• Journal of Integrative Natural Science
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• v.9 no.4
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• pp.241-248
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• 2016

Corticotropin-releasing factor receptors (CRFRs) activate the hypothalamic-pituitary-adrenal axis, which is an integral part of the fight or flight response to stress. Increase in CRH level is observed in Alzheimer's disease and major depression and hypoglycemia. Here, we report on the relevant physicochemical parameters required for the CRFR inhibitors. Comparative molecular similarity indices analysis (CoMSIA) was performed with the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolinesas CRFR inhibitors. The best predictions were obtained for the best CoMSIA model with a $q^2$ of 0.576 with 6 components and $r^2$ of 0.977. The statistical parameters from the generated CoMSIA models indicated that the data are well fitted and have high predictive ability. CoMSIA contour maps could be useful in the designing of more potent and novel CRFR derivatives.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2003.11a
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• pp.67-72
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• 2003

The present article evaluates a performance hall, which improves sound efficiency. In general, the sidewall of the music hall is plane circle. thus there happens a focus phenomenon. To overcome it. the music hall improves its sound efficiency by making its sidewall irregular. After measuring impulse response from the performance hall, evaluation indices on the temporal distribution of sound energy such as RT, EDT, D50, C80, RASTI and BR were obtained, and based on them, indoor acoustic characteristics and the generation of echoes were determined. According to the results, evaluation indices showed that the acoustic condition was satisfactory in general. This study is to provide fundamental data for acoustic design of music hall with round form by analyzing the room acoustic characteristics of music hall.

• Journal of Integrative Natural Science
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• v.9 no.3
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• pp.177-184
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• 2016

CXC chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils and it regulates the neutrophilic inflammation in the lung diseases. CXCR2 antagonist may reduce the neutrophil chemotaxis and alter the inflammatory response. Hence, in the present study, ligand based Comparative Molecular Similar Indices Analysis (CoMSIA) was performed on a series of CXCR2 antagonist named pyrimidine-5-carbonitrile-6-alkyl derivatives. The optimum CoMSIA model was obtained with statistically significant cross-validated coefficients ($q^2$) of 0.582 and conventional coefficients ($r^2$) of 0.987 with steric, electrostatic, hydrophobic, donor and acceptor fields. The contour maps suggest the important structural modifications and this study can be used to guide the development of potent CXCR2 antagonist.

• Journal of the Korea Safety Management & Science
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• v.5 no.3
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• pp.145-156
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• 2003

As we understand it, Process Capability indices are intended to provide single-number assessments of ability to meet specification limits on quality characteristics of interest. As a consequence of the varied ways in which PCIs are used, there have been two natural lines of research work: $\circled1$ studies on the properties of PCIs and their estimators in many different environments; $\circled2$ construction of new PCIs purporting to have better properties in certain circumstances. The most of existing process capability indices are concerned with the single variable. But, in many cases, a quality characteristic is composed with several factors. In that case, we want to know the integrated process capability of a quality characteristic not those of each factor. In this paper, we proposed a new multivariate system process capability index called $MSPCI:SC_{psk}$ which is the geometric mean of performance measure $C_{psk}$'S, and will be used as the criterion to assess multiple response process designs. Numerical illustration is done for $SC_{psk}$, $\overline{C_p}$(f), Cp, Cpk, Cpm, and Cpsk.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.870-874
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• 2004

This work presents a study on development of a practical and quantitative technique for assessment of the structural health condition by Piezoelectric impedance-based technique associated with longitudinal wave propagation method. The bolt fastening condition is adjusted by torque wrench. In order to estimate the damage condition numerically, three damage indices, impedance peak frequency shift ${\Delta}F$, peak amplitude ratio $\delta$ and quality factor ratio $\gamma$, are proposed in this paper. Furthermore, an assessment method is described for estimation of the damage by using these three damage indices.

• The Korean Journal of Nuclear Medicine
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• v.1 no.1
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• pp.79-82
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• 1967

Patients with aplastic anemia were treated with a combination of depo-testosterone cyclopentylpropionate(Upjohn) and dexamethasone. In 7 of 15 patients treated, there was response in which either a significant increase in hemoglobin concentration, a prolonged interval or a cessation of blood transfusion requirement developed during androgen therapy. Younger patients with cellular marrow appeared to be better responding to androgen. EEI(Effective Erythropoietic Index) formulated by Gardner & Nathan(1966) which was a helpful measurement as to whether patients with myelofibrosis whould respond to androgen, was evaluated in patients with aplastic anemia. It was concluded that EEI as well as ferrokinetics indices (Plasma-$^{59}Fe$-disappearance rate, RBC $^{59}Fe$ net incorporation) did not significantly correlate with the degree of response to androgen in aplastic anemia.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.8
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• pp.1074-1079
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• 2013

Demand response(DR) is potential generation alternative to improve the reliability indices of system and load points. However, when demand resources scheduled in DR market fail to reduce demand, it can create new problems associated with maintaining a reliable supply. In this paper, a reliability model of demand resource is constructed considering customers' behaviors in the same form as conventional generation units, where availability and unavailability are associated with the simple two-state model. As a result, the generalized reliability model of demand resources is represented by multi-state model.

• Coupled systems mechanics
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• v.6 no.1
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• pp.55-74
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• 2017

The evaluation of torsional effects on multistory buildings remains an open issue, despite considerable research efforts and numerous publications. In this study, a large number of multiple test structures are considered with normally distributed topological attributes, in order to quantify the statistically derived relationships between the torsional criteria and response parameters. The linear regression analysis results, depict that the center of twist and the ratio of torsion (ROT) index proved numerically to be the most reliable criteria for the prediction of the modal rotation and displacements, however the residuals distribution and R-squared derived for the ductility demands prediction, was not constant and low respectively. Thus, the assessment of the torsional parameters' contribution to the nonlinear structural response was investigated using artificial neural networks. Utilizing the connection weights approach, the Center of Strength, Torsional Stiffness and the Base Shear Torque curves were found to exhibit the highest impact numerically, while all the other torsional indices' contribution was investigated and quantified.

• The Journal of the Korean bone and joint tumor society
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• v.5 no.4
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• pp.221-228
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• 1999

The purpose of this study was to verify the importance of apoptosis in genesis of osteosarcoma and whether apoptosis may play an important role as a predictive factor for the response to chemotherapy. Of the patients who were diagnosed osteosarcoma between January 1995 and June 1999, ten patients were selected. All specimens were obtained before and after preoperative chemotherapy and examined for the occurrence of apoptosis. Apoptosis was investigated by in situ end-labeling technique on paraffin-embedded sections and apoptotic indices were calculated before and after chemotherapy. The ages of ten patients ranged from 15 to 59 with equal sex ratio. All patients completed the planned pre-operative chemotherapy. Apoptosis occurs in osteosarcoma and apoptotic indices are increased after chemotherapy. Mean apoptotic index (AI) before and after chemotherapy were 17.2 (range 6-28.9) and 26.3 (9.6-46.2), respectively. Apoptotic cells were usually present around the necrotic area. The AI was increased as the progression of stage and in responder group more than in non-responder. Apoptosis is induced by pre-operative chemotherapy and the response is variable. Changes in AI levels before and after chemotherapy may possibly predict an individual patient's overall response.

• Journal of Korean Critical Care Nursing
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• v.15 no.3
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• pp.37-50
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• 2022

Purpose : This study aimed to examine the item characteristics of the Korean version of the intensive care experience questionnaire (K-ICEQ) using the Rasch analysis model of the item response theory. Methods : In this methodological study, the validity of the scale was examined, and a secondary analysis was conducted using cohort data of patients who were discharged from the intensive care units (ICU). Data from 891 patients who responded to the K-ICEQ upon ICU discharge were analyzed. The WINSTEP program was used to analyze item characteristics, including item difficulty, fit indices, appropriateness scale, and separation reliability. Results : The difficulty level of all 26 items of the K-ICEQ was appropriate, and the fit indices of the 25 items, except for item 18, were good. The 5-point scale of the K-ICEQ was not appropriate in the three subscales. The item separation reliability was good in all subscales, but did not meet the criteria in terms of respondents. Conclusion : The results of examining the item characteristics of the K-ICEQ revealed a good degree of difficulty, fitness, and item separation reliability. To increase the validity of the K-ICEQ, we suggest the rearrangement of the overall item order, modification of the item description of the "recall of experience" subscale, and reduction of the scale response level.