• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4041-4047
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• 2013

Cancer vaccine development is in the process of becoming reality in future, due to successful phase II/III clinical trials. However, there are still problems due to the specificity of tumor antigens and weakness of tumor associated antigens in eliciting an effective immune response. Computational models to assess the vaccine efficacy have helped to improve and understand what is necessary for personalized treatment. Further research is needed to elucidate the mechanisms of activation of antigen specific cytotoxic T lymphocytes, decreased TREG number functionality and antigen cascade, so that overall improvement in vaccine efficacy and disease free survival can be attained. T cell epitomic based in sillico approaches might be very effective for the design and development of novel cancer vaccines.

• The Korean Journal of Pharmacology
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• v.13 no.1 s.21
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• pp.23-27
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• 1977

To investigate the efficacy, tolerance of Vibramycin Precon PT-122 M and to determine the nature, incidence and severity of side effects of this formulation, 19 patients with urogenital infections were studied. 1. Vibramycin Precon PT-122 M reduced the signs and symptoms of various urogenital infections so as to determine the overall efficacy as good or satisfactory. 2. Intravenous injection of PT-122 M was generally well tolerated in all patients except 2 case of discontinuation because of adverse effect. 3. PT-122 M showed mild to moderate side effects but clinical features ana response to therapy were not influencea by those side effects.

• Korean Journal of Clinical Pharmacy
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• v.14 no.1
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• pp.24-31
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• 2004

There was clinical study to support the efficacy that the anti-inflammatory and analgesic properties of deoxyribonuclease, bromelain helped to reduce symptoms of inflammation. The current study investigated the effects of deoxyribonuclease, bromelain on local traumatic edema. The author used a drug containing proteolytic and mucolytic enzymes, deoxyribonuclease and bromelain, into 61 patients from 16 to 89 years old. The therapeutic response and tolerance had been excellent, which was permitted to a swift resolution on local traumatic edema and a prompt functional reestablishment. These results demonstrated that the drug was effective in local edema symptoms, pains and improving general condition suffering from trauma. Consequently, the use of the proteolytic and mucolytic enzyme$(Deanase^{(R)})$ require improvement in the rehabilitation of the injured.

• Asia pacific journal of information systems
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• v.31 no.3
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• pp.257-276
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• 2021

This study investigates the factors that facilitate or hinder people to use mobile payment, especially drawing upon the theoretical perspectives on individual's privacy protection motivation and perceived market condition. Survey data (n = 200) were collected through a web-based platform and used to test a theoretical model. The results show that one's privacy protection power is formed by various individual and technological factors (i.e., perceived data exposure, self-efficacy, and response efficacy), and in turn it determines his/her intention to use mobile payment. Moreover, the relationship between privacy protection power and mobile payment use is conditional on the perceived market control by the service provider - with a perception of the high level of provider's market control, one uses mobile payment regardless of his/her privacy protection power, while under the low level of provider's market control, the decision depends on the degree of privacy protection power. The findings would help our understanding of why some people are more susceptible to mobile payment and others are not.

• IMMUNE NETWORK
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• v.16 no.2
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• pp.134-139
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• 2016

Programmed death-1 (PD-1) is a strong negative regulator of T lymphocytes in tumor-microenvironment. By engaging PD-1 ligand (PD-L1) on tumor cells, PD-1 on T cell surface inhibits anti-tumor reactivity of tumor-infiltrating T cells. Systemic blockade of PD-1 function using blocking antibodies has shown significant therapeutic efficacy in clinical trials. However, approximately 10 to 15% of treated patients exhibited serious autoimmune responses due to the activation of self-reactive lymphocytes. To achieve selective activation of tumor-specific T cells, we generated T cells expressing a dominant-negative deletion mutant of PD-1 (PD-1 decoy) via retroviral transduction. PD-1 decoy increased IFN-γ secretion of antigen-specific T cells in response to tumor cells expressing the cognate antigen. Adoptive transfer of PD-1 decoy-expressing T cells into tumor-bearing mice potentiated T cell-mediated tumor regression. Thus, T cell-specific blockade of PD-1 could be a useful strategy for enhancing both efficacy and safety of anti-tumor T cell therapy.

• Journal of the Korean Society of School Health
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• v.23 no.1
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• pp.41-52
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• 2010

Purpose: The objective of this study is to investigate the relationship between middle and high school students' internet addiction, social support, self-efficacy and school life adjustment. Data were collected by self-administered questionnaires at middle and high school students located in Seoul and the metropolitan areas. Methods: The response rate is 94.8% (474 cases). The internet addition was measured by K Scale. The various methods of analysis were used, for example, frequency analysis, t-test, analysis of variance, and multiple regression analysis. Results: First, the mean score of internet addiction level is 2.07 in 5 Likert scale. the internet addiction level of the male students are higher than female students (p<.05). Second, as a result of classification of internet addiction groups by K Scale, 11 students (2.3%) are included in high risk group, 27 students (5.7%) are in potential risk group, 436 students (92.0%) are in general group. Third, the level of social support and self-efficacy of middle and high school students are very high. The difference of social support by internet addiction groups was not statistically significant. But, the difference of self-efficacy by internet addiction groups was statistically significant. The level of self-efficacy of the students in general groups are more higher than in high risk group and in potential risk group (p<.01). Fourth, the difference of school adjustment by internet addiction groups was very statistically significant. The level of school life adjustment of the students in general groups are more higher than in high risk group and in potential risk group (p<.01). Fifth, the internet addiction have a negative correlation with school life adjustment. And the social support and self-efficacy have a positive correlation with school life adjustment (p<.01). Finally, in stepwise multiple regression analysis, the internet addiction affects negatively on the school adjustment. And the support of teacher among three types of them affects positively on the school life adjustment. And the social self-efficacy among two types of them affects positively on the school adjustment (p<.01). Conclusion: to adjust desirably the school environment of the middle and high school students, optimal and efficient management of internet addiction was needed in the future and the improvement and promotion of social support and social self-efficacy of the students was also demanded.

• Journal of Oriental Neuropsychiatry
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• v.21 no.4
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• pp.41-51
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• 2010

Objectives : Samul-tang(SM). Sagunja-tang(SG). Pamul-tang(PM) and Sipjeondaebo-tang(SJ) was used many diseases such as sterility. menstrual disorder. general prostration. recruitment in Korea. We investigated the immune stimulatory activities of SG. SM. PM and SJ in in vitro. Methods: For comparision for effective of SM. SG. PM and SJ. this study examined anti-inflammation(NO. PGE2 assay). anti-oxidation(DPPH assay) and immune response in in vitro assay. For immune response activities. this study used NO synthesis on RAW 264.7 cells, splenocyte proliferation and cytokine assay(IL-2, IL-4) in splenocyte. Results: The results showed that SG. SM. PM and SJ were no significant effect anti-oxidation and anti-inflammatory effects. For immune response. they showed the splenocyte proliferation and macrophage proliferation. We confirmed that they synthesised NO a dose-dependent manner significantly and secreted the IL-4. Conclusions : These results suggested the SG, SM, PM and SJ had immune stimulatory activity. A efficacy of immune response in them had produced similar results.

• Structural Engineering and Mechanics
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• v.15 no.6
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• pp.669-683
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• 2003

The stochastic optimal nonlinear control of coupled adjacent building structures is studied based on the stochastic dynamical programming principle and the stochastic averaging method. The coupled structures with control devices under random seismic excitation are first condensed to form a reduced-order structural model for the control analysis. The stochastic averaging method is applied to the reduced model to yield stochastic differential equations for structural modal energies as controlled diffusion processes. Then a dynamical programming equation for the energy processes is established based on the stochastic dynamical programming principle, and solved to determine the optimal nonlinear control law. The seismic response mitigation of the coupled structures is achieved through the structural energy control and the dimension of the optimal control problem is reduced. The seismic excitation spectrum is taken into account according to the stochastic dynamical programming principle. Finally, the nonlinear controlled structural response is predicted by using the stochastic averaging method and compared with the uncontrolled structural response to evaluate the control efficacy. Numerical results are given to demonstrate the response mitigation capabilities of the proposed stochastic optimal control method for coupled adjacent building structures.

• IMMUNE NETWORK
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• v.23 no.2
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• pp.19.1-19.10
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• 2023

Endemic human coronaviruses (HCoVs) have been evidenced to be cross-reactive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although a correlation exists between the immunological memory to HCoVs and coronavirus disease 2019 (COVID-19) severity, there is little experimental evidence for the effects of HCoV memory on the efficacy of COVID-19 vaccines. Here, we investigated the Ag-specific immune response to COVID-19 vaccines in the presence or absence of immunological memory against HCoV spike Ags in a mouse model. Pre-existing immunity against HCoV did not affect the COVID-19 vaccine-mediated humoral response with regard to Ag-specific total IgG and neutralizing Ab levels. The specific T cell response to the COVID-19 vaccine Ag was also unaltered, regardless of pre-exposure to HCoV spike Ags. Taken together, our data suggest that COVID-19 vaccines elicit comparable immunity regardless of immunological memory to spike of endemic HCoVs in a mouse model.

• Korean journal of communication and information
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• v.51
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• pp.5-25
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• 2010

The purpose of this research examined the relationship between the level of news usage on Influenza A(H1N1) and media users' behavioral intention toward health protection. Specifically, the study investigated causal relationships among exposure of media information on Influenza A(H1N1) as an independent variable, psychological protection motivation factors such as perceived severity, vulnerability, response efficacy, & self-efficacy as mediated variables and behavioral intention on personal and public health protection as dependent variables using structure equation model analysis. Self-reported questionnaires were administrated to 460 college students. The result indicated the followings. First, the level of news usage on Influenza A(H1N1) was not statistically significant on influencing behavioral intention toward personal and public health protection. Second, perceived severity, vulnerability, and self-efficacy were significant variables on behavioral intention toward personal health protection whereas perceived vulnerability and response efficacy were significant on public health protection. The function among factors in protection motivation theory is dependent upon whom protected from illness.