• 응용통계연구
• /
• 제30권6호
• /
• pp.993-1004
• /
• 2017

표본조사에서는 추정의 정확성 및 정밀성 향상을 위해 흔히 층화추출법을 사용하며 층 내에서는 동일한 표본 가중치를 이용하여 표본을 추출한다. 그러나 실제 응답률은 관심변수 값에 영향을 받을 수 있기 때문에 주어진 동일한 가중치는 응답률을 반영하여 보정되어야 한다. 또한 관심변수가 연속형 보조변수와 선형 관계가 있고 보조변수를 기준으로 층이 나누어진 경우에는 층 내에서 동일한 가중치를 사용하는 것 보다 층을 세분화한 후 얻어진 가중치를 사용하는 것이 효과적일 수 있다. 본 연구에서는 응답률이 관심변수 자료 값의 지수함수이고, 관심변수가 보조변수와 선형 관계가 있을 때 정보적 표본설계 기법을 이용하여 추정의 정확성과 정밀성을 높이는 방법을 제안하였다. 또한 모의실험을 통하여 제안된 방법의 우수성을 확인하였다.

• Journal of Mechanical Science and Technology
• /
• 제19권5호
• /
• pp.1194-1205
• /
• 2005

The common-rail injection systems, as a new diesel injection system for passenger car, have more degrees of freedom in controlling both the injection timing and injection rate with the high pressure. In this study, a piezo-driven injector was applied to a high pressure common-rail type fuel injection system for the control capability of the high pressure injector's needle and firstly examined the piezo-electric characteristics of a piezo-driven injector. Also in order to analyze the effect of injector's needle response driven by different driving method on the injection, we investigated the diesel spray characteristics in a constant volume chamber pressurized by nitrogen gas for two injectors, a solenoid-driven injector and a piezo-driven injector, both equipped with the same injection nozzle with sac type and 5-injection hole. The experimental method for spray visualization was based on back-light photography technique by utilizing a high speed framing camera. The macroscopic spray propagation was geometrically measured and characterized in term of the spray tip penetration, spray cone angle and spray tip speed. For the evaluation of the needle response of the above two injectors, we indirectly estimated the needle's behavior with an accelerometer and injection rate measurement employing Bosch's method was conducted. The experimental results show that the spray tip penetrations of piezo­driven injector were longer, on the whole, than that of the solenoid-driven injector. Besides we found that the piezo-driven injector have a higher injection flow rate by a fast needle response and it was possible to control the injection rate slope in piezo-driven injector by altering the induced current.

• Radiation Oncology Journal
• /
• 제34권3호
• /
• pp.168-176
• /
• 2016

Purpose: The purpose of current study is to evaluate the response of the patients with portal vein thrombosis (PVT) or hepatic vein thrombosis (HVT) in hepatocellular carcinoma (HCC) treated with three-dimensional conformal radiation therapy (3D-CRT). In addition, survival of patients and potential prognostic factors of the survival was evaluated. Materials and Methods: Forty-seven patients with PVT or HVT in HCC, referred to our department for radiotherapy, were retrospectively reviewed. For 3D-CRT plans, a gross tumor volume (GTV) was defined as a hypodense filling defect area in the portal vein (PV) or hepatic vein (HV). Survival of patients, and response to radiation therapy (RT) were analyzed. Potential prognostic factors for survival and response to RT were evaluated. Results: The median survival time of 47 patients was 8 months, with 1-year survival rate of 15% and response rate of 40%. Changes in Child-Pugh score, response to RT, Eastern cooperative oncology group performance status (ECOG PS), hepatitis C antibody (HCVAb) positivity, and additional post RT treatment were statistically significant prognostic factors for survival in univariate analysis (p = 0.000, p = 0.018, p = 0.000, p = 0.013, and p = 0.047, respectively). Of these factors, changes in Child-Pugh score, and response to RT were significant for patients' prognosis in multivariate analysis (p = 0.001 and p = 0.035, respectively). Conclusion: RT could constitute a reasonable treatment option for patients with PVT or HVT in HCC with acceptable toxicity. Changes in Child-Pugh score, and response to RT were statistically significant factors of survival of patients.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권5호
• /
• pp.2093-2098
• /
• 2015

In patients with multiple myeloma (MM), once-weekly intravenous injection or twice-weekly subcutaneous injection (SC) of bortezomib has been proven to offer non-inferior efficacy to standard twice-weekly intravenous administration, with an improved safety profile. However, whether once-weekly SC bortezomib can further reduce the incidence rate of peripheral neuropathy (PN) and not compromise the efficacy remains to be investigated. 25 patients of MM treated with once-weekly SC bortezomib were reviewed in this study. The median treatment cycles were 4 (range, 2-9 cycles). Complete response (CR) rate was 52%, ${\geq}$very good partial response (VGPR) rate was 72%, and ${\geq}$partial response (PR) rate was 84%. 1-year and 2-year PFS rate was 63.0% and 34.3%, respectively, and 2-year OS rate was 100%. Any grade of PN was reported in 9 patients (36.0%), with 7 patients (28.0%) had grade 1 PN, and 2 patients (8.0%) had grade 2 PN. No patients reported grade 3/4 PN in this cohort. In conclusion, once-weekly subcutaneous administration of bortezomib offers excellent efficacy with a further improved safety profile, especially with regard to PN. It needs to be validated in future prospective randomized trials.

• 한국구조물진단유지관리공학회 논문집
• /
• 제22권1호
• /
• pp.48-55
• /
• 2018

본 연구의 목적은 구조 시스템의 구조적 손상에 의한 고유주파수 감소율과 감쇠변수 증가율을 비교 분석하는 것이다. 이를 위하여 저주파 영역의 고유주파수와 비교적 높은 감쇠변수 특성을 갖는 2경간 H-Beam을 대상으로 실내실험과 수치해석을 수행하였으며, 충격하중에 대한 손상 전과 손상 후 응답신호를 각각 14개 위치에서 분석하였다. 각 위치에 대한 손상 전과 손상 후 응답신호는 푸리에 변환을 통하여 고유주파수 감소율을 분석하였으며, 감쇠변수 증가율은 웨이블릿 변환을 통하여 수행되었다. 웨이블릿 변환은 최대 웨이블릿 계수에 대응되는 스케일의 시간함수 분리가 가능하기 때문에 감쇠변수 평가에 대한 정확성을 높일 수 있다. 손상 전과 손상 후 계측된 응답신호에 대하여 고유주파수 감소율은 민감하지 못한 결과로 평가되었고, 감쇠변수 증가율은 비교적 큰 변화량을 보여 구조 시스템의 손상도 평가에 신뢰할 수 있는 결과를 보여주었다.

• 보건교육건강증진학회지
• /
• 제19권1호
• /
• pp.45-58
• /
• 2002

This research was conducted to understand and analyze the physical awareness symptoms of college students and get fundamental research data essential to provide efficient student guidance and public health service at schools. The survey was carried out for 1 month from May 7th, 2001 to June 7th, 2001. The interviewees were 950 enrolled students at junior colleges in Daegu. 26.5% of them were men and 73.5% women. Among the surveyed, public health majors were 76.9%. Daytime students were 64.1 %, and the majority of the students, 42.8%, were atheistic. 56.0% of the students grew up in big cities, 22.2% in medium and small-sized cities, and 21.8% in farming and fishing communities. 66.1 % used public transportation. The majority of the students, 48.7%, answered that the satisfaction level for their majors was average. The result shows that the ocular fatigue was indicated as a greatest complaint, and the female students showed the higher complaint rate than the males. In the study of the complaining rate of physical symptoms by major, the public health majors showed the highest complaining rate in gasping when going up/down stairs, shoulder pain, a burning feeling on empty stomach, and leg/knee pain. On the other hand, the highest complaint factors for the technical majors were ocular fatigue and the feelings of heavy head. In the study of the complaining rate of physical symptoms by transportation, gasping during going up/down stairs and shoulder pain were most common, which were 52.2% and 36.0% respectively. In the study of the insecurity response distribution by transportation, college students who drive a car showed 3.8% and students using public transportation 3.7%. In the study of the insecurity response by subject satisfaction, students who answered dissatisfactory were 8.3%, average 3.9%, satisfied 3.0%. Therefore, it was concluded that students who were dissatisfied with their subjects showed the higher rate of insecurity response. it can be recommended that a school health education program regarding ocular fatigue and shoulder pain should be developed.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권15호
• /
• pp.6627-6632
• /
• 2015

Background: We conducted a study exploring the clinical safety and efficacy of decitabine in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), combined with a complex karyotype. Materials and Methods: From April 2009 to September 2013, a total of 35 patients with AML/MDS combined with a complex karyotype diagnosed in the First Affiliated Hospital of Soochow University were included for retrospective analysis. All patients were treated with decitabine alone ($20mg/m^2$ daily for 5 days) or combination AAG chemotherapy (Acla 20mg qod*4d, Ara-C $10mg/m^2$ q12h*7d, G-CSF $300{\mu}g$ qd, the dose of G-CSF adjusted to the amount in blood routinely). Results: In 35 patients, 15 exhibited a complete response (CR), and 6 a partial response (PR), the overall response rate (CR+PR) being 60% (21 of 35). Median disease-free survival was 18 months and overall survival was 14 months. In the 15 MDS patients with a complex karyotype, the CR rate was 53.3% (8 of 15); in 20 AML patients with complex karyotype, the overall response rate was 65% (13 of 20). The response rate of decitabine alone (22 cases) was 56.5% (13 of 22), while in the combination chemotherapy group (13 cases), the effective rate was 61.5% (8 of 13)(P>0.05). There are 15 patients with chromosome 7 aberration, after treatment with decitabine, 7 CR, 3 PR, overall response rate was 66.7% (10 of 15). Of 18 patients with 3 to 5 kinds of chromosomal abnormalities, 66.7% demonstrated a response; of 17 with more than 5 chromosomal abnormalities, 52.9% had a response. In the total of 35 patients, with one course (23 patients) and ${\geq}$two courses (12 patients), the overall response rate was 40.9% and 92.3% (P<0.05). Grade III to IV hematological toxicity was observed in 27 cases (75%). Grade III to IV infections were clinically documented in 7 (20%). Grades I to II non-hematological toxicity were infections (18 patients), haematuria (2 patients), and bleeding (3 patients). With follow-up until September 2013, 7 patients were surviving, 18 had died and 10 were lost to follow-up. In the 6 cases who underwent allogeneic hematopoietic stem cell transplantation (HSCT) all were still relapse-free survivors. Conclusions: Decitabine alone or combination with AAG can improve outcome of AML/MDS with a complex karyotype, there being no significant difference decitabine in inducing remission rates in patients with different karyotype. Increasing the number of courses can improve efficiency. This approach with fewer treatment side effects in patients with a better tolerance should be employed in order to create an improved subsequent chance for HSCT.

• 대한간호학회지
• /
• 제36권4호
• /
• pp.621-629
• /
• 2006

Purpose. The purpose of this study was to identify the clinical variables that predict functional and cognitive recovery at 1- and 6-month in both severe and moderate/mild traumatic brain injury patients. Methods. The subjects of this study were 82 traumatically brain-injured patients who were admitted to a Neurological Intensive Care Unit at a university hospital. Potential prognostic factors included were age, motor and pupillary response, systolic blood pressure, heart rate, and the presence of intracranial hematoma at admission. Results. The significant predictors of functional disability in severe traumatic brain injury subjects were, age, systolic blood pressure, the presence of intracranial hematoma, motor response, and heart rate at admission. In moderate/mild traumatic brain injury patients, motor response, abnormal pupil reflex, and heart rate at admission were identified as significant predictors of functional disability. On the other hand, the significant predictors of cognitive ability for severe traumatic brain injury patients were motor response and the presence of intracranial hematoma at admission, whereas those for moderate/mild patients were motor response, pupil reflex, systolic blood pressure at admission, and age. Conclusions. The results of the present study indicate that the significant predictors of TBI differ according to TBI severity on admission, outcome type, and outcome measurement time. This can be meaningful to critical care nurses for a better understanding on the prediction of brain injury patients. On the other hand, the model used in the present study appeared to produce relatively low explicabilities for functional and cognitive recovery although a direct comparison of our results with those of others is difficult due to differences in outcome definition and validation methods. This implies that other clinical variables should be added to the model used in the present study to increase its predicting power for determining functional and cognitive outcomes.

• 상하수도학회지
• /
• 제29권2호
• /
• pp.193-202
• /
• 2015

The determining the appropriate dosage of coagulant is very important, because dosage of coagulant in the coagulation process for wastewater affects removing the amount of pollutants, cost, and producing sludge amount. Accordingly, in this study, in order to determine the optimal PAC dosage in the coagulation process, CCD (Central composite design) was used to proceed experimental design, and the quadratic regression models were constructed between independent variables (pH, influent turbidity, PAC dosage) and each response variable (Total coliform, E.coli, PSD (Particle size distribution) (< $10{\mu}m$), TP, $PO_4$-P, and $COD_{cr}$) by the RSM (Response surface methodology). Also, Considering the various response variables, the optimum PAC dosage and range were derived. As a result, in order to maximize the removal rate of total coliform and E.coli, the values of independent variables are the pH 6-7, the influent turbidity 100-200 NTU, and the PAC dosage 0.07-0.09 ml/L. For maximizing the removal rate of TP, $PO_4$-P, $COD_{cr}$, and PSD(< $10{\mu}m$), it is required for the pH 9, the influent turbidity 200-250 NTU, and the PAC dosage 0.05-0.065 ml/L. In the case of multiple independent variables, when the desirable removal rate for total coliform, E.coli, TP, and $PO_4$-P is 90-100 % and that for $COD_{cr}$ and PSD(< $10{\mu}m$) is 50-100 %, the required PAC dosage is 0.05-0.07 ml/L in the pH 9 and influent turbidity 200-250 NTU. Thus, if the influent turbidity is high, adjusting pH is more effective way in terms of cost since a small amount of PAC dosage is required.

• 동아시아식생활학회지
• /
• 제22권2호
• /
• pp.255-263
• /
• 2012

Tuile containing retrograded rice and black sesame was developed by optimization of the mixing rate of retrograded rice and egg white using response surface methodology. Nine samples of design points were obtained according to central composite design, and the optimal mixing rate of retrograded rice flour and egg white as independent variables was calculated with the sensory score, color, and texture as response variables. Nine samples of the experimental group and no added retrograded rice flour Tuile were also compared in terms of sensory properties, color and texture. According to the results, the optimal mixing rate of black sesame Tuile was 8.6 g of retrograded rice and 33.5 g of egg white. Regression analysis of the response showed that retrograded rice flour and egg white had effect on the color and texture of black sesame Tuile, with egg white more influential rather than retrograded rice. In a comparison of quality between retrograded rice flour added Tuile and no retrograded rice flour Tuile, lightness ($p$<0.05), hardness ($p$<0.001) and fracturability ($p$<0.001) of retrograded rice flour added Tuile was better than those of the other sample, and sensory quality in terms of color ($p$<0.01), taste ($p$<0.001), texture ($p$<0.01) were more excellent as well.