• 제목/요약/키워드: Respiratory tract disease

검색결과 181건 처리시간 0.034초

The Role of Some Vitamins in Respiratory-related Viral Infections: A Narrative Review

  • Jae-Hee Park;Yunjung Lee;Mijoo Choi;Eunju Park
    • Clinical Nutrition Research
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    • 제12권1호
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    • pp.77-89
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    • 2023
  • This study aimed to find out the effect of vitamins on respiratory-related viral infections, including coronavirus disease 2019 (COVID-19), through the literature reviews. From January 2000 to June 2021, the studies (cohort studies, cross-sectional studies, case-control studies, randomized control trials) related to vitamins (vitamin A, D, E, C, B6, folate, and B12) and COVID-19/severe acute respiratory syndrome/Middle East respiratory syndrome/cold/influenza were selected from the PubMed, Embase, and Cochrane libraries and analyzed. The relationship between vitamins and virus-related respiratory diseases was identified. Through the review, 39 studies were selected on vitamin D, one study on vitamin E, 11 studies on vitamin C, and 3 studies on folate. Regarding COVID-19, 18 studies on vitamin D, 4 studies on vitamin C, and 2 studies on folate showed significant effects of the intake of these nutrients in preventing COVID-19. Regarding colds and influenza, 3 studies on vitamin D, 1 study on vitamin E, 3 studies on vitamin C, and 1 study on folate demonstrated that the intake of these nutrients significantly prevents these diseases. Therefore, this review suggested the intake of vitamins D, E, C, and folate is important for preventing respiratory diseases related to viruses, such as COVID-19, colds, and influenza. The relationship between these nutrients and virus-related respiratory diseases should be continuously monitored in the future.

임상 침법의 사상의학적 활용 (A Study on the Sasang Constitutional application of Clinical Acupuncture)

  • 유종향;김윤영;박기현;장은수;이시우
    • 한국한의학연구원논문집
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    • 제16권3호
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    • pp.15-22
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    • 2010
  • Objective : This study aims to search Four-constitution Medicine based acupuncture by investigators and its effect on constitution-specific symptoms. Method : Among 463 oriental medical doctors who are the members of society of Four-constitution Medicine, 191 results are collected. The items of the questionnaire are sex, age, work experiences, working type, constitution diagnosis & prescription, the use of constitution acupuncture and so on. Result : The proportion of acupuncture treatment applied constitution-based acupuncture to patients are "Must Use" 12.6%, "Almost Use" 14.1%, "Sometimes Use" 42.9% and "Never Use" is 1.0%. The average ratio of patients treated by constitution-based acupuncture to all patients is 47%. 1. Digestive tract disease is found to be the most effective disease with constitution based acupuncture. Musculoskelectal problems, cardiovascular disease, respiratory disease, neuropsychiatric disease and urogenital disease are followed. On the oriental medicine, spleen system disease is the most frequently applied and heart system disease, neuropsychiatric disease, liver system disease, locomotorium disease and pulmonary system disease are followed. 2. Acupuncture therapeutic measures are different according to disease. For example, Sa-am acupuncture is the most widely used for spleen system disease, locomotorium disease, heart system disease, neuropsychiatric disease, pulmonary system disease. Eight constitution medicine acupuncture is effective for ophthalmic & otolaryngologic disease. Conclusion : This study is to investigate constitution-based acupuncture technique. In conclusion, the most widely used technique is Sa-am acupuncture and it is the most successful in treating digestive tract disease.

폐쇄성 수면 무호흡증과 간질성 폐질환 (Obstructive Sleep Apnea in Interstitial Lung Disease)

  • 김신범;이상학;강현희
    • 수면정신생리
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    • 제24권1호
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    • pp.19-23
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    • 2017
  • Obstructive sleep apnea is a common disorder in which respiratory flow decreases or disappears despite respiratory effort due to occlusion of the upper respiratory tract during sleep. Oxidative stress and systemic inflammatory reaction induced by the obstruction cause complications such as hypertension, coronary artery disease, and diabetes and increase cancer incidence. Furthermore, in patients with interstitial lung disease, obstructive sleep apnea has a very high prevalence and is thought to have a close pathophysiological and clinical correlation. In other words, obstructive sleep apnea could be the cause or a complication of interstitial lung disease ; when these two afflictions coexist, the prognosis of the patient is worse. In patients with interstitial lung disease with obstructive sleep apnea, CPAP treatment significantly improved sleep and quality of life, as well as improved morbidity and mortality in a recent study. Therefore, early diagnosis and treatment of obstructive sleep apnea in patients with interstitial lung disease are very important, and additional studies designed to include patients with idiopathic pulmonary fibrosis as well as patients with advanced interstitial lung disease should be performed.

소아 human bocavirus의 임상적 고찰 (Clinical manifestation of human bocavirus infection in children)

  • 최창선;박찬희;정권;이건;선규근;김은영;김경심;김용욱;서진종;정윤석
    • Pediatric Infection and Vaccine
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    • 제14권2호
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    • pp.136-144
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    • 2007
  • 목 적 : 호흡기 감염의 중요 바이러스 중에 하나인 보카바이러스는 2005년 8월, 스웨덴의 Allander 등에 의해 처음 보고된 이후 전세계적으로 보고되고 있지만, 국내 보고는 드문 실정이다. 이에 저자들은 급성 호흡기 질환으로 입원한 환아들을 대상으로 보카바이러스의 유병률 및 임상양상에 대해 알아보고자 본 연구를 실시하였다. 방 법 : 2005년 4월부터 2006년 5월까지 광주기독병원에 입원한 호흡기 질환 환아 1,777명의 입원 중 비인두 흡인물을 채취하였고, PCR을 시행하였고, 보카바이러스가 검출된 84명의 환아들의 임상 기록지를 후향적으로 검토하여 이들의 검출률과 임상 증상 및 검사 소견을 조사였다. 결 과 : 총 1,777명의 의뢰 환아 중 84명(4.7%)에서 보카바이러스가 검출되었으며, 평균연령은 1세 7개월이었고, 2세 이하에서 전체 검출 84명 중 64명을 차지(76.2%)하였으며, 남녀비는 1.04:1로 큰 차이는 없는 것으로 나타났다. 2005년 4월에서 6월, 11월과 12월, 2006년 4-5월에 집중적으로 검출된 것으로 보아 겨울과 봄에 호발하는 것을 알 수 있다. 진단별로는 폐렴이 67.8%으로 가장 많았으며, 모세기관지염이 35.7%, 기관지염 27.3%, 급성 인두염 21.4%의 순으로 나타났다. 임상 증상으로는 기침이 94.0%, 가래 83.3%, 발열 78.5%, 콧물 69.0%, 인후통 27.3%, 호흡 곤란 및 빈호흡 22.6%, 설사 20.2%, 구토 9.5%, 이통 5.9%, 눈꼽 4.7%순 이었으며, 평균 발열 기간은 4.7일, 기침 지속 기간 15.5일, 평균 재원 기간 9.4일을 보였다. 신체 검사상 나음 65.4%, 천명 59.5%, 흉부 함몰 22.6%, 고막 발적 9.5%, 결막충혈 3.5%, 피부발진 2.3%이 나타났다. 흉부 방사선 소견상 상 폐문 주위 간질 침윤 58%, 과도통기 47%에서 보였으며, 말초 혈액 검사상 백혈구는 $9,400/mm^3$, 다핵구 41.7 (8.7-91)%, 림프구 44.3 (5-82.4)%, 적혈구 침강 속도는 33 (2-120) mm/hr, C반응 단백은 3.5 (0.1-10) mg/dL이었다. 결 론 : 보카바이러스는 소아 하기도 감염의 비교적 흔한 원인이며 위장관 및 피부 증상도 유발할 수 있는 것으로 생각되며, 입원이 요구되는 주로 2세 이하 영유아 호흡기 감염의 중요한 원인 바이러스 중 하나로, 겨울과 봄에 호발하며, 폐렴을 주로 일으키는 것으로 나타났다. 또한, 연령이 낮을수록, 천식을 포함한 기저질환 동반시 증상이 심해지는 경향이 있었다. 따라서, 보카바이러스와 관련된 호흡기 및 기타 질환의 진단과 치료를 위해서는 더 많은 환자들을 대상으로 조속한 연구가 필요할 것으로 생각된다.

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바이러스성 하기도 감염 환자에서 간기능 이상과 중증도와의 연관성에 관한 연구 (A study about the relation between elev ated transaminase lev el and severity of viral lower respiratory tract infection in children)

  • 이철희;신선희;이정원;성태정;김성구;이규만
    • Pediatric Infection and Vaccine
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    • 제14권1호
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    • pp.47-54
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    • 2007
  • 목 적 : 소아의 바이러스에 의한 급성 하기도 감염시간기능 이상을 동반하는 경우가 많다. 저자들은 바이러스성 하기도 감염시 간기능 이상이 질병의 중증도에 미치는 영향과 원인 바이러스, 연령별 분포에 대하여 알아보고자 본 연구를 시행하였다. 방 법 : 2003년 1월부터 2005년 6월까지 급성 하기도 감염으로 한림대학교 강남성심병원 소아과에 입원한 환아들의 비인두 분비물을 Hep-2세포를 이용하여 배양하였으며 의무기록지를 후향적으로 검토하였다. 비말 흡인 검사를 통한 바이러스 배양검사에서 양성결과가 나온 환아를 환자군(AST 혹은 ALT >45)과 대조군(AST 혹은 ALT ${\leq}45$)으로 나누어 연령, 성별, 진단명, 발열 기간, RR(Respiratory Rate)점수, RDAI(Respiratory Distress Assessment Instrument)점수, 산소흡입 여부, 입원 기간 등과 원인바이러스를 비교 분석하였다. 결 과 : 바이러스가 검출된 181례 중에서 기저 질환이 동반되거나 간독성 약제를 복용한 16례는 제외되었고, 환자군이 28례(17.0%), 대조군이 137례(83.0%)였다. 환자군과 대조군에서 연령, 성별 간에 유의한 차이는 없었으며 발열 기간, RR score, RDAI score, 산소흡입 여부, 입원 기간 등의 임상양상에서 유의한 차이점은 없는 것으로 나타났다(P>0.05). 바이러스 배양 결과 환자군에서는 RSV 17례(60.7%), parainfluenza virus 4례(14.3%), influenza B virus 4례(14.3%), adenovirus 3례(10.7%), influenza A virus 1례(3.6%)였고 대조군에서는 RSV 78례(56.9%) parainfluenza virus 28례(20.4%), influenza A virus 13례(9.5%), influenza B virus 9례(6.6%), adenovirus 6례(4.4%), coxsackie virus 3례(2.2%)로 양 군 간에 의미있는 차이는 없었으며 연령별 분포에서도 양 군 간에 큰 차이는 없었다. 결 론 : 본 연구에서 호흡기 바이러스 감염으로 진단된 환아 165례 중 환자군이 28례(17.0%)였고 대조군과의 비교 분석 결과 간기능 이상이 병의 중증도와 임상양상에 큰 영향을 미치지 않으며 원인 바이러스와 연령별분포 경향에서도 큰 차이는 없는 것으로 나타났다.

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면역글로부린의 수준변화에 따른 신생송아지의 건강상태에 관한 연구 (Study on the Health Condition of Newbron Beef Calves According to Their Serum Ig Levels)

  • 김정우
    • 한국가축번식학회지
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    • 제11권2호
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    • pp.112-121
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    • 1987
  • After a detailed review of the literature availabe on the problems of immunoglobulin level in colostrum and blood serum of calves and after a discussion of its impact on health condition, the following investigations on this subject are presented. 1. Calves to fail ill in the rearing period show significantly lower serum Ig levels even during the first two days of life, when they are still clinically healthy, as well as up to the end of the first week of life than those of calves remaining in good health. 2. Ig values sharply rise during the disease period, IgA and IgM responding more rapidly than IgG. 3. In calves suffering from a disease of the gastrointestinal tract serum IgM titer is lowest, while in calves suffering from a disease of the respiratory duct serum IgA titer is lowest and in those suffering or dying from both disease complexes all Ig titers are reduced. 4. Calves showing high serum Ig levels during the first three days of life reveal higher daily gains in weight than those with lower serum Ig levels during that period.

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미만성 기관지 침범으로 발현한 재발성 다발성 연골염 1예 (A Case of Relapsing Polychondritis Presenting As a Diffuse Tracheobronchial Tree Involvement)

  • 황진수;박지현;류완희;이홍범;이용철;이양근
    • Tuberculosis and Respiratory Diseases
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    • 제46권6호
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    • pp.861-868
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    • 1999
  • 재발성 다발성 연골염은 전신 연골에 염증반응을 특징으로 하는 드문 전신 질환으로, 대개 외이나 비부의 연골 침범이 가장 흔한 증상이나, 이러한 특징적 증상 없이 기도에 연골염의 형태로 발현하는 경우도 드물게 보고되어 있다. 저자들은 최근 64세 남자에서 흔히 발생하는 연골의 침범에 의한 전형적인 증상없이 미만성 기도 연골 침범으로 발현한 재발성 다발성 연골염 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

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Sputum Processing Method for Lateral Flow Immunochromatographic Assays to Detect Coronaviruses

  • Aram Kang;Minjoo Yeom;Hyekwon Kim;Sun-Woo Yoon;Dae-Gwin Jeong;Hyong-Joon Moon;Kwang-Soo Lyoo;Woonsung Na;Daesub Song
    • IMMUNE NETWORK
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    • 제21권1호
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    • pp.11.1-11.10
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    • 2021
  • Coronavirus causes an infectious disease in various species and crosses the species barriers leading to the outbreak of zoonotic diseases. Due to the respiratory diseases are mainly caused in humans and viruses are replicated and excreted through the respiratory tract, the nasal fluid and sputum are mainly used for diagnosis. Early diagnosis of coronavirus plays an important role in preventing its spread and is essential for quarantine policies. For rapid decision and prompt triage of infected host, the immunochromatographic assay (ICA) has been widely used for point of care testing. However, when the ICA is applied to an expectorated sputum in which antigens are present, the viscosity of sputum interferes with the migration of the antigens on the test strip. To overcome this limitation, it is necessary to use a mucolytic agent without affecting the antigens. In this study, we combined known mucolytic agents to lower the viscosity of sputum and applied that to alpha and beta coronavirus, porcine epidemic diarrhea virus (PEDV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively, spiked in sputum to find optimal pretreatment conditions. The pretreatment method using tris(2-carboxyethyl)phosphine (TCEP) and BSA was suitable for ICA diagnosis of sputum samples spiked with PEDV and MERS-CoV. This sensitive assay for the detection of coronavirus in sputum provides an useful information for the diagnosis of pathogen in low respiratory tract.

Surgical Treatment of Bronchobiliary Fistula with Pulmonary Resection and Omentopexy

  • Joh, Hyon Keun;Park, Seong Yong
    • Journal of Chest Surgery
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    • 제53권1호
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    • pp.38-40
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    • 2020
  • Bronchobiliary fistula is a rare disease defined as an abnormal connection between the biliary tract and the bronchial tree. We report the successful surgical repair of bronchobiliary fistula. A 78-year-old man underwent surgery and several rounds of transcatheter arterial chemoembolization and radiofrequency ablation as treatment for hepatocellular carcinoma. He presented with greenish sputum and chronic cough for several months, and his symptoms did not resolve after endoscopic treatment. We performed lobectomy of the right lower lobe and omentopexy for bronchobiliary fistula under laparotomy and thoracotomy. The bronchobiliary fistula was successfully closed, and the bilious sputum disappeared after surgery.

Exploring the Association of Bacterial Coinfections with Clinical Characteristics of Patients with Nontuberculous Mycobacterial Pulmonary Disease

  • Seong Mi Moon;Hyunkyu Cho;Beomsu Shin
    • Tuberculosis and Respiratory Diseases
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    • 제87권4호
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    • pp.505-513
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    • 2024
  • Background: Clinical data for bacterial coinfection of the lower respiratory tract in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) are scarce. This study aims to assess the prevalence of bacterial coinfection and clinical features in NTM-PD patients. Methods: This retrospective study screened 248 patients with NTM-PD who underwent bronchoscopy between July 2020 and July 2022, from whom newly diagnosed NTM-PD patients were analyzed. Bacterial culture using bronchial washing fluid was performed at the time of NTM-PD diagnosis. Results: In the 180 patients (median age 65 years; 68% female), Mycobacterium avium complex (86%) was the most frequent NTM isolated. Bacterial coinfections were detected in 80 (44%) patients. Among them, the most common bacterium was Klebsiella pneumoniae (n=25/80, 31.3%), followed by Pseudomonas aeruginosa (n=20/80, 25%) and Staphylococcus aureus (n=20/80, 25%). Compared with NTM-PD patients without bacterial coinfections, patients with bacterial coinfections showed more frequent extensive lung involvement (33% vs. 1%, p<0.001). Additionally, compared with NTM-PD patients without P. aeruginosa infection, those with P. aeruginosa infection were older (74 years vs. 64 years, p=0.001), had more frequent respiratory symptoms (cough/excessive mucus production 70% vs. 38%, p=0.008; dyspnea 30% vs. 13%, p=0.047), and had extensive lung involvement (60% vs. 9%, p<0.001). Conclusion: Less than half of patients with newly diagnosed NTM-PD had bacterial coinfections, linked to extensive lung involvement. Specifically, P. aeruginosa coinfection was significantly associated with older age, more frequent respiratory symptoms, and extensive lung involvement.