• Anxiety and mood
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• v.2 no.2
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• pp.101-107
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• 2006

Object : Since autonomic nerve system dysfunction was known as the mechanism of panic disorder, many researchers used heart rate variability (HRV) as means of measuring autonomic nerve function of patients with panic disorder. We aimed to examine the effect of paroxetine medication for 3 months on symptom improvement and change of heart rate variability of the patients with panic disorder. Methods : The subjects were patients with panic disorder who visited the psychiatric outpatient clinic of Samsung Medical Center in Seoul. We included panic disorder patients who were aged from 20 to 50 and in normal BMI range (from 18 to 30) to minimize the effect of age and weight on HRV data. We excluded the patients with EKG abnormalities, hypertension or other major psychiatric disorders. They took 20-40 mg paroxetine medication a day for 3 months. Alprazolam was used only during the first month to control the acute panic symptoms and was tapered off after that. We measured the acute panic inventory (API), Hamilton rating scale for anxiety and depression (HAM-A & HAM-D), Spielberger state-trait anxiety inventory (STAIS, STAIT), and Beck depression inventory (BDI) in order to assess clinical improvement of the patients. And we measured time and frequency domain HRV in the resting, standing and cognitive stress states to assess the change of HRV. All measurements were done before and after paroxetine treatment. Result : After paroxetine medication, patients showed significant improvement in all psychiatric scales. In time domain of HRV, standard deviations of all R-R intervals (SDNN) were significantly increased in all states. In frequency domain of HRV, the ratio of high frequency to total power (HF/TP) in the standing state was significantly increased. Conclusion : After 3 months paroxetine medication, panic disorder patients showed significant clinical improvement and change in HRV data such as SDNN in all states and HF/TP ratio in the standing state. This result suggests that paroxetine medication is effective for the improvement of autonomic nerve system dysfunction in panic disorder patients.

• Journal of Oriental Neuropsychiatry
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• v.7 no.1
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• pp.39-48
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• 1996

This study was performed to investigate the effects of Qigong training after physical training stress in untrained college students For this study, 6 voluntary subjects(male 4, female 2) were chosen in untrained students of K University. they were trained by teachers during 6 weeks and tested just before Qingong training and after 6 weeks. Each subject was performed a treadmill exercise(model Q65, Quinton Co, U.S.A.) to the all-out state. During exercise stress test, electrocardiogram, heart rate were checked by stress test monitor(model Q4500, Quinton Co, U.S.A) and also oxygen uptake, maximal oxygen uptake analyzed continuously by automatic gas analysis(model QMC, Quinton Co, U.S.A). During physical training the serum were collected 3 times, pre-experimental rest time, and serum catecholamine were measured by HPLC.T-test of statistical analysis system was used in every experiment for statistical assessment. The results of T-test on these data were summarized as follow:1.Heart rate change during exercise stress test after Qigong training was shown more decreasing tendency than before training. Especially, heart rate change after Qigong training during resting periods was decreased significantly than before training.2. Oxygen uptake change during exercise stress test after Qigong training was shown more increasing tendency than before training, And also maximal oxygen uptake after Qigong training was shown more increasing tendency than before 6 weeks.3. Epinephrine level of after Qigong training was more decreased significantly than before training in all-out state. And norepinephrine level of after Qigong training was shown more decreasing tendency than before training in all-out state and after 30 minutes rest time. Above results indicate that Qigong training for 6 weeks could be effective to elevate the cardiopulmonary functions and diminish the stress responses of the physical stress.

• Journal of Digital Convergence
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• v.19 no.10
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• pp.295-301
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• 2021

Individual mental fatigue not only reduces cognitive ability and work performance, but also becomes a major factor in large and small accidents occurring in daily life. In this paper, a CNN model for EEG-based mental fatigue discrimination was proposed. To this end, EEG in the resting state and task state were collected and applied to the proposed CNN model, and then the model performance was analyzed. All subjects who participated in the experiment were right-handed male students attending university, with and average age of 25.5 years. Spectral analysis was performed on the measured EEG in each state, and the performance of the CNN model was compared and analyzed using the raw EEG, absolute power, and relative power as input data of the CNN model. As a result, the relative power of the occipital lobe position in the alpha band showed the best performance. The model accuracy is 85.6% for training data, 78.5% for validation, and 95.7% for test data. The proposed model can be applied to the development of an automated system for mental fatigue detection.

• Clinical Psychopharmacology and Neuroscience
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• v.16 no.4
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• pp.494-496
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• 2018

No previous reports have described a case in which deep brain stimulation elicited an acute mood swing from a depressive to manic state simply by switching one side of the bilateral deep brain stimulation electrode on and off. The patient was a 68-year-old woman with a 10-year history of Parkinson's disease. She underwent bilateral subthalamic deep brain stimulation surgery. After undergoing surgery, the patient exhibited hyperthymia. She was scheduled for admission. On the first day of admission, it was clear that resting tremors in the right limbs had relapsed and her hyperthymia had reverted to depression. It was discovered that the left-side electrode of the deep brain stimulation device was found to be accidentally turned off. As soon as the electrode was turned on, motor impairment improved and her mood switched from depression to mania. The authors speculate that the lateral balance of stimulation plays an important role in mood regulation. The current report provides an intriguing insight into possible mechanisms of mood swing in mood disorders.

• The Journal of the Korea Contents Association
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• v.14 no.11
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• pp.858-863
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• 2014

Through this study, we found out whether to measure objectively by using Transactional Analysis(TA) evaluating their own growth and benefit of health through the change of Ego-state, the personality structure and brain waves monitoring electric signals occurring in the brain of the human biological signals. According to the results of brain-wave test, M-type is brain-waves of healthy adults and a, ${\beta}$ were dominantly observed in the occipital while not sleeping. In particular, ${\beta}$ appears widely throughout the brain during nervous or concentrating metal activities and unlike N-type experimenters, ${\beta}$ was found to be dominant in M-type experimenters even in stable condition. N-type is brain waves of healthy adults and a, ${\beta}$ were dominantly observed in the occipital while not sleeping. In particular, unlike nervous or concentrating M-type, there was no noise such as tension and blink while resting. In addition, it turned out that subjects with high levels of A ego do not return quickly to the stable state and show a lot of Blinking and swallowing saliva, noise regardless of the pattern of Egogram. And brain waves of 11 people that the difference in data of OK-gram and Ego-state is the same in all items or less than -5 showed a low amplitude of $20{\mu}V$ in general. In conclusion, this study identified that the theory of personality pattern of Transactional Analysis Theory and brain-wave findings are consistent and also found out that brain waves are also associated according to each Ego-state of Egogram.

• Korean Journal of Health Education and Promotion
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• v.24 no.3
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• pp.21-34
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• 2007

Objectives: This study aims to examined whether physical activity prevent the negative effect of psychological stress on cardiovascular reactivity by reducing stress induced sympathetic output and preventing norepinephrine depletion negative psych-affective responses. It is assumed that physical activity reduces the magnitude of cardiovascular responses and psychological responses to stress which threaten individuals' physical and mental health. The result of investigating the effect of physical activity on reducing negative physiological and psychological responses would suggest useful information health for practitioners who want to prevent stress-induced diseases, especially coronary heart disease. Methods: participants of this study were 30 students (10 males & 20 females), whose mean age was 21.30 (SD=2.29). Fifteen students (5 males & 10 females) were assigned for in each group, treatment and control groups. They were interviewed and given a survey that included a consent form, demographics sheet and psychological tests, such as State-Trait Anger Expression Inventory and State-Trait Anxiety Inventory. Before the application of psychological stress, participants in treatment group were going through with a course of physical exercise, running on treadmill 15minutes, while participants in control group were not physically active. After exercise, there was 15 minutes resting period before applying cognitive stress. During the experiment, all participants performed challenging cognitive tasks for 20minutes in situations that were designed to experience learned helplessness and measured their cardiovascular reactivity including blood pressure and heart rate every 5 minutes, until 10 minutes after finishing the application of psychological stress(recovering state). In the end of experiment, they were given some psychological test again. Results: Heart rates of exercise group were significantly higher than non-exercise group, especially, five minute after applying cognitive stress and at the end of recovery, in other word 10 minutes after stressful event. Systolic blood pressures of exercise group were lower than those of non-exercise group during the stressful event, but this differences in borderline level of significance. state anger level of exercise group decreased even experiencing stress, while those of non-exercise group increase. And state anxiety level of exercise group decreased in borderline level of significance. Conclusion: This study reiterate health benefits of physical activity and suggest that regular moderate exercise may regulate cardiovascular reactivity and psycho-affective responses from stress by reducing stress induced sympathetic output.

• Steel and Composite Structures
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• v.36 no.6
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• pp.689-702
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• 2020

The current study deals with the size-dependent free vibration analysis of graphene nanoplatelets (GNPs) reinforced polymer nanocomposite plates resting on Pasternak elastic foundation containing different boundary conditions. Based on a four variable refined shear deformation plate theory, which considers shear deformation effect, in conjunction with the Eringen nonlocal elasticity theory, which contains size-dependency inside nanostructures, the equations of motion are established through Hamilton's principle. Moreover, the effective material properties are estimated via the Halpin-Tsai model as well as the rule of mixture. Galerkin's mathematical formulation is utilized to solve the equations of motion for the vibrational problem with different boundary conditions. Parametrical examples demonstrate the influences of nonlocal parameter, total number of layers, weight fraction and geometry of GNPs, elastic foundation parameter, and boundary conditions on the frequency characteristic of the GNPs reinforced nanoplates in detail.

• Korean Journal of Biological Psychiatry
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• v.25 no.1
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• pp.1-8
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• 2018

Insomnia is a common sleep-related symptom which occurs in many populations, however, the neural mechanism underlying insomnia is not yet known. The hyperarousal model explains the neural mechanism of insomnia to some extent, and the frontal cortex dysfunction has been known to be related to primary insomnia. In this review, we discuss studies that applied resting state and/or task-related functional magnetic resonance imaging to demonstrate the deficits/dysfunctions of functional activation and network in primary insomnia. Empirical evidence of the hyperarousal model and proposed relation between the frontal cortex and other brain regions in primary insomnia are examined. Reviewing these studies could provide critical insights regarding the pathophysiology, brain network and cerebral activation in insomnia and the development of novel methodologies for the diagnosis and treatment of insomnia.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2001.05a
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• pp.225-230
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• 2001

Intensity of background noise is a factor significantly affecting both subjective evaluation of experienced stress level and associated electroencephalographic (EEG) responses during mental load in noisy environments. In the study on 27 subjects we analyzed the influence of the background white noise (WN) intensity on psychophysiological responses during a word recognition test. Electrocortical activity were recorded during baseline resting state and 40 s long performance on 3 similar Korean word recognition tests with different intensities of background WN (55, 70 and 85 dB).. An important finding in terms of physiological reactivity was similarity of all physiological response profiles between 55 and 70dB WN, i.e., none of physiological variables differentiated the two conditions, while 85dB WN resulted in a significantly different profile of reactions (higher fast beta power in EEG spectra). This condition was characterized by highest subjective rating of experienced stress, had more fast beta activity and had tendency of right hemisphere dominance, emphasizing the role of brain lateralization in negative affect control.

• Korean Journal of Biological Psychiatry
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• v.22 no.3
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• pp.101-108
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• 2015

Recent breakthroughs in functional neuroimaging techniques have launched the quest of mapping the connections of the human brain, otherwise known as the human connectome. Imaging connectomics is an umbrella term that refers to the neuroimaging techniques used to generate these maps, which recently has enabled comprehensive brain mapping of network connectivity combined with graph theoretic methods. In this review, we present an overview of the key concepts in functional connectomics. Furthermore, we discuss articles that applied task-based and/or resting-state functional magnetic resonance imaging to examine network deficits in post-traumatic stress disorder (PTSD). These studies have provided important insights regarding the etiology of PTSD, as well as the overall organization of the brain network. Advances in functional connectomics are expected to provide insight into the pathophysiology and the development of biomarkers for diagnosis and treatment of PTSD.