Browse > Article
http://dx.doi.org/10.5487/TR.2008.24.4.245

Molecular Mechanism of Dietary Restriction in Neuroprevention and Neurogenesis: Involvement of Neurotrophic Factors  

Park, Hee-Ra (Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University)
Park, Mi-Kyung (Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University)
Kim, Hyung-Sik (Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University)
Lee, Jae-Won (Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University)
Publication Information
Toxicological Research / v.24, no.4, 2008 , pp. 245-251 More about this Journal
Abstract
Dietary restriction (DR) is the most efficacious intervention for retarding the deleterious effects of aging. DR increases longevity, decreases the occurrence and severity of age-related diseases, and retards the physiological decline associated with aging. The beneficial effects of DR have been mostly studied in non-neuronal tissues. However, several studies have showed that DR attenuate neuronal loss after several different insults including exposure to kainate, ischemia, and MPTP. Moreover, administration of the non-metabolizable glucose analog 2-deoxy-D-glucose (2DG) could mimic the neuroprotective effect of DR in rodent, presumably by limiting glucose availability at the cellular level. Based on the studies of chemically induced DR, it has been proposed that the mechanism whereby DR and 2DG protect neurons is largely mediated by stress response proteins such as HSP70 and GRP78 which are increased in neurons of rats and mice fed a DR regimen. In addition, DR, as mild metabolic stress, could lead to the increased activity in neuronal circuits and thus induce expression of neurotrophic factors. Interestingly, such increased neuronal activities also enhance neurogenesis in the brains of adult rodents. In this review, we focus on what is known regarding molecular mechanisms of the protective role of DR in neurodegenerative diseases and aging process. Also, we propose that DR is a mild cellular stress that stimulates production of neurotrophic factors, which are major regulators of neuronal survival, as well as neurogenesis in adult brain.
Keywords
Aging; Brain; Caloric restriction; Neurodegenerative diseases; Neurogenesis;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Ayala, V., Naudi, A., Sanz, A., Caro, P., Portero-Otin, M., Barja, G. and Pamplona, R. (2007). Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver. J. Gerontol. Biol. Sci. Med. Sci., 62, 352-360   DOI
2 Bengzon, J., Kokaia, Z., Elmer, E., Nanobashvili, A., Kokaia, M. and Lindvall, O. (1997). Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc. Natl. Acad. Sci. U.S.A., 94, 10432-10437
3 Kim, H.J., Jung, K.J., Yu, B.P., Cho, C.G., Choi, J.S. and Chung, H.Y. (2002). Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech. Ageing Dev., 123, 1589-1595   DOI   ScienceOn
4 Lee, J., Duan, W., Long, J.M., Ingram, D.K. and Mattson, M.P. (2000). Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. J. Mol. Neurosci., 15, 99-108   DOI   ScienceOn
5 Major, D.E., Kesslak, J.P., Cotman, C.W., Finch, C.E. and Day, J.R. (1997). Life-long dietary restriction attenuates age-related increases in hippocampal glial fibrillary acidic protein mRNA. Neurobiol. Aging, 18, 523-526   DOI   ScienceOn
6 Mattson, M.P. (2003). Will caloric restriction and folate protect against AD and PD? Neurology, 60, 690-695   DOI   ScienceOn
7 Mattson, M.P., Culmsee, C. and Yu, Z.F. (2000). Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res., 301, 173-187   DOI   ScienceOn
8 Mattson, M.P., Lovell, M.A., Furukawa, K. and Markesbery, W.R. (1995). Neurotrophic factors attenuate glutamateinduced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J. Neurochem., 65, 1740-1751
9 Patel, N.V., Gordon, M.N., Connor, K.E. Good, R.A., Engelman, R.W., Mason, J., Morgan, D.G., Morgan, T.E. and Finch, C.E. (2005). Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models. Neurobiol. Aging, 26, 995-1000   DOI   ScienceOn
10 Sharma, S. and Kaur, G. (2008). Dietary restriction enhances kainate-induced increase in NCAM while blocking the glial activation in adult rat brain. Neurochem. Res., 33, 1178- 1188   DOI
11 Wang, J., Ho, L., Qin, W., Rocher, A.B., Seror, I., Humala, N., Maniar, K., Dolios, G., Wang, R., Hof, P.R. and Pasinetti, G.M. (2005). Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. Faseb. J., 19, 659-661   DOI
12 Adams, M.M., Shi, L., Linville, M.C., Forbes, M.E., Long, A.B., Bennett, C., Newton, I.G., Carter, C.S., Sonntag, W.E., Riddle, D.R. and Brunso-Bechtold, J.K. (2008). Caloric restriction and age affect synaptic proteins in hip- pocampal CA3 and spatial learning ability. Exp. Neurol., 211, 141-149   DOI   ScienceOn
13 Chung, H.Y., Kim, H.J., Kim, J.W. and Yu, B.P. (2001). The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann. N.Y. Acad. Sci., 928, 327-335
14 Mattson, M.P. (2000). Emerging neuroprotective strategies for Alzheimer's disease: dietary restriction, telomerase activation, and stem cell therapy. Exp. Gerontol., 35, 489-502   DOI   ScienceOn
15 Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.J. and Mattson, M.P. (2003). Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc. Natl. Acad. Sci. U.S.A., 100, 2911-2916
16 Lee, J., Bruce-Keller, A.J., Kruman, Y., Chan, S.L. and Mattson, M.P. (1999b). 2-Deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins. J. Neurosci. Res., 57, 48-61   DOI   ScienceOn
17 Sohal, R.S. and Weindruch, R. (1996). Oxidative stress, caloric restriction, and aging. Science, 273, 59-63   DOI   ScienceOn
18 Gage, F.H., Kempermann, G., Palmer, T.D., Peterson, D.A. and Ray, J. (1998). Multipotent progenitor cells in the adult dentate gyrus. J. Neurobiol., 36, 249-266   DOI   ScienceOn
19 Lee, J., Duan, W. and Mattson, M.P. (2002a). Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J. Neurochem., 82, 1367-1375   DOI   ScienceOn
20 Duman, R.S., Malberg, J. and Nakagawa, S. (2001). Regulation of adult neurogenesis by psychotropic drugs and stress. J. Pharmacol. Exp. Ther., 299, 401-407
21 Lee, C.K., Klopp, R.G., Weindruch, R. and Prolla, T.A. (1999a). Gene expression profile of aging and its retardation by caloric restriction. Science, 285, 1390-1393   DOI   ScienceOn
22 Magavi, S.S., Leavitt, B.R. and Macklis, J.D. (2000). Induction of neurogenesis in the neocortex of adult mice. Nature, 405, 951-955   DOI   ScienceOn
23 Weindruch, R. and Sohal, R.S. (1997). Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N. Engl. J. Med., 337, 986-994   DOI   ScienceOn
24 Mattson, M.P. (2008). Hormesis and disease resistance: activation of cellular stress response pathways. Hum. Exp. Toxicol., 27, 155-162   DOI
25 Yu, B.P. (1996). Aging and oxidative stress: modulation by dietary restriction. Free Radic. Biol. Med., 21, 651-68   DOI   ScienceOn
26 Frame, L.T., Hart, R.W. and Leakey, J.E. (1998). Caloric restriction as a mechanism mediating resistance to environmental disease. Environ. Health Perspect., 106 Suppl 1, 313-324   DOI
27 Roberge, M.C., Hotte-Bernard, J., Messier, C. and Plamondon, H. (2008). Food restriction attenuates ischemia-induced spatial learning and memory deficits despite extensive CA1 ischemic injury. Behav. Brain Res., 187, 123-132   DOI   ScienceOn
28 van Praag, H., Kempermann, G. and Gage, F.H. (1999). Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci., 2, 266-270   DOI   ScienceOn
29 Duan, W. and Mattson, M.P. (1999). Dietary restriction and 2- deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J. Neurosci. Res., 57, 195-206   DOI   ScienceOn
30 Gould, E. and Tanapat, P. (1997). Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat. Neuroscience, 80, 427-436   DOI   ScienceOn
31 Weindruch, R., Naylor, P.H., Goldstein, A.L. and Walford, R.L. (1988). Influences of aging and dietary restriction on serum thymosin alpha 1 levels in mice. J. Gerontol., 43, B40- B42
32 Duffy, P.H., Leakey, J.E., Pipkin, J.L., Turturro, A. and Hart, R.W. (1997). The physiologic, neurologic, and behavioral effects of caloric restriction related to aging, disease, and environmental factors. Environ. Res., 73, 242-248   DOI   ScienceOn
33 Rocamora, N., Palacios, J.M. and Mengod, G. (1992). Limbic seizures induce a differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, in the rat hippocampus. Brain Res. Mol. Brain Res., 13, 27-33   DOI   ScienceOn
34 Prolla, T.A. and Mattson, M.P. (2001). Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction. Trends Neurosci., 24, S21-S31   DOI   ScienceOn
35 Yu, Z.F. and Mattson, M.P. (1999). Dietary restriction and 2- deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J. Neurosci. Res., 57, 830-839   DOI   ScienceOn
36 Fontan-Lozano, A., Lopez-Lluch, G., Delgado-Garcia, J.M., Navas, P. and Carrion, A.M. (2008). Molecular bases of caloric restriction regulation of neuronal synaptic plasticity. Mol. Neurobiol., 38, 167-177   DOI   ScienceOn
37 Morgan, T.E., Rozovsky, I., Goldsmith, S.K., Stone, D.J., Yoshida, T. and Finch, C.E. (1997). Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: implications for the role of oxidative stress. Free Radic. Biol. Med., 23, 524-528   DOI   ScienceOn
38 Nilsson, M., Perfilieva, E., Johansson, U., Orwar, O. and Eriksson, P.S. (1999). Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory. J. Neurobiol., 39, 569-578   DOI   ScienceOn
39 Kitamura, T., Mishina, M. and Sugiyama, H. (2006). Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors. Neurosci. Lett., 393, 94-96   DOI   ScienceOn
40 Dubey, A., Forster, M.J., Lal, H. and Sohal, R.S. (1996). Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse. Arch. Biochem. Biophys., 333, 189-197   DOI   ScienceOn
41 Yu, B.P. and Chung, H.Y. (2001b). Stress resistance by caloric restriction for longevity. Ann. N.Y. Acad. Sci., 928, 39-47
42 Lee, J., Seroogy, K.B. and Mattson, M.P. (2002b). Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J. Neurochem., 80, 539-547   DOI   ScienceOn
43 Lowenstein, D.H. and Arsenault, L. (1996). The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons. J. Neurosci., 16, 1759-1769   DOI
44 McCay, C.M., Crowell, M.F. and Maynard, L.A. (1935). The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutrition., 10, 63-79   DOI
45 Christie, B.R. and Cameron, H.A. (2006). Neurogenesis in the adult hippocampus. Hippocampus, 16, 199-207   DOI   ScienceOn
46 Yu, B.P. and Chung, H.Y. (2001a). Oxidative stress and vascular aging. Diabetes Res. Clin. Pract., 54 Suppl 2, S73- S80   DOI   ScienceOn
47 Duan, W., Lee, J., Guo, Z. and Mattson, M.P. (2001). Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury. J. Mol. Neurosci., 16, 1-12   DOI   ScienceOn