• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7701-7706
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• 2013

Background: In a prospective cohort study of antiemetic therapy conducted in Malaysia, a total of 94 patients received low emetogenic chemotherapy (LEC) with or without granisetron injections as the primary prophylaxis for chemotherapy-induced nausea and vomiting (CINV). This study is a retrospective cost analysis of two antiemetic regimens from the payer perspective. Materials and Methods: This cost evaluation refers to 2011, the year in which the observation was conducted. Direct costs incurred by hospitals including the drug acquisition, materials and time spent for clinical activities from prescribing to dispensing of home medications were evaluated (MYR 1=$0.32 USD). As reported to be significantly different between two regimens (96.1% vs 81.0%; p=0.017), the complete response rate of acute emesis which was defined as a patient successfully treated without any emesis episode within 24 hours after LEC was used as the main indicator for effectiveness. Results: Antiemetic drug acquisition cost per patient was 40.7 times higher for the granisetron-based regimen than for the standard regimen (MYR 64.3 vs 1.58). When both the costs for materials and clinical activities were included, the total cost per patient was 8.68 times higher for the granisetron-based regimen (MYR 73.5 vs 8.47). Considering the complete response rates, the mean cost per successfully treated patient in granisetron group was 7.31 times higher (MYR 76.5 vs 10.5). The incremental cost-effectiveness ratio (ICER) with granisetron-based regimen, relative to the standard regimen, was MYR 430.7. It was found to be most sensitive to the change of antiemetic effects of granisetron-based regimen. Conclusions: While providing a better efficacy in acute emesis control, the low incidence of acute emesis and high ICER makes use of granisetron as primary prophylaxis in LEC controversial.

• Journal of the Korea Society for Simulation
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• v.29 no.4
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• pp.85-94
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• 2020

In determining the feasibility of planning and launching railway transportation projects, various decision-making processes are essentially required. LCC(Life Cycle Cost) value including total construction cost and operation cost is estimated in approximation Model with rough guideline. In this study, modeling and simulation-based analysis method is proposed to support the decision making process of railroad transportation and derivation of LCC. Firstly, cost analysis model was constructed by collecting various existing rail transportation business data to enable analyze based on numerical data, and the result were analyzed by DOE(Design Of Experiments) and RSM (Response Surface Method) simulation. Professional commercial software tools were used for effective model construction and simulation. In order to verify the research results, the actual railroad transportation projects were selected, and the results of the analysis were compared.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2000.10a
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• pp.440-447
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• 2000

In order to evaluate the cost effectiveness of seismic isolation for bridges in low and moderate seismic region, a method of calculation minimum life-cycle cost of seismic-isolated bridges under specific acceleration level and soil condition is developed. Input ground motion is modeled as spectral density function compatible with response spectrum for combination of acceleration coefficient and site coefficient. Failure probability is calculated by spectrum analysis based on random vibration theories to simplify repetitive calculations in the minimization procedure. Ductility of piers and its effects on cost effectiveness are considered by stochastic linearization method. Cost function and cost effectiveness index are defined by taking into consideration the characteristics of seismic isolated bridges. Limit states for calculation of failure probability are defined on superstructure, isolator and pier, respectively. The results of example design and analysis show that seismic isolation is more cost-effective in low and moderate seismic region than in high seismic region.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.12
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• pp.2208-2212
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• 2008

This paper deals with the cost reduction design of a single-phase line-start permanent magnet(LSPM) motor. Due to high cost of the permanent magnet(PM), cost reduction can be effectively achieved by reducing PM volume. Therefore, motor characteristics according to the PM volume are calculated by using d-q axis equivalent circuit analysis, and the characteristic map is made. In the characteristic map, maximum torque and efficiency are shown according to motor parameters such as back electromotive force(back emf) and inductances; back emf represents the PM volume. Minimum back emf and inductances satisfying output performance are determined in the characteristic map. Then, motor geometry based on the prototype motor is optimized to get the determined parameters using response surface methodology(RSM) and finite element method(FEM). Through the presented cost reduction design, total PM volume is reduced to 32% of prototype model.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.27 no.1
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• pp.17-23
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• 2013

The BESS(Battery Energy Storage System) is an useful device for load leveling, but the high cost, installation space and safety issues are the main barriers for supplying it widely. The important factor in supplying BESS to customers successfully is the payback period. As most of the H/W cost factors are uncontrollable, the optimization of storage volume can be useful factor in improving payback period. In order to obtain optimized BESS volume, the load factor, demand ratio, peak shaving ratio, electric rates and benefits from DR participation of customer should be analyzed. In this paper, we could verify the peak cutting capability and cost effectiveness under the some proposed conditions and changing value of PCS and battery based on the customers data after volume optimization process was applied, and we can identified the saturation point of load factor and shortening of customer's payback period.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.10
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• pp.1561-1570
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• 1997

This study explores the treatment of the max-value cost function over a parameter interval in parametric optimization. To avoid the computational burden of the transformation treatment using an artificial variable, a direct treatment of the original max-value cost function is proposed. It is theoretically shown that the transformation treatment results in demanding an additional equality constraint of dual variables as a part of the Kuhn-Tucker necessary conditions. Also, it is demonstrated that the usability and feasibility conditions on the search direction of the transformation treatment retard convergence rate. To investigate numerical performances of both treatments, typical optimization algorithms in ADS are employed to solve a min-max steady-state response optimization. All the algorithm tested reveal that the suggested direct treatment is more efficient and stable than the transformation treatment. Also, the better performing of the direct treatment over the transformation treatment is clearly shown by constrasting the convergence paths in the design space of the sample problem. Six min-max transient response optimization problems are also solved by using both treatments, and the comparisons of the results confirm that the performances of the direct treatment is better than those of the tranformation treatment.

• Korean Journal of Clinical Pharmacy
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• v.26 no.1
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• pp.59-69
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• 2016

Background: The subcutaneous formulation of biologic disease-modifying antirheumatic drugs (DMARDs) was preferred due to favored self-administration and would be an economical treatment option for patients with rheumatoid arthritis. This study was to compare the economic impact of biologic DMARDs administered by subcutaneous injection in patients with rheumatoid arthritis who had inadequate response to conventional DMARDs. Methods: The cost-minimization analysis was conducted to estimate the lifetime health care costs of treatment sequences with subcutaneous biologic DMARDs as first-line therapy from a health care system perspective. The Markov model was developed to represent the transitions through treatment sequences based on American College of Rheumatology response rate and discontinuation rate. The health care costs comprised the cost of medications, administration, dispensing, outpatient visits, test/diagnostic examination, palliative therapy and treatment of serious infection. All costs were expressed in 2016 Korean Won (KRW) and discounted at 5%. Results: The mean lifetime health care cost per patient was lowest in the etanercept sequence, which was estimated at KRW 63,441,679. The incremental costs of the treatment sequence started with adalimumab, golimumab, abatacept, and tocilizumab were KRW 7,985,730, KRW 4,064,669, KRW 2,869,947, and KRW 4,282,833, respectively, relative to etanercept sequence. These differences in costs mainly were attributable to medication costs. One-way and probabilistic sensitivity analyses confirmed that etanercept represented the option with the lowest cost compared with comparators. Conclusion: This study found that etanercept is likely a cost-saving treatment option among subcutaneous biologic DMARDs in patients with rheumatoid arthritis.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.9
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• pp.71-77
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• 2020

In recent years, as a consequence of the technological advancements in the automobile industry and changes in consumer demands, the reduction of noise inside vehicles rather than vehicle performance has increasingly become an important factor of interest. To date, most studies have focused on noise and vibration reduction techniques for the engine and drive system of vehicles. In this research, a comparative analysis for reducing the effect of vehicle seatbelts on the transient response is performed using the test of vehicle conditions and transient response analysis in accordance with seatbelt conditions. After the sensitivity analysis, the specifications for improvement were designed based on the transient response analysis. It was confirmed that the transient response characteristics were improved by the transient response analysis and vehicle conditions test. Through computer-aided engineering, the transient response characteristics of seatbelts were checked with less cost and time.

• Korean Management Science Review
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• v.24 no.2
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• pp.73-80
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• 2007

Robust Design(RD) is a cost-effective methodology to determine the optimal settings of control factors that make a product performance insensitive to the influence of noise factors. To better facilitate the robust design optimization, a dual response surface approach, which models both the process mean and standard deviation as separate response surfaces, has been successfully accepted by researchers and practitioners. However, the construction of response surface approximations has been limited to problems with only a few variables, mainly due to an excessive number of experimental runs necessary to fit sufficiently accurate models. In this regard, an innovative response surface approach has been proposed to investigate robust design optimization problems with larger number of variables. Response surfaces for process mean and standard deviation are partitioned and estimated based on the multi-level approximation method, which may reduce the number of experimental runs necessary for fitting response surface models to a great extent. The applicability and usefulness of proposed approach have been demonstrated through an illustrative example.

• Journal of Electrical Engineering and Technology
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• v.9 no.3
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• pp.789-795
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• 2014

In a demand response (DR) market run by independent system operators (ISOs), load aggregators are important market participants who aggregate small retail customers through various DR programs. A load aggregator can minimize the allocation cost by efficiently allocating its demand response resources (DRRs) considering retail customers' characteristics. However, the uncertain response behaviors of retail customers can influence the allocation strategy of its DRRs, increasing the economic risk of DRR allocation. This paper presents a risk-based DRR allocation method for the load aggregator that takes into account not only the physical characteristics of retail customers but also the risk due to the associated response uncertainties. In the paper, a conditional value-at-risk (CVaR) is applied to deal with the risk due to response uncertainties. Numerical results are presented to illustrate the effectiveness of the proposed method.