• Advances in nano research
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• v.14 no.3
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• pp.247-259
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• 2023

Muscle strength and hypertrophy are equivalent when low-intensity resistance exercise is paired with blood flow restriction. This paper deals with the impact of physical exercise in the form of body activities on drug delivery using nanodevices. The body's actions impact the blood flow since the nano drug delivery devices are released into the bloodstream, and physical exercise and all the activities that change the blood flow influence the stability of these nanodevices. The nanodevice for the drug delivery purpose is modeled via nonuniform tube structures based on the high-order beam theory along with the nonlocal strain gradient theory. The nanodevice is made by a central nanomotor as well as two nanoblade in the form of truncated conical nanotubes carrying the nanomedicine. The mathematical simulation of rotating nanodevices is numerically solved, and the effect of various parameters on the stability of nanodevices has been studied in detail after the validation study.

• The Korean Journal of Health Service Management
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• v.14 no.2
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• pp.1-14
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• 2020

Objectives : The purpose of this study was to test fitness of the structured model of SNS activities for health information. Methods : A structured questionnaire were administered to 500 subjects. A structural equation model was applied to collected data. Results : The response rate was 73.9%. The respondents mostly used Facebook and KakaoStory. They spent 70 minutes per day and 21~30% of this usage was taken by health information. In the variances, those who has religion more actively exchanged information about diseases and medical institutions. The goodness-of-fit of the model was .81(GFI) and .90(CFI). The main path was bridging capital -> bonding capital -> credibility -> SNS activities for health information. The path from quality of sharing information to SNS activities was not significant. It could be explained by the restriction of digital literacy. Conclusions : SNS activities for health information were determined by credibility, currency and bonding social capital. Bridging social capital, indirectly, influenced SNS activities through bonding social capital. Thus building bonding social capital would be a critical success factor for SNS.

• Research in Community and Public Health Nursing
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• v.29 no.4
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• pp.520-529
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• 2018

Purpose: The purpose of this study is to identify factors influencing activities-specific balance confidence in community-dwelling older adults. Methods: This is secondary analysis of data from an intervention study for improving cognitive function. The data were collected from March 2 to September 30, 2017 at a senior center. Data of 131 older adults were included for this secondary analysis, and were analyzed by using t-test, ANOVA, and multiple regression. Results: The mean score of activities-specific balance confidence is 65.08 out of a possible range of 0-100. The significant factors affecting activities-specific balance confidence among old adults include 'more than 85 years old', 'waist circumference', 'depressive symptoms', 'activity restriction due to fear of falling', and 'self-rated health' which explained 52.8% of the variance. Conclusion: The study results indicate that psychologic factors as well as physical condition should be considered for interventions to increase activities-specific balance confidence.

• Journal of Life Science
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• v.28 no.8
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• pp.931-937
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• 2018

Triptolide is a compound found in Tripterygium wilfordii and reported to have an anti-inflammatory and anti-oxidant activities. A previous study shows that the dietary supplementation with triptolide increases resistance to environmental stressors, including oxidative stress, heat shock, and ultraviolet irradiation, and extends lifespan in C. elegans. Here, we investigated the underlying mechanisms involved in the lifespan-extending effect of triptolide. The effect of triptolide on age-related diseases, such as diabetes mellitus and Alzheimer's disease, was also examined using animal disease models. The longevity phenotype conferred by triptolide was not observed in the eat-2 mutant, a well-known genetic model of dietary restriction, while there was an additional lifespan extension with triptolide in age-1 and clk-1 mutants. The long lifespan of age-1 mutant is resulted from a reduced insulin/IGF-1-like signaling and the clk-1 mutant lives longer than wild-type due to dysfunction of mitochondrial electron transport chain reaction. The effect of dietary restriction using bacterial dilution on lifespan also overlapped with that of triptolide. The toxicity of high glucose diet or transgenic human amyloid beta gene was significantly suppressed by the supplementation with triptolide. These findings suggest that triptolide can mimic the effect of dietary restriction on lifespan and onset of age-related diseases. We conclude that triptolide can be a strong candidate for the development of dietary restriction mimetics.

• Journal of Family Resource Management and Policy Review
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• v.12 no.3
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• pp.23-43
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• 2008

This research investigates the effect of leisure activities on lifestyle satisfaction of senior citizens. The target of this research is 202 people over 60 years of age who live in Seoul. Collected data was analyzed using frequency, percentage, average, T-test, one-way ANONA, and logistic regression analysis. SPSS and the Excel PC Program were used for the analysis. The following is the summary of the result of this research. First - in terms of participation in leisure activities: more active participation is observed with the elderly who have a spouse than with those who do not in every kind of leisure activity (except for the pastime activities). Second - all of the variables indicating the level of satisfaction from activities of the seniors who have a spouse are by far higher than those of the elderly who have no spouse. Third - the leisure activities and the satisfaction from the activities prove affective variables on whether they have a spouse or not. Notably, the religious leisure activities are enjoyed more by those senior citizens who are married. Comparatively, the unmarried senior citizens participate more actively in recreational and pastime leisure activities. This study suggests various practical means to promote leisure activities to the elderly and to raise the level of satisfaction received from those activities, as well as to help those who are concerned with understanding and improving lifestyle satisfaction of the elderly population. Nonetheless, this analysis is limited due to the restriction on the number of objects and samples studied. Therefore, studies to analyze leisure activities by regions in order to account for a more balanced set of systematical tools should follow.

• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.5
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• pp.743-749
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• 1994

This study was designed to investigate the effect of dietary ${\beta}-carotene$ level on the lipid metabolism and lipid peroxide metabolizing enzyme activities in rats. Male Sprague -Dawley rats were fed on diets containing five levels of ${\beta}-carotene$ (0, 10, 120, 1200, 12000mg/kg diet ; BC 0, BC 1, BC 2, BC 3, BC 4 group). The rats were sacrificed after 7 weeks of the feeding periods. Lipid peroxide value of mitochondrial fraction of rat liver was elevated in ${\beta}-carotene$ restriction group when compared to $\beta$ -carotene groups. Superxide dismutase activity increased significantly by ${\beta}-carotene$ supplementation. Both catalase and glutathione peroxidase activities were reduced with increasing ${\beta}-carotene$ supplementation, except only ${\beta}-carotene$ restriction group. In liver, the contents of total lipid and cholestero decreased by ${\beta}-carotene$ supplementation but triglyceride content was not different among treatment groups. HDL-and total cholesterol ratio in plasma of 12, 000 ${\beta}-carotene$ group decreased, and was similar to that of ${\beta}-carotene$ restriction group.

• Journal of Technologic Dentistry
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• v.30 no.2
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• pp.105-119
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• 2008

This study explored the status of free time activities among the dental technicians who are working at Seoul, Gyonggido, and Gangwondo. On the basis of this research, we aim to present needs and applicable solutions to improve the working conditions and enhance the quality of life through more effective time management in free time activities that lead to their self development and far more enriched life. 500 subjects were randomly chosen and the questionary sheets were provided. Among them, 305 sheets were returned to be analysed through SPSS Win 10.0 software and the results are as follows; First, mean in the satisfaction of leisure activities was 3.44(SD=.73). Mean in sub categories was as follows; psychological factor(M=3.65, SD=.71), social factor(M=3.54, SD=.75), rest factors(M=3.52, SD=.63), physical factor(M=3.43, SD=.88), other factors(M=3.40, SD=.66), circumstantial factor(M=3.33, SD=.63), educational factor(M=3.24, SD=.73). Second, the most relevant sub categories in the satisfaction of leisure activities were social, educational, physical, and other circumstantial factors by sequence. Factors that affect leisure activities satisfaction were career and status of health, which shows statistical significance(p<.001). That is to say, contention of this study is that the general characteristics are closely related with and affect the types and the level of satisfaction in leisure activities of the subjects. Considering these results, the dental businesses and the associations of dental technicians should recognize the needs to improve the time management through more efficient cooperations between dentists and back office dental team, systemized working time, and introduction of incentive system among others. On the basis of this appreciation, the dental business should provide more time and various opportunities with the dental technicians. Dental technicians also need to reconsider their appreciations of leisure activities, that is, leisure activities are not just spending time doing something but they refresh them and enable them to be more active and faithful to home and work.

• Journal of Korean Physical Therapy Science
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• v.26 no.3
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• pp.15-22
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• 2019

Background: The purpose of this study is to explore the effect of the functions of GMFM and ICF-CY on the activities and participation of ICF-CY sub-items. Design: Cross-sectional study. Method: This study compared and analyzed 95 children with cerebral palsy [type of CP: spasticity 86 (90.5%), hypotonia 4 (4.2%), mixed 5 (5.3%); type of palsy: quadriplegia 13 (13.7%), diplegia 71 (74.7%), hemiplegia 11 (11.6%)] using sub-items of functions, activities and participation from GMFM and ICF-CY. Result: The results show that the activities and participation of ICF-CY (9 sub-items) have significant effect on the functions of GMFM and ICF-CY (8 sub-items) (p<0.05). Conclusion: It is intended to provide data to establish practical therapeutic goals and interventions for functions, activities and participation, which are sub-categories of ICF-CY in cerebral palsy.

• The Korean Journal of Community Living Science
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• v.19 no.1
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• pp.87-99
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• 2008

The purpose of this study was to examine the effects of child rearing behavior and child rearing involvement on elementary school children's stress. The subjects were 201 children selected from 2 elementary schools and their parents. Data was collected using the children's stress index, the child rearing behavior questionnaire, and the child rearing involvement questionnaire, and was statistically analyzed using t-test, one-way ANOVA (Duncan test), correlation analysis and multiple regression analysis. The study showed that there were some significant differences in children's stress according to the child's gender, grade, and scholastic achievement. Correlation analysis indicated that the child's stress and the mother's child rearing behavior had significant correlation, especially the warmth acceptance behavior of the mother indicated negative high correlation. Also, the child's stress and father's child rearing behavior had significant correlation, especially the rejection restriction behavior of the father indicated positive high correlation. Correlation analysis indicated that the child's stress and the mother's child rearing involvement had significant correlation, especially the family activities involvement of the mother indicated negative high correlation. As well, the child's stress and the father's child rearing involvement had significant correlation, especially the day to day guidance involvement of the father indicated negative high correlation. It was also found that rejection restriction behavior of the father, permissiveness non-intervention behavior of the father, day to day guidance involvement of the father, family activities involvement of the father, and warmth acceptance behavior of the mother were all significant predictors of the elementary school child's stress.

• Toxicological Research
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• v.24 no.4
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• pp.245-251
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• 2008

Dietary restriction (DR) is the most efficacious intervention for retarding the deleterious effects of aging. DR increases longevity, decreases the occurrence and severity of age-related diseases, and retards the physiological decline associated with aging. The beneficial effects of DR have been mostly studied in non-neuronal tissues. However, several studies have showed that DR attenuate neuronal loss after several different insults including exposure to kainate, ischemia, and MPTP. Moreover, administration of the non-metabolizable glucose analog 2-deoxy-D-glucose (2DG) could mimic the neuroprotective effect of DR in rodent, presumably by limiting glucose availability at the cellular level. Based on the studies of chemically induced DR, it has been proposed that the mechanism whereby DR and 2DG protect neurons is largely mediated by stress response proteins such as HSP70 and GRP78 which are increased in neurons of rats and mice fed a DR regimen. In addition, DR, as mild metabolic stress, could lead to the increased activity in neuronal circuits and thus induce expression of neurotrophic factors. Interestingly, such increased neuronal activities also enhance neurogenesis in the brains of adult rodents. In this review, we focus on what is known regarding molecular mechanisms of the protective role of DR in neurodegenerative diseases and aging process. Also, we propose that DR is a mild cellular stress that stimulates production of neurotrophic factors, which are major regulators of neuronal survival, as well as neurogenesis in adult brain.