• Structural Engineering and Mechanics
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• v.17 no.1
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• pp.69-85
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• 2004

The novel form of composite walling system consists of two skins of profiled steel sheeting with an in-fill of concrete. Such walling system can be used as shear elements in steel framed building subjected to lateral load. This paper presents the results of small-scale model tests on composite wall and its components manufactured from very thin sheeting and micro-concrete tested under monotonic and cyclic shear loading conditions. The heavily instrumented small-scale tests provided information on the load-deformation response, strength, stiffness, strain condition, sheet-concrete interaction and failure modes. Analytical models for shear strength and stiffness are derived with some modification factor to take into account the effect of quasi-static cycling loading. The performance of design equations is validated through experimental results.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2003.03a
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• pp.377-384
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• 2003

Recently, there are much concerns about new and innovative transverse materials which could be used instead of conventional transverse steel in reinforced concrete bridge piers. FRP materials could be substituted for conventional transverse steel because of their sufficient strength, light weight, easy fabrication, and useful applicability to any shapes of pier sections, such as rectangular or circular sections. The objective of this research is to evaluate the seismic performance of reinforced concrete bridge pier specimens with FRP transverse reinforcement by means of the Quasi-Static test. In the first task, test columns were made using FRP rope, but these specimens appeared to fail at low displacement ductility levels due to insufficient confinement of strand extension itself. Therefore, the second task was to evaluate the seismic performance of test specimens transversely confined with FRP band. Although FRP banded specimens showed lower seismic performance than the specimen with spiral reinforcing steel, it satisfied with the response modification factor, 3, required for the single column of Korea bridge roadway design code. It was concluded that FRP band could be efficiently substituted for conventional reinforcing steel.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.1
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• pp.31-38
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• 2015

In this paper, change of load carrying capacity of bridges with time was analyzed referring to the safety inspect data stored in the KISTEC. From this study, it was known that the capacity is rated differently by various parameters such as inspector's subjective. Accordingly, an improved method, in this paper, is suggested which can correct deviation due to several uncertainties involved in rating process. The suggested method can be utilized for efficient maintenance of bridges such as cycles and determination of priority of retrofit, and estimation of service life etc.

• Journal of Korean Society of Steel Construction
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• v.23 no.2
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• pp.189-198
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• 2011

Many new structural systems have been developed to build free-form structures, which is the new architectural trend for aesthetic beauty. The diagrid system resists both gravity and later loads, with its perimeter-diagonal columns. In the current seismic-design provisions, however, a seismic-performance factor for a new structural system has not yet been provided. ATC-63 provides a new methodology for defining various seismic-performance factors, including the response modification factor. In this paper, nonlinear static and dynamic analyses were conducted for the 3D diagrid frame, with each load applied at $0-180^{\circ}$ degrees. Through these analyses, the seismic performance of the diagrid system was evaluated.

• Journal of The Korean Society of Grassland and Forage Science
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• v.41 no.4
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• pp.242-249
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• 2021

Forage crop management is severely challenged by global warming-induced climate changes representing diverse a/biotic stresses. Thus, screening of valuable genetic resources would be applied to develop stress-tolerant forage crops. We isolated two NAC (NAM, ATAF1, ATAF2, CUC2) transcription factors (ANAC032 and ANAC083) transcriptionally activated by multi-abiotic stresses (salt, drought, and cold stresses) from Arabidopsis by microarray analysis. The NAC family is one of the most prominent transcription factor families in plants and functions in various biological processes. The enhanced expressions of two ANACs by multi-abiotic stresses were validated by quantitative RT-PCR analysis. We also confirmed that both ANACs were localized in the nucleus, suggesting that ANAC032 and ANAC083 act as transcription factors to regulate the expression of downstream target genes. Promoter activities of ANAC032 and ANAC083 through histochemical GUS staining again suggested that various abiotic stresses strongly drive both ANACs expressions. Our data suggest that ANAC032 and ANAC083 would be valuable genetic candidates for breeding multi-abiotic stress-tolerant forage crops via the genetic modification of a single gene.

• Korean Journal of Microbiology
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• v.49 no.3
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• pp.215-220
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• 2013

Against environmental stresses, many bacteria utilize the alternate sigma factor RpoS that induces transcription of the specific set of genes helpful in promoting bacterial survival. Intracellular levels of RpoS are determined mainly by its turnover through proteolysis of ClpXP protease. Delivery of RpoS to ClpXP strictly requires the adaptor protein RssB. The two-component-type response regulator RssB constantly interacts with RpoS, but diverse environmental changes inhibit this interaction through modification of RssB activity, which increases RpoS levels in bacteria. This review discusses and summarizes recent findings on regulatory factors in RssB-RpoS interactions, including IraD, IraM, IraP anti-adaptor proteins of RssB and phosphorylation of N-terminal receiver domain of RssB. New information shows that the coordinated regulation of RssB activity in controlling RpoS turnover confers efficient bacterial defense against stresses.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.6
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• pp.235-244
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• 2021

This study analyzes the applicability of limit state design method on bridge evaluation by considering the experiment of the existing bridge. The test strength of the member is obtained from the PSC beam bridge experiment. The test strength is compared with the calculated strength obtained from the statistical characteristics of material test strength and the two values are almost the same. The response modification factor and dynamic impact factor are obtained from the vehicle loading test. The rating factor is calculated by applying limit state design method as well as current evaluation method and the results are compared. The reliability index of the test bridge is calculated by using the statistical properties of the member strength obtained from material test and simulation. When the statistical properties of the PSC beam tested in this study are applied, the reliability index with a larger value was obtained than the reliability index obtained with the statistical properties of the design code.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.3
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• pp.191-200
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• 2014

We investigated the anxiolytic-like activity of ${\alpha}$-asarone (AAS) from Acorus gramineus in an experimental rat model of anxiety induced by repeated administration of the exogenous stress hormone corticosterone (CORT). The putative anxiolytic effect of AAS was studied in behavioral tests of anxiety, such as the elevated plus maze (EPM) test and the hole-board test (HBT) in rats. For 21 consecutive days, male rats received 50, 100, or 200 mg/kg AAS (i.p.) 30 min prior to a daily injection of CORT. Dysregulation of the HPA axis in response to the repeated CORT injections was confirmed by measuring serum levels of CORT and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Daily AAS (200 mg/kg) administration increased open-arm exploration significantly in the EPM test, and it increased the duration of head dipping activity in the HBT. It also blocked the increase in tyrosine hydroxylase (TH) expression in the locus coeruleus (LC) and decreased mRNA expression of brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, in the hippocampus. These results indicated that the administration of AAS prior to high-dose exogenous CORT significantly improved anxiety-like behaviors, which are associated with modification of the central noradrenergic system and with BDNF function in rats. The current finding may improve understanding of the neurobiological mechanisms responsible for changes in emotions induced by repeated administration of high doses of CORT or by elevated levels of hormones associated with chronic stress. Thus, AAS did exhibit an anxiolytic-like effects in animal models of anxiety.

• Advances in Computational Design
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• v.4 no.4
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• pp.327-342
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• 2019

Rehabilitation and retrofitting of structures designed in accordance to standard design codes is an essential practice in structural engineering and design. For steel structures, one of the challenges is to strengthen the panel zone as well as its analysis in moment-resisting frames. In this research, investigations were undertaken to analyze the influence of the panel zone in the response of structural frames through a computational approach using ETABS software. Moment-resisting frames of six stories were studied in supposition of real panel zone, different values of rigid zone factor, different thickness of double plates, and both double plates and rigid zone factor together. The frames were analyzed, designed and validated in accordance to Iranian steel building code. The results of drift values for six stories building models were plotted. After verifying and comparing the results, the findings showed that the rigidity lead to reduction in drifts of frames and also as a result, lower rigidity will be used for high rise building and higher rigidity will be used for low rise building. In frames with story drifts more than the permitted rate, where the frames are considered as the weaker panel zone area, the story drifts can be limited by strengthening the panel zone with double plates. It should be noted that higher thickness of double plates and higher rigidity of panel zone will result in enhancement of the non-linear deformation rates in beam elements. The resulting deformations of the panel zone due to this modification can have significant influence on the elastic and inelastic behavior of the frames.

• Biomolecules & Therapeutics
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• v.29 no.1
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• pp.90-97
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• 2021

Ultraviolet B (UVB) radiation causes DNA base modifications. One of these changes leads to the generation of 8-oxoguanine (8-oxoG) due to oxidative stress. In human skin, this modification may induce sunburn, inflammation, and aging and may ultimately result in cancer. We investigated whether phloroglucinol (1,3,5-trihydroxybenzene), by enhancing the expression and activity of 8-oxoG DNA glycosylase 1 (Ogg1), had an effect on the capacity of UVB-exposed human HaCaT keratinocytes to repair oxidative DNA damage. Here, the effects of phloroglucinol were investigated using a luciferase activity assay, reverse transcription-polymerase chain reactions, western blot analysis, and a chromatin immunoprecipitation assay. Phloroglucinol restored Ogg1 activity and decreased the formation of 8-oxoG in UVB-exposed cells. Moreover, phloroglucinol increased Ogg1 transcription and protein expression, counteracting the UVB-induced reduction in Ogg1 levels. Phloroglucinol also enhanced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) as well as Nrf2 binding to an antioxidant response element located in the Ogg1 gene promoter. UVB exposure inhibited the phosphorylation of protein kinase B (PKB or Akt) and extracellular signal-regulated kinase (Erk), two major enzymes involved in cell protection against oxidative stress, regulating the activity of Nrf2. Akt and Erk phosphorylation was restored by phloroglucinol in the UVB-exposed keratinocytes. These results indicated that phloroglucinol attenuated UVB-induced 8-oxoG formation in keratinocytes via an Akt/Erk-dependent, Nrf2/Ogg1-mediated signaling pathway.