of $T_3$-Tyrode. 2. Absolute refractory Period was shortened by $T_3$-Tryrode perfusion. (117 msec./114 msec., 90 msec./78 msec.) 3. Maximal Ca currents ($i_{Ca}$) were decreased in single: ventricular myocytes under the $T_3$-Tyrode (2.98 nA) than under the normal Tyrode (6.65 nA) 4. On I-V relation, reversal potential was shifted to lower membrane potential and membrane potential showing maximal $i_{Ca}$was lowered from +10mV to -20mV by $T_3$ effect. 5. Above results were likely to explain that tachycardia in the hyperthyroid state was caused in part by the reduced repolarization phase and the reduced refractory period due to the decrease of the Ca current.

• Journal of Ginseng Research
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• 제30권1호
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• pp.1-7
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• 2006

Ceramide has been involved in celt death and acted as a lipid mediator of stress responses. Elevation of ceramide level was reported to occur in oxidative stress and lead to cell death in many cell types. This study was undertaken to elucidate a protective role of ginsenoside Rgl in cell death induced by oxidative stress. When LLC-PK1 cells were treated with $H_2O_2$ at a concentration of $400{\mu}M$ for 5 hr, cell death was observed and a released LDH activity indicative of cytotoxicity was Increased. $H_2O_2$ exposure to LLC-PK1 cells was shown to elevate the content of total ceramide by approximately 200% compared to control cells. Ceramide level was hypothesized to be a key to a reversal of cell death to survival. Ginsenoside Rgl at the concentrations ranging from 12.5 to $250{\mu}M$ protected LLC-PK1 cells from cell death induced by $H_2O_2\;at\;400{\mu}M$ for 5 hr, and decreased the ceramide level relative to $H_2O_2$. Ginsenoside Rgl inhibited neutral human ceramidase by 71% of controls, while sphingomyelinase was not inhibited. These results suggest that ginsenoside Rgl show the protection against cell death via the modulation of ceramide metabolism, and ceramide may be a promising therapeutic target for human diseases related to cell death.

• 한국자기학회지
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• 제9권6호
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• pp.312-320
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• 1999

RF 마그네트론 스퍼터링으로 제조한 SmCo/Cr 박막의 스퍼터 제조조건에 따르는 자기적 특성에 관하여 연구하였다. Sm 조성이 약 20 at %이고 Cr(50 nm)/SmCo(40 nm, 50W, 20mT)/Cr(150 nm, 100W, 30 mT)인 조건에서 제조한 시편에서 3.2 kOe의 최대 보자력을 얻었다. SmCo/Cr의 보자력은 하지층 표면거칠기와 SmCo의 조성에 크게 영향을 받았다. Cr 하지층의 거칠기는 Ar 분압과 두께가 증가할수록 증가하고 이는 SmCo 입자의 고립을 증가시켜 보자력이 증가된다. 본 SmCo 박막 증착시 사용한 RF 투입전력 및 Ar 분압은 SmCo의 조성을 변화시키며 최적의 조성(약 20 at.%Sm)에서 최대 보자력을 보인다. 또한 RF 파워 증가나 Ar 분압 증가에 의해 생긴 Cr 하지층의 표면거칠기, 치밀하지 않은 주상 계면구조등의 결함이 자구벽 이동을 방해하여 보자력 증가에 영향을 끼친다.

• 한국전자통신학회논문지
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• 제8권9호
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• pp.1413-1420
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• 2013

연구는 직접 삼킴 치료가 삼킴 기능 회복과 삶의 질에 미치는 효과를 알아보고자 실시하였다. 연구는 뇌졸중 환자 중 삼킴장애로 진단받은 1명의 환자를 2012년 12월 3일부터 동년 12월 21일 까지 3주간 실시하였다. 연구 디자인은 개별사례 연구 방법 중 반전 설계(AB)를 이용하였다. 직접 삼킴 치료는 주 5회, 1회기에 20분씩, 총 10회기를 실시하였고, 결과는 기초선과 직접 삼킴 치료 기간의 점수 차이를 비교하여 분석하였다. 직접 삼킴 치료 후에 뇌졸중 환자의 삼킴 기능은 향상되었고 향상된 삼킴 기능은 삶의 질 향상에 긍정적인 영향을 미쳤다. 이러한 결과를 근거로 임상에서는 직접 삼킴 치료가 가능한 대상자은 조기에 구강 섭취를 통한 직접 삼킴 치료를 실시해 환자들의 삼킴 기능과 삶의 질을 향상시킬 수 있도록 노력해야 할 것이다.

• 조명전기설비학회논문지
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• 제22권9호
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• pp.25-31
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• 2008

유도전동기의 자계는 전류의 방향에 따라 자화 및 감자되는 특성을 가지고 있다. 전통기의 자계를 형성하는데 필요한 자화전류는 유도성으로 무효전력의 대부분을 차지하고 있다. 무효전력은 유도전동기가 동작하는데 필요한 자계를 지속시키는 역할을 한다. 유도전통기의 역률은 낮은 편이므로 역률 보상이 필요하다. 유도전동기를 정격출력보다 낮은 부하로 운전할 경우 유효전력에 비해 무효성분의 비율증가로 역률이 낮아진다. 역률 보상장치의 용량은 전동기 정격에 맞도록 설치하기를 권고하고 있다. 그러나 부하의 운전상황에 따라 역률 보상용 커패시터 값은 수정하기가 어렵다. 본 논문에서는 저압 소용량 유도 전동기에 연결된 부하의 변화에 따라 전력 및 역률의 동작특성을 해석한 결과 기존에 제시된 낮은 역률 보상용 파라미터는 수정되어야 함을 확인하였다.

• 융합정보논문지
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• 제11권8호
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• pp.1-7
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• 2021

본 논문에서는 병렬 인터페이스형 디지털/아날로그 변환회로에 외부 소자를 추가해 1개 비트를 확장하는 방법을 제시했다. 이를 위해 디지털/아날로그 변환회로의 원리를 살펴보고 개별 소자를 추가해 1개 비트를 확장하는 경우에 발생되는 문제점을 분석했으며, 연산증폭기 회로를 이용한 디지털/아날로그 소자의 비트 확장 방법을 제시했다. 제시한 방법은 연산증폭기의 고정밀도 특성을 이용함에 따라 소자에 오차가 발생하더라도 출력파형의 전체적인 크기에만 영향을 미치고 각 비트 사이에서 발생하는 전압역전 현상은 발생하지 않는 특징을 지닌다. 제시한 방법의 효과를 확인하기 위해 실험회로를 구성해 출력의 절대전압 측정과 상대적 오차 측정을 실시한 결과 0.0756%의 전압오차가 나타남으로서 개별소자 추가에 의해 1개 비트 확장 시 요건인 0.195%를 충분히 충족함을 확인했다.

• The Journal of Korean Physical Therapy
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• 제35권4호
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• pp.95-104
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• 2023

Purpose: This study was undertaken to identify the effects of apparatus Pilates exercise on Cobb's angle, angle of trunk rotation, and depression in female patients with idiopathic scoliosis. Methods: Participants included five patients with idiopathic scoliosis presenting with Cobb's angle of 10 degrees or more. Among the single-subject experimental research designs, the reversal (ABA) design was selected and performed. The apparatus Pilates exercise was performed for a total of 16 weeks, comprising 8 weeks between the baseline and intervention 1 period and 8 weeks between intervention 1 and intervention 2 periods. The patients were then followed up for 5 weeks. Results: In all subjects, compared to the baseline, Cobb's angle and the angle of trunk rotation decreased after application of the apparatus Pilates exercise. The follow-up period also showed a similar continuous decline. Following the apparatus Pilates exercise, the depression scale in subject 3 was increased during the intervention 1 period as compared to the baseline. However, the patient displayed a reduced depression scale in intervention 2 and follow-up periods. The depression scale in all other subjects was decreased for both intervention periods and the follow-up period. Conclusion: The application of apparatus Pilates exercise improves Cobb's angle and the angle of trunk rotation for female patients with idiopathic scoliosis in their 10s and 20s. Our results also indicate that this is potentially an effective intervention method to overcome depression.